Post-translational modification of recombinant proteins

Animal Cell Technology: From Biopharmaceuticals to Gene Therapy

Volumn , Issue , 2008, Pages 129-146

  Butler, Michael ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84937759554     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (54)

1. Akagawa M, Sasaki T, Suyama K (2002), Oxidative deamination of lysine residue in plasma protein of diabetic rats. Novel mechanism via the Maillard reaction, Eur. J. Biochem. 269:5451-5458.
2. Allen S, Naim HY, Bulleid NJ (1995), Intracellular folding of tissue-type plasminogen activator. Effects of disulfide bond formation on N-linked glycosylation and secretion, J. Biol. Chem. 270:4797-4804.
3. Backstrom M, Link T, Olson FJ, Karlsson H, Graham R, Picco G, Burchell J, Taylor-Papadimitriou J, Noll T, Hansson GC (2003), Recombinant MUC1 mucin with a breast cancer-like O-glycosylation produced in large amounts in Chinese-hamster ovary cells, Biochem. J. 376:677-686.
4. Camire RM, Larson PJ, Stafford DW, High KA (2000), Enhanced gamma-carboxylation of recombinant factor X using a chimeric construct containing the prothrombin propeptide, Biochemistry 39:14322-14329.
5. Chee F, Wong D, Tin Kam Wong K, Tang Goh L, Kiat Heng C, Gek Sim Yap M (2005), Impact of dynamic online fed-batch strategies on metabolism, productivity and N-glycosylation quality in CHO cell cultures, Biotechnol. Bioeng. 89:164-177.
6. Curling EM, Hayter PM, Baines AJ, Bull AT, Gull K, Strange PG, Jenkins N (1990), Recombinant human interferon-gamma. Differences in glycosylation and proteolytic processing lead to heterogeneity in batch culture, Biochem. J. 272:333-337.
7. Davidson DJ, Fraser MJ, Castellino FJ (1990) Oligosaccharide processing in the expression of human plasminogen cDNA by lepidopteran insect (Spodoptera frugiperda) cells. Biochemistry. 29(23):5584-90.
8. Donaldson M, Wood HA, Kulakosky PC (1999), Glycosylation of a recombinant protein in the Tn5B1-4 insect cell line: influence of ammonia, time of harvest, temperature, and dissolved oxygen, Biotechnol. Bioeng. 63:255-262.
9. Ellgaard L, Helenius A (2003), Quality control in the endoplasmic reticulum, Nat. Rev. Mol. Cell Biol. 4:181-191.
10. Farrell PJ, Lu M, Prevost J, Brown C, Behie L, Iatrou K (1998), High-level expression of secreted glycoproteins in transformed lepidopteran insect cells using a novel expression vector, Biotechnol. Bioeng. 60:656-663.
11. Friedman AR, Ichhpurani AK, Brown DM, Hillman RM, Krabill LF, Martin RA, Zurcher-Neely HA, Guido DM (1991), Degradation of growth hormone releasing factor analogs in neutral aqueous solution is related to deamidation of asparagine residues. Replacement of asparagine residues by serine stabilizes, Int. J. Pept. Protein Res. 37:14-20.
12. Furie B, Bouchard BA, Furie BC (1999), Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid, Blood 93:1798-1808.
13. Gavel Y, von Heijne G (1990), Sequence differences between glycosylated and nonglycosylated Asn-X-Thr/Ser acceptor sites: implications for protein engineering, Protein Eng. 3:433-442.
14. Gill AC, Ritchie MA, Hunt LG, Steane SE, Davies KG, Bocking SP, Rhie AG, Bennett AD, Hope J (2000), Post-translational hydroxylation at the N-terminus of the prion protein reveals presence of PPII structure in vivo, EMBO J. 19:5324-5331.
15. Goochee CF, Gramer J, Andersen DC, Bahr JB, Rasmussen JR (1991), The oligosaccharides of glycoproteins: bioprocess factors affecting oligosaccharide structure and their effect on glycoprotein properties, Bio/Technology 9:1347-1355.
16. Guarna MM, Fann CH, Busby SJ, Walker KM, Kilburn DG, Piret JM (1995), Effect of cDNA copy number on secretion rate of activated protein C, Biotechnol. Bioeng. 46:22-27.
17. Harris RJ (1995), Processing of C-terminal lysine and arginine residues of proteins isolated from mammalian cell culture, J. Chromatogr. A 705:129-134.
18. Hayter PM, Curling EMA, Baines AJ., Jenkins N, Salmon I, Strange PG, Tong JM, Bull AT (1992), Glucose-limited chemostat culture of chinese hamster ovary cells producing recombinant human interferon- Biotechnol. Bioeng. 39:327-335.
19. Hersecovics A, Orlean P (1993), Glycoprotein biosynthesis in yeast. FASEB J. 7:540-550.
20. Huang L, Lu J, Wroblewski VJ, Beals JM, Riggin RM (2005), In vivo deamidation characterization of monoclonal antibody by LC/MS/MS, Anal. Chem. 77:1432-1439.
21. Jarvis DL, Finn E (1996), Modifying the insect cell N-glycosylation pathway with immediate early baculovirus expression vectors, Nat. Biotechnol. 14:1288-1292.
22. Jarvis DL, Kawar ZS, Hollister JR (1998), Engineering N-glycosylation pathways in the baculovirus-insect cell system, Curr. Opin. Biotech. 9:528-533.
23. Jenkins N, Curling EM (1994), Glycosylation of recombinant proteins: problems and prospects. Enzyme Microb. Technol. 16:354-364
24. Jenkins N, Parekh RB, James DC (1996), Getting the glycosylation right: implications for the biotechnology industry. Nat. Biotechnol. 14:975-981.
25. Kivirikko KI, Myllyla R, Pihlajaniemi T (1989), Protein hydroxylation: prolyl 4- hydroxylase, an enzyme with four cosubstrates and a multifunctional subunit. FASEB J. 3:1609-1617.
26. Kornfeld R, Kornfeld S (1985), Assembly of asparagine-linked oligosaccharides, Annu. Rev. Biochem. 54:631-664.
27. Kulakosky PC, Shuler ML, Wood HA (1998), N-Glycosylation of a baculovirusexpressed recombinant glycoprotein in three insect cell lines, In Vitro Cell. Dev. Biol. 34:101-108.
28. Kunkel JP, Jan DC, Jamieson JC, Butler M (1998), Dissolved oxygen concentration in serum-free continuous culture affects N-linked glycosylation of a monoclonal antibody, J. Biotechnol. 62:55-71
29. Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML (2002), Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science 295:858-861.
30. Lazar AC, Kloczewiak MA, Mazsaroff I (2004), Matrix-assisted laser desorption/ ionization mass spectrometry for the evaluation of the C-terminal lysine distribution of a recombinant monoclonal antibody, Rapid Commun. Mass Spectrom. 18:239-244.
31. Leonard CK, Spellman MW, Riddle L, Harris RJ, Thomas JN, Gregory TJ (1990), Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells, J. Biol. Chem. 265:10373-10382.
32. Lopez M, Tetaert D, Juliant S, Gazon M, Cerutte M, Verbert A, Delannoy P (1999), O-glycosylation potential of lepidopteran insect cell lines, Biochim. Biophys. Acta 1427:49-61.
33. Maras M, Saelens X, Laroy W, Piens K, Claeyssens M, Fiers W, Contreras R (1997), In vitro conversion of the carbohydrate moiety of fungal glycoproteins to mammalian- type oligosaccharides. Evidence for N-acetylglucosaminyltransferase-Iaccepting glycans from Trichoderma reesei. Eur. J. Biochem. 249:701-707.
34. Meynial-Salles I, Combes D (1996), In vitro glycosylation of proteins: an enzymatic approach. J. Biotechnol. 46:1-14.
35. Nilsson MR, Driscoll M, Raleigh DP (2002), Low levels of asparagine deamidation can have a dramatic effect on aggregation of amyloidogenic peptides: implications for the study of amyloid formation. Protein Sci. 11:342-349.
36. Nyberg GB, Balcarcel RR, Follstad BD, Stephanopoulos G, Wang DI (1999), Metabolic effects on recombinant interferon-gamma glycosylation in continuous culture of Chinese hamster ovary cells, Biotechnol. Bioeng. 62:336-347.
37. Palacpac NQ, Yoshida S, Sakai H, Kimura Y, Fujiyama K (1999), Stable expression of human _ 1,4-galactosyltransferase in plant cells modifies N-linked glycosylation patterns, Proc. Natl Acad. Sci. U S A 96:4692-4697.
38. Parekh RB, Dwek RA, Edge CJ, Rademacher TW (1989), N-glycosylation and the production of recombinant glycoproteins, Tibtech 7:117-122.
39. Pels Rijcken WR, Overdijk B, Van den Eijnden DH, Ferwerda W (1995), The effect of increasing nucleotide-sugar concentrations on the incorporation of sugars into glycoconjugates in rat hepatocytes, Biochem. J. 305:865-870.
40. Petrescu AJ, Milac AL, Petrescu SM, Dwek RA, Wormald MR (2004), Statistical analysis of the protein environment of N-glycosylation sites: implications for occupancy, structure, and folding, Glycobiology 14:103-114.
41. Raju TS, Briggs JB, Borge SM, Jones AJ (2000), Species-specific variation in glycosylation of IgG: evidence for the species-specific sialylation and branch-specific galactosylation and importance for engineering recombinant glycoprotein therapeutics, Glycobiology 10:477-486.
42. Requena JR, Chao CC, Levine RL, Stadtman ER (2001), Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proc. Natl Acad. Sci. U S A 98:69-74.
43. Rudd PM, Dwek RA (1997), Glycosylation: heterogeneity and the 3D structure of proteins, Crit. Rev. Biochem. Mol. Biol. 32:1-100.
44. Smales CM, Pepper DS, James DC (2002), Protein modification during anti-viral heattreatment bioprocessing of factor VIII concentrates, factor IX concentrates, and model proteins in the presence of sucrose, Biotechnol. Bioeng. 77:37-48.
45. Spellman MW (1990), Carbohydrate characterization of recombinant glycoproteins of pharmaceutical interest, Anal. Chem. 62:1714-1722.
46. Stark NJ, Heath EC (1979), Glucose-dependent glycosylation of secretory glycoprotein in mouse myeloma cells, Arch. Biochem. Biophys. 192:599-609.
47. Storring PL (1992), Assaying glycoprotein hormones - the influence of glycosylation on immunoreactivity, Tibtech 10:427-432.
48. Sugiura T, Maruyama HB (1992), Factors influencing expression and post-translational modification of recombinant protein C, J. Biotechnol. 22:353-360.
49. Thornalley PJ, Langborg A, Minhas HS (1999), Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose, Biochem J. 344:109-116.
50. Van den Steen P, Rudd PM, Dwek RA, Opdenakker G (1998), Concepts and principles of O-linked glycosylation, Crit. Rev. Biochem. Mol. Biol. 33:151-208.
51. Walmsley AR, Hooper NM (2003), Glycosylation efficiency of Asn-Xaa-Thr sequons is independent of distance from the C-terminus in membrane dipeptidase, Glyco- biology 13:641-646
52. Xie L, Wang DI (1997), Integrated approaches to the design of media and feeding strategies for fed-batch cultures of animal cells, Trends Biotechnol. 15:109-113.
53. Yan A, Lennarz WJ (2005), Unraveling the mechanism of protein N-glycosylation, J. Biol. Chem. 280:3121-3124.
54. Yang M, Butler M (2000), Effects of ammonia on CHO cell growth, erythropoietin production, and glycosylation, Biotechnol. Bioeng. 68:370-380.