Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: Evidence for non-canonical activation of RhoA and Rac1 GTPases

Cell Death and Disease

Volumn 4, Issue 4, 2013, Pages

  Zhu, Y ^a,b   Casey, P J ^c,d   Kumar, A P ^a,e,f,g   Pervaiz, S ^a,b,d,e,g,h  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d DUKE NUS MEDICAL SCHOOL   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^f CURTIN UNIVERSITY   (Australia)

^g UNIVERSITY OF NORTH TEXAS   (United States)

^h SINGAPORE MIT ALLIANCE   (Singapore)

Author keywords

Apoptosis; JNK; Rho; Simvastatin; Superoxide

Indexed keywords

BIM PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN CDC42; RAC1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SIMVASTATIN; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE; GERANYLGERANYL PYROPHOSPHATE; JANUS KINASE; ANTINEOPLASTIC AGENT; APOPTOSIS REGULATORY PROTEIN; BCL 2 LIKE PROTEIN 11; BCL-2-LIKE PROTEIN 11; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEMBRANE PROTEIN; MEVALONIC ACID; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; ONCOPROTEIN; RAC1 PROTEIN, HUMAN; RHO GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR 1; RHOA PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; COLORECTAL CARCINOMA; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; PRENYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; CARCINOMA CELL; CONTROLLED STUDY; CYTOSOL; DRUG BINDING; ENZYME INHIBITION; MOLECULAR MECHANICS; CELL CYCLE; DRUG EFFECT; DRUG POTENTIATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PROTEIN BINDING; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CDC42 GTP-BINDING PROTEIN; CELL CYCLE; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MAP KINASE KINASE 4; MEMBRANE PROTEINS; MEVALONIC ACID; PRENYLATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; RAC1 GTP-BINDING PROTEIN; RHO GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR ALPHA; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; SIMVASTATIN; SUPEROXIDES;

EID: 84879711057     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.103     Document Type: Article

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