Bariatric and metabolic surgery: A shift in eligibility and success criteria

Nature Reviews Endocrinology

Volumn 11, Issue 8, 2015, Pages 465-477

  Frühbeck, Gema ^a  

^a UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BARIATRIC SURGERY; BODY FAT DISTRIBUTION; BODY MASS; HUMAN; METABOLIC SURGERY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REVIEW; SURGERY; WEIGHT REDUCTION; DIABETES MELLITUS, TYPE 1; METABOLIC DISEASES; PROCEDURES; STANDARDS; TREATMENT OUTCOME;

BARIATRIC SURGERY; DIABETES MELLITUS, TYPE 1; HUMANS; METABOLIC DISEASES; OBESITY; TREATMENT OUTCOME;

EID: 84937733513     PISSN: 17595029     EISSN: 17595037     Source Type: Journal    
DOI: 10.1038/nrendo.2015.84     Document Type: Review

References (140)

1. Frühbeck, G. et al. Obesity: the gateway to ill health-An EASO position statement on a rising public health, clinical and scientific challenge in Europe. Obes. Facts 6, 117-120 (2013
2. Flegal, K.M., Kit, B.K., Orpana, H. & Graubard, B.I. Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-Analysis. JAMA 309, 71-82 (2013
3. Grieve, E., Fenwick, E., Yang, H.C. & Lean, M. The disproportionate economic burden associated with severe and complicated obesity: a systematic review. Obes. Rev. 14, 883-894 (2013
4. Scully, T. Public health: Society at large. Nature 508, S50-S51 (2014
5. Ng, M. et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 384, 766-781 (2014
6. Kitahara, C.M. et al. Association between class III obesity (BMI of 40-59 kg/m2) and mortality: a pooled analysis of 20 prospective studies. PLoS Med. 11, e1001673 (2014
7. Fried, M. et al. Interdisciplinary European guidelines on metabolic and bariatric surgery. Obes. Surg. 24, 42-55 (2014
8. Tack, J. & Deloose, E. Complications of bariatric surgery: dumping syndrome, reflux and vitamin deficiencies. Best Pract. Res. Clin. Gastroenterol. 28, 741-749 (2014
9. Kashyap, S.R. et al. Metabolic effects of bariatric surgery in patients with moderate obesity and type 2 diabetes: analysis of a randomized control trial comparing surgery with intensive medical treatment. Diabetes Care 36, 2175-2182 (2013
10. Schauer, P.R. et al. Bariatric surgery versus intensive medical therapy for diabetes-3 year outcomes. N. Engl. J. Med. 370, 2002-2013 (2014
11. Sjöström, L. et al. Bariatric surgery and long-term cardiovascular events. JAMA 307, 56-65 (2012
12. Rubino, F. & Cummings, D.E. Surgery: The coming of age of metabolic surgery. Nat. Rev. Endocrinol. 8, 702-704 (2012
13. Rubino, F. et al. Bariatric, metabolic, and diabetes surgery: what's in a name?. Ann. Surg. 259, 117-122 (2014
14. Smyth, S. & Heron, A. Diabetes and obesity: the twin epidemics. Nat. Med. 12, 75-80 (2006
15. Gregg, E.W. et al. Changes in diabetes-related complications in the United States, 1990-2010. N. Engl. J. Med. 370, 1514-1523 (2014
16. Gregg, E.W. et al. Trends in death rates among U.S. adults with and without diabetes between 1997 and 2006: findings from the National Health Interview Survey. Diabetes Care 35, 1252-1257 (2012
17. Frühbeck, G. Obesity: Screening for the evident in obesity. Nat. Rev. Endocrinol. 8, 570-572 (2012
18. Anthes, E. Treatment: Marginal gains. Nature 508, S54-S56 (2014
19. Schauer, P.R. et al. Bariatric surgery versus intensive medical therapy in obese patients with diabetes. N. Engl. J. Med. 366, 1567-1576 (2012
20. Buchwald, H. et al. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-Analysis. Am. J. Med. 122, 248-256 (2009
21. Sjöström, L. Review of the key results from the Swedish Obese Subjects (SOS) trial-A prospective controlled intervention study of bariatric surgery. J. Intern. Med. 273, 219-234 (2013
22. Buchwald, H. & Oien, D.M. Metabolic/bariatric surgery worldwide 2011. Obes. Surg. 23, 427-436 (2013
23. Neovius, M. et al. Health care use during 20 years following bariatric surgery. JAMA 308, 1132-1141 (2012
24. Busetto, L. et al. Bariatric surgery in class I obesity: a Position Statement from the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO). Obes. Surg. 24, 487-519 (2014
25. Apovian, C.M. & Gokce, N. Obesity and cardiovascular disease. Circulation 125, 1178-1182 (2012
26. Chapman, J.L., Zechel, A., Carter, Y.H. & Abbott, S. Systematic review of recent innovations in service provision to improve access to primary care. Br. J. Gen. Pract. 54, 374-381 (2004
27. Buchwald, H. et al. Bariatric surgery: a systematic review and meta-Analysis. JAMA 292, 1724-1737 (2004
28. O-Brien, P.E., McPhail, T., Chaston, T.B. & Dixon, J.B. Systematic review of medium-term weight loss after bariatric operations. Obes. Surg. 16, 1032-1040 (2006
29. Dixon, J.B. et al. Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial. JAMA 299, 316-323 (2008
30. Flum, D.R. et al. Perioperative safety in the longitudinal assessment of bariatric surgery. N. Engl. J. Med. 361, 445-454 (2009
31. Rubino, F., Schauer, P.R., Kaplan, L.M. & Cummings, D.E. Metabolic surgery to treat type 2 diabetes: clinical outcomes and mechanisms of action. Annu. Rev. Med. 61, 393-411 (2010
32. Mingrone, G. et al. Bariatric surgery versus conventional medical therapy for type 2 diabetes. N. Engl. J. Med. 366, 1577-1585 (2012
33. Romeo, S. et al. Cardiovascular events after bariatric surgery in obese subjects with type 2 diabetes. Diabetes Care 35, 2613-2617 (2012
34. Bal, B.S., Finelli, F.C., Shope, T.R. & Koch, T.R. Nutritional deficiencies after bariatric surgery. Nat. Rev. Endocrinol. 8, 544-556 (2012
35. Stefater, M.A., Wilson-Perez, H.E., Chambers, A.P., Sandoval, D.A. & Seeley, R.J. All bariatric surgeries are not created equal: Insights from mechanistic comparisons. Endocr. Rev. 33, 595-622 (2012
36. Ikramuddin, S. et al. Roux en Y gastric bypass vs intensive medical management for the control of type 2 diabetes, hypertension, and hyperlipidemia: the Diabetes Surgery Study randomized clinical trial. JAMA 309, 2240-2249 (2013
37. Maggard-Gibbons, M. et al. Bariatric surgery for weight loss and glycemic control in nonmorbidly obese adults with diabetes: a systematic review. JAMA 309, 2250-2261 (2013
38. Chang, S.H. et al. The effectiveness and risks of bariatric surgery: an updated systematic review and meta-Analysis, 2003-2012. JAMA Surg. 149, 275-287 (2014
39. Miras, A.D. & le Roux, C.W. Metabolic surgery: shifting the focus from glycaemia and weight to end-organ health. Lancet Diabetes Endocrinol. 2, 141-151 (2014
40. Arterburn, D.E. & Courcoulas, A.P. Bariatric surgery for obesity and metabolic conditions in adults. Br. Med. J. 349, g3961 (2014
41. Sjöström, L. et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N. Engl. J. Med. 351, 2683-2693 (2004
42. Sjöström, L. et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N .Engl. J. Med. 357, 741-752 (2007
43. Sjöström, L. Bariatric surgery and reduction in morbidity and mortality: experiences from the SOS study. Int. J. Obes. (Lond.) 32 (Suppl. 7), S93-S97 (2008
44. Sjöström, L. et al. Association of bariatric surgery with long-term remission of type 2 diabetes and with microvascular and macrovascular complications. JAMA 311, 2297-2304 (2014
45. Courcoulas, A.P. et al. Weight change and health outcomes at 3 years after bariatric surgery among individuals with severe obesity. JAMA 310, 2416-2425 (2013
46. Christou, N.V. et al. Surgery decreases long-term mortality, morbidity, and health care use in morbidly obese patients. Ann. Surg. 240, 416-423 (2004
47. Adams, T.D. et al. Long-term mortality after gastric bypass surgery. N. Engl. J. Med. 357, 753-761 (2007
48. Pontiroli, A.E. & Morabito, A. Long-term prevention of mortality in morbid obesity through bariatric surgery. A systematic review and meta-Analysis of trials performed with gastric banding and gastric bypass. Ann. Surg. 253, 484-487 (2011
49. Kwok, C.S. et al. Bariatric surgery and its impact on cardiovascular disease and mortality: A systematic review and meta-Analysis. Int. J. Cardiol. 173, 20-28 (2014
50. Carlsson, L.M. et al. Bariatric surgery and prevention of type 2 diabetes in Swedish obese subjects. N. Engl. J. Med. 367, 695-704 (2012
51. Sjöholm, K. et al. Evaluation of current eligibility criteria for bariatric surgery: diabetes prevention and risk factor changes in the Swedish obese subjects (SOS) study. Diabetes Care 36, 1335-1340 (2013
52. Calle, E.E. & Kaaks, R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat. Rev. Cancer 4, 579-591 (2004
53. Ribeiro, R. et al. Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue. BMC Med. 10, 108 (2012
54. Diehl, A.M. Hepatic complications of obesity. Gastroenterol. Clin. North Am. 39, 57-68 (2010
55. Wluka, A.E., Lombard, C.B. & Cicuttini, F.M. Tackling obesity in knee osteoarthritis. Nat. Rev. Rheumatol. 9, 225-235 (2013
56. Campo, A. et al. Hyperleptinaemia, respiratory drive and hypercapnic response in obese patients. Eur. Respir. J. 30, 223-231 (2007
57. Jordan, A.S., McSharry, D.G. & Malhotra, A. Adult obstructive sleep apnoea. Lancet 383, 736-747 (2014
58. Acosta, A. & Camilleri, M. Gastrointestinal morbidity in obesity. Ann. NY Acad. Sci. 1311, 42-56 (2014
59. Stenvinkel, P., Zoccali, C. & Ikizler, T.A. Obesity in CKD-what should nephrologists know?. J. Am. Soc. Nephrol. 24, 1727-1736 (2013
60. Jungheim, E.S., Travieso, J.L. & Hopeman, M.M. Weighing the impact of obesity on female reproductive function and fertility. Nutr. Rev. 71 (Suppl. 1), S3-S8 (2013
61. Ashrafian, H., le Roux, C.W., Darzi, A. & Athanasiou, T. Effects of bariatric surgery on cardiovascular function. Circulation 118, 2091-2102 (2008
62. Maciejewski, M.L. & Arterburn, D.E. Cost-effectiveness of bariatric surgery. JAMA 310, 742-743 (2013
63. Ashrafian, H. et al. Metabolic surgery and cancer: protective effects of bariatric procedures. Cancer 117, 1788-1799 (2011
64. Pérez-Hernández, A.I., Catalán, V., Gómez-Ambrosi, J., Rodríguez, A. & Frühbeck, G. Mechanisms linking excess adiposity and carcinogenesis promotion. Front. Endocrinol. (Lausanne) 5, 65 (2014
65. Park, J., Morley, T.S., Kim, M., Clegg, D.J. & Scherer, P.E. Obesity and cancer-mechanisms underlying tumour progression and recurrence. Nat. Rev. Endocrinol. 10, 455-465 (2014
66. O-Brien P, E., Macdonald, L., Anderson, M., Brennan, L. & Brown, W.A. Long-term outcomes after bariatric surgery: fifteen-year follow-up of adjustable gastric banding and a systematic review of the bariatric surgical literature. Ann. Surg. 257, 87-94 (2013
67. Pournaras, D.J. et al. Remission of type 2 diabetes after gastric bypass and banding: mechanisms and 2 year outcomes. Ann. Surg. 252, 966-971 (2010
68. Geloneze, B. et al. Surgery for nonobese type 2 diabetic patients: an interventional study with duodenal-jejunal exclusion. Obes. Surg. 19, 1077-1083 (2009
69. Cohen, R. et al. Role of proximal gut exclusion from food on glucose homeostasis in patients with type 2 diabetes. Diabet. Med. 30, 1482-1486 (2013
70. Cummings, B.P. Duodenal exclusion devices: promising tools in treating obesity and type 2 diabetes. Gut 63, 1201-1202 (2014
71. Promintzer-Schifferl, M. et al. Effects of gastric bypass surgery on insulin resistance and insulin secretion in nondiabetic obese patients. Obesity (Silver Spring) 19, 1420-1426 (2011
72. Anderwald, C.H. et al. Alterations in gastrointestinal, endocrine, and metabolic processes after bariatric Roux en Y gastric bypass surgery. Diabetes Care 35, 2580-2587 (2012
73. Papamargaritis, D. et al. Changes in gut hormone profile and glucose homeostasis after laparoscopic sleeve gastrectomy. Surg. Obes. Relat. Dis. 9, 192-201 (2013
74. Sarkhosh, K., Birch, D.W., Shi, X., Gill, R.S. & Karmali, S. The impact of sleeve gastrectomy on hypertension: a systematic review. Obes. Surg. 22, 832-837 (2012
75. Pournaras, D.J. et al. The role of bile after Roux en Y gastric bypass in promoting weight loss and improving glycaemic control. Endocrinology 153, 3613-3619 (2012
76. Kral, J.G., Sjöström, L.V. & Sullivan, M.B. Assessment of quality of life before and after surgery for severe obesity. Am. J. Clin. Nutr. 55, 611S-614S (1992
77. Warkentin, L.M. et al. Predictors of health-related quality of life in 500 severely obese patients. Obesity (Silver Spring) 22, 1367-1372 (2014
78. Warkentin, L.M. et al. Weight loss required by the severely obese to achieve clinically important differences in health-related quality of life: two-year prospective cohort study. BMC Med. 12, 175 (2014
79. Karlsson, J., Taft, C., Ryden, A., Sjöström, L. & Sullivan, M. Ten-year trends in health-related quality of life after surgical and conventional treatment for severe obesity: the SOS intervention study. Int. J. Obes. (Lond.) 31, 1248-1261 (2007
80. O-Brien, P.E. Controversies in bariatric surgery. Br. J. Surg. 102, 611-618 (2015
81. Karlsen, T.I. et al. Health related quality of life after gastric bypass or intensive lifestyle intervention: a controlled clinical study. Health Qual. Life Outcomes 11, 17 (2013
82. Svensson, P.A. et al. Alcohol consumption and alcohol problems after bariatric surgery in the Swedish Obese Subjects study. Obesity (Silver Spring) 21, 2444-2451 (2013
83. Ostlund, M.P. et al. Increased admission for alcohol dependence after gastric bypass surgery compared with restrictive bariatric surgery. JAMA Surg. 148, 374-377 (2013
84. Dirksen, C. et al. Mechanisms of improved glycaemic control after Roux en Y gastric bypass. Diabetologia 55, 1890-1901 (2012
85. Madsbad, S., Dirksen, C. & Holst, J.J. Mechanisms of changes in glucose metabolism and bodyweight after bariatric surgery. Lancet Diabetes Endocrinol. 2, 152-164 (2014
86. Rubino, F. Bariatric surgery: effects on glucose homeostasis. Curr. Opin. Clin. Nutr. Metab. Care 9, 497-507 (2006
87. Muñoz, R., Carmody, J.S., Stylopoulos, N., Davis, P. & Kaplan, L.M. Isolated duodenal exclusion increases energy expenditure and improves glucose homeostasis in diet-induced obese rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 303, R985-R993 (2012
88. Jiao, J. et al. Restoration of euglycemia after duodenal bypass surgery is reliant on central and peripheral inputs in Zucker fa/fa rats. Diabetes 62, 1074-1083 (2013
89. Habegger, K.M. et al. Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia. Gut 63, 1238-1246 (2014
90. Rubino, F. & Marescaux, J. Effect of duodenal-jejunal exclusion in a non-obese animal model of type 2 diabetes: a new perspective for an old disease. Ann. Surg. 239, 1-11 (2004
91. Rubino, F. et al. The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes. Ann. Surg. 244, 741-749 (2006
92. Ke, J. & Wang, Y. Duodenum exclusion alone is sufficient to reduce fasting blood glucose in non-obese diabetic Goto-Kakizaki rats. Obes. Surg. 24, 433-434 (2014
93. Argyropoulos, G. Bariatric surgery: prevalence, predictors, and mechanisms of diabetes remission. Curr. Diab. Rep. 15, 590 (2015
94. Ashrafian, H. et al. Metabolic surgery and obstructive sleep apnoea: the protective effects of bariatric procedures. Thorax 67, 442-449 (2012
95. Wu, Y.W. et al. Association of esophageal inflammation, obesity and gastroesophageal reflux disease: from FDG PET/CT perspective. PLoS ONE 9, e92001 (2014
96. Pallati, P.K. et al. Improvement in gastroesophageal reflux disease symptoms after various bariatric procedures: review of the Bariatric Outcomes Longitudinal Database. Surg. Obes. Relat. Dis. 10, 502-507 (2014
97. Kardassis, D., Grote, L., Sjostrom, L., Hedner, J. & Karason, K. Sleep apnea modifies the long-term impact of surgically induced weight loss on cardiac function and inflammation. Obesity (Silver Spring) 21, 698-704 (2013
98. Huettner, F. et al. Body composition analysis in bariatric surgery: use of air displacement plethysmograph. Am. Surg. 78, 698-701 (2012
99. Kardassis, D., Bech-Hanssen, O., Schonander, M., Sjöström, L. & Karason, K. The influence of body composition, fat distribution, and sustained weight loss on left ventricular mass and geometry in obesity. Obesity (Silver Spring) 20, 605-611 (2012
100. Kardassis, D. et al. Impact of body composition, fat distribution and sustained weight loss on cardiac function in obesity. Int. J. Cardiol. 159, 128-133 (2012
101. Kardassis, D., Schonander, M., Sjöström, L. & Karason, K. Carotid artery remodelling in relation to body fat distribution, inflammation and sustained weight loss in obesity. J. Intern. Med. 275, 534-543 (2014
102. Frühbeck, G. & Gómez-Ambrosi, J. Control of body weight: a physiologic and transgenic perspective. Diabetologia 46, 143-172 (2003
103. Dulloo, A.G., Jacquet, J., Solinas, G., Montani, J.P. & Schutz, Y. Body composition phenotypes in pathways to obesity and the metabolic syndrome. Int. J. Obes. (Lond.) 34 (Suppl. 2), S4-S17 (2010
104. Coen, P.M. et al. Clinical trial demonstrates exercise following bariatric surgery improves insulin sensitivity. J. Clin. Invest. 125, 248-257 (2015
105. Blundell, J.E. et al. Body composition and appetite: fat-free mass (but not fat mass or BMI) is positively associated with self-determined meal size and daily energy intake in humans. Br. J. Nutr. 107, 445-449 (2012
106. Caudwell, P. et al. Resting metabolic rate is associated with hunger, self-determined meal size, and daily energy intake and may represent a marker for appetite. Am. J. Clin. Nutr. 97, 7-14 (2013
107. Knuth, N.D. et al. Metabolic adaptation following massive weight loss is related to the degree of energy imbalance and changes in circulating leptin. Obesity (Silver Spring) 22, 2563-2569 (2014
108. Garciacaballero, M. et al. Changes of body composition in patients with BMI 23-50 after tailored one anastomosis gastric bypass (BAGUA). influence of diabetes and metabolic syndrome. Obes. Surg. 24, 2040-2047 (2014
109. Gómez-Ambrosi, J. et al. Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors. Clin. Biochem. 35, 315-320 (2002
110. Frühbeck, G. Obesity: Aquaporin enters the picture. Nature 438, 436-437 (2005
111. Gómez-Ambrosi, J. et al. Increased serum amyloid A concentrations in morbid obesity decrease after gastric bypass. Obes. Surg. 16, 262-269 (2006
112. Catalán, V. et al. Proinflammatory cytokines in obesity: impact of type 2 diabetes mellitus and gastric bypass. Obes. Surg. 17, 1464-1474 (2007
113. Catalán, V. et al. Up-regulation of the novel proinflammatory adipokines lipocalin 2, chitinase 3 like 1 and osteopontin as well as angiogenic-related factors in visceral adipose tissue of patients with colon cancer. J. Nutr. Biochem. 22, 634-641 (2011
114. Khandekar, M.J., Cohen, P. & Spiegelman, B.M. Molecular mechanisms of cancer development in obesity. Nat. Rev. Cancer 11, 886-895 (2011
115. Rubino, F. From bariatric to metabolic surgery: definition of a new discipline and implications for clinical practice. Curr. Atheroscler. Rep. 15, 369 (2013
116. Rubino, F., R-Bibo, S.L., del Genio, F., Mazumdar, M. & McGraw, T.E. Metabolic surgery: the role of the gastrointestinal tract in diabetes mellitus. Nat. Rev. Endocrinol. 6, 102-109 (2010
117. Gomez-Ambrosi, J. et al. Cardiometabolic profile related to body adiposity identifies patients eligible for bariatric surgery more accurately than BMI. Obes. Surg. http: //dx.doi.org/10.1007/s11695-014-1566-6
118. Gómez-Ambrosi, J. et al. Body mass index classification misses subjects with increased cardiometabolic risk factors related to elevated adiposity. Int. J. Obes. 36, 286-294 (2012
119. Fried, M. et al. Interdisciplinary European guidelines on metabolic and bariatric surgery. Obes. Facts 6, 449-468 (2013
120. Sjöström, L. et al. Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study). a prospective, controlled intervention trial. Lancet Oncol. 10, 653-662 (2009
121. Serrot, F.J. et al. Comparative effectiveness of bariatric surgery and nonsurgical therapy in adults with type 2 diabetes mellitus and body mass index<35 kg/m2 Surgery 2011 150 684-691
122. Cummings, D.E. & Cohen, R.V. Beyond BMI: the need for new guidelines governing the use of bariatric and metabolic surgery. Lancet Diabetes Endocrinol. 2, 175-181 (2014
123. Gómez-Ambrosi, J. et al. Body adiposity and type 2 diabetes: Increased risk with a high body fat percentage even having a normal BMI. Obesity 19, 1439-1444 (2011
124. Lutz, T.A. & Bueter, M. The physiology underlying Roux en Y gastric bypass: a status report. Am. J. Physiol. Regul. Integr. Comp. Physiol. 307, R1275-R1291 (2014
125. Ahima, R.S. & Lazar, M.A. Physiology. The health risk of obesity-better metrics imperative. Science 341, 856-858 (2013
126. World Health Organization. Obesity and Overweight. Fact Sheet No.311 [online], http: //www.who.int/mediacentre/factsheets/fs311/en/(2015
127. Blundell, J.E. et al. Beyond BMI-phenotyping the obesities. Obes. Facts 7, 322-328 (2014
128. Heuckmann, J.M. & Thomas, R.K. A new generation of cancer genome diagnostics for routine clinical use: overcoming the roadblocks to personalized cancer medicine. Ann. Oncol. http: //dx.doi.org/10.1093/annonc/mdv184
129. Neff, K.J., Olbers, T. & le Roux, C.W. Bariatric surgery: the challenges with candidate selection, individualizing treatment and clinical outcomes. BMC Med. 11, 8 (2013
130. Kuk, J.L. et al. Edmonton Obesity Staging System: association with weight history and mortality risk. Appl. Physiol. Nutr. Metab. 36, 570-576 (2011
131. Padwal, R.S., Pajewski, N.M., Allison, D.B. & Sharma, A.M. Using the Edmonton obesity staging system to predict mortality in a population-representative cohort of people with overweight and obesity. CMAJ 183, E1059-E1066 (2011
132. Gill, R.S., Karmali, S. & Sharma, A.M. The potential role of the Edmonton obesity staging system in determining indications for bariatric surgery. Obes. Surg. 21, 1947-1949 (2011
133. Klenov, V.E. & Jungheim, E.S. Obesity and reproductive function: a review of the evidence. Curr. Opin. Obstet. Gynecol. 26, 455-460 (2014
134. Chor, J., Chico, P., Ayloo, S., Roston, A. & Kominiarek, M.A. Reproductive health counseling and practices: A cross-sectional survey of bariatric surgeons. Surg. Obes. Relat. Dis. 11, 187-192 (2015
135. Sharma, A., Bahadursingh, S., Ramsewak, S. & Teelucksingh, S. Medical and surgical interventions to improve outcomes in obese women planning for pregnancy. Best Pract. Res. Clin. Obstet. Gynaecol. 29, 565-576 (2015
136. Jauch-Chara, K. & Oltmanns, K.M. Obesity-A neuropsychological disease?. Systematic review and neuropsychological model. Prog. Neurobiol. 114, 84-101 (2014
137. Bray, G.A. et al. Is it time to change the way we report and discuss weight loss?. Obesity (Silver Spring) 17, 619-621 (2009
138. [No authors listed] 1983 metropolitan height and weight tables. Stat. Bull. Metrop. Life Found. 64, 2-9 (1983
139. Ulrich-Lai, Y.M. & Ryan, K.K. Neuroendocrine circuits governing energy balance and stress regulation: functional overlap and therapeutic implications. Cell Metab. 19, 910-925 (2014
140. Reverchon, M., Rame, C., Bertoldo, M. & Dupont, J. Adipokines and the female reproductive tract. Int. J. Endocrinol. 2014, 232454 (2014