Induction of cytosine arabinoside-resistant human myeloid leukemia cell death through autophagy regulation by hydroxychloroquine

Biomedicine and Pharmacotherapy

Volumn 73, Issue , 2015, Pages 87-96

  Kim, Yundeok ^a   Eom, Ju In ^a   Jeung, Hoi Kyung ^a   Jang, Ji Eun ^a   Kim, Jin Seok ^a   Cheong, June Won ^a   Kim, Young Sam ^a   Min, Yoo Hong ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

Acute myeloid leukemia; Apoptosis; Autophagy; Chemoresistance; Hydroxychloroquine

Indexed keywords

AUTOPHAGY PROTEIN 5; BECLIN 1; CASPASE 3; CYTARABINE; GREEN FLUORESCENT PROTEIN; HYDROXYCHLOROQUINE; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN LIGHT CHAIN 3 I; MICROTUBULE ASSOCIATED PROTEIN LIGHT CHAIN 3 II; PROTEIN; PROTEIN P62; PROTEIN SQSTM1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIMETABOLITE;

ACUTE MYELOBLASTIC LEUKEMIA; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER RESISTANCE; CELL CYCLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG MECHANISM; DRUG SENSITIVITY; GENE SILENCING; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MYELOID LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; TRANSMISSION ELECTRON MICROSCOPY; U937 CELL LINE; CELL DEATH; DRUG EFFECTS; DRUG RESISTANCE; LEUKEMIA, MYELOID, ACUTE; PATHOLOGY; PHYSIOLOGY;

ANTIMETABOLITES, ANTINEOPLASTIC; AUTOPHAGY; CELL DEATH; CYTARABINE; DRUG RESISTANCE, NEOPLASM; HUMANS; HYDROXYCHLOROQUINE; LEUKEMIA, MYELOID, ACUTE; U937 CELLS;

EID: 84937795164     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2015.05.012     Document Type: Article

References (44)

1. Derolf A.R., Kristinsson S.Y., Andersson T.M., Landgren O., Dickman P.W., Bjorkholm M. Improved patient survival for acute myeloid leukemia: a population-based study of 9729 patients diagnosed in Sweden between 1973 and 2005. Blood 2009, 113(16):3666-3672. Periodical literature.
2. Lowenberg B. Strategies in the treatment of acute myeloid leukemia. Haematologica 2004, 89(9):1029-1032.
3. Cassileth P.A., Harrington D.P., Appelbaum F.R., Lazarus H.M., Rowe J.M., Paietta E., et al. Chemotherapy compared with autologous or allogeneic bone marrow transplantation in the management of acute myeloid leukemia in first remission. N. Engl. J. Med. 1998, 339(23):1649-1656.
4. Lowenberg B., Downing J.R., Burnett A. Acute myeloid leukemia. N. Engl. J. Med. 1999, 341(14):1051-1062.
5. Cheong J.W., Jung H.I., Eom J.I., Kim S.J., Jeung H.K., Min Y.H. Aurora-A kinase inhibition enhances the cytosine arabinoside-induced cell death in leukemia cells through apoptosis and mitotic catastrophe. Cancer Lett. 2010, 297(2):171-181.
6. Cai J., Damaraju V.L., Groulx N., Mowles D., Peng Y., Robins M.J., et al. Two distinct molecular mechanisms underlying cytarabine resistance in human leukemic cells. Cancer Res. 2008, 68(7):2349-2357.
7. Negoro E., Yamauchi T., Urasaki Y., Nishi R., Hori H., Ueda T. Characterization of cytarabine-resistant leukemic cell lines established from five different blood cell lineages using gene expression and proteomic analyses. Int. J. Oncol. 2011, 38(4):911-919.
8. Song J.H., Kim S.H., Kweon S.H., Lee T.H., Kim H.J., Kim H.J., et al. Defective expression of deoxycytidine kinase in cytarabine-resistant acute myeloid leukemia cells. Int. J. Oncol. 2009, 34(4):1165-1171.
9. Kroemer G., Jaattela M. Lysosomes and autophagy in cell death control. Nat. Rev. Cancer 2005, 5(11):886-897.
10. Glick D., Barth S., Macleod K.F. Autophagy: cellular and molecular mechanisms. J. Pathol. 2010, 221(1):3-12.
11. Levine B., Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008, 132(1):27-42.
12. Yang Z.N.J., Chee C.E., Huang S.B., Sinicrope F.A. The role of autophagy in cancer: therapeutic implications. Mol. Cancer Ther. 2011, 10(9):1533-1541.
13. Han W., Sun J., Feng L., Wang K., Li D., Pan Q., et al. Autophagy inhibition enhances daunorubicin-induced apoptosis in K562 cells. PLoS One 2011, 6(12):e28491.
14. Huang S.W., Liu K.T., Chang C.C., Chen Y.J., Wu C.Y., Tsai J.J., et al. Imiquimod simultaneously induces autophagy and apoptosis in human basal cell carcinoma cells. Br. J. Dermatol. 2010, 163(2):310-320.
15. Sharma N., Thomas S., Golden E.B., Hofman F.M., Chen T.C., Petasis N.A., et al. Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent. Cancer Lett. 2012, 326(2):143-154.
16. Sui X., Chen R., Wang Z., Huang Z., Kong N., Zhang M., et al. Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment. Cell Death Dis. 2013, 4:e838.
17. Hu Y.L., Jahangiri A., DeLay M., Aghi M.K. Tumor cell autophagy as an adaptive response mediating resistance to treatments such as antiangiogenic therapy. Cancer Res. 2012, 72(17):4294-4299.
18. Janku F., McConkey D.J., Hong D.S., Kurzrock R. Autophagy as a target for anticancer therapy. Nat. Rev. Clin. Oncol. 2011, 8(9):528-539.
19. Cecconi F. c-Cbl targets active Src for autophagy. Nat. Cell Biol. 2012, 14(1):48-49.
20. Carew J.S., Nawrocki S.T., Kahue C.N., Zhang H., Yang C., Chung L., et al. Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance. Blood 2007, 110(1):313-322.
21. Nilsson J.R. Does chloroquine, an antimalarial drug, affect autophagy in tetrahymena-pyriformis. J. Protozool. 1992, 39(1):9-16.
22. Gunja N., Roberts D., McCoubrie D., Lamberth P., Jan A., Simes D.C., et al. Survival after massive hydroxychloroquine overdose. Anaesth. Intensive Care 2009, 37(1):130-133.
23. Kimura T., Takabatake Y., Takahashi A., Isaka Y. Chloroquine in cancer therapy: a double-edged sword of autophagy. Cancer Res. 2013, 73(1):3-7.
24. Solomon V.R., Lee H. Chloroquine and its analogs: a new promise of an old drug for effective and safe cancer therapies. Eur. J. Pharmacol. 2009, 625(1-3):220-233.
25. Livesey K.M., Tang D., Zeh H.J., Lotze M.T. Autophagy inhibition in combination cancer treatment. Curr. Opin. Investig. Drugs 2009, 10(12):1269-1279.
26. Kim E.L., Wustenberg R., Rubsam A., Schmitz-Salue C., Warnecke G., Bucker E.M., et al. Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells. Neuro. Oncol. 2010, 12(4):389-400.
27. Song J.H., Kim S.H., Kim H.J., Hwang S.Y., Kim T.S. Alleviation of the drug-resistant phenotype in idarubicin and cytosine arabinoside double-resistant acute myeloid leukemia cells by indomethacin. Int. J. Oncol. 2008, 32(4):931-936.
28. Kim J.S., Eom J.I., Cheong J.W., Choi A.J., Lee J.K., Yang W.I., et al. Protein kinase CK2 alpha as an unfavorable prognostic marker and novel therapeutic target in acute myeloid leukemia. Clin. Cancer Res. 2007, 13(3):1019-1028.
29. Vergne I., Roberts E., Elmaoued R.A., Tosch V., Delgado M.A., Proikas-Cezanne T., et al. Control of autophagy initiation by phosphoinositide 3-phosphatase jumpy (vol 28, pg 2244, 2009). EMBO J. 2009, 28(15):2244-2258.
30. Kim Y.R., Eom J.I., Kim S.J., Jeung H.K., Cheong J.W., Kim J.S., et al. Myeloperoxidase Expression as a Potential Determinant of Parthenolide-Induced Apoptosis in Leukemia Bulk and Leukemia Stem Cells. J. Pharmacol. Exp. Ther. 2010, 335(2):389-400.
31. Kern M.A., Haugg A.M., Koch A.F., Schilling T., Breuhahn K., Walczak H., et al. Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma. Cancer Res. 2006, 66(14):7059-7066.
32. O'Donovan T.R., O'Sullivan G.C., McKenna S.L. Induction of autophagy by drug-resistant esophageal cancer cells promotes their survival and recovery following treatment with chemotherapeutics. Autophagy 2011, 7(5):509-524.
33. Rusten T.E., Stenmark H. p62, an autophagy hero or culprit?. Nat. Cell Biol. 2010, 12(3):207-209.
34. Myeku N., Figueiredo-Pereira M.E. Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62. J. Biol. Chem. 2011, 286(25):22426-22440.
35. Chou T.C., Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv. Enzyme Regul. 1984, 22:27-55.
36. Duran A., Linares J.F., Galvez A.S., Wikenheiser K., Flores J.M., Diaz-Meco M.T., et al. The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis. Cancer Cell 2008, 13(4):343-354.
37. Morselli E., Tasdemir E., Maiuri M.C., Galluzzi L., Kepp O., Criollo A., et al. Mutant p53 protein localized in the cytoplasm inhibits autophagy. Cell Cycle 2008, 7(19):3056-3061.
38. Ojha R., Singh S.K., Bhattacharyya S., Dhanda R.S., Rakha A., Mandal A.K., et al. Inhibition of grade dependent autophagy in urothelial carcinoma increases cell death under nutritional limiting condition and potentiates the cytotoxicity of chemotherapeutic agent. J. Urol. 2014, 10.1016/j.juro.2014.01.006.
39. Sotelo J., Briceno E., Lopez-Gonzalez M.A. Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial. Ann. Intern. Med. 2006, 144(5):337-343.
40. Sasaki K., Tsuno N.H., Sunami E., Tsurita G., Kawai K., Okaji Y., et al. Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells. BMC Cancer 2010, 10:370.
41. Bellodi C., Lidonnici M.R., Hamilton A., Helgason G.V., Soliera A.R., Ronchetti M., et al. Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J. Clin. Invest. 2009, 119(5):1109-1123.
42. Han W.D., Sun J., Feng L.F., Wang K.F., Li D., Pan Q., et al. Autophagy inhibition enhances daunorubicin-induced apoptosis in K562 cells. PLoS One 2011, 6(12).
43. Mahoney E., Lucas D.M., Gupta S.V., Wagner A.J., Herman S.E.M., Smith L.L., et al. ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol. Blood 2012, 120(6):1262-1273.
44. Evangelisti C., Ricci F., Tazzari P., Chiarini F., Battistelli M., Falcieri E., et al. Preclinical testing of the Akt inhibitor triciribine in T-cell acute lymphoblastic leukemia. J. Cell. Physiol. 2011, 226(3):822-831.