Flow- and voltage-dependent blocking effect of ethosuximide on the inward rectifier K+ (Kir2.1) channel

Pflugers Archiv European Journal of Physiology

Volumn 467, Issue 8, 2015, Pages 1733-1746

  Huang, Chiung Wei ^a   Kuo, Chung Chin ^a,b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Absence seizure; Ethosuximide; Flow dependent block; Inward rectifier K+ channels; Voltage dependent block

Indexed keywords

CALCIUM CHANNEL T TYPE; ETHOSUXIMIDE; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.1; ANTICONVULSIVE AGENT; INWARDLY RECTIFYING POTASSIUM CHANNEL; POTASSIUM; POTASSIUM CHANNEL BLOCKING AGENT; PROTEIN BINDING;

ABSENCE; ANIMAL CELL; ARTICLE; BINDING KINETICS; MEMBRANE POTENTIAL; MEMBRANE STEADY POTENTIAL; MOLECULAR DYNAMICS; NERVE CELL; NERVE CELL MEMBRANE; NERVE CELL MEMBRANE STEADY POTENTIAL; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; THALAMOCORTICAL TRACT; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; GENETICS; KINETICS; METABOLISM; OOCYTE; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; XENOPUS;

ANIMALS; ANTICONVULSANTS; BINDING SITES; CALCIUM CHANNELS, T-TYPE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHOSUXIMIDE; KINETICS; MEMBRANE POTENTIALS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; OOCYTES; POINT MUTATION; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 84937808820     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-014-1611-2     Document Type: Article

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