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Volumn 8, Issue 5, 2015, Pages 4627-4638

Rapamycin reverses paraquat-induced acute lung injury in a rat model through inhibition of NFκB activation

Author keywords

Acute lung injury; Glutathione peroxidase; Malondialdehyde; NF B; Paraquat; Paraquat induced acute lung injury rat model; Rapamycin; Superoxide dismutase

Indexed keywords

BIOLOGICAL MARKER; CARBON DIOXIDE; GLUTATHIONE PEROXIDASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE P38; PARAQUAT; RAPAMYCIN; SUPEROXIDE DISMUTASE;

EID: 84937792822     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (23)

References (46)
  • 1
    • 84881183934 scopus 로고    scopus 로고
    • Prognostic value of initial arterial lactate level and lactate metabolic clearance rate in patients with acute paraquat poisoning
    • Liu XW, Ma T, Qu B, Ji Y and Liu Z. Prognostic value of initial arterial lactate level and lactate metabolic clearance rate in patients with acute paraquat poisoning. Am J Emerg Med 2013; 31: 1230-1235.
    • (2013) Am J Emerg Med , vol.31 , pp. 1230-1235
    • Liu, X.W.1    Ma, T.2    Qu, B.3    Ji, Y.4    Liu, Z.5
  • 2
    • 79151483124 scopus 로고    scopus 로고
    • The significance of serum xanthine oxidase and oxidation markers in acute paraquat poisoning in humans
    • Zhang J, Lv G and Zhao Y. The significance of serum xanthine oxidase and oxidation markers in acute paraquat poisoning in humans. Clin Biochem 2011; 44: 221-225.
    • (2011) Clin Biochem , vol.44 , pp. 221-225
    • Zhang, J.1    Lv, G.2    Zhao, Y.3
  • 3
    • 77952918322 scopus 로고    scopus 로고
    • Peripheral burning sensation: a novel clinical marker of poor prognosis and higher plasma-paraquat concentrations in paraquat poisoning
    • Gawarammana IB and Dawson AH. Peripheral burning sensation: a novel clinical marker of poor prognosis and higher plasma-paraquat concentrations in paraquat poisoning. Clin Toxicol (Phila) 2010; 48: 347-349.
    • (2010) Clin Toxicol (Phila) , vol.48 , pp. 347-349
    • Gawarammana, I.B.1    Dawson, A.H.2
  • 7
    • 84862963452 scopus 로고    scopus 로고
    • Arterial lactate as a predictor of mortality in emergency department patients with paraquat intoxication
    • Lee Y, Lee JH, Seong AJ, Hong CK, Lee HJ, Shin DH and Hwang SY. Arterial lactate as a predictor of mortality in emergency department patients with paraquat intoxication. Clin Toxicol (Phila) 2012; 50: 52-56.
    • (2012) Clin Toxicol (Phila) , vol.50 , pp. 52-56
    • Lee, Y.1    Lee, J.H.2    Seong, A.J.3    Hong, C.K.4    Lee, H.J.5    Shin, D.H.6    Hwang, S.Y.7
  • 9
    • 62449297900 scopus 로고    scopus 로고
    • Comparison between kidney and hemoperfusion for paraquat elimination
    • Kang MS, Gil HW, Yang JO, Lee EY and Hong SY. Comparison between kidney and hemoperfusion for paraquat elimination. J Korean Med Sci 2009; 24 Suppl: S156-160.
    • (2009) J Korean Med Sci , vol.24 , pp. S156-S160
    • Kang, M.S.1    Gil, H.W.2    Yang, J.O.3    Lee, E.Y.4    Hong, S.Y.5
  • 10
    • 4344616096 scopus 로고    scopus 로고
    • Effect of haemoperfusion on plasma paraquat concentration in vitro and in vivo
    • Hong SY, Yang JO, Lee EY and Kim SH. Effect of haemoperfusion on plasma paraquat concentration in vitro and in vivo. Toxicol Ind Health 2003; 19: 17-23.
    • (2003) Toxicol Ind Health , vol.19 , pp. 17-23
    • Hong, S.Y.1    Yang, J.O.2    Lee, E.Y.3    Kim, S.H.4
  • 11
    • 46249123205 scopus 로고    scopus 로고
    • Association between plasma paraquat level and outcome of paraquat poisoning in 375 paraquat poisoning patients
    • Gil HW, Kang MS, Yang JO, Lee EY and Hong SY. Association between plasma paraquat level and outcome of paraquat poisoning in 375 paraquat poisoning patients. Clin Toxicol (Phila) 2008; 46: 515-518.
    • (2008) Clin Toxicol (Phila) , vol.46 , pp. 515-518
    • Gil, H.W.1    Kang, M.S.2    Yang, J.O.3    Lee, E.Y.4    Hong, S.Y.5
  • 12
    • 79952626214 scopus 로고    scopus 로고
    • Therapeutic hypothermia attenuates acute lung injury in paraquat intoxication in rats
    • Jo YH, Kim K, Rhee JE, Suh GJ, Kwon WY, Na SH and Alam HB. Therapeutic hypothermia attenuates acute lung injury in paraquat intoxication in rats. Resuscitation 2011; 82: 487-491.
    • (2011) Resuscitation , vol.82 , pp. 487-491
    • Jo, Y.H.1    Kim, K.2    Rhee, J.E.3    Suh, G.J.4    Kwon, W.Y.5    Na, S.H.6    Alam, H.B.7
  • 13
    • 79551696012 scopus 로고    scopus 로고
    • Unbalanced MMP/TIMP-1 expression during the development of experimental pulmonary fibrosis with acute paraquat poisoning
    • Wang BL, Tu YY, Fu JF, Zhong YX, Fu GQ, Tian XX, Wang LH, Gong L and Ren QY. Unbalanced MMP/TIMP-1 expression during the development of experimental pulmonary fibrosis with acute paraquat poisoning. Mol Med Rep 2011; 4: 243-248.
    • (2011) Mol Med Rep , vol.4 , pp. 243-248
    • Wang, B.L.1    Tu, Y.Y.2    Fu, J.F.3    Zhong, Y.X.4    Fu, G.Q.5    Tian, X.X.6    Wang, L.H.7    Gong, L.8    Ren, Q.Y.9
  • 14
    • 76749088358 scopus 로고    scopus 로고
    • Pathological roles of MAPK signaling pathways in human diseases
    • Kim EK and Choi EJ. Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta 2010; 1802: 396-405.
    • (2010) Biochim Biophys Acta , vol.1802 , pp. 396-405
    • Kim, E.K.1    Choi, E.J.2
  • 19
    • 59749091850 scopus 로고    scopus 로고
    • A complex interplay between Akt, TSC2 and the two mTOR complexes
    • Huang J and Manning BD. A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem Soc Trans 2009; 37: 217-222.
    • (2009) Biochem Soc Trans , vol.37 , pp. 217-222
    • Huang, J.1    Manning, B.D.2
  • 20
    • 78650510609 scopus 로고    scopus 로고
    • mTOR: from growth signal integration to cancer, diabetes and ageing
    • Zoncu R, Efeyan A and Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011; 12: 21-35.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 21
    • 63849149937 scopus 로고    scopus 로고
    • LKB1 and AMP-activated protein kinase control of mTOR signalling and growth
    • Shaw RJ. LKB1 and AMP-activated protein kinase control of mTOR signalling and growth. Acta Physiol (Oxf) 2009; 196: 65-80.
    • (2009) Acta Physiol (Oxf) , vol.196 , pp. 65-80
    • Shaw, R.J.1
  • 22
    • 84555187728 scopus 로고    scopus 로고
    • Biochemical and pharmacological inhibition of mTOR by rapamycin and an ATP-competitive mTOR inhibitor
    • Yu K and Toral-Barza L. Biochemical and pharmacological inhibition of mTOR by rapamycin and an ATP-competitive mTOR inhibitor. Methods Mol Biol 2012; 821: 15-28.
    • (2012) Methods Mol Biol , vol.821 , pp. 15-28
    • Yu, K.1    Toral-Barza, L.2
  • 23
    • 77950617652 scopus 로고    scopus 로고
    • Inhibition of mammalian target of rapamycin: the janus face of immunosuppression?
    • Soll C and Clavien PA. Inhibition of mammalian target of rapamycin: the janus face of immunosuppression? Hepatology 2010; 51: 1113-1115.
    • (2010) Hepatology , vol.51 , pp. 1113-1115
    • Soll, C.1    Clavien, P.A.2
  • 25
    • 84880740183 scopus 로고    scopus 로고
    • The role of AKT/mTOR pathway in stress response to UV-irradiation: implication in skin carcinogenesis by regulation of apoptosis, autophagy and senescence
    • Strozyk E and Kulms D. The role of AKT/mTOR pathway in stress response to UV-irradiation: implication in skin carcinogenesis by regulation of apoptosis, autophagy and senescence. Int J Mol Sci 2013; 14: 15260-15285.
    • (2013) Int J Mol Sci , vol.14 , pp. 15260-15285
    • Strozyk, E.1    Kulms, D.2
  • 26
    • 84872543209 scopus 로고    scopus 로고
    • mTor as a potential target for the prevention and treatment of hepatocellular carcinoma
    • Buitrago-Molina LE and Vogel A. mTor as a potential target for the prevention and treatment of hepatocellular carcinoma. Curr Cancer Drug Targets 2012; 12: 1045-1061.
    • (2012) Curr Cancer Drug Targets , vol.12 , pp. 1045-1061
    • Buitrago-Molina, L.E.1    Vogel, A.2
  • 27
  • 28
    • 0003633755 scopus 로고    scopus 로고
    • Washington (DC): National Academies Press (US)
    • National Research Council (US) Institute for Laboratory Animal Research. Guide for the Care and Use of Laboratory Animals. Washington (DC): National Academies Press (US); 1996.
    • (1996) Guide for the Care and Use of Laboratory Animals
  • 29
    • 78149465001 scopus 로고    scopus 로고
    • Cytotoxicity and gene array analysis of alveolar epithelial A549 cells exposed to paraquat
    • Mitsopoulos P and Suntres ZE. Cytotoxicity and gene array analysis of alveolar epithelial A549 cells exposed to paraquat. Chem Biol Interact 2010; 188: 427-436.
    • (2010) Chem Biol Interact , vol.188 , pp. 427-436
    • Mitsopoulos, P.1    Suntres, Z.E.2
  • 30
    • 84862506060 scopus 로고    scopus 로고
    • Resveratrol inhibits paraquat-induced oxidative stress and fibrogenic response by activating the nuclear factor erythroid 2-related factor 2 pathway
    • He X, Wang L, Szklarz G, Bi Y and Ma Q. Resveratrol inhibits paraquat-induced oxidative stress and fibrogenic response by activating the nuclear factor erythroid 2-related factor 2 pathway. J Pharmacol Exp Ther 2012; 342: 81-90.
    • (2012) J Pharmacol Exp Ther , vol.342 , pp. 81-90
    • He, X.1    Wang, L.2    Szklarz, G.3    Bi, Y.4    Ma, Q.5
  • 33
    • 84865630968 scopus 로고    scopus 로고
    • Anti-inflammatory and antioxidant effects of infliximab on acute lung injury in a rat model of intestinal ischemia/reperfusion
    • Guzel A, Kanter M, Guzel A, Pergel A and Erboga M. Anti-inflammatory and antioxidant effects of infliximab on acute lung injury in a rat model of intestinal ischemia/reperfusion. J Mol Histol 2012; 43: 361-369.
    • (2012) J Mol Histol , vol.43 , pp. 361-369
    • Guzel, A.1    Kanter, M.2    Guzel, A.3    Pergel, A.4    Erboga, M.5
  • 36
    • 84879250657 scopus 로고    scopus 로고
    • Mammalian target of rapamycin-independent S6K1 and 4E-BP1 phosphorylation during contraction in rat skeletal muscle
    • Liu Y, Vertommen D, Rider MH and Lai YC. Mammalian target of rapamycin-independent S6K1 and 4E-BP1 phosphorylation during contraction in rat skeletal muscle. Cell Signal 2013; 25: 1877-1886.
    • (2013) Cell Signal , vol.25 , pp. 1877-1886
    • Liu, Y.1    Vertommen, D.2    Rider, M.H.3    Lai, Y.C.4
  • 37
    • 77952520262 scopus 로고    scopus 로고
    • Obesity, hyperinsulinemia and breast cancer: novel targets and a novel role for metformin
    • Wysocki PJ and Wierusz-Wysocka B. Obesity, hyperinsulinemia and breast cancer: novel targets and a novel role for metformin. Expert Rev Mol Diagn 2010; 10: 509-519.
    • (2010) Expert Rev Mol Diagn , vol.10 , pp. 509-519
    • Wysocki, P.J.1    Wierusz-Wysocka, B.2
  • 39
    • 79951561948 scopus 로고    scopus 로고
    • The role of anti-inflammatory agents in age-related macular degeneration (AMD) treatment
    • Wang Y, Wang VM and Chan CC. The role of anti-inflammatory agents in age-related macular degeneration (AMD) treatment. Eye (Lond) 2011; 25: 127-139.
    • (2011) Eye (Lond) , vol.25 , pp. 127-139
    • Wang, Y.1    Wang, V.M.2    Chan, C.C.3
  • 41
    • 60749126275 scopus 로고    scopus 로고
    • Inflammation markers in point-of-care testing (POCT)
    • Pfafflin A and Schleicher E. Inflammation markers in point-of-care testing (POCT). Anal Bioanal Chem 2009; 393: 1473-1480.
    • (2009) Anal Bioanal Chem , vol.393 , pp. 1473-1480
    • Pfafflin, A.1    Schleicher, E.2
  • 42
    • 79953146630 scopus 로고    scopus 로고
    • Selective abrogation of BiP/GRP78 blunts activation of NF-kappaB through the ATF6 branch of the UPR: involvement of C/EBPbeta and mTOR-dependent dephosphorylation of Akt
    • Nakajima S, Hiramatsu N, Hayakawa K, Saito Y, Kato H, Huang T, Yao J, Paton AW, Paton JC and Kitamura M. Selective abrogation of BiP/GRP78 blunts activation of NF-kappaB through the ATF6 branch of the UPR: involvement of C/EBPbeta and mTOR-dependent dephosphorylation of Akt. Mol Cell Biol 2011; 31: 1710-1718.
    • (2011) Mol Cell Biol , vol.31 , pp. 1710-1718
    • Nakajima, S.1    Hiramatsu, N.2    Hayakawa, K.3    Saito, Y.4    Kato, H.5    Huang, T.6    Yao, J.7    Paton, A.W.8    Paton, J.C.9    Kitamura, M.10
  • 43
    • 44849117768 scopus 로고    scopus 로고
    • Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK
    • Dan HC, Cooper MJ, Cogswell PC, Duncan JA, Ting JP and Baldwin AS. Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. Genes Dev 2008; 22: 1490-1500.
    • (2008) Genes Dev , vol.22 , pp. 1490-1500
    • Dan, H.C.1    Cooper, M.J.2    Cogswell, P.C.3    Duncan, J.A.4    Ting, J.P.5    Baldwin, A.S.6
  • 44
    • 83755173518 scopus 로고    scopus 로고
    • Glutamine modulates lipopolysaccharide-induced activation of NF-kappaB via the Akt/mTOR pathway in lung epithelial cells
    • Hou YC, Chiu WC, Yeh CL and Yeh SL. Glutamine modulates lipopolysaccharide-induced activation of NF-kappaB via the Akt/mTOR pathway in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 2012; 302: L174-183.
    • (2012) Am J Physiol Lung Cell Mol Physiol , vol.302 , pp. L174-L183
    • Hou, Y.C.1    Chiu, W.C.2    Yeh, C.L.3    Yeh, S.L.4
  • 45
    • 84860253348 scopus 로고    scopus 로고
    • Protective effect of ischemic postconditioning against ischemia reperfusion-induced myocardium oxidative injury in IR rats
    • Zhang L, Ma J and Liu H. Protective effect of ischemic postconditioning against ischemia reperfusion-induced myocardium oxidative injury in IR rats. Molecules 2012; 17: 3805-3817.
    • (2012) Molecules , vol.17 , pp. 3805-3817
    • Zhang, L.1    Ma, J.2    Liu, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.