PDLIM2 inhibits T helper 17 cell development and granulomatous inflammation through degradation of STAT3

Science Signaling

Volumn 4, Issue 202, 2011, Pages

  Tanaka, Takashi ^a   Yamamoto, Yu ^b   Muromoto, Ryuta ^b   Ikeda, Osamu ^b   Sekine, Yuichi ^b   Grusby, Michael J ^c   Kaisho, Tsuneyasu ^a,d   Matsuda, Tadashi ^b  

^a RIKEN Center for Integrative Medical Sciences   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PDZ LIM DOMAIN PROTEIN 2; PDZ PROTEIN; STAT3 PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; LIM PROTEIN; PDLIM2 PROTEIN, HUMAN; PDLIM2 PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SMALL INTERFERING RNA; STAT3 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; GRANULOMATOUS INFLAMMATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TH17 CELL; UBIQUITINATION; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL DIFFERENTIATION; CELL LINE; CELL STRAIN HEK293; CYTOLOGY; DRUG ANTAGONISM; GENETICS; GRANULOMA; IMMUNOLOGY; INFLAMMATION; METABOLISM; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PHYSIOLOGY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; CELL LINE; GRANULOMA; HEK293 CELLS; HUMANS; INFLAMMATION; LIM DOMAIN PROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROFILAMENT PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TH17 CELLS; UBIQUITINATION;

EID: 83155175597     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2001637     Document Type: Article

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