Bone morphogenetic protein 4 inhibits insulin secretion from rodent beta cells through regulation of calbindin1 expression and reduced voltage-dependent calcium currents

Diabetologia

Volumn 58, Issue 6, 2015, Pages 1282-1290

  Christensen, Gitte L ^a,b,c,d   Jacobsen, Maria L B ^a,b,c,d   Wendt, Anna ^a,b,c,d   Mollet, Ines G ^a,b,c,d   Friberg, Josefine ^a,b,c,d   Frederiksen, Klaus S ^a,b,c,d   Meyer, Michael ^a,b,c,d   Bruun, Christine ^a,b,c,d   Eliasson, Lena ^a,b,c,d   Billestrup, Nils ^a,b,c,d  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b LUND UNIVERSITY DIABETES CENTRE   (Sweden)

^c NOVO NORDISK A S   (Denmark)

^d UNIVERSITY OF MUNICH   (Germany)

Author keywords

Beta cells; BMP4; Calb1; Calbindin1; Diabetes; Exocytosis; Insulin secretion

Indexed keywords

BMP4 PROTEIN, MOUSE; BMP4 PROTEIN, RAT; BONE MORPHOGENETIC PROTEIN 4; CALB1 PROTEIN, MOUSE; CALB1 PROTEIN, RAT; CALBINDIN 1; CALCIUM; INS1 PROTEIN, MOUSE; INSULIN; MESSENGER RNA;

ANIMAL; CYTOLOGY; DNA MICROARRAY; ELECTROPHYSIOLOGY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; MOUSE; PANCREAS ISLET; PANCREAS ISLET BETA CELL; RAT; SECRETION (PROCESS); UPREGULATION; WISTAR RAT;

ANIMALS; BONE MORPHOGENETIC PROTEIN 4; CALBINDIN 1; CALCIUM; ELECTROPHYSIOLOGICAL PHENOMENA; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; MICE; MICE, KNOCKOUT; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, WISTAR; RNA, MESSENGER; UP-REGULATION;

EID: 84937764635     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3568-x     Document Type: Article

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