Polyphenol-rich extract of Pimenta dioica berries (Allspice) kills breast cancer cells by autophagy and delays growth of triple negative breast cancer in athymic mice

Oncotarget

Volumn 6, Issue 18, 2015, Pages 16379-16395

  Zhang, Lei ^a   Shamaladevi, Nagarajarao ^b   Jayaprakasha, Guddadarangavvanahally ^c   Patil, Bhimu S ^c   Lokeshwar, Bal L ^a,b,d  

^a UNIVERSITY OF MIAMI   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c TEXAS A AND M UNIVERSITY   (United States)

^d Research Service Bruce Carter Memorial Veterans Health Administration Medical Center   (United States)

Author keywords

Autophagy; Breast cancer; Chemo dietary cancer prevention; Chemoprevention; mTOR signaling

Indexed keywords

ALLSPICE EXTRACT; ANTINEOPLASTIC AGENT; MAMMALIAN TARGET OF RAPAMYCIN; PLANT EXTRACT; PROTEIN KINASE B; RAPAMYCIN; UNCLASSIFIED DRUG; ATG5 PROTEIN, HUMAN; ATG7 PROTEIN, HUMAN; AUTOPHAGY RELATED PROTEIN 5; AUTOPHAGY RELATED PROTEIN 7; MAP1LC3B PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; MTOR PROTEIN, HUMAN; SMALL INTERFERING RNA; TARGET OF RAPAMYCIN KINASE; UBIQUITIN PROTEIN LIGASE;

ALLSPICE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; BREAST CANCER CELL LINE; CANCER INHIBITION; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG EFFICACY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; TRIPLE NEGATIVE BREAST CANCER; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; DRUG EFFECTS; DRUG SCREENING; GENETICS; MCF-7 CELL LINE; METABOLISM; NUDE MOUSE; PIMENTA; RANDOMIZATION; RNA INTERFERENCE; TRIPLE NEGATIVE BREAST NEOPLASMS; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; AUTOPHAGY; AUTOPHAGY-RELATED PROTEIN 5; AUTOPHAGY-RELATED PROTEIN 7; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; HETEROGRAFTS; HUMANS; MCF-7 CELLS; MICE; MICE, NUDE; MICROTUBULE-ASSOCIATED PROTEINS; PIMENTA; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-AKT; RANDOM ALLOCATION; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRIPLE NEGATIVE BREAST NEOPLASMS; UBIQUITIN-ACTIVATING ENZYMES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84937931043     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3834     Document Type: Article

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