Post-translational hydroxylation at the N-terminus of the prion protein reveals presence of PPII structure in vivo

EMBO Journal

Volumn 19, Issue 20, 2000, Pages 5324-5331

  Gill, Andrew C ^a   Ritchie, Mark A ^a   Hunt, Lawrence G ^a   Steane, Sarah E ^a   Davies, Kenneth G ^a   Bocking, Sharon P ^a   Rhie, Alexandre G O ^a   Bennett, Alan D ^a   Hope, James ^a  

^a INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

Author keywords

4 hydroxyproline; Polyproline II helix; Post translational modifications; Prion protein; Prolyl 4 hydroxylase

Indexed keywords

CATION; HYDROXYPROLINE; POLYMER; PRION PROTEIN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLINE; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CIRCULAR DICHROISM; ENZYME SUBSTRATE; HYDROXYLATION; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MODIFICATION; PROTEIN PROCESSING; PROTEIN STRUCTURE; SCRAPIE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMAL; CHO CELLS; CIRCULAR DICHROISM; GUANIDINE; HAMSTERS; HYDROXYLATION; MICE; MOLECULAR SEQUENCE DATA; OSMOLAR CONCENTRATION; OXIDATION-REDUCTION; PEPTIDE FRAGMENTS; PEPTIDES; PRIONS; PROLINE; PROTEIN DENATURATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PRPSC PROTEINS; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUPPORT, NON-U.S. GOV'T; TEMPERATURE; TRANSFECTION;

EID: 0034676088     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.20.5324     Document Type: Article

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