Inhibition of grade dependent autophagy in urothelial carcinoma increases cell death under nutritional limiting condition and potentiates the cytotoxicity of chemotherapeutic agent

Journal of Urology

Volumn 191, Issue 6, 2014, Pages 1889-1898

  Ojha, Rani ^a   Singh, Shrawan K ^a   Bhattacharyya, Shalmoli ^a   Dhanda, Rakesh Singh ^a   Rakha, Aruna ^a   Mandal, Arup K ^a   Jha, Vivekanand ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

apoptosis; autophagy; carcinoma; urinary tract; urothelium

Indexed keywords

3 METHYLADENINE; ATG7 PROTEIN; BECLIN 1; CASPASE 3; CASPASE 9; CHLOROQUINE; CISPLATIN; CYTOCHROME C; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LC3 PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN; UNCLASSIFIED DRUG; WORTMANNIN; ANTINEOPLASTIC AGENT;

ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; MITOCHONDRIAL MEMBRANE POTENTIAL; MTT ASSAY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSITIONAL CELL CARCINOMA; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; CANCER GRADING; CELL CULTURE; CELL LINE; CELL VACUOLE; ENZYME INHIBITION; PRIMARY CULTURE; STARVATION; SURVIVAL; TUMOR CELL; DRUG EFFECTS; DRUG RESISTANCE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE; URINARY BLADDER NEOPLASMS; UROTHELIUM;

ANTINEOPLASTIC AGENTS; AUTOPHAGY; CARCINOMA, TRANSITIONAL CELL; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; DRUG RESISTANCE, NEOPLASM; HUMANS; SIGNAL TRANSDUCTION; URINARY BLADDER NEOPLASMS; UROTHELIUM;

EID: 84900426789     PISSN: 00225347     EISSN: 15273792     Source Type: Journal    
DOI: 10.1016/j.juro.2014.01.006     Document Type: Article

References (30)

1. M.C. Hall, S.S. Chang, and G. Dalbagni et al. Guidelines for the management of non-muscle invasive bladder cancer (stages Ta, T1, and Tis): 2007 update J Urol 178 2007 2314
2. B.W. Van Rhijn, M. Burger, and Y. Lotan et al. Recurrence and progression of disease in non-muscle-invasive bladder cancer: from epidemiology to treatment strategy Eur Urol 56 2009 430
3. R.J. DeBerardinis, J.J. Lum, and G. Hatzivassiliou et al. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation Cell Metab 7 2008 11
4. P. Boya, F. Reggiori, and P. Codogno Emerging regulation and functions of autophagy Nature Cell Biol 15 2013 713
5. E. White, and R.S. DiPaola The double-edged sword of autophagy modulation in cancer Clin Cancer Res 15 2009 5308
6. R. Mathew, C. Karp, and B. Beaudoin et al. Autophagy suppresses tumorigenesis through elimination of p62 Cell 137 2009 1062
7. K. Degenhardt, R. Mathew, and B. Beaudoin et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis Cancer Cell 10 2006 51
8. R.K. Amaravadi, J. Lippincott-Schwartz, and X.M. Yin et al. Principles and current strategies for targeting autophagy for cancer treatment Cancer Res 17 2011 654
9. J.N. Eble, G. Sauter, and J. Epstein et al. WHO Classification of Tumors of the Urinary System and Male Genital Organs 2004 IARC Press Lyon
10. J.D. Chester, W. Kennedy, and G.D. Hall et al. Adenovirus-mediated gene therapy for bladder cancer: efficient gene delivery to normal and malignant human urothelial cells in vitro and ex vivo Gene Ther 10 2003 172
11. Y. Wei, S. Pattingre, and S. Sinha et al. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy Mol Cell 30 2008 678
12. J.M. Adams Ways of dying: multiple pathways to apoptosis Genes Dev 17 2003 2481
13. K.N. Dalby, I. Tekedereli, and G. Lopez-Berestein et al. Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer Autophagy 6 2010 322
14. K. Moreau, S. Luo, and D.C. Rubinsztein Cytoprotective roles for autophagy Curr Opin Cell Biol 22 2010 206
15. A.C. Kimmelman The dynamic nature of autophagy in cancer Genes Dev 25 2011 1999
16. D. Hanahan, and A.R. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646
17. R. Mathew, and E. White Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night Curr Opin Genet Dev 21 2011 113
18. X.H. Ma, S. Piao, and D. Wang et al. Measurements of tumor cell autophagy predict invasiveness, resistance to chemotherapy, and survival in melanoma Clin Cancer Res 17 2011 3478
19. J.J. Lum, D.E. Bauer, and M. Kong et al. Growth factor regulation of autophagy and cell survival in the absence of apoptosis Cell 120 2005 237
20. A.D. Rubinstein, and K. Kimchi Life in the balance a mechanistic view of the crosstalk between autophagy and apoptosis J Cell Sci 125 2012 5259
21. M. Salazar, A. Carracedo, and I.J. Salanueva et al. Cannabinoid action induces autophagy mediated cell death through stimulation of ER stress in human glioma cells J Clin Invest 119 2009 1359
22. N. Chen, and J. Debnath Autophagy and tumorigenesis FEBS Lett 584 2010 1427
23. R.J. Chen, C.T. Ho, and Y.J. Wang Pterostilbene induces autophagy and apoptosis in sensitive and chemoresistant human bladder cancer cells Mol Nutr Food Res 54 2010 1819
24. X.Q. Zhang, K. Dunner Jr., and W.F. Benedict Autophagy is induced by adenoviral-mediated interferon alpha treatment in interferon resistant bladder cancer and normal urothelial cells as a cell death protective mechanism but not by the bystander factors produced Cancer Gene Ther 17 2010 579
25. P. Boya, P.A. Gonzalez-Polo, and N. Casares et al. Inhibition of macroautophagy triggers autophagy Mol Cell Biol 25 2005 1025
26. J. Kim, M. Kundu, and B. Viollet et al. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 Nat Cell Biol 13 2011 132
27. R.J. Dickstein, G. Nitti, and C.P. Dinney et al. Autophagy limits the cytotoxic effects of the AKT inhibitor AZ7328 in human bladder cancer cells Cancer Biol Ther 13 2012 1325
28. J. Sotelo, E. Briceno, and M.A. Lopez-Gonzalez Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial Ann Intern Med 144 2006 337
29. R.K. Amaravadi, D. Yu, and J.J. Lum et al. Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma J Clin Invest 117 2007 326
30. D. Liu, Y. Yang, and Q. Liu et al. Inhibition of autophagy by 3-MA potentiates cisplatin induced apoptosis in esophageal squamous cell carcinoma cells Med Oncol 28 2011 105