Morphinan biosynthesis in opium poppy requires a P450-oxidoreductase fusion protein

Science

Volumn 349, Issue 6245, 2015, Pages 309-312

  Winzer, Thilo ^a   Kern, Marcelo ^a   King, Andrew J ^a   Larson, Tony R ^a   Teodor, Roxana I ^a   Donninger, Samantha L ^a   Li, Yi ^a   Dowle, Adam A ^a   Cartwright, Jared ^a   Bates, Rachel ^a   Ashford, David ^a   Thomas, Jerry ^a   Walker, Carol ^b   Bowser, Tim A ^b   Graham, Ian A ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b GLAXOSMITHKLINE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; HYBRID PROTEIN; MORPHINAN DERIVATIVE; OPIATE; OXIDOREDUCTASE; RETICULINE; BENZYLISOQUINOLINE DERIVATIVE; ISOQUINOLINE DERIVATIVE; QUATERNARY AMMONIUM DERIVATIVE; VEGETABLE PROTEIN;

ALKALOID; ALLELE; ENZYME ACTIVITY; EVERGREEN TREE; GENE EXPRESSION; METABOLITE; MUTATION; PROTEIN;

ALLELE; ARTICLE; BIOSYNTHESIS; CULTIVAR; EPIMERIZATION; GENE LOCUS; HETEROLOGOUS EXPRESSION; IN VIVO STUDY; MICHAELIS CONSTANT; MOLECULAR CLONING; NONHUMAN; PLANT GENETICS; PLANT METABOLISM; PRIORITY JOURNAL; PROTEOMICS; SACCHAROMYCES CEREVISIAE; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION REACTION; PAPAVER;

PAPAVER; PAPAVER SOMNIFERUM;

BASE SEQUENCE; BENZYLISOQUINOLINES; CYTOCHROME P-450 ENZYME SYSTEM; GENETIC LOCI; ISOQUINOLINES; MOLECULAR SEQUENCE DATA; MORPHINANS; MUTATION; OXIDATION-REDUCTION; PAPAVER; PLANT PROTEINS; QUATERNARY AMMONIUM COMPOUNDS;

EID: 84937845964     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aab1852     Document Type: Article

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