MTOR complex signaling through the SEMA4A-plexin B2 axis is required for optimal activation and differentiation of CD8+ T cells

Journal of Immunology

Volumn 195, Issue 3, 2015, Pages 934-943

  Ito, Daisuke ^a,b,c   Nojima, Satoshi ^a,b,c   Nishide, Masayuki ^a,b,c   Okuno, Tatsusada ^a,b   Takamatsu, Hyota ^a,b,c   Kang, Sujin ^a,b,c   Kimura, Tetsuya ^a,b,c   Yoshida, Yuji ^a,b,c   Morimoto, Keiko ^a,b,c   Maeda, Yohei ^a,b   Hosokawa, Takashi ^a,b,c   Toyofuku, Toshihiko ^a,b,c   Ohshima, Jun ^a,d   Kamimura, Daisuke ^e   Yamamoto, Masahiro ^a,d   Murakami, Masaaki ^e   Morii, Eiichi ^b   Rakugi, Hiromi ^b   Isaka, Yoshitaka ^b   Kumanogoh, Atsushi ^a,b,c  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d OSAKA UNIVERSITY   (Japan)

^e HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EOMESODERMIN; FAS LIGAND; GAMMA INTERFERON; GRANZYME B; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PERFORIN; PLEXIN; PLEXIN B2; PROTEIN KINASE B; S6 KINASE; SEMA4A PROTEIN; SEMAPHORIN; TRANSCRIPTION FACTOR T BET; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; FASL PROTEIN, MOUSE; GRANZYME; GZMB PROTEIN, MOUSE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; NERVE PROTEIN; PERFORIN, MOUSE; PLEXIN B2 PROTEIN, MOUSE; PORE FORMING CYTOTOXIC PROTEIN; PROTEIN BINDING; RECOMBINANT PROTEIN; SEMA4A PROTEIN, MOUSE; SMALL INTERFERING RNA; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CELLULAR IMMUNITY; CONTROLLED STUDY; CROSS PRESENTATION; CYTOKINE PRODUCTION; DENDRITIC CELL; DOWN REGULATION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; IN VIVO STUDY; LISTERIOSIS; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL DIFFERENTIATION; CYTOLOGY; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LISTERIA MONOCYTOGENES; LYMPHOCYTE ACTIVATION; METABOLISM; PHYSIOLOGY; RNA INTERFERENCE;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; FAS LIGAND PROTEIN; GRANZYMES; INTERFERON-GAMMA; LISTERIA MONOCYTOGENES; LISTERIOSIS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIPROTEIN COMPLEXES; NERVE TISSUE PROTEINS; PORE FORMING CYTOTOXIC PROTEINS; PROTEIN BINDING; RECOMBINANT PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SEMAPHORINS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84937698850     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1403038     Document Type: Article

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