Increasing striatal iron content associated with normal aging

Movement Disorders

Volumn 13, Issue 2, 1998, Pages 281-286

  Martin, W R Wayne ^a,b   Ye, Frank Q ^a   Allen, Peter S ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b GLENROSE REHABILITATION HOSPITAL   (Canada)

Author keywords

Aging; Iron; Magnetic resonance imaging; Parkinson's disease

Indexed keywords

FREE RADICAL; IRON;

ADULT; AGED; AGING; ARTICLE; BASAL GANGLION; BRAIN LEVEL; CAUDATE NUCLEUS; CELL MEMBRANE; CORPUS STRIATUM; GLOBUS PALLIDUS; HUMAN; HUMAN EXPERIMENT; NERVE DEGENERATION; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARKINSON DISEASE; PRIORITY JOURNAL; PUTAMEN; RISK FACTOR;

ADULT; AGED; AGING; FEMALE; FREE RADICALS; HUMANS; IRON; LIPID PEROXIDATION; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; REFERENCE VALUES; SUBSTANTIA NIGRA;

EID: 0031930949     PISSN: 08853185     EISSN: None     Source Type: Journal    
DOI: 10.1002/mds.870130214     Document Type: Article

References (33)

1. Halliwell B, Gutteridge JM. Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts. Arch Biochem Biophys 1986;246:501-514.
2. Perl DP, Good PF. Comparative techniques for determining cellular iron distribution in brain tissues. Ann Neurol 1992;32(suppl): S76-S81.
3. Youdim MBH, Ben-Shachar D, Yehuda S, Riederer P. The role of iron in the basal ganglion. Adv Neurol 1990;53:155-162.
4. Hallgren B, Sourander P. The effect of age on the nonhaemin iron in the human brain. J Neurochem 1958;3:41-51.
5. Hill JM, Switzer RC. The regional distribution and cellular localization of iron in the rat brain. Neuroscience 1984;11:595-603.
6. Riederer P, Sofic E, Rausch W-D, et al. Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains. J Neurochem 1989;52:515-520.
7. Earle KM. Studies on Parkinson's disease including x-ray fluorescent spectroscopy of formalin fixed brain tissue. J Neuropathol Exp Neurol 1968;27:1-14.
8. Dexter DT, Wells FR, Lees AJ, et al. Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease. J Neurochem 1989;52:1830-1836.
9. Sofic E, Riederer P, Heinsen H, et al. Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain. J Neural Transm 1988;74:199-205.
10. Ye FQ, Allen PS, Martin WRW. Basal ganglia iron content in Parkinson's disease measured with magnetic resonance. Mov Disord 1996;11:243-249.
11. Ye FQ, Martin WRW. Allen PS. Estimation of brain iron in vivo by means of the interecho time dependence of image contrast. Magn Reson Med 1996;36:153-158.
12. Uitti RJ, Rajput AH, Rozdilsky B, Bickis M, Wollin T, Yuen WK. Regional metal concentrations in Parkinson's disease, other chronic neurological diseases, and control brains. Can J Neurol Sci 1989;16:310-314.
13. Ye FQ, Allen PS. Ferritin as a susceptibility agent. In: Proceedings 12th Annual Meeting of Society of Magnetic Resonance in Medicine: Berkeley, CA: Society of Magnetic Resonance 1993:800.
14. Ye FQ, Allen PS. Relaxation enhancement of the transverse magnetization of water protons in paramagnetic suspensions of red blood cells. Magn Reson Med 1995;34:713-720.
15. 3+ core ions. Magn Reson Med 1986;3:755-767.
16. Brooks RA, Vymazal J, Bulte JWM. Baumgarner CD, Tran V. Comparison of T2 relaxation in blood, brain and ferritin. J Magn Reson Imaging 1995;4:446-450.
17. Ye FQ, Martin WRW, Allen PS. Estimation of the iron concentration in excised gray matter by means of proton relaxation measurements. Magn Reson Med 1996;35:285-289.
18. Olanow CW, Holgate RC, Murtaugh R, Martinez C. MR imaging in Parkinson's disease and aging. In: Calne DB, Crippa D, Comi G, Horowski R, Trabucchi M, eds. Parkinsonism and aging. New York: Raven, 1989:155-164.
19. Pujol J, Junque C, Vendrell P, et al. Biological significance of iron-related magnetic resonance imaging changes in the brain. Arch Neurol 1992;49:711-717.
20. Chen JC, Hardy PA, Kucharczyk W, et al. MR of human postmortem brain tissue: correlative study between T2 and assays of iron and ferritin in Parkinson and Huntington disease. AJNR 1993;14: 275-281.
21. Chen JC, Hardy PA, Clauberg M, et al. T2 values in the human brain: comparison with quantitative assays of iron and ferritin. Radiology 1989;173:521-526.
22. Bartzokis G, Mintz J, Sultzer D, et al. In vivo MR evaluation of age-related increases in brain iron. AJNR 1994;15:1129-1138.
23. Connor JR, Menzies SL, St. Martin SM, Mufson EJ. Cellular distribution of transferrin, ferritin and iron in normal and aged human brains. J Neurosci Res 1990;27:595-611.
24. Leenders KL, Perani D, Lammertsma AA, et al. Cerebral blood flow, blood volume and oxygen utilization: normal values and effect of age. Brain 1990;113:27-47.
25. Ordidge RJ, Gorell JM, Deniau JC, Knight RA, Helpern JA. Assessment of relative brain iron concentrations using T2-weighted and T2*-weighted MRI at 3 Tesla. Magn Reson Med 1994;32:335-341.
26. Fishman JB, Rubin JB, Handrahan JV, Connor JR, Fine RE. Receptor-mediated transcytosis of transferrin across the blood-brain barrier. J Neurosci Res 1987;18:299-304.
27. Halliwell B. Oxidants in the central nervous system: some fundamental questions. Acta Neurol Scand 1989;126:23-33.
28. Ben-Shachar D, Riederer P, Youdim MBH. Iron-melanin interaction and lipid peroxidation: implications for Parkinson's disease. J Neurochem 1991;57:1609-1614.
29. Fahn S, Cohen G. The oxidant stress hypothesis in Parkinson's disease: evidence supporting it. Ann Neurol 1992;32:804-812.
30. Graham DG. Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones. Mol Pharmacol 1978;14: 633-643.
31. Fornstedt B, Pileblad E, Carlsson A. In vivo autoxidation of dopamine in guinea pig striatum increases with age. J Neurochem 1990;55:655-659.
32. Mochizuki H, Imai H, Endo K, et al. Iron accumulation in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys. Neurosci Lett 1994; 168:251-253.
33. Temlett JA, Landsberg JP, Watt F, Grime GW. Increased iron in the substantia nigra compacta of the MPTP-lesioned hemiparkinsonian African green monkey: evidence from proton microprobe elemental microanalysis. J Neurochem 1994;62:134-146.