Ethanol modulation of intestinal epithelial tight junction barrier

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 276, Issue 4 39-4, 1999, Pages

  Ma, Thomas Y ^a   Nguyen, Don ^b   Bui, Vuong ^b   Nguyen, Hanh ^b   Hoa, Neil ^b  

^a VA LONG BEACH HEALTHCARE SYSTEM   (United States)

^b NONE

Author keywords

Actin; Myosin light chain kinase; Paracellular permeability

Indexed keywords

2,4 DINITROPHENOL; ACTIN; ALCOHOL; MYOSIN LIGHT CHAIN KINASE; SODIUM AZIDE;

ALCOHOL BLOOD LEVEL; ARTICLE; CELL MEMBRANE PERMEABILITY; CYTOTOXICITY; DIGESTIVE SYSTEM INJURY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; INTESTINE MUCOSA; PRIORITY JOURNAL; PROTEIN ASSEMBLY; TIGHT JUNCTION;

EID: 0032938095     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1999.276.4.g965     Document Type: Article

References (40)

1. Anderson, J. M., and C. M. van Itallie. Tight junctions and the molecular basis for regulation of paracellular permeability. Am. J. Physiol. 269 (Gastrointest. Liver Physiol. 32): G497-G475, 1995.
2. Baraona, E., R. C. Pirola, and C. H. Lieber. Small intestinal damage and changes in cell population produced by ethanol ingestion in the rat. Gastroenterology 66: 226-235, 1974.
3. Beck, J. T. Small bowel injury by ethanol. In: Alcohol and Gastrointestinal Tract, edited by V. R. Preedy and R. R. Watson. Boca Raton, FL: CRC, 1995, p. 163-202.
4. Bjarnason, I., P. Williams, P. Smethurst, T. J. Peters, and A. J. Levi The effect of NSAIDs and prostaglandins on the permeability of the human small intestine. Gut 27, 1292-1297, 1986.
5. Fasano, A., C. Fiorentini, G. Donelli, S. Uzzau, J. B. Kaper, K. Margaretten, X. Ding, S. Guandalini, L. Comstock, and S. E. Goldblum. Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization in vitro. J. Clin. Invest. 96: 711-720, 1995.
6. Fox, J. E., R. Bourdages, and I. T. Beck. Effect of ethanol on glucose and water absorption in hamster jejunum in vivo methodological problems: anesthesia, nonabsorbable markers, and osmotic effect. Dig. Dis. 23: 193-200, 1978.
7. Hecht, G., L. Pestic, G. Nikcevi, A. Koutsouris, J. Tripuraneni, D. D. Lorimer, G. Nowak, V. Guerriero, Jr., E. L. Elson, and P. de Lanerolle. Expression of the catalytic domain of myosin light chain kinase increases paracellular permeability. Am. J. Physiol. 271 (Cell Physiol. 40): C1676-C1684, 1996.
8. Hecht, G., C. Pothoulakis, J. T. LaMont, and J. L. Madara. Clostridium difficile toxin a perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers. J. Clin. Invest. 82: 1516-1524, 1988.
9. Hernandez, A., G. M. Nichols, and J. Glass. Caco-2 cell line: a system for studying intestinal iron transport across epithelial cell monolayers. Biochim. Biophys. Acta 1079: 205-208, 1991.
10. Hidalgo, I. J., T. J. Raub, and R. T. Borchardt. Characterization of human colon carcinoma cell line (Caco-2) as a model system of intestinal epithelial permeability. Gastroenterology 96: 736-749, 1989.
11. Hollander, D. Crohn's disease - a permeability disorder of the tight junction? Gut 26: 1621-1624, 1988.
12. Hoyumpa, A. M., K. J. Breen, S. Schenker, and F. A. Wilson. Thiamine transport across the rat intestine. II. Effect of ethanol. J. Lab. Clin. Med. 86: 803-816, 1975.
13. Itoh, T., M. Ikebe, K. Kargacin, D. Hartshorne, B. Kemp, and F. Fay. Effects of modulators of myosin light-chain kinase activity in single smooth muscle cells. Nature 388: 164-167, 1989.
14. Kamm, K., and J. Stull. The function of myosin and myosin light chain kinase phosphorylation in smooth muscle. Annu. Rev. Pharmacol. Toxicol. 25: 593-620, 1985.
15. Laine, L., and W. Weinstein. Histology of alcoholic hemorrhagic "gastritis": a prospective evaluation. Gastroenterology 94: 1254-1272, 1988.
16. Ma, T. Y. Intestinal epithelial barrier dysfunction in Crohn's disease. Proc. Soc. Exp. Biol. Med. 214: 318-327, 1997.
17. Ma, T. Y., D. L. Dyer, and H. M. Said. Human intestinal cell line Caco-2: a useful model for studying cellular and molecular regulation of biotin uptake. Biochim. Biophys. Acta 1189: 81-88, 1994.
18. Ma, T. Y., D. Hollander, R. A. Erickson, H. Truong, and P. Krugliak. Is the small intestinal epithelium truly "tight" to inulin permeation? Am. J. Physiol. 260 (Gastrointest. Liver Physiol. 23): G669-G676, 1991.
19. Ma, T. Y., D. Hollander, H. Nguyen, D. Bhalla, and P. Krugliak. IEC-18 a non-transformed small intestinal cell line for studying epithelial permeability. J. Lab. Clin. Med. 120: 329-341, 1992.
20. Ma, T. Y., D. Hollander, L. T. Tran, D. Nguyen, N. Hoa, and D. Bhalla. Cytoskeletal regulation of Caco-2 intestinal monolayer paracellular permeability. J. Cell. Physiol. 164: 533-545, 1995.
21. Madara, J. L. Loosening tight junction lessons from the intestine. J. Clin. Invest. 83: 1089-1094, 1989.
22. Madara, J. L. Relationships between the tight junctions and the cytoskeleton. In: Tight Junctions, edited by M. Cerreijido. Boca Raton, FL: CRC, 1992, p. 105-120.
23. Madara, J. L., D. Barenberg, and S. Carlson. Effect of cytochalasin D on occluding junctions of intestinal absorptive cells. Further evidence that the cytoskeleton may influence paracellular permeability. J. Cell Biol. 97: 2125-2135, 1986.
24. Madara, J. L., and K. Dharmsathaphorn. Occluding junction structure-function relationships in a cultured epithelial monolayer. J. Cell Biol. 101: 2124-2133, 1985.
25. Madara, J. L., R. Moore, and S. Carlson. Alteration of intestinal tight junction structure and permeability by cytoskeletal contraction. Am. J. Physiol. 253 (Cell Physiol. 22): C854-C861, 1987.
26. Makhlouf, G. M. Smooth muscle of the gut. In: Textbook of Gastroenterology, edited by T. Yamada. Philadelphia, PA: Lippincott, 1995, p. 86-110.
27. McRoberts, J. A., R. Aranda, N. Riley, and H. Kang. Insulin regulates the paracellular permeability of cultured intestinal epithelial cell monolayers. J. Clin. Invest. 85: 1125-1134, 1990.
28. Millan, M. S., G. P. Morris, I. T. Beck, and J. T. Henson. Villus damage induced by suction biopsy and by acute ethanol intake in normal human small intestine. Dig. Dis. Sci. 25: 513-525, 1980.
29. Nusrat, A., M. Giry, J. M. Turner, S. F. Colgan, C. A. Parkos, D. Carnes, E. Lemichez, P. Boquet, and J. L. Madara. Rho protein regulates tight junctions and perijunctinal actin organization in polarized epithelia. Proc. Natl. Acad. Sci. USA 92: 10629-10633, 1995.
30. Pinto, M., S. Robine-Leon, M. Tappay, M. Kedinger, N. Triadou, M. Dussayi, B. Lacvri, P. Simon-Assway, K. Haffer, J. Fough, and A. Zwiebaum. Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture. Biol. Cell 47: 323-330, 1983.
31. Said, H. M., and T. Y. Ma. Mechanisms of riboflavine uptake by Caco-2 human intestinal epithelial cells. Am. J. Physiol. 266 (Gastrointest. Liver Physiol. 29): G15-G21, 1994.
32. Spitz, J., R. Yuhan, A. Koutsouri, C. Blatt, J. Alverdy, and G. Hecth. Enteropathogenic Escherichia coli adherence to intestinal epithelial monolayers diminishes barrier function. Am. J. Physiol. 268 (Gastrointest. Liver Physiol. 31): G374-G379, 1995.
33. Stevenson, B. R., J. D. Siliciano, M. S. Mooseker, and D. A. Goodenough. Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonular occludens) in a variety of epithelial. J. Cell Biol. 103: 766-777, 1986.
34. Szabo, S., and I. Goldberg. Experimental pathogenesis: drugs and chemical lesions in the gastric mucosa. Scand. J. Gastroenterol. 25, Suppl. 174: 1-8, 1990.
35. Szabo, S., J. S. Trier, B. Brown, and J. Schnoor. Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology 88: 228-236, 1985.
36. Tarnawski, A., D. Hollander, and H. Gergely. Ethanol-induced gastric mucosal injury: sequential analysis of morphologic and functional changes. Gastroenterol. Clin. Biol. 9: 88-92, 1995.
37. Tarnawski, A., D. Hollander, and J. Stachura. Alcohol injury to the normal human gastric mucosa. Endoscopic, histologic and functional assessment. Clin. Invest. Med. 10: 259-263, 1987.
38. Tarnawski, A., J. Stachura, H. Gergely, and D. Hollander. Microvascular endothelium - a major target for alcohol injury of the human gastric mucosa. J. Clin. Gastroenterol. 19, Suppl. 1: S53-S64, 1988.
39. Turner, J., B. K. Rill, S. L. Carlson, D. Carnes, R. Kerner, R. J. Mrsny, and J. L. Madara. Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation. Am. J. Physiol. 273 (Cell Physiol. 42): C1378-C1385, 1997.
40. Wilson, F. A., and A. M. Hoyumpa, Jr. Ethanol and small intestinal transport. Gastroenterology 76: 388-403, 1979.