Thrombin generation in abdominal sepsis is Rho-kinase-dependent

Biochemical and Biophysical Research Communications

Volumn 460, Issue 3, 2015, Pages 691-696

  Wang, Yongzhi ^a   Braun, Oscar Ö ^b   Zhang, Su ^a   Norström, Eva ^c   Thorlacius, Henrik ^a  

^a LUND UNIVERSITY   (Sweden)

^b Lund's Universitet   (Sweden)

^c Section of Clinical Chemistry   (Sweden)

Author keywords

Coagulation; Inflammation; Sepsis; Thrombin

Indexed keywords

PEROXIDASE; RHO KINASE; THROMBIN;

ABDOMEN; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYMOLOGY; LUNG; METABOLISM; MOUSE; PATHOLOGY; SEPSIS;

ABDOMEN; ANIMALS; ENZYME-LINKED IMMUNOSORBENT ASSAY; LUNG; MICE; MICE, INBRED C57BL; PEROXIDASE; RHO-ASSOCIATED KINASES; SEPSIS; THROMBIN;

EID: 84937758222     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.03.091     Document Type: Article

References (40)

1. K.M. Kaukonen, M. Bailey, S. Suzuki, D. Pilcher, and R. Bellomo Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012 JAMA 311 2014 1308 1316
2. H. Saito, I. Maruyama, S. Shimazaki, Y. Yamamoto, N. Aikawa, R. Ohno, A. Hirayama, T. Matsuda, H. Asakura, M. Nakashima, and N. Aoki Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial J. Thromb. Haemost. 5 2007 31 41
3. R. Ferrer, I. Martin-Loeches, G. Phillips, T.M. Osborn, S. Townsend, R.P. Dellinger, A. Artigas, C. Schorr, and M.M. Levy Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program Crit. Care Med. 42 2014 1749 1755
4. M. Bhatia, R.L. Zemans, and S. Jeyaseelan Role of chemokines in the pathogenesis of acute lung injury Am. J. Respir. Cell. Mol. Biol. 46 2012 566 572
5. Y. Wang, O.B. O, S. Zhang, L. Luo, E. Norstrom, and H. Thorlacius Dynamic changes in thrombin generation in abdominal sepsis in mice Shock 42 2014 343 349
6. M. Levi, and T. van der Poll The role of natural anticoagulants in the pathogenesis and management of systemic activation of coagulation and inflammation in critically ill patients Semin. Thromb. Hemost. 34 2008 459 468
7. A.D. Shaw, G.M. Vail, D.J. Haney, J. Xie, and M.D. Williams Severe protein C deficiency is associated with organ dysfunction in patients with severe sepsis J. Crit. Care 26 2011 539 545
8. N. Semeraro, C.T. Ammollo, F. Semeraro, and M. Colucci Sepsis, thrombosis and organ dysfunction Thromb. Res. 129 2012 290 295
9. N. Mackman Role of tissue factor in hemostasis, thrombosis, and vascular development Arterioscler. Thromb. Vasc. Biol. 24 2004 1015 1022
10. K. Johnson, Y. Choi, E. DeGroot, I. Samuels, A. Creasey, and L. Aarden Potential mechanisms for a proinflammatory vascular cytokine response to coagulation activation J. Immunol. 160 1998 5130 5135
11. H. Yasuda, P.S. Yuen, X. Hu, H. Zhou, and R.A. Star Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects Kidney Int. 69 2006 1535 1542
12. P.S. Kruger, M.L. Harward, M.A. Jones, C.J. Joyce, K.M. Kostner, M.S. Roberts, and B. Venkatesh Continuation of statin therapy in patients with presumed infection: a randomized controlled trial Am. J. Respir. Crit. Care Med. 183 2011 774 781
13. A.P. Liappis, V.L. Kan, C.G. Rochester, and G.L. Simon The effect of statins on mortality in patients with bacteremia Clin. Infect. Dis. 33 2001 1352 1357
14. S. Zhang, M. Rahman, S. Zhang, Z. Qi, and H. Thorlacius Simvastatin antagonizes CD40L secretion, CXC chemokine formation, and pulmonary infiltration of neutrophils in abdominal sepsis J. Leukoc. Biol. 89 2011 735 742
15. M.W. Merx, E.A. Liehn, U. Janssens, R. Lutticken, J. Schrader, P. Hanrath, and C. Weber HMG-CoA reductase inhibitor simvastatin profoundly improves survival in a murine model of sepsis Circulation 109 2004 2560 2565
16. F. Violi, C. Calvieri, D. Ferro, and P. Pignatelli Statins as antithrombotic drugs Circulation 127 2013 251 257
17. A. Endo, Y. Tsujita, M. Kuroda, and K. Tanzawa Inhibition of cholesterol synthesis in vitro and in vivo by ML-236A and ML-236B, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase Eur. J. Biochem. 77 1977 31 36
18. A. Malliri, and J.G. Collard Role of Rho-family proteins in cell adhesion and cancer Curr. Opin. Cell. Biol. 15 2003 583 589
19. Y. Wang, J. Roller, J.E. Slotta, S. Zhang, L. Luo, M. Rahman, I. Syk, M.D. Menger, and H. Thorlacius Distinct patterns of leukocyte recruitment in the pulmonary microvasculature in response to local and systemic inflammation Am. J. Physiol. Lung Cell. Mol. Physiol. 304 2013 L298 L305
20. Y. Zhu, P.J. Casey, A.P. Kumar, and S. Pervaiz Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases Cell. Death Dis. 4 2013 e568
21. J. Park, Y. Gu, Y. Lee, Z. Yang, and Y. Lee Phosphatidic acid induces leaf cell death in Arabidopsis by activating the Rho-related small G protein GTPase-mediated pathway of reactive oxygen species generation Plant Physiol. 134 2004 129 136
22. J.E. Slotta, M.W. Laschke, M.D. Menger, and H. Thorlacius Rho-kinase signalling mediates endotoxin hypersensitivity after partial hepatectomy Br. J. Surg. 95 2008 976 984
23. Z. Hasan, K. Palani, M. Rahman, S. Zhang, I. Syk, B. Jeppsson, and H. Thorlacius Rho-kinase signaling regulates pulmonary infiltration of neutrophils in abdominal sepsis via attenuation of CXC chemokine formation and Mac-1 expression on neutrophils Shock 37 2012 282 288
24. T. Ishizaki, M. Uehata, I. Tamechika, J. Keel, K. Nonomura, M. Maekawa, and S. Narumiya Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases Mol. Pharmacol. 57 2000 976 983
25. S.P. Davies, H. Reddy, M. Caivano, and P. Cohen Specificity and mechanism of action of some commonly used protein kinase inhibitors Biochem. J. 351 2000 95 105
26. M.W. Laschke, S. Dold, M.D. Menger, B. Jeppsson, and H. Thorlacius The Rho-kinase inhibitor Y-27632 inhibits cholestasis-induced platelet interactions in the hepatic microcirculation Microvasc. Res. 78 2009 95 99
27. S. Santen, Y. Wang, M.W. Laschke, M.D. Menger, B. Jeppsson, and H. Thorlacius Rho-kinase signalling regulates CXC chemokine formation and leukocyte recruitment in colonic ischemia-reperfusion Int. J. Colorectal Dis. 25 2010 1063 1070
28. D. Rittirsch, M.S. Huber-Lang, M.A. Flierl, and P.A. Ward Immunodesign of experimental sepsis by cecal ligation and puncture Nat. Protoc. 4 2009 31 36
29. L. Luo, S. Zhang, Y. Wang, M. Rahman, I. Syk, E. Zhang, and H. Thorlacius Proinflammatory role of neutrophil extracellular traps in abdominal sepsis Am. J. Physiol. Lung Cell. Mol. Physiol. 307 2014 L586 L596
30. S.K. Picoli-Quaino, B.E. Alves, V.B. Faiotto, S.A. Montalvao, C.A. De Souza, J.M. Annichino-Bizzacchi, and E.V. De Paula Impairment of thrombin generation in the early phases of the host response of sepsis J. Crit. Care 29 2014 31 36
31. A. Tripodi, Q.M. Anstee, K.K. Sogaard, M. Primignani, and D.C. Valla Hypercoagulability in cirrhosis: causes and consequences J. Thromb. Haemost. 9 2011 1713 1723
32. J.L. Kashuk, E.E. Moore, M. Wohlauer, J.L. Johnson, M. Pezold, J. Lawrence, W.L. Biffl, C.C. Burlew, C. Barnett, M. Sawyer, and A. Sauaia Initial experiences with point-of-care rapid thrombelastography for management of life-threatening postinjury coagulopathy Transfusion 52 2012 23 33
33. T.J. Gould, T.T. Vu, L.L. Swystun, D.J. Dwivedi, S.H. Mai, J.I. Weitz, and P.C. Liaw Neutrophil extracellular traps promote thrombin generation through platelet-dependent and platelet-independent mechanisms Arterioscler. Thromb. Vasc. Biol. 34 2014 1977 1984
34. J.E. Aslan, and O.J. McCarty Rho GTPases in platelet function J. Thromb. Haemost. 11 2013 35 46
35. C.T. Esmon, K. Fukudome, T. Mather, W. Bode, L.M. Regan, D.J. Stearns-Kurosawa, and S. Kurosawa Inflammation, sepsis, and coagulation Haematologica 84 1999 254 259
36. M. Pastuszczak, A. Kotlarz, M. Mostowik, J. Zalewski, K. Zmudka, and A. Undas Prior simvastatin treatment is associated with reduced thrombin generation and platelet activation in patients with acute ST-segment elevation myocardial infarction Thromb. Res. 125 2010 382 386
37. A. Szczeklik, J. Musial, A. Undas, P. Gajewski, P. Gora, J. Swadzba, and M. Jankowski Inhibition of thrombin generation by simvastatin and lack of additive effects of aspirin in patients with marked hypercholesterolemia J. Am. Coll. Cardiol. 33 1999 1286 1293
38. Y. Rikitake, and J.K. Liao Rho GTPases, statins, and nitric oxide Circ. Res. 97 2005 1232 1235
39. S. Krishnaswamy, W.R. Church, M.E. Nesheim, and K.G. Mann Activation of human prothrombin by human prothrombinase. Influence of factor Va on the reaction mechanism J. Biol. Chem. 262 1987 3291 3299
40. C.E. Dempfle Disseminated intravascular coagulation and coagulation disorders Curr. Opin. Anaesthesiol. 17 2004 125 129