1,25-Dihydroxyvitamin D3 preserves intestinal epithelial barrier function from TNF-α induced injury via suppression of NF-kB p65 mediated MLCK-P-MLC signaling pathway

Biochemical and Biophysical Research Communications

Volumn 460, Issue 3, 2015, Pages 873-878

  Chen, Shanwen ^a   Zhu, Jing ^a   Chen, Guowei ^a   Zuo, Shuai ^a   Zhang, Junling ^a   Chen, Ziyi ^a   Wang, Xin ^a   Li, Junxia ^a   Liu, Yucun ^a   Wang, Pengyuan ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

Author keywords

1,25(OH)2D3; MLCK; Tight junction (TJ); TNF ; Trans epithelial electrical resistance (TEER)

Indexed keywords

CALCITRIOL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYOSIN LIGHT CHAIN; MYOSIN LIGHT CHAIN KINASE; PRIMER DNA; TUMOR NECROSIS FACTOR ALPHA;

ANTAGONISTS AND INHIBITORS; CACO 2 CELL LINE; DRUG EFFECTS; HUMAN; INTESTINE MUCOSA; METABOLISM; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

BASE SEQUENCE; CACO-2 CELLS; CALCITRIOL; DNA PRIMERS; HUMANS; INTESTINAL MUCOSA; MYOSIN LIGHT CHAINS; MYOSIN-LIGHT-CHAIN KINASE; NF-KAPPA B; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84937761805     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.03.125     Document Type: Article

References (33)

1. J.R. Turner Intestinal mucosal barrier function in health and disease Nat. Rev. Immunol. 9 2009 799 809
2. S.S. Salim, and J.D. Soderholm Importance of disrupted intestinal barrier in inflammatory bowel diseases Inflamm. Bowel Dis. 17 2011 362 381
3. F. Wang, W.V. Graham, Y.M. Wang, E.D. Witkowski, B.T. Schwarz, R. Jerrold, and Turner Interferon-γ and tumor necrosis factor-a synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression Am. J. Pathol. 166 2005 409 419
4. C. Beaurepaire, D. Smyth, and D.M. McKay Interferon-γ regulation of intestinal epithelial permeability J. Interf. Cytok Res. 29 2009 133 143
5. M. Cao, P. Wang, C. Sun, W. He, and F. Wang Amelioration of IFN-γ and TNF-α-induced intestinal epithelial barrier dysfunction by berberine via suppression of MLCK-MLC phosphorylation signaling pathway PLoS One 5 2013 e61944
6. R. Al-Sadi, S. Guo, D. Ye, and T.Y. Ma TNF-α modulation of intestinal epithelial tight junction barrier is regulated by ERK1/2 activation of Elk-1 Am. J. Pathol. 183 2013 1871 1884
7. J. Kong, Z. Zhang, M.W. Musch, G. Ning, J. Sun, J. Hart, M. Bissonnette, and Y.C. Li Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier Am. J. Physiol. Gastrointest. Liver Physiol. 294 2008 208 216
8. W. Liu, Y. Chen, M.A. Golan, M.L. Annunziata, J. Du, U. Dougherty, J. Kong, M. Musch, Y. Huang, J. Pekow, C. Zheng, M. Bissonnette, S.B. Hanauer, and Y.C. Li Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis J. Clin. Investigation 123 2013 3983 3996
9. H. Zhao, H. Zhang, H. Wu, H. Li, L. Liu, J. Guo, C. Li, D.Q. Shih, and X. Zhang Protective role of 1,25(OH)2 vitamin D3 in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice BMC Gastroenterol. 12 2012 58
10. S.W. Chen, P.Y. Wang, J. Zhu, G.W. Chen, J.L. Zhang, Z.Y. Chen, S. Zuo, Y.C. Liu, and Y.S. Pan Protective effect of 1,25-Dihydroxyvitamin D3 on lipopolysaccharide-induced intestinal epithelial tight Junction injury in Caco-2 cell monolayers Inflammation 38 2014 375 383
11. D. Ye, S. Guo, R. Al-Sadi, and T.Y. Ma MicroRNA regulation of intestinal epithelial tight junction permeability Gastroenterology 141 2011 1323 1333
12. L.F. Xu, X. Teng, J. Guo, and M. Sun Protective effect of intestinal trefoil factor on injury of intestinal epithelial tight junction induced by platelet activating factor Inflammation 35 2012 308 315
13. M.K. Puthia, S.W. Sio, J. Lu, and K.S. Tan Blastocystis ratti induces contact-independent apoptosis, F-actin rearrangement, and barrier function disruption in IEC-6 cells Infect. Immun. 74 2006 4114 4123
14. T.Y. Ma, N.T. Hoa, D.D. Tran, V. Bui, A. Pedram, S. Mills, and M. Merryfield Cytochalasin B modulation of Caco-2 tight junction barrier: role of myosin light chain kinase Am. J. Physiol. Gastrointest. Liver Physiol. 279 2000 875 885
15. T.Y. Ma, D. Nguyen, V. Bui, H. Nguyen, and N. Hoa Ethanol modulation of intestinal epithelial tight junction barrier Am. J. Physiol. Gastrointest. Liver Physiol. 276 1999 965 974
16. S. Guo, R. Al-Sadi, H.M. Said, and T.Y. Ma Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14 Am. J. Pathol. 182 2013 375 387
17. N. Schlegel, M. Meir, V. Spindler, C.T. Germer, and J. Waschke Differential role of RhoGTPases in intestinal epithelial barrier regulation in vitro J. Cell. Physiology 226 2011 1196 1203
18. M. Schliwa Action of cytochalasin D on cytoskeletal networks J. Cell Biol. 92 1982 79 91
19. M. Qasim, H. Rahman, R. Ahmed, M. Oellerich, and A.R. Asif Mycophenolic acid mediated disruption of the intestinal epithelial tight junctions Exp. Cell. Res. 322 2014 277 289
20. L. Shen, E.D. Black, E.D. Witkowski, W.I. Lencer, V. Guerriero, E.E. Schneeberger, and J.R. Turner Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure J. Cell. Sci. 119 2006 2095 2106
21. R. Al-Sadi, D. Ye, K. Dokladny, and T.Y. Ma Mechanism of IL-1beta induced increase in intestinal epithelial tight junction permeability J. Immunol. 180 2008 5653 5661
22. D.R. Clayburgh, T.A. Barrett, Y. Tang, J.B. Meddings, L.J. Van Eldik, D.M. Watterson, L.L. Clarke, R.J. Mrsny, and J.R. Turner Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo J. Clin. Invest 115 2005 2702 2715
23. D. Ye, I. Ma, and T.Y. Ma Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier Am. J. Physiol. Gastrointest. Liver Physiol. 290 2006 496 504
24. T.Y. Ma, M.A. Boivin, D. Ye, A. Pedram, and H.M. Said Mechanism of TNF-α modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression Am. J. Physiol. Gastrointest. Liver Physiol. 288 2005 422 430
25. S. Wu, A.P. Liao, Y. Xia, Y.C. Li, J.D. Li, R.B. Sartor, and J. Sun Vitamin D receptor negatively regulates bacterial-stimulated NF-kappaB activity in intestine Am. J. Pathol. 177 2010 686 697
26. C. Stevens, G. Walz, C. Singaram, M.L. Lipman, B. Zanker, A. Muggia, D. Antonioli, M.A. Peppercorn, and T.B. Strom Tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 expression in inflammatory bowel disease Dig. Dis. Sci. 37 1992 818 826
27. K.E. Cunningham, and J.R. Turner Myosin light chain kinase: pulling the strings of epithelial tight junction function Ann. N. Y. Acad. Sci. 1258 2012 34 42
28. D. Ye, and T.Y. Ma Cellular and molecular mechanisms that mediate basal and tumor necrosis factor-a induced regulation of myosin light chain kinase gene activity J. Cell. Mol. Med. 12 2008 1331 1346
29. M.A. Boivin, D. Ye, J.C. Kennedy, R. Al-Sadi, C. Shepela, and T.Y. Ma Mechanism of glucocorticoid regulation of the intestinal tight junction barrier Am. J. Physiol. Gastrointest. Liver Physiol. 292 2007 590 598
30. R. Moriez, C. Salvador-Cartier, V. Theodorou, J. Fioramonti, H. Eutamene, and L. Bueno Myosin light chain kinase is involved in lipopolysaccharide-induced disruption of colonic epithelial barrier and bacterial translocation in rats Am. J. Pathol. 167 2005 1071 1079
31. P. Martínez-Miguel, J.M. Valdivielso, D. Medrano-Andrés, P. Román-García, J.L. Cano-Peñalver, M. Rodríguez-Puyol, D. Rodríguez-Puyol, and S. López-Ongil The active form of vitamin d, calcitriol, induces a complex dual up-regulation of endothelin and nitric oxide in cultured endothelial cells Am. J. Physiol. Endocrinol. Metab. 15 2014 1085 1096
32. Y. Chen, J. Zhang, X. Ge, J. Du, D.K. Deb, and Y.C. Li Vitamin D receptor inhibits nuclear factor κB activation by interacting with IκB kinase β protein J. Biol. Chem. 288 2013 19450 19458
33. F. He, J. Peng, X.L. Deng, L.F. Yang, A.D. Camara, A. Omran, G.L. Wang, L.W. Wu, C.L. Zhang, and F. Yin Mechanisms of tumor necrosis factor-alpha-induced leaks in intestine epithelial barrier Cytokine 59 2012 264 272