Glial membrane channels and receptors in epilepsy: Impact for generation and spread of seizure activity

European Journal of Pharmacology

Volumn 447, Issue 2-3, 2002, Pages 227-237

  Steinhäuser, Christian ^a   Seifert, Gerald ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Epilepsy; Glial cell; Glutamate receptor; Hippocampus; Ion channel

Indexed keywords

GLUTAMATE RECEPTOR; IONOTROPIC RECEPTOR; METABOTROPIC RECEPTOR; POTASSIUM; POTASSIUM CHANNEL; RECEPTOR; SODIUM CHANNEL; SODIUM ION;

CELL MEMBRANE; ELECTRIC POTENTIAL; EPILEPSY; GAP JUNCTION; GLIA CELL; HUMAN; MACROGLIA; MEMBRANE CHANNEL; PRIORITY JOURNAL; REVIEW; SEIZURE;

EID: 0037025262     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)01846-0     Document Type: Article

References (118)

1. 2+ currents
2. Upregulation of metabotropic glutamate receptor subtype mGluR3 and mGluR5 in reactive astrocytes in a rat model of mesial temporal lobe epilepsy
3. 2+ of AMPA receptors in presumed hilar glial precursor cells
4. Sodium and calcium currents in glial cells of the mouse corpus callosum slice
5. Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus
6. Prostaglandins stimulate calcium-dependent glutamate release in astrocytes
7. Type II sodium channels in spinal cord astrocytes in situ: Immunocytochemical observations
8. + channel mRNA and protein in spinal cord astrocytes
9. Immunohistochemical distribution of metabotropic glutamate receptor subtypes mGluR1b, mGluR2/3, mGluR4a and mGluR5 in human hippocampus
10. Postnatal development of ionic currents in rat hippocampal astrocytes in situ
11. Properties of human glial cells associated with epileptic seizure foci
12. Electrophysiological characteristics of reactive astrocytes in experimental cortical dysplasia
13. Expression of potassium channels during postnatal differentiation of rabbit Muller glial cells
14. Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-β
15. Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice
16. Electrophysiological properties of reactive glial cells in the kainate-lesioned hippocampal slice
17. Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit
18. Reciprocal communication systems between astrocytes and neurones
19. Opposite influence of the metabotropic glutamate receptor subtypes mGlu3 and -5 on astrocyte proliferation in culture
20. + channels
21. Glutamate induces calcium waves in cultured astrocytes: Long-range glial signaling
22. + homeostasis and altered electrophysiological properties of post-traumatic hippocampal glia
23. Neuronal activity triggers calcium waves in hippocampal astrocyte networks
24. Differential expression of the three gap junction proteins in developing and mature brain tissues
25. Potassium-dependent calcium influx in acutely isolated hippocampal astrocytes
26. Connexin 43 mRNA expression in two experimental models of epilepsy
27. Hippocampal connexin 43 expression in human complex partial seizure disorder
28. Action of antiepileptic and anaesthetic drugs on Na- and Ca-spikes in mammalian non-myelinated axons
29. Nomenclature of voltage-gated calcium channels
30. Activated astrocytes in areas of kainate-induced neuronal injury upregulate the expression of the metabotropic glutamate receptors 2/3 and 5
31. The role of extracellular potassium in hippocampal epilepsy
32. Loss of inwardly rectifying potassium currents by human retinal glial cells in diseases of the eye
33. Effects of barium on stimulus induced changes in extracellular potassium concentration in area CA1 of hippocampal slices from normal and pilocarpine-treated epileptic rats
34. o in juvenile rat hippocampal area CA1
35. o and field potentials in dentate gyrus and area CA1 of human epileptic hippocampus
36. Seizures and the regulation of neurotrophic factor expression: Associations with structural plasticity in epilepsy
37. Clearance of extracellular potassium: Evidence for spatial buffering by glial cells in the retina of the drone
38. + channel rNa (v) 1.5a in the rat hippocampal progenitor stem cell line HiB5
39. Control of gap-junctional communication in astrocytic networks
40. Neurochemical and morphological changes associated with human epilepsy
41. Editing status at the Q/R site of the GluR2 and GluR6 glutamate receptor subunits in the surgically excised hippocampus of patients with refractory epilepsy
42. Human glia cultured from epileptogenic foci demonstrate increased basal and glutamate-induced calcium fluxes
43. Low-calcium field burst discharges of CA1 pyramidal neurones in rat hippocampal slices
44. Metabotropic glutamate receptor activation induces astroglial swelling
45. GLIA: Listening and talking to the synapse
46. Calcium and epileptogenesis
47. Extracellular free calcium and potassium during paroxsmal activity in the cerebral cortex of the cat
48. Epilepsy
49. Astrocytes in the hippocampus of patients with temporal lobe epilepsy display changes in potassium conductances
50. Transforming growth factor-beta 1 and -beta 2 promote neurite sprouting and elongation of cultured rat hippocampal neurons
51. + currents in glial cells of mouse hippocampal slices
52. 2 purinergic responses
53. Effects of barium, furosemide, ouabaine and 4,4′-diisothiocyanatostilbene-2,2′-disulfonic acid (DIDS) on ionophoretically-induced changes in extracellular potassium concentration in hippocampal slices from rats and from patients with epilepsy
54. Glial potassium uptake following depletion by intracellular ionophoresis
55. Astrocytes in kindling: Relevance to epileptogenesis
56. o in human epileptic non-sclerotic and sclerotic hippocampal area CA1
57. Nonsynaptic epileptogenesis in the mammalian hippocampus in vitro: I. Development of seizurelike activity in low extracellular calcium
58. RNA editing at the Q/R site for the glutamate receptor subunits GluR2, GluR5, and GluR6 in hippocampus and temporal cortex from epileptic patients
59. + conductances in glial cells of mouse hippocampal brain slices
60. Physiological properties of glial cells in the central nervous system of amphibia
61. Late onset and increasing expression of the gap junction protein connexin30 in adult murine brain and long-term cultured astrocytes
62. Human epileptic astrocytes exhibit increased gap junction coupling
63. + during spinal epileptiform seizures
64. Ionic changes and alterations in the size of the extracellular space during epileptic activity
65. Electrophysiological changes that accompany reactive gliosis in vitro
66. Spontaneous intracellular calcium oscillations in cortical astrocytes from a patient with intractable childhood epilepsy (Rasmussen's encephalitis)
67. Cellular and molecular basis of epilepsy
68. Growth factor upregulation of a phosphoinositide-coupled metabotropic glutamate receptor in cortical astrocytes
69. Extracellular potassium activity during epileptogenesis
70. A molecular determinant for submillisecond desensitization in glutamate receptors
71. Connexin30 in rodent, cat and human brain: Selective expression in gray matter astrocytes, co-localization with connexin43 at gap junctions and late developmental appearance
72. Gap junction gene expression in human seizure disorder
73. Voltage-dependent calcium and potassium channels in retinal glial cells
74. High potassium conductance in astrocyte endfeet
75. Inward-rectifying potassium channels in retinal glial (Müller) cells
76. Calcium waves in retinal glial cells
77. Astrocytes from human hippocampal epileptogenic foci exhibit action potential-like responses
78. + channel mRNAs in astrocytes
79. A nuclear microscopic study of elemental changes in the rat hippocampus after kainate-induced neuronal injury
80. Glial-interstitial fluid exchange
81. Intracellular calcium oscillations in astrocytes: A highly plastic, bidirectional form of communication between neurons and astrocytes in situ
82. The metabotropic glutamate receptors: Structure and functions
83. Neuroglia: Gliosis and focal epilepsy
84. Hippocampal astrocytes in situ respond to glutamate released from synaptic terminals
85. The tetrameric structure of a glutamate receptor channel
86. Gap junctions in the nervous system
87. A novel, abundant sodium channel expressed in neurons and glia
88. 2+ waves trigger responses in microglial cells in brain slices
89. MGluR3 and mGluR5 are the predominant metabotropic glutamate receptor mRNAs expressed in hippocampal astrocytes acutely isolated from young rats
90. Lesion-induced changes of electrophysiological properties in astrocytes of the rat dentate gyrus
91. Functional and molecular properties of human astrocytes in acute hippocampal slices obtained from patients with temporal lobe epilepsy
92. + channels in astrocytes of mouse hippocampus
93. Effects of phenytoin, carbamazepine, and gabapentin on calcium channels in hippocampal granule cells from patients with temporal lobe epilepsy
94. 2+ permeability
95. Ionotropic glutamate receptors in astrocytes
96. Analysis of AMPA receptor properties during postnatal development of mouse hippocampal astrocytes
97. Changes in flip/flop splicing of astroglial AMPA receptors in human temporal lobe epilepsy
98. Combining patch-clamp techniques with RT-PCR
99. +-ATPase activity
100. Expression of connexin genes in hippocampus of kainate-treated and kindled rats under conditions of experimental epilepsy
101. News on glutamate receptors in glial cells
102. + currents in hippocampal astrocytes of patients with temporal lobe epilepsy are mediated by Kir4.1 and Kir6/SUR channels
103. Expression of the group II and III metabotropic glutamate receptors in the hippocampus of patients with mesial temporal lobe epilepsy
104. Metabotropic glutamate receptor 8 in the rat hippocampus after pilocarpine induced status epilepticus
105. Potassium-induced spontaneous electrographic seizures in the rat hippocampal slice
106. Expression of metabotropic glutamate receptor 5 is increased astrocytes after kainate-induced epileptic seizures
107. Gap junctions, synchrony and seizures
108. Ion channels in glial cells
109. Glial calcium: Homeostasis and signaling function
110. Role of glial cells in the regulation of the brain ion microenvironment
111. Role of astrocytes in the clearance of excess extracellular potassium
112. Independent mechanisms of potassium clearance by astrocytes in gliotic tissue
113. 2+ channels in reactive astrocytes after brain injury, hypomyelination, and ischemia
114. Pharmacological regulation of astrocytic calcium channels: Implications for the treatment of seizure disorders
115. GluR3 autoantibodies destroy neural cells in a complement-dependent manner modulated by complement regulatory proteins
116. Roles of metabotropic glutamate receptors in glial function and glial-neuronal communication
117. Activity-dependent intracellular acidification correlates with the duration of seizure activity
118. Phenytoin: Mechanisms of its anticonvulsant action