Involvement of a natural fusion of a cytochrome P450 and a hydrolase in mycophenolic acid biosynthesis

Applied and Environmental Microbiology

Volumn 78, Issue 14, 2012, Pages 4908-4913

  Hansen, Bjarne Gram ^a,b   Mnich, Ewelina ^a   Nielsen, Kristian Fog ^a   Nielsen, Jakob Blæsbjerg ^a   Nielsen, Morten Thrane ^a   Mortensen, Uffe Hasbro ^a   Larsen, Thomas Ostenfeld ^a   Patil, Kiran Raosaheb ^a,c  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b NOVOZYMES A S   (Denmark)

^c Structural and Computational Biology Unit   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE COMPONENTS; ASPERGILLUS NIDULANS; BIOINFORMATIC ANALYSIS; BIOSYNTHESIS PATHWAYS; BIOSYNTHETIC PATHWAY; C-TERMINAL REGIONS; CHIMERIC ENZYMES; CO-EXPRESSION; CYTOCHROME P450; FUSION ENZYMES; FUSION GENES; GENE CLUSTERS; GENETIC ORGANIZATION; METHYL BENZOIC ACID; MYCOPHENOLIC ACIDS; N-TERMINALS; PENICILLIUM BREVICOMPACTUM; POLYKETIDE SYNTHASES; RING CLOSURES; SECONDARY METABOLITES; SYNTHASES;

BIOCHEMISTRY; BIOINFORMATICS; BIOSYNTHESIS; CATALYSIS; ENZYME ACTIVITY; HYDROLASES; METHANOL; RNA;

GENES;

CYTOCHROME P450; FUNGAL PROTEIN; HYBRID PROTEIN; HYDROLASE; MYCOPHENOLIC ACID;

BIOCHEMISTRY; CARBOXYLIC ACID; CATALYSIS; CHIMERA; CYTOCHROME; DRUG; ENZYME ACTIVITY; FUNGUS; GENE EXPRESSION; GENETIC ANALYSIS; PHENOLIC COMPOUND; SECONDARY METABOLITE;

AMINO ACID SEQUENCE; ARTICLE; BIOSYNTHESIS; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; PENICILLIUM; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; CYTOCHROME P-450 ENZYME SYSTEM; FUNGAL PROTEINS; HYDROLASES; MOLECULAR SEQUENCE DATA; MYCOPHENOLIC ACID; PENICILLIUM; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT;

EMERICELLA NIDULANS; PENICILLIUM BREVICOMPACTUM;

EID: 84863743745     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.07955-11     Document Type: Article

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