Inhibition of human hepatitis B virus (HBV) by a novel non-nucleosidic compound in a transgenic mouse model

Antiviral Research

Volumn 54, Issue 2, 2002, Pages 69-78

  Weber, O ^a,b   Schlemmer, K H ^a   Hartmann, E ^a   Hagelschuer, Ina ^a   Paessens, A ^a   Graef, E ^a   Deres, K ^a   Goldmann, S ^a   Niewoehner, U ^a   Stoltefuss, J ^a   Haebich, D ^a   Ruebsamen Waigmann, H ^a   Wohlfeil, Stefan ^a  

^a BAYER AG   (Germany)

^b BAYER CORPORATION   (United States)

Author keywords

Animal models; Antiviral activity; Human hepatitis B virus; Transgenic mice

Indexed keywords

4 (2 CHLORO 4 FLUOROPHENYL) 2 (3,5 DIFLUORO 2 PYRIDINYL) 6 METHYL 1,4 DIHYDROPYRIMIDINE 5 CARBOXYLIC ACID METHYL ESTER; ANTIVIRUS AGENT; BAY 414109; HEPATITIS B CORE ANTIGEN; LAMIVUDINE; UNCLASSIFIED DRUG; VIRUS DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG POTENCY; HEPATITIS B VIRUS; LIVER LEVEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE; VIRUS INHIBITION; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; CELLS, CULTURED; DNA, VIRAL; FEMALE; HEPATITIS B; HEPATITIS B CORE ANTIGENS; HEPATITIS B VIRUS; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER; MALE; MICE; MICE, TRANSGENIC; NUCLEIC ACID HYBRIDIZATION; PYRIDINES; PYRIMIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

ANIMALIA; HEPATITIS B VIRUS; MUS MUSCULUS;

EID: 0036227850     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(01)00216-9     Document Type: Article

References (22)

1. The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks
2. Antiviral drugs: Current state of the art
3. Hepatitis B surface antigen gene expression is regulated by sex steroids and glucocorticoids in transgenic mice
4. Long-term follow up of anti Hbe positive chronic active hepatitis B
5. The molecular biology of the hepatitis B virus
6. High-level hepatitis B virus replication in transgenic mice
7. Use of standardized cell culture assay to assess activities of nucleoside analogs against hepatitis B virus replication
8. A virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus
9. Lamivudine therapy of WHV-infected woodchucks
10. Prolonged interferon alpha therapy of hepatitis B virus-related decompensated cirrhosis
11. Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus
12. Utilization of transgenic mice replicating high levels of hepatitis B virus for antiviral evaluation of lamivudine
13. Inhibition of intrahepatic hepatitis B virus replication by antiviral drugs in a novel transgenic mouse model
14. Evolving therapies for the treatment of viral hepatitis
15. Production of hepatitis B virus particles in HepG2 cells transfected with cloned hepatitis B virus DNA
16. A virus similar to hepatitis B virus associated with hepatitis and hepatoma in woodchucks
17. Animal models of hepatitis B virus infection
18. Antiviral activity and toxicity of Fialuridine in the woodchuck model of hepatitis B virus infection
19. Treatment of hepatitis B viral infection
20. Woodchuck hepatitis virus X protein is required for viral infection in vivo