Cytochalasin B modulation of Caco-2 tight junction barrier: Role of myosin light chain kinase

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 279, Issue 5 42-5, 2000, Pages

  Ma, Thomas Y ^a,b,c   Hoa, Neil T ^a,b   Tran, Daniel D ^a,b   Bui, Vuong ^a,b   Pedram, Ali ^a   Mills, Susan ^a,b   Merryfield, Margaret ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CALIFORNIA STATE UNIVERSITY   (United States)

^c VA LONG BEACH HEALTHCARE SYSTEM   (United States)

Author keywords

Actin filaments; Myosin light chain kinase; Paracellular permeability; ZO 1 protein

Indexed keywords

ACTIN; CELL PROTEIN; CYTOCHALASIN B; MYOSIN ADENOSINE TRIPHOSPHATASE; MYOSIN LIGHT CHAIN KINASE INHIBITOR; PROTEIN ZO1; UNCLASSIFIED DRUG;

ARTICLE; CELL ACTIVITY; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HYDROPHILICITY; INTESTINE EPITHELIUM CELL; INTRACELLULAR MEMBRANE; PRIORITY JOURNAL; TIGHT JUNCTION;

EID: 0033672943     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2000.279.5.g875     Document Type: Article

References (43)

1. Regulation and kinetics of the actin-myosin-ATP interaction
2. Tight junctions and the molecular basis for regulation of paracellular permeability
3. Effect on non-steroidal anti-inflammatory drugs and prostaglandins on permeability of the human small intestine
4. Cytochalasin inhibits the rate of elongation actin filament fragments
5. Mechanism of action of cytochalasin evidence that it binds to actin filament ends
6. Effects of actin filament cross-linking and filament length of actin-myosin interaction
7. Molecular structure and assembly of the tight junction
8. Cytochalasin B and the kinetics of inhibition of biological transport: A case of asymmetric binding to the glucose carrier
9. Selective inhibition of the facilitated mode of sugar uptake by cytochalasin B in culture chick fibroblasts
10. The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton
11. Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro
12. Cytochalasins block actin filament elongation by binding to high affinity sites associated with F-actin
13. Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions
14. Clostridium difficile toxin a perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers
15. Caco-2 cell line: A system for studying intestinal iron transport across epithelial cell monolayers
16. Characterization of human colon carcinoma cell line (Caco-2) as a model system of intestinal epithelial permeability
17. Butanedione monoxime suppresses contraction and ATPase activity of rabbit skeletal muscle
18. Crohn's disease: A permeability disorder of the tight junction?
19. Increased intestinal permeability in patients with Crohn's disease and their relatives
20. Mechanism of action of 2.3-butanedione 2-monoxime on contraction of frog skeletal muscle fibers
21. The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction associated protein in epithelial cells: cDNA cloning and immunolocalization
22. Effects of modulators of myosin light-chain kinase activity in single smooth muscle cells
23. The function of myosin and myosin light chain kinase phosphorylation in smooth muscle
24. Mechanism and sites of mannitol permeability of small and large intestine in the rat
25. Intestinal epithelial barrier dysfunction in Crohn's disease
26. Human intestinal cell line Caco-2: A useful model for studying cellular and molecular regulation of biotin uptake
27. IEC-18: A non-transformed small intestinal cell line for studying epithelial permeability
28. Autoradiographic determination of permeation pathway of permeability probes across intestinal and tracheal epithelia
29. Cytoskeletal regulation of Caco-2 intestinal monolayer paracellular permeability
30. Mechanism of action of cytochalasin B on actin
31. Loosening tight junction lessons from the intestine
32. Relationships between the tight junctions and the cytoskeleton
33. Effect of cytochalasin D on occluding junctions of intestinal absorptive cells. Further evidence that the cytoskeleton may influence paracellular permeability
34. Occluding junction structure-function relationships in a cultured epithelial monolayer
35. Alteration of intestinal tight junction structure and permeability by cytoskeletal contraction
36. Is small intestinal permeability really increased in relatives of patients with Crohn's disease?
37. KT 5926, a potent and selective inhibitor of myosin light chain kinase
38. Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture
39. Action of cytochalasin D on cytoskeleton networks
40. Enteropathogenic Escherichia coli adherence to intestinal epithelial monolayers diminished barrier function
41. Identification of ZO-1: A high molecular weight polypeptide associated with the tight junction (zonular occludens) in a variety of epithelial
42. Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation
43. The tight junction protein ZO-1 is homologous to the drophila discs-large tumor suppressor protein of septate junctions