Inhibitory effect of Phyllanthus urinaria L. extract on the replication of lamivudine-resistant hepatitis B virus in vitro

BMC Complementary and Alternative Medicine

Volumn 15, Issue 1, 2015, Pages

  Jung, Jaesung ^a   Kim, Nam Keun ^b   Park, Sun ^a   Shin, Ho Joon ^a   Hwang, Seong Gyu ^b   Kim, Kyongmin ^a  

^a Ajou University School of Medicine   (South Korea)

^b CHA University   (South Korea)

Author keywords

Hepatitis B virus DNA synthesis; Lamivudine resistant HBV; Phyllanthus extract

Indexed keywords

BETA INTERFERON; CORILAGIN; CYCLOOXYGENASE 2; GALLIC ACID; GERANIIN; HEPATITIS B CORE ANTIGEN; HEPATITIS B SURFACE ANTIGEN; INTERLEUKIN 6; LAMIVUDINE; MESSENGER RNA; MYELOID DIFFERENTIATION FACTOR 88; PHYLLANTHUS URINARIA EXTRACT; PLANT EXTRACT; QUERCETIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; VIRUS DNA; ANTIVIRUS AGENT;

ANTIGEN DETECTION; ARTICLE; CELL VIABILITY; CHRONIC HEPATITIS B; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVE SITE; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN EXPRESSION; PROTEIN SECRETION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; STRUCTURAL GENE; TIME OF FLIGHT MASS SPECTROMETRY; VIRUS REPLICATION; ANTIVIRAL RESISTANCE; CHEMISTRY; DRUG EFFECTS; HEP-G2 CELL LINE; PHYLLANTHUS;

ANTIVIRAL AGENTS; DRUG RESISTANCE, VIRAL; HEP G2 CELLS; HEPATITIS B VIRUS; HUMANS; LAMIVUDINE; PHYLLANTHUS; PLANT EXTRACTS;

EID: 84937927572     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/s12906-015-0792-3     Document Type: Article

References (58)

1. Brechot C. Pathogenesis of hepatitis B virus-related hepatocellular carcinoma: old and new paradigms. Gastroenterology. 2004;127:S56-61.
2. Chisari FV, Isogawa M, Wieland SF. Pathogenesis of hepatitis B virus infection. Pathol Biol. 2010;58:258-66.
3. Guidotti LG, Chisari FV. Immunobiology and pathogenesis of viral hepatitis. Annu Rev Pathol. 2006;1:23-61.
4. Seeger C, Ganem D, Harold EV. Biochemical and genetic evidence for the hepatitis B virus replication strategy. Science. 1986;232:477-84.
5. Dienstag JL. Hepatitis B Virus Infection. N Engl J Med. 2008;359:1486-500.
6. Delaney WE, Yang H, Westland CE, Das K, Arnold E, Gibbs CS, et al. The hepatitis B virus polymerase mutation rtV173L is selected during lamivudine therapy and enhances viral replication in vitro. J Virol. 2003;77:11833-41.
7. Shaw T, Bartholomeusz A, Locarnini S. HBV drug resistance: mechanisms, detection and interpretation. J Hepatol. 2006;44:593-606.
8. Zoulim F, Locarnini S. Hepatitis B Virus Resistance to Nucleos(t)ide Analogues. Gastroenterology. 2009;137:1593-608.
9. Ono-Nita SK, Kato N, Shiratori Y, Masaki T, Lan KH, Carrilho FJ, et al. YMDD Motif in Hepatitis B Virus DNA Polymerase Influences on Replication and Lamivudine Resistance: A Study by In Vitro Full-Length Viral DNA Transfection. Hepatology. 1999;29:939-45.
10. Niesters HG, De Man RA, Pas SD, Fries E, Osterhaus AD. Identification of a new variant in the YMDD motif of the hepatitis B virus polymerase gene selected during lamivudine therapy. J Med Microbiol. 2002;51:695-9.
11. Bozdayi AM, Uzunalimoglu O, Turkyilmaz AR, Aslan N, Aslan N, Sezgin O, et al. YSDD: a novel mutation in HBV DNA polymerase confers clinical resistance to lamivudine. J Viral Hepat. 2003;10:256-65.
12. Ogata N, Fujii K, Takigawa S, Nomoto M, Ichida T, Asakura H. Novel patterns of amino acid mutations in the hepatitis B virus polymerase in association with resistance to lamivudine therapy in japanese patients with chronic hepatitis B. J Med Virol. 1999;59:270-6.
13. Chong Y, Stuyver L, Otto MJ, Schinazi RF, Chu CK. Mechanism of antiviral activities of 3′-substituted L-nucleosides against 3TC resistant HBV polymerase: a molecular modelling approach. Antivir Chem Chemother. 2003;14:309-19.
14. Villeneuve J-P, Durantel D, Durantel S, Westland C, Xiong S, Brosgart CL, et al. Selection of a hepatitis B virus strain resistant to adefovir in a liver transplantation patient. J Hepatol. 2003;39:1085-9.
15. Lee YS, Chung YH, Kim JA, Kim SE, Shin JW, Kim KM, et al. Hepatitis B virus with rtL80V/I mutation associates with poor response to adefovir dipivoxil therapy. Liver Int. 2009;29:552-6.
16. Tenney DJ, Levine SM, Rose RE, Walsh AW, Weinheimer SP, Discotto L, et al. Clinical emergence of entecavir-resistant hepatitis B virus requires additional substitutions in virus already resistant to Lamivudine. Antimicrob Agents Chemother. 2004;48:3498-507.
17. Yanni YN, Henry LY. A review of telbivudine for the management of chronic hepatitis B virus infection. Drug Eval. 2008;4:1351-61.
18. Yuen MF, Lai CL. Adefovir dipivoxil in chronic hepatitis B infection. Expert Opin Pharmacother. 2004;5:2361-7.
19. Van Bömmel F, Zöllner B, Sarrazin C, Spengler U, Hüppe D, Möller B, et al. Tenofovir for patients with lamivudine-resistant hepatitis B virus (HBV) infection and high HBV DNA level during adefovir therapy. Hepatology. 2006;44:318-25.
20. Delmas J, Schorr O, Jamard C, Gibbs C, Trépo C, Hantz O, et al. Inhibitory effect of adefovir on viral DNA synthesis and covalently closed circular DNA formation in duck hepatitis B virus-infected hepatocytes in vivo and in vitro. Antimicrob Agents Chemother. 2002;46:425-33.
21. King RW, Ladner SK, Miller TJ, Zaifert K, Perni RB, Conway SC, et al. Inhibition of human hepatitis B virus replication by AT-61, a phenylpropenamide derivative, alone and in combination with (-)b-L- 2′,3′-dideoxy-3′-thiacytidine. Antimicrob Agents Chemother. 1998;42:3179-86.
22. Delaney WE, Edwards R, Colledge D, Shaw T, Furman P, Painter G, et al. Phenylpropenamide derivatives AT-61 and AT-130 inhibit replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro. Antimicrob Agents Chemother. 2002;46:3057-60.
23. Wang GF, Shi LP, Zuo JP. Anti-hepatitis B virus drugs in clinical and preclinical development. Virol Sin. 2008;2:137-45.
24. Weber O, Schlemmer KH, Hartmann E, Hagelschuer I, Paessens A, Graef E, et al. Inhibition of human hepatitis B virus (HBV) by a novel non-nucleosidic compound in a transgenic mouse model. Antiviral Res. 2002;54:69-78.
25. Deres K, Schroder CH, Paessens A, Goldmann S, Hacker HJ, Weber O, et al. Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids. Science. 2003;299:893-6.
26. Weinberg MS, Arbuthnot P. Progress in the use of RNA interference as a therapy for chronic hepatitis B virus infection. Genome Med. 2010;2:28-34.
27. Ely A, Naidoo T, Mufamadi S, Crowther C, Arbuthnot P. Expressed anti-HBV primary microRNA shuttles inhibit viral replication efficiently in vitro and in vivo. Mol Ther. 2008;16:1105-12.
28. Iwamoto M, Watashi K, Tsukuda S, Aly HH, Fukasawa M, Fujimoto A, et al. Evaluation and identification of hepatitis B virus entry inhibitors using HepG2 cells overexpressing a membrane transporter NTCP. Biochem Biophys Res Commun. 2014;17:808-13.
29. Wang GF, Shia LP, Ren YD, Liu QF, Liu HF, Zhang RJ, et al. Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro. Antiviral Res. 2009;83:186-90.
30. Kim HJ, Yoo HS, Kim JC, Park CS, Choi MS, Kim M, et al. Antiviral effect of Curcuma longa Linn extract against hepatitis B virus replication. J Ethnopharmacol. 2009;124:189-96.
31. Zhao G, Yin Z, Dong J. Antiviral efficacy against hepatitis B virus replication of oleuropein isolated from Jasminum officinale L. var. grandiflorum. J. J Ethnopharmacol. 2009;125:265-8.
32. Shuangsuo D, Zhengguo Z, Yunru C, Xin Z, Baofeng W, Lichao Y, et al. Inhibition of the replication of hepatitis B virus in vitro by emodin. Med Sci Monit. 2006;12:BR302-6.
33. Wu XN, Wang GJ. Experimental studies of oxymatrine and its mechanisms of action in hepatitis B and C viral infections. Chin J Dig Dis. 2004;5:12-6.
34. Guo Q, Zhao L, You Q, Yang Y, Gu H, Song G, et al. Anti-hepatitis B virus activity of wogonin in vitro and in vivo. Antiviral Res. 2007;74:16-24.
35. Penolazzi L, Lampronti I, Borgatti M, Khan MT, Zennaro M, Piva R, et al. Induction of apoptosis of human primary osteoclasts treated with extracts from the medicinal plant Emblica officinalis. BMC Complement Altern Med. 2008;30(8):59.
36. Kusirisin W, Srichairatanakool S, Lerttrakarnnon P. Antioxidative activity, polyphenolic content and anti-glycation effect of some Thai medicinal plants traditionally used in diabetic patients. Med Chem. 2009;5:139-47.
37. Ogata T, Higuchi H, Mochida S. HIV-1 reverse transcriptase inhibitor from Phyllanthus niruri. AIDS Res Hum Retroviruses. 1992;8:1937-44.
38. Venkateswaran PS, Millman I, Blumberg BS. Effect of extract from Phyllanthus niruri on hepatitis B and woodchuck hepatitis Viruses: In vitro and in vivo studies. Proc Natl Acad Sci U S A. 1987;84:274-8.
39. Ott M, Thyagarajan SP, Gupta S. Phyllanthus amarus suppresses hepatitis B virus by interrupting interactions between HBV enhancer I and cellular transcription factors. Eur J Clin Invest. 1997;27:908-15.
40. Lee CD, Ott M, Thyagarajan SP, Shafritz DA, Burk RD, Gupta S. Phyllanthus amarus down-regulates hepatitis B virus mRNA transcription and replication. Eur J Clin Invest. 1996;26:1069-76.
41. Lam WY, Leung KT, Law PT, Lee SM, Chan HL, Fung KP, et al. Antiviral Effect of Phyllanthus nanus Ethanolic Extract Against Hepatitis B Virus (HBV) by Expression Microarray Analysis. J Cell Biochem. 2006;97:795-812.
42. Shin MS, Kang EH, Lee YI. A flavonoid from medicinal plants blocks hepatitis B virus-e antigen secretion in HBV-infected hepatocytes. Antiviral Res. 2005;67:163-8.
43. Kim HY, Park GS, Kim EG, Kang SH, Shin HJ, Park S, et al. Oligomer synthesis by priming deficient polymerase in hepatitis B virus core particle. Virology. 2004;322:22-30.
44. Mahdi ES, Noor AM, Sakeena MH, Abdullah GZ, Abdulkarim M, Sattar MA. Identification of phenolic compounds and assessment of in vitro antioxidants activity of 30 % ethanolic extracts derived from two Phyllanthus species indigenous to Malaysia. Afr J Pharm Pharmacol. 2011;5:1967-78.
45. Calixto JB, Santos AR, Cechinel Filho V, Yunes RA. A review of the plants of the genus Phyllanthus: their chemistry, pharmacology, and therapeutic potential. Med Res Rev. 1998;18:225-58.
46. Kim H-Y, Eo E-Y, Park HP, Kim YC, Park S, Shin HJ, et al. Medicinal herbal extracts of Sophorae radix, Acanthopanacis cortex, Sanguisorbae radix and Torilis fructus inhibit coronavirus replication in vitro. Antivir Ther. 2010;15:697-709.
47. Sharma M, Anderson SA, Schoop R, Hudson JB. Induction of multiple pro-inflammatory cytokines by respiratory viruses and reversal by standardized Echinacea, a potent antiviral herbal extract. Antiviral Res. 2009;83:165-70.
48. Keskinen P, Nyqvist M, Sareneva T, Pirhonen J, Melean K, Julkunen I. Impaired Antiviral Response in Human Hepatoma Cells. Virology. 1999;263:364-75.
49. Biermer M, Puro R, Schneider RJ. Tumor necrosis factor alpha inhibition of hepatitis B virus replication involves disruption of capsid Integrity through activation of NF-kappaB. J Virol. 2003;77:4033-42.
50. Tanaka Y, Marusawa H, Seno H, Matsumoto Y, Ueda Y, Kodama Y, et al. Anti-viral protein APOBEC3G is induced by interferon-alpha stimulation in human hepatocytes. Biochem Biophys Res Commun. 2006;341:314-9.
51. Soulat D, Burckstummer T, Westermayer S, Goncalves A, Bauch A, Stefanovic A, et al. The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response. EMBO J. 2008;27:2135-46.
52. Kock J, Blum HE. Hypermutation of hepatitis B virus genomes by APOBEC3G, APOBEC3C and APOBEC3H. J Gen Virol. 2008;89:1184-91.
53. Wang H, Kim SH, Ryu WS. DDX3 DEAD-Box RNA Helicase Inhibits Hepatitis B Virus Reverse Transcription by Incorporation into Nucleocapsids. J Virol. 2009;83:5815-24.
54. Lara-Pezzi E, Gomez-Gaviro MV, Galvez BG, Mira E, Iniguez MA, Fresnon M, et al. The hepatitis B virus X protein promoter tumor cell invasion by inducing membrane type matrix metalloproteinase-1 and cyclooxygenase-2 expression. J Clin Invest. 2002;110:1831-8.
55. Cho HK, Cheong KJ, Kim HY, Cheong JH. Endoplasmic reticulum stress induced by hepatitis B virus X protein enhances cyclo-oxygenase 2 expression via activating transcription factor 4. Biochem J. 2011;435:431-9.
56. Corasaniti MT, Bellizzi C, Russo R, Colica C, Amantea D, Rezo GD. Caspase-1 inhibitors abolish deleterious enhancement of COX-2 expression induced by HIV-1 gp120 in human neuroblastoma cells. Toxicol Lett. 2003;139:213-9.
57. Hung J-H, Su I-J, Lei H-Y, Wang H-C, Lin W-C, Chang W-T, et al. Endoplasmic Reticulum Stress Stimulates the Expression of Cyclooxygenase-2 through Activation of NF-kB and pp 38 Mitogen-activated Protein Kinase. J Biol Chem. 2004;279:46384-92.
58. Hösel M, Quasdorff M, Wiegmann K, Webb D, Zedler U, Broxtermann M, et al. Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection. Hepatology. 2009;50:1773-82.