Comparison of the reporter gene assay for ER-alpha antagonists with the immature rat uterotrophic assay of 10 chemicals

Toxicology Letters

Volumn 142, Issue 1-2, 2003, Pages 119-131

  Yamasaki, Kanji ^a   Takeyoshi, Masahiro ^a   Yakabe, Yoshikuni ^a   Sawaki, Masakuni ^a   Takatsuki, Mineo ^a  

^a CHEMICALS EVALUATION AND RESEARCH INSTITUTE   (Japan)

Author keywords

Agonist; Antagonist; Endocrine; Estrogen effect; Rat; Receptor gene assay; Uterotrophic assay

Indexed keywords

2,2 BIS(4 HYDROXYPHENYL) 4 METHYL N PENTANE; 2,2',4,4' TETRAHYDROXYBENZOPHENONE; 2,4,4' TRIHYDROXYBENZOPHENONE; 4 (PHENYLMETHYL)PHENOL; 4 (TERT PENTYL)PHENOL; 4 HYDROXYBENZOPHENONE; 4,4' (HEXAFLUOROISOPROPYLIDENE)BISPHENOL; 4,4' (OCTAHYDRO 4,7 METHANO 5H INDEN 5 YLIDENE)BISPHENOL; 4,4' DIHYDROXYBENZOPHENONE; 4,4' THIOBISPHENOL; ESTROGEN RECEPTOR ALPHA; ETHINYLESTRADIOL; PHENOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; ASSAY; COMPARATIVE STUDY; ESTROGEN ACTIVITY; GENETIC ANALYSIS; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE;

EID: 0037473416     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(03)00019-5     Document Type: Article

References (13)

1. Boffelli D., Zajchowski D.A., Yang Z., Lawn R.M. Estrogen modulation of polipoprotein(a) expression. Identification of a regulatory element. J. Biol. Chem. 274:1999;15569-15574.
2. Legler J., van den Brink C.E., Brouwer A., Murk A.J., van der Saag P.T., Vethaak A.D., van der Burg B. Development of a stably transfected estrogen receptor-mediated luciferase reporter gene assay in the human T47D breast cancer cell line. Toxicol. Sci. 48:1999;55-66.
3. McLachlan J.A. Functional toxicology: a new approach to detect functionally active xenobiotics. Environ. Health Perspect. 101:1993;386-387.
4. McLachlan J.A., Korach K.S. Estrogens in the environment global health implications. Environ. Health Perspect. 103:(Suppl. 7):1995;3-4.
5. Miller S., Kennedy D., Thomson J., Han F., Smith R., Ing N., Piedrahita J., Busbee D. A rapid and sensitive reporter gene that uses green fluorescent protein expression to detect chemicals with estrogenic activity. Toxicol. Sci. 55:2000;69-77.
6. Nakai M., Tabira Y., Asai D., Yakabe Y., Shimyozu T., Noguchi M., Takatsuki M., Shimohigashi Y. Binding characteristics of dialkyl phtalates for the estrogen receptor. Biochem. Biophys. Res. Commun. 254:1999;311-314.
7. Nishihara T., Nishikawa J., Kanayama T., Dakeyama F., Saito K., Imagawa M., Takatori S., Kitagawa Y., Hori S., Utsumi H. Estrogenic activities of 517 chemicals by yeast two-hybrid assay. J. Health Sci. 46:2000;282-298.
8. Organisation for Economic Cooperation and Development (OECD), 2001. Third meeting of the validation management group for the screening and testing of endocrine disupters (mammalian effects), Joint meeting of the chemicals committee and the working party on chemicals, pesticides and biotechnology.
9. Organisation for Economic Cooperation and Development (OECD), 2002. Sixth meeting of the task force on endocrine disrupters testing and assessment: special session on frameworks for the testing and assessment of endocrine disrupters and sharing of the work, Joint meeting of the chemicals committee and the working party on chemicals, pesticides and biotechnology.
10. Rogers J.M., Denison M.S. Recombinant cell bioassays for endocrine disruptors: development of a stably transfected human ovarian cell line for the detection of estrogenic and anti-estrogenic chemicals. In Vitro Mol. Toxicol. 13:2000;67-82.
11. Yamasaki K., Takeyoshi M., Yakabe Y., Sawaki M., Imatanaka N., Takatsuki T. Comparison of reporter gene assay and immature rat uterotrophic assay of twenty-three chemicals. Toxicology. 170:2002;21-30.
12. Yamasaki K., Takeyoshi M., Sawaki M., Imatanaka N., Takatsuki M. Immature rat uterotrophic assay of eighteen chemicals and Hershberger assay of thirty chemicals. Toxicology. 183:2003;95-113.
13. Zhang Z., Teng C.T. Estrogen receptor-related receptor alpha 1 interacts with coactivator and constitutively activates the estrogen response elements of the human lactoferrin gene. J. Biol. Chem. 275:2000;20837-20846.