In vitro and in vivo characterization of a new recombinant antimicrobial peptide, MP1102, against methicillin-resistant Staphylococcus aureus

Applied Microbiology and Biotechnology

Volumn 99, Issue 15, 2015, Pages 6255-6266

  Zhang, Yong ^a,b   Teng, Da ^a,b   Wang, Xiumin ^a,b   Mao, Ruoyu ^a,b   Cao, Xintao ^a,b   Hu, Xiaoyuan ^a,b   Zong, Lifen ^a,b   Wang, Jianhua ^a,b  

^a AGRO ENVIRONMENTAL PROTECTION INSTITUTE   (China)

^b INSTITUTE OF PLANT PROTECTION   (China)

Author keywords

Antimicrobial peptides; Molecular design; MP1102; MRSA; Pichia pastoris

Indexed keywords

ANTIMICROBIAL AGENTS; BACTERIA; BIOMATERIALS; DRUG THERAPY; PEPTIDES; POLYPEPTIDES; RECOMBINANT PROTEINS; YEAST;

ANTIMICROBIAL PEPTIDE; MOLECULAR DESIGN; MP1102; MRSA; PICHIA PASTORIS;

MICROORGANISMS;

AMPICILLIN; MP 1102; NZ 2114; POLYPEPTIDE ANTIBIOTIC AGENT; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; ANTIMICROBIAL CATIONIC PEPTIDE;

ANTIMICROBIAL ACTIVITY; BACTERIUM; CELLS AND CELL COMPONENTS; CONCENTRATION (COMPOSITION); FERMENTATION; GENE EXPRESSION; ION EXCHANGE; PEPTIDE; PROTEIN; RECOMBINATION; SECRETION; YEAST;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL COUNT; BACTERICIDAL ACTIVITY; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG DESIGN; DRUG PURIFICATION; DRUG SCREENING; DRUG STRUCTURE; EFFECTIVE CONCENTRATION; ERYTHROCYTE; EUKARYOTIC CELL; FEMALE; FERMENTATION; GENE EXPRESSION SYSTEM; HEMOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; ION EXCHANGE CHROMATOGRAPHY; KOMAGATAELLA PASTORIS; LARGE SCALE PRODUCTION; LIPID MEMBRANE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PH; PHARMACODYNAMICS; POLYACRYLAMIDE GEL ELECTROPHORESIS; RECOMBINANT PLASMID; TEMPERATURE; THERMOSTABILITY; ANIMAL; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIAL VIABILITY; MICROBIOLOGY; PHYSIOLOGY; PICHIA; STAPHYLOCOCCUS INFECTION;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PICHIA PASTORIS; POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CHROMATOGRAPHY, ION EXCHANGE; DISEASE MODELS, ANIMAL; GENE EXPRESSION; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE; MICROBIAL SENSITIVITY TESTS; MICROBIAL VIABILITY; PICHIA; RECOMBINANT PROTEINS; STAPHYLOCOCCAL INFECTIONS;

EID: 84937631097     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-015-6394-7     Document Type: Article

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