Structural features of endocrine active chemicals - A comparison of in vivo and in vitro data

Reproductive Toxicology

Volumn 55, Issue , 2015, Pages 81-94

  Lewin, Geertje ^a   Escher, Sylvia E ^a   van der Burg, Bart ^b   Simetska, Nelly ^a   Mangelsdorf, Inge ^a  

^a FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^b BIODETECTION SYSTEMS B V   (Netherlands)

Author keywords

Category approach; Estrogen receptor; Predictive screening; Reproductive toxicity; Structural features; Toxicological databases

Indexed keywords

ALDEHYDE DERIVATIVE; ALIPHATIC COMPOUND; ALKANE DERIVATIVE; ALKANOL; AMIDE; ANILINE; AROMATIC NITRO COMPOUND; BENZOIC ACID DERIVATIVE; BENZOPHENONE; CARBOXYLIC ACID; CHLORPHENOTANE; CYCLOSPORIN; DEXTRIN; DIETHYLSTILBESTROL; DIPHENYL ETHER; HALOOLEFIN; IMIDAZOLE DERIVATIVE; KETONE DERIVATIVE; NAPHTHALENE DERIVATIVE; PHENOL DERIVATIVE; PHOSPHOROTHIOIC ACID DERIVATIVE; PHTHALIC ACID DERIVATIVE; POLYCHLORINATED BIPHENYL; PYRIDINE DERIVATIVE; SILOXANE; STEROID; TEREPHTHALIC ACID; TRIAZINE DERIVATIVE; UNINDEXED DRUG; UREA DERIVATIVE; ANDROGEN RECEPTOR; ENDOCRINE DISRUPTOR; ESTROGEN RECEPTOR ALPHA;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; COMPARATIVE STUDY; DEVELOPMENTAL TOXICITY; ENDOCRINE FUNCTION; FEMALE GENITAL SYSTEM; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MALE GENITAL SYSTEM; NONHUMAN; PRENATAL DEVELOPMENT; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REPRODUCTIVE TOXICITY; TOXICITY TESTING; TOXICOKINETICS; ANIMAL; CHEMISTRY; DRUG EFFECTS; FACTUAL DATABASE; FEMALE; MALE; METABOLISM; MOUSE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PROCEDURES; RABBIT; RAT; REPRODUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

ANIMALS; DATABASES, FACTUAL; ENDOCRINE DISRUPTORS; ESTROGEN RECEPTOR ALPHA; FEMALE; MALE; MICE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; RABBITS; RATS; RECEPTORS, ANDROGEN; REPRODUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TOXICITY TESTS;

EID: 84937943256     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2014.10.009     Document Type: Article

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