메뉴 건너뛰기




Volumn 23, Issue 2, 2008, Pages 137-145

Anti-hepatitis B virus drugs in clinical and preclinical development

Author keywords

Anti HBV drugs; HBV; Immunomodulatory agents

Indexed keywords

16ALPHA BROMOEPIANDROSTERONE; ADEFOVIR DIPIVOXIL; ALPHA INTERFERON; AMPLIGEN; ANTIVIRUS AGENT; AT 130; BAY 38 7690; BAY 39 5493; BAY 41 4109; EHT 899; ENTECAVIR; HEPATITIS B VACCINE; HEPEX B; HORMONE; IMMUNOMODULATING AGENT; INTERFERON; LAMIVUDINE; LIVER PROTECTIVE AGENT; MOLIXAN; MONOCLONAL ANTIBODY; N [1 (ALPHA CHLOROBENZYLIDENE) 2 OXO 2 (1 PIPERIDINYL)ETHYL]BENZAMIDE; NEW DRUG; NOV 205; NUCLEOSIDE ANALOG; NUCLEOTIDE DERIVATIVE; ORPHAN DRUG; PEGINTERFERON ALPHA2A; PYRIMIDINE DERIVATIVE; TELBIVUDINE; THYMOSIN ALPHA1; UNINDEXED DRUG; XTL 001;

EID: 49749136164     PISSN: 16740769     EISSN: 1995820X     Source Type: Journal    
DOI: 10.1007/s12250-008-2945-8     Document Type: Article
Times cited : (9)

References (41)
  • 1
    • 49749145873 scopus 로고    scopus 로고
    • Announces of cubo pharmaceuticals
    • Announces of cubo pharmaceuticals: http://findarticles.com/p/articles/ mi_m0EIN/is_2005_August_9/ai_n1487-3142
  • 2
    • 0032191176 scopus 로고    scopus 로고
    • Role of early cytokines, including alpha and beta interferons (IFN-alpha/ beta), in innate and adaptive immune responses to viral infections
    • Biron C A. 1998. Role of early cytokines, including alpha and beta interferons (IFN-alpha/beta), in innate and adaptive immune responses to viral infections. Semin Immunol, 10: 383-390.
    • (1998) Semin Immunol , vol.10 , pp. 383-390
    • Biron, C.A.1
  • 3
    • 15244343119 scopus 로고    scopus 로고
    • Quantification of HBV Covalently Closed Circular DNA from Liver Tissue by Real-Time PCR
    • In: (Lau J Y N, Hamatake R, eds.), Volume 1: Detection, Genotypes, and Characterization. Robert K. Hamatake, Johnson Y. N. Lau: HumanaPress, 41-51. ISBN: 1-59259-669-X Series: Methods in Molecular Medicine
    • Bowden S, Jackson K, Littlejohn M, et al. 2004. Quantification of HBV Covalently Closed Circular DNA from Liver Tissue by Real-Time PCR. In: Hepatitis B and D protocols (Lau J Y N, Hamatake R, eds.), Volume 1: Detection, Genotypes, and Characterization. Robert K. Hamatake, Johnson Y. N. Lau: HumanaPress, 41-51. ISBN: 1-59259-669-X Series: Methods in Molecular Medicine.
    • (2004) Hepatitis B and D Protocols
    • Bowden, S.1    Jackson, K.2    Littlejohn, M.3
  • 4
    • 0038045171 scopus 로고    scopus 로고
    • Peginterferon a-2a (40 kDa): An advance in the treatment of hepatitis B e antigen-positive chronic hepatitis B
    • Cooksley W G, Piratvisuth T, Lee S D, et al. 2003. Peginterferon a-2a (40 kDa): An advance in the treatment of hepatitis B e antigen-positive chronic hepatitis B, J Viral Hepat, 10: 298-305.
    • (2003) J Viral Hepat , vol.10 , pp. 298-305
    • Cooksley, W.G.1    Piratvisuth, T.2    Lee, S.D.3
  • 5
    • 0142126681 scopus 로고    scopus 로고
    • Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections
    • De Clercq E. 2003. Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections. Clin Microbiol Rev, 16: 569-596.
    • (2003) Clin Microbiol Rev , vol.16 , pp. 569-596
    • De Clercq, E.1
  • 6
    • 0036721178 scopus 로고    scopus 로고
    • Phenylpropenamide derivatives AT-61 and AT-130 inhibit replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro
    • Delaney W E 4th, Edwards R, Colledge D, et al. 2002. Phenylpropenamide derivatives AT-61 and AT-130 inhibit replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro. Antimicrob Agents Chemother, 46: 3057-3060.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 3057-3060
    • Delaney IV, W.E.1    Edwards, R.2    Colledge, D.3
  • 7
    • 0347928672 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids
    • Deres K, Schröder C H, Paessens A, et al. 2005. Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids. Science, 299: 893-896.
    • (2005) Science , vol.299 , pp. 893-896
    • Deres, K.1    Schröder, C.H.2    Paessens, A.3
  • 8
    • 49749088636 scopus 로고    scopus 로고
    • May 19-24, 2007, Washington DC
    • Digestive Disease Week, May 19-24, 2007, Washington DC. http://www.hivandhepatitis.com/2007icr/ddw/docs/052507b.html
    • Digestive Disease Week
  • 9
    • 49749099176 scopus 로고    scopus 로고
    • Enzo therapeutics: http://www.enzobio.com/therapeutics/ product_pipeline.asp.
    • Enzo Therapeutics
  • 10
    • 49749139639 scopus 로고    scopus 로고
    • Hepatitis B fact sheet WHO/204 Geneva: World Health Organization. 2000. (21 December 2005, date last accessed)
    • Hepatitis B fact sheet WHO/204 Geneva: World Health Organization. 2000. http:/www.who.int/infs/en/fact204. html (21 December 2005, date last accessed).
  • 11
    • 0041880359 scopus 로고    scopus 로고
    • Novel antiviral agents: A medicinal plant perspective
    • Jassim S A and Naji M A. 2003. Novel antiviral agents: A medicinal plant perspective. J Appl Microbiol, 95: 412-427.
    • (2003) J Appl Microbiol , vol.95 , pp. 412-427
    • Jassim, S.A.1    Naji, M.A.2
  • 12
    • 0037394275 scopus 로고    scopus 로고
    • Hepatitis B virus: Old, new and future approaches to antiviral treatment
    • Karayiannis P. 2003. Hepatitis B virus: Old, new and future approaches to antiviral treatment. J. Antimicrob. Chemother, 51: 761-785.
    • (2003) J. Antimicrob. Chemother , vol.51 , pp. 761-785
    • Karayiannis, P.1
  • 13
    • 33947110871 scopus 로고    scopus 로고
    • New and emerging treatment of chronic hepatitis B
    • Keeffe E B, Marcellin P. 2007. New and emerging treatment of chronic hepatitis B. Clin Gastroenterol Hepatol. 5: 285-294.
    • (2007) Clin Gastroenterol Hepatol , vol.5 , pp. 285-294
    • Keeffe, E.B.1    Marcellin, P.2
  • 14
    • 0031758695 scopus 로고    scopus 로고
    • Inhibition of human hepatitis B virus replication by AT-61, a phenylpropenamide derivative, alone and in combination with (-) beta-L-2′, 3′-dideoxy-3′-thiacytidine
    • King R W, Ladner S K, Miller T J, et al. 1998. Inhibition of human hepatitis B virus replication by AT-61, a phenylpropenamide derivative, alone and in combination with (-) beta-L-2′, 3′-dideoxy-3′-thiacytidine. Antimicrob Agents Chemother, 42: 3179-3186.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 3179-3186
    • King, R.W.1    Ladner, S.K.2    Miller, T.J.3
  • 15
    • 3042802378 scopus 로고    scopus 로고
    • Novel treatment options for hepatitis B virus infection
    • Kumar R, Agrawal B. 2004. Novel treatment options for hepatitis B virus infection. Curr Opin Investig Drugs, 5: 171-178.
    • (2004) Curr Opin Investig Drugs , vol.5 , pp. 171-178
    • Kumar, R.1    Agrawal, B.2
  • 16
    • 23244453590 scopus 로고    scopus 로고
    • Telbivudine Phase II Investigator Group. A 1-Year Trial of Telbivudine, Lamivudine, and the Combination in Patients with Hepatitis B e Antigen-Positive Chronic Hepatitis B
    • Lai C L, Leung N, Teo E K, et al. 2005. Telbivudine Phase II Investigator Group. A 1-Year Trial of Telbivudine, Lamivudine, and the Combination in Patients with Hepatitis B e Antigen-Positive Chronic Hepatitis B. Gastroenterology, 129: 528-536.
    • (2005) Gastroenterology , vol.129 , pp. 528-536
    • Lai, C.L.1    Leung, N.2    Teo, E.K.3
  • 17
    • 33646585175 scopus 로고    scopus 로고
    • A 12-week clevudine therapy showed potent and durable antiviral activity in HBeAg-positive chronic hepatitis B
    • Lee H S, Chung Y H, Lee K, et al. 2006. A 12-week clevudine therapy showed potent and durable antiviral activity in HBeAg-positive chronic hepatitis B. Hepatology, 43: 982-988.
    • (2006) Hepatology , vol.43 , pp. 982-988
    • Lee, H.S.1    Chung, Y.H.2    Lee, K.3
  • 18
    • 33846042915 scopus 로고    scopus 로고
    • A study on the sero-epidemiology of hepatitis B in Chinese population aged over 3-years old
    • Liang X F, Chen Y S, Wang X J, et al. 2005. A study on the sero-epidemiology of hepatitis B in Chinese population aged over 3-years old. Chin J Epidemiol, 26:655-660.
    • (2005) Chin J Epidemiol , vol.26 , pp. 655-660
    • Liang, X.F.1    Chen, Y.S.2    Wang, X.J.3
  • 19
    • 2642516484 scopus 로고    scopus 로고
    • Detection of Hepatitis B Virus X Antigen by Immunohistochemistry and Western Blotting
    • In: (Lau J Y N, Hamatake R, eds.) Detection, Genotypes, and Characterization. Robert K. Hamatake, Johnson Y. N. Lau: Humana-Press, 71-84. ISBN: 1-59259-669-X Series: Methods in Molecular Medicine
    • Liu J, Feitelson MA. 2004. Detection of Hepatitis B Virus X Antigen by Immunohistochemistry and Western Blotting. In: Hepatitis B and D protocols (Lau J Y N, Hamatake R, eds.), Volume 1: Detection, Genotypes, and Characterization. Robert K. Hamatake, Johnson Y. N. Lau: Humana-Press, 71-84. ISBN: 1-59259-669-X Series: Methods in Molecular Medicine.
    • (2004) Hepatitis B and D Protocols , vol.1
    • Liu, J.1    Feitelson, M.A.2
  • 20
    • 33746741042 scopus 로고    scopus 로고
    • Synthesis and anti-hepatitis B virus activity of novel benzimidazole derivatives
    • Li Y F, Wang G F, He P L, et al. 2006. Synthesis and anti-hepatitis B virus activity of novel benzimidazole derivatives. J Med Chem, 49: 4790-4794.
    • (2006) J Med Chem , vol.49 , pp. 4790-4794
    • Li, Y.F.1    Wang, G.F.2    He, P.L.3
  • 21
    • 33847701354 scopus 로고    scopus 로고
    • AASLD practice guidelines: Chronic hepatitis B
    • Lok A S F, McMahon B J. 2007. AASLD practice guidelines: Chronic hepatitis B. Hepatology, 45:507-539.
    • (2007) Hepatology , vol.45 , pp. 507-539
    • Lok, A.S.F.1    McMahon, B.J.2
  • 23
    • 49749098316 scopus 로고    scopus 로고
    • A meta-analysis of thymosin-monotherapy for chronic hepatitis B virus infection
    • Nie Q H, Zhang J C. 2006. A meta-analysis of thymosin-monotherapy for chronic hepatitis B virus infection. Chin J Pract Int Med, 26: 382-386.
    • (2006) Chin J Pract Int Med , vol.26 , pp. 382-386
    • Nie, Q.H.1    Zhang, J.C.2
  • 24
    • 7244242469 scopus 로고    scopus 로고
    • Mismatched double-stranded RNA: Polyi:polyC12U
    • No author listed
    • NO author listed. 2004. Mismatched double-stranded RNA: PolyI:polyC12U. Drugs R D, 5: 297-304.
    • (2004) Drugs R D , vol.5 , pp. 297-304
  • 25
    • 49749135427 scopus 로고    scopus 로고
    • Novartis Pharmaceuticals Corporation
    • Novartis Pharmaceuticals Corporation: http://daily med.nlm.nih.gov/ dailymed/drugInfo.cfm?id=3365
  • 26
    • 49749106930 scopus 로고    scopus 로고
    • Novelos
    • Novelos: http://www.novelos.com
  • 27
    • 2942590565 scopus 로고    scopus 로고
    • Antiviral therapy: Nucleotide and nucleoside analogs
    • Quan D J, Peters M G. 2004. Antiviral therapy: nucleotide and nucleoside analogs. Clin Liver Dis, 8: 371-385.
    • (2004) Clin Liver Dis , vol.8 , pp. 371-385
    • Quan, D.J.1    Peters, M.G.2
  • 28
    • 27644565158 scopus 로고    scopus 로고
    • Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system
    • Romero M R, Efferth T, Serrano M A et al. 2005. Effect of artemisinin/ artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system. Antiviral Res, 68: 75-83.
    • (2005) Antiviral Res , vol.68 , pp. 75-83
    • Romero, M.R.1    Efferth, T.2    Serrano, M.A.3
  • 29
    • 0034767753 scopus 로고    scopus 로고
    • Antiviral actions of interferons
    • Samuel C E. 2001. Antiviral actions of interferons. Clin Microbiol Rev, 14: 778-809.
    • (2001) Clin Microbiol Rev , vol.14 , pp. 778-809
    • Samuel, C.E.1
  • 31
    • 49749122934 scopus 로고    scopus 로고
    • Source Hollis-Eden Pharmaceuticals, Inc
    • Source Hollis-Eden Pharmaceuticals, Inc. http://phx.corporate-ir.net/ phoenix.zhtml?c=113795&p=irol-newsar-ticle_print&ID=212253
  • 32
    • 33646241328 scopus 로고    scopus 로고
    • Identification of a structural motif crucial for infectivity of hepatitis B viruses
    • Stoeckl L, Funk A, Kopitzki A, et al. 2006. Identification of a structural motif crucial for infectivity of hepatitis B viruses. Proc Natl Acad Sci USA, 103: 6730-6734.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 6730-6734
    • Stoeckl, L.1    Funk, A.2    Kopitzki, A.3
  • 33
    • 20444421508 scopus 로고    scopus 로고
    • A heteroaryldihydropyrimidine activates and can misdirect hepatitis B virus capsid assembly
    • Stray S J, Bourne C R, Punna S, et al. 2005. A heteroaryldihydropyrimidine activates and can misdirect hepatitis B virus capsid assembly. Proc Natl Acad Sci USA, 102: 8138-8143.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 8138-8143
    • Stray, S.J.1    Bourne, C.R.2    Punna, S.3
  • 34
    • 49749129931 scopus 로고    scopus 로고
    • Pradefovir a promising prodrug for hepatitis B. Meeting report
    • January 21
    • Sullivan S. 2006. Pradefovir a promising prodrug for hepatitis B. Meeting report. Inpharma Weekly, 1521:7-9, January 21.
    • (2006) Inpharma Weekly , vol.1521 , pp. 7-9
    • Sullivan, S.1
  • 35
    • 10644275213 scopus 로고    scopus 로고
    • Comparison of adefovir and tenofovir in the treatment of lamivudine-resistant hepatitis B virus infection
    • van Bömmel F, Wünsche T, Mauss S, et al. 2004. Comparison of adefovir and tenofovir in the treatment of lamivudine-resistant hepatitis B virus infection. Hepatology, 40: 1421-1425.
    • (2004) Hepatology , vol.40 , pp. 1421-1425
    • van Bömmel, F.1    Wünsche, T.2    Mauss, S.3
  • 36
    • 33747041958 scopus 로고    scopus 로고
    • Tenofovir for patients with lamivudine-resistant hepatitis B virus (HBV) infection and high HBV DNA level during adefovir therapy
    • van Bömmel F, Zöllner B, Sarrazin C, et al. 2006. Tenofovir for patients with lamivudine-resistant hepatitis B virus (HBV) infection and high HBV DNA level during adefovir therapy. Hepatology, 44:318-325.
    • (2006) Hepatology , vol.44 , pp. 318-325
    • van Bömmel, F.1    Zöllner, B.2    Sarrazin, C.3
  • 37
    • 0036733542 scopus 로고    scopus 로고
    • Viral dynamics in chronic hepatitis B patients treated with lamivudine, lamivudine-famciclovir or lamivudine-ganci-clovir
    • Wolters L M, Hansen B E, Niesters H G, et al. 2002. Viral dynamics in chronic hepatitis B patients treated with lamivudine, lamivudine-famciclovir or lamivudine-ganci-clovir, Eur J Gastroenterol Hepatol, 123: 1007-1011.
    • (2002) Eur J Gastroenterol Hepatol , vol.123 , pp. 1007-1011
    • Wolters, L.M.1    Hansen, B.E.2    Niesters, H.G.3
  • 38
    • 34347223650 scopus 로고    scopus 로고
    • Unique antiviral mechanism discovered in anti-hepatitis B virus research with a natural product analogue
    • Ying C, Li Y, Leung C H, et al. 2007. Unique antiviral mechanism discovered in anti-hepatitis B virus research with a natural product analogue. Proc Natl Acad Sci USA, 104: 8526-8531.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 8526-8531
    • Ying, C.1    Li, Y.2    Leung, C.H.3
  • 39
    • 49749130737 scopus 로고    scopus 로고
    • ZADAXIN® (thymosin alpha 1)
    • ZADAXIN® (thymosin alpha 1): http://www.sciclone-international.com/ zadaxin.shtml
  • 41
    • 4744354693 scopus 로고    scopus 로고
    • Mechanism of viral persistence and resistance to nucleoside and nucleotide analogs in chronic hepatitis B virus infection
    • Zoulim F. 2004. Mechanism of viral persistence and resistance to nucleoside and nucleotide analogs in chronic hepatitis B virus infection. Antiviral Res, 64:1-15.
    • (2004) Antiviral Res , vol.64 , pp. 1-15
    • Zoulim, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.