Hydrophilicity of quinolones is not an exclusive factor for decreased activity in efflux-mediated resistant mutants of Staphylococcus aureus

Antimicrobial Agents and Chemotherapy

Volumn 40, Issue 8, 1996, Pages 1835-1842

  Takenouchi, Takashi ^a   Tabata, Fumiko ^a   Iwata, Yoriko ^a   Hanzawa, Hiroyuki ^a   Sugawara, Mie ^a   Ohya, Satoshi ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 CYCLOPROPYL 8 DIFLUOROMETHOXY 6 FLUORO 1,4 DIHYDRO 7 (3 METHYL 1 PIPERAZINYL) 4 OXO 3 QUINOLINECARBOXYLIC ACID; AM 1115; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; CINOXACIN; CIPROFLOXACIN; ENOXACIN; FLEROXACIN; LOMEFLOXACIN; NALIDIXIC ACID; NORFLOXACIN; OFLOXACIN; OXOLINIC ACID; PIPEMIDIC ACID; PIROMIDIC ACID; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SPARFLOXACIN; TOSUFLOXACIN; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIUM MUTANT; HYDROPHILICITY; HYDROPHOBICITY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

EID: 0029849429     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.40.8.1835     Document Type: Article

References (39)

1. Adams, D. E., E. M. Shekhtman, E. L. Zechiedrich, M. B. Schmid, and N. R. Cazzarelli. 1992. The role of topoisomerase IV in partitioning bacterial replicons and the structure of catenated intermediates in DNA replication. Cell 71:277-288.
2. Asuquo, A. E., and L. J. V. Piddock. 1993. Accumulation and killing kinetics of fifteen quinolones for Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. J. Antimicrob. Chemother. 31:865-880.
3. Ball, P. 1990. Emergent resistance to ciprofloxacin amongst Pseudomonas aeruginosa and Staphylococcus aureus: clinical significance and therapeutic approaches. J. Antimicrob. Chemother. 26(Suppl. F):165-179.
4. Bazile, S., N. Moreau, D. Bouzard, and M. Essiz. 1992. Relationships among antibacterial activity, inhibition of DNA gyrase, and intracellular accumulation of 11 fluoroquinolones. Antimicrob. Agents Chemother. 36:2622-2627.
5. Brockbank, S. M. V., and P. T. Barth. 1993. Cloning, sequencing, and expression of the DNA gyrase genes from Staphylococcus aureus. J. Bacteriol. 175:3269-3277.
6. Bryan, L. E., and J. Bedard. 1991. Impermeability to quinolones in gram-positive and gram-negative bacteria. Eur. J. Clin. Microbiol. Infect. Dis. 10:232-239.
7. Chapman, J. S., and N. H. Georgopapadakou. 1988. Routes of quinolone permeation in Escherichia coli. Antimicrob. Agents Chemother. 32:438-442.
8. Denis, A., and N. J. Moreau. 1993. Mechanisms of quinolone resistance in clinical isolates: accumulation of sparfloxacin and fluoroquinolones of various hydrophohicity, and analysis of membrane composition. J. Antimicrob. Chemother. 32:379-392.
9. Fasching, C. E., F. C. Tenover, T. G. Slama, L. M. Fisher, S. Sreedharan, M. Oram, K. Willard, L. M. Sinn, D. N. Gerding, and L. R. Peterson. 1991. gyrA mutations in ciprofloxacin-resistant, methicillin-resistant Siaphylococcus aureus from Indiana, Minnesota, and Tennessee. J. Infect. Dis. 164:976-979.
10. Ferrero, L., B. Cameron, B. Manse, D. Lagneaux, J. Crouzet, A. Famechon, and F. Blanche. 1994. Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones. Mol. Microbiol. 13:641-653.
11. Furet, Y. X., J. Deshusses, and J.-C. Pechère. 1992. Transport of pefloxacin across the bacterial cytoplasmic membrane in quinolone-susceptible Staphylococcus aureus. Antimicrob. Agents Chemother. 36:2506-2511.
12. Goswitz, J. J., K. E. Willard, C. E. Fasching, and L. R. Peterson. 1992. Detection of gyrA gene mutations associated with ciprofloxacin resistance in methicillin-resistant Staphylococcus aureus: analysis by polymerase chain reaction and automated direct DNA sequencing. Antimicrob. Agents Chemother. 36:1166-1169.
13. Hirai, K., H. Aoyama, T. Irikura, S. Iyobe, and S. Mitsuhashi. 1986. Differences in susceptibility to quinolones for outer membrane mutants of Salmonella typhimurium and Escherichia coli. Antimicrob. Agents Chemother. 29: 535-538.
14. Hooper, D. C. 1995. Quinolone mode of action. Drugs 49(Suppl. 2):10-15.
15. Hooper, D. C., and J. S. Wolfson. 1991. Fluoroquinolone antimicrobial agents. N. Engl. J. Med. 324:384-394.
16. Ito, H., H. Yoshida, M. Bogaki-Shonai, T. Niga, H. Hattori, and S. Nakamura. 1994. Quinolone resistance mutations in the DNA gyrase gyrA and gyrB genes of Staphytococcus aureus. Antimicrob. Agents Chemother. 38: 2014-2023.
17. Japanese Society of Chemotherapy. 1981. Revision of methods for determining minimum inhibitory concentrations. Chemotherapy (Tokyo) 29:76-79.
18. Kaatz, G. W., S. L. Barriere, D. R. Schaberg, and R. Fekety. 1987. The emergence of resistance to ciprofloxacin during treatment of experimental Staphylococcus aureus endocarditis. J. Antimicrob. Chemother. 20:753-758.
19. Kaatz, G. W., S. M. Seo, and C. A. Ruble. 1991. Mechanisms of fluoroquinolone resistance in Staphylococcus aureus. J. Infect. Dis. 163:1080-1086.
20. Kaatz, G. W., S. M. Seo, and C. A. Ruble. 1993. Efflux-mediated fluoroquinolone resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 37:1086-1094.
21. Lewis, K. 1994. Multidrug resistance pumps in bacteria: variations on a theme. Trends Biochem. Sci. 19:119-123.
22. Luttinger, A. 1995. The twisted 'life' of DNA in the cell: bacterial topoisomerases. Mol. Microbiol. 15:601-606.
23. McCaffrey, C., A. Bertasso, J. Pace, and N. H. Georgopapadakou. 1992. Quinolone accumulation in Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. Antimicrob. Agents Chemother. 36:1601-1605.
24. Mortimer, P. G. S., and L. J. V. Piddock. 1991. A comparison of methods used for measuring the accumulation of quinolones by Enterobacteriaceae, Pseudomonas aeruginosa and Staphylococcus aureus. J. Antimicrob. Chemother. 28:639-653.
25. Ng, E. Y. W., M. Trucksis, and D. C. Hooper. 1994. Quinolone resistance mediated by norA: physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome. Antimicrob. Agents Chemother. 38:1345-1355.
26. Nikaido, H., and D. G. Thanassl. 1993. Penetration of lipophilic agents with multiple protonation sites into bacterial cells: tetracyclines and fluoroquinolones as examples. Antimicrob. Agents Chemother. 37:1393-1399.
27. Ohshita, Y., K. Hiramatsu, and T. Yokota. 1990. A point mutation in norA gene is responsible for quinolone resistance in Staphylococcus aureus. Biochem. Biophys. Res. Commun. 172:1028-1034.
28. Organization for Economic Cooperation and Development. 1981. OECD guidelines for testing of chemicals. Organization for Economic Cooperation and Development, Washington, D.C.
29. Reece, R. J., and A. Maxwell. 1991. DNA gyrase: structure and function. Crit. Rev. Biochem. Mol. Biol. 26:335-375.
30. Saier, M. H., Jr. 1994. Computer-aided analyses of transport protein sequences: gleaning evidence concerning function, structure, biogenesis, and evolution. Microbiol. Rev. 58:71-93.
31. Schaefler, S. 1989. Methicillin-resistant strains of Staphylococcus aureus resistant to quinolones. J. Clin. Microbiol. 27:335-336.
32. Shalit, I., S. A. Berger, A. Gorea, and H. Frimerman. 1989. Widespread quinolone resistance among methicillin-resistant Staphylococcus aureus isolates in a general hospital. Antimicrob. Agents Chemother. 33:593-594.
33. Takács-Novák, K., B. Noszál, I. Hermecz, G. Keresztúri, B. Podányi, and G. Szász. 1990. Protonation equilibria of quinolone antibacterials. J. Pharm. Sci. 79:1023-1028.
34. Takenouchi, T., C. Ishii, M. Sugawara, Y. Tokue, and S. Ohya. 1995. Incidence of various gyrA mutants in 451 Staphylococcus aureus strains isolated in Japan and their susceptibilities to 10 fluoroquinolones. Antimicrob. Agents Chemother. 39:1414-1418.
35. Trucksis, M., J. S. Wolfson, and D. C. Hooper. 1991. A novel locus conferring fluoroquinolone resistance in Staphylococcus aureus. J. Bacteriol. 173: 5854-5860.
36. Ubukata, K., N. Itoh-Yamashita, and M. Konno. 1989. Cloning and expression of the norA gene for fluoroquinolone resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 33:1535-1539.
37. Verloop, A., W. Hoogenstraaten, and J. Tipker. 1976. Development and application of new steric substituent parameters in drug design, p. 165-208. In E. J. Ariens (ed.), Drug design, vol. 7. Academic Press, Inc., New York.
38. Wang, J. C. 1985. DNA topoisomerases. Annu. Rev. Biochem. 54:665-697.
39. Yoshida, H., M. Bogaki, S. Nakamura, K. Ubukata, and M. Konno. 1990. Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones. J. Bacteriol. 172:6942-6949.