Interactions among catechol-O-methyltransferase genotype, parenting, and sex predict children's internalizing symptoms and inhibitory control: Evidence for differential susceptibility

Development and Psychopathology

Volumn 27, Issue 3, 2015, Pages 709-723

  Sulik, Michael J ^a,c   Eisenberg, Nancy ^a   Spinrad, Tracy L ^a   Lemery Chalfant, Kathryn ^a   Swann, Gregory ^a   Silva, Kassondra M ^a   Reiser, Mark ^a   Stover, Daryn A ^a   Verrelli, Brian C ^b  

^a ARIZONA STATE UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3' UNTRANSLATED REGION; CATECHOL METHYLTRANSFERASE; COMT PROTEIN, HUMAN; METHIONINE; VALINE;

3' UNTRANSLATED REGION; CHILD; CHILD PARENT RELATION; DISEASE PREDISPOSITION; EXECUTIVE FUNCTION; FEMALE; GENETICS; GENOTYPE; HAPLOTYPE; HUMAN; INFANT; INHIBITION (PSYCHOLOGY); INTRON; MALE; PHYSIOLOGY; PRESCHOOL CHILD; PROBLEM BEHAVIOR; PSYCHOLOGY; SEX DIFFERENCE;

3' UNTRANSLATED REGIONS; CATECHOL O-METHYLTRANSFERASE; CHILD; CHILD, PRESCHOOL; DISEASE SUSCEPTIBILITY; EXECUTIVE FUNCTION; FEMALE; GENOTYPE; HAPLOTYPES; HUMANS; INFANT; INHIBITION (PSYCHOLOGY); INTRONS; MALE; METHIONINE; PARENTING; PROBLEM BEHAVIOR; SEX FACTORS; VALINE;

EID: 84937562810     PISSN: 09545794     EISSN: 14692198     Source Type: Journal    
DOI: 10.1017/S0954579414000807     Document Type: Article

References (85)

1. Aiken, L. S., & West, S. G. (1991). Multiple regression: Testing and interpreting interactions. Newbury Park, CA: Sage.
2. Arnsten, A. F., & Pliszka, S. R. (2011). Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders. Pharmacology Biochemistry and Behavior, 99, 211-216.
3. Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2011). Differential susceptibility to rearing environment depending on dopamine-related genes: New evidence and a meta-analysis. Development and Psychopathology, 23, 39-52.
4. Barnett, J. H., Jones, P. B., Robbins, T. W., & Müller, U. (2007). Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: A meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls. Molecular Psychiatry, 12, 502-509.
5. Bayer, J. K., Sanson, A. V., & Hemphill, S. A. (2006). Parent influences on early childhood internalizing difficulties. Journal of Applied Developmental Psychology, 27, 542-559.
6. Belsky, J., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2007). For better and for worse: Differential susceptibility to environmental influences. Current Directions in Psychological Science, 16, 300-304.
7. Belsky, J., & Beaver, K. M. (2011). Cumulative-genetic plasticity, parenting and adolescent self-regulation. Journal of Child Psychology and Psychiatry, 52, 619-626.
8. Bishop, S. J., Cohen, J. D., Fossella, J., Casey, B. J., & Farah, M. J. (2006). COMT genotype influences prefrontal response to emotional distraction. Cognitive, Affective, & Behavioral Neuroscience, 6, 62-70.
9. Blasi, G., Mattay, V. S., Bertolino, E., Callicott, J. H., Das, S., Kolachana, B. S., et al. (2005). Effect of catechol-O-methyltransferase Val158Met genotype on attentional control. Journal of Neuroscience, 25, 5038-5045.
10. Boyce, W. T., & Ellis, B. J. (2005). Biological sensitivity to context: I. An evolutionary-developmental theory of the origins and functions of stress reactivity. Development and Psychopathology, 17, 271-301.
11. Braungart-Rieker, J., Garwood, M. M., & Stifter, C. A. (1997). Compliance and noncompliance: The roles of maternal control and child temperament. Journal of Applied Developmental Psychology, 18, 411-428.
12. Bray, N. J., Buckland, P. R., Williams, N. M., Williams, H. J., Norton, N., Owen, M. J., et al. (2003). A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. American Journal of Human Genetics, 73, 152-161.
13. Briggs-Gowan, M. J., & Carter, A. S. (1998). Preliminary acceptability and psychometrics of the Infant-Toddler Social and Emotional Assessment (ITSEA): A new adult-report questionnaire. Infant Mental Health Journal, 19, 422-445.
14. Bruder, G. E., Keilp, J. G., Xu, H., Shikhman, M., Schori, E., Gorman, J. M., et al. (2005). Catechol-O-methyltransferase (COMT) genotypes and working memory: Associations with differing cognitive operations. Biological Psychiatry, 58, 901-907.
15. Burdick, K. E., Funke, B., Goldberg, J. F., Bates, J. A., Jaeger, J., Kucherlapati, R., et al. (2007). COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance. Bipolar Disorders, 9, 370-376.
16. Claw, K. G., Tito, R. Y., Stone, A. C., & Verrelli, B. C. (2010). Haplotype structure and divergence at human and chimpanzee serotonin transporter and receptor genes: Implications for behavioral disorder association analyses. Molecular Biology and Evolution, 27, 1518-1529.
17. nd ed.). Hillsdale, NJ: Erlbaum.
18. De Frias, C. M., Annerbrink, K., Westberg, L., Eriksson, E., Adolfsson, R., &Nilsson, L. (2005). Catechol-O-methyltransferase Val158Met polymorphism is associated with cognitive performance in nondemented adults. Journal of Cognitive Neuroscience, 17, 1018-1025.
19. Del Giudice, M., Ellis, B. J., & Shirtcliff, E. A. (2011). The adaptive calibration model of stress responsivity. Neuroscience & Biobehavioral Reviews, 35, 1562-1592.
20. Diamond, A., Briand, L., Fossella, J., & Gehlbach, L. (2004). Genetic and neurochemical modulation of prefrontal cognitive functions in children. American Journal of Psychiatry, 161, 125-132.
21. Duncan, L. E., & Keller, M. C. (2011). A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry. American Journal of Psychiatry, 168, 1041-1049.
22. Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., et al. (2001). Effect of COMT Val108/158Met genotype on frontal lobe function and risk for schizophrenia. Proceedings of the National Academy of Sciences, 98, 6917-6922.
23. Eisenberg, N., Spinrad, T. L., & Eggum, N. D. (2010). Emotion-related self-regulation and its relation to children's maladjustment. Annual Review of Clinical Psychology, 6, 495-525.
24. Eisenberg, N., Spinrad, T. L., Eggum, N. M., Silva, K. M., Reiser, M., Hofer, C., et al. (2010). Relations among maternal socialization, effortful control, and maladjustment in early childhood. Development and Psychopathology, 22, 507-525.
25. Eisenberg, N., Zhou, Q., Spinrad, T. L., Valiente, C., Fabes, R. A., & Liew, J. (2005). Relations among positive parenting, children's effortful control, and externalizing problems: A three-wave longitudinal study. Child Development, 76, 1055-1071.
26. Ellis, B. J., Boyce, W. T., Belsky, J., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2011). Differential susceptibility to the environment: An evolutionary-neurodevelopmental theory. Development and Psychopathology, 23, 7-23.
27. Enoch, M. A., Waheed, J. F., Harris, C. R., Albaugh, B., & Goldman, D. (2009). COMT Val158Met and cognition: Main effects and interaction with educational attainment. Genes, Brain and Behavior, 8, 36-42.
28. Fish, M., Stifter, C. A., & Belsky, J. (1991). Conditions of continuity and discontinuity in infant negative emotionality: Newborn to five months. Child Development, 62, 1525-1537.
29. Harrison, P. J., & Tunbridge, E. M. (2008). Catechol-O-methyltransferase (COMT): A gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders. Neuropsychopharmacology, 33, 3037-3045.
30. Hettema, J. M., An, S., Bukszar, J., van den Oord, E. J., Neale, M. C., Kendler, K. S., et al. (2008). Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes. Biological Psychiatry, 64, 302-310.
31. Holmboe, K., Nemoda, Z., Fearon, R. M., Csibra, G., Sasvari-Szekely, M., &Johnson, M. H. (2010). Polymorphisms in dopamine system genes are associated with individual differences in attention in infancy. Developmental Psychology, 46, 404-416.
32. Johnson, P. O., & Neyman, J. (1936). Tests of certain linear hypotheses and their application to some educational problems. Statistical Research Memoirs, 1, 57-93.
33. Kocabas, N. A., Faghel, C., Barreto, M., Kasper, S., Linotte, S., Mendlewicz, J., et al. (2010). The impact of catechol-O-methyltransferase SNPs and haplotypes on treatment response phenotypes in major depressive disorder: A case-control association study. International Clinical Psychopharmacology, 25, 218-227.
34. Kochanska, G., Aksan, N., & Nichols, K. E. (2003). Maternal power assertion in discipline and moral discourse contexts: Commonalities, differences, and implications for children's moral conduct and cognition. Developmental Psychology, 39, 949-963.
35. Kochanska, G., Kim, S., Barry, R. A., & Philibert, R. A. (2011). Children's genotypes interact with maternal responsive care in predicting children's competence: Diathesis-stress or differential susceptibility? Development and Psychopathology, 23, 605-616.
36. Kochanska, G., Murray, K. T., & Harlan, E. T. (2000). Effortful control in early childhood: Continuity and change, antecedents, and implications for social development. Developmental Psychology, 36, 220-232.
37. Kochanska, G., Murray, K., Jacques, T. Y., Koenig, A. L., & Vandegeest, K. A. (1996). Inhibitory control in young children and its role in emerging internalization. Child Development, 67, 490-507.
38. Kok, R., Linting, M., Bakermans-Kranenburg, M., IJzendoorn, M. H., Jaddoe, V. W., Hofman, A., et al. (2013). Maternal sensitivity and internalizing problems: Evidence from two longitudinal studies in early childhood. Child Psychiatry and Human Development, 44, 751-765.
39. Lachman, H. M., Papolos, D. F., Saito, T., Yu, Y. M., Szumlanski, C. L., &Weinshilboum, R. M. (1996). Human catechol-O-methyltransferase pharmacogenetics: Description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics, 6, 243-250.
40. Laucht, M., Blomeyer, D., Buchmann, A. F., Treutlein, J., Schmidt, M. H., Esser, G., et al. (2012). Catechol-O-methyltransferase Val158Met genotype, parenting practices and adolescent alcohol use: Testing the differential susceptibility hypothesis. Journal of Child Psychology and Psychiatry, 53, 351-359.
41. Lemery-Chalfant, K. (2010). Genes and environments: How they work together to promote resilience. In J. W. Reich, A. J. Zautra, & J. S. Hall (Eds.), Handbook of adult resilience (pp. 55-78). New York: Guilford Press.
42. Lengua, L. J., Honorado, E., & Bush, N. R. (2007). Contextual risk and parenting as predictors of effortful control and social competence in preschool children. Journal of Applied Developmental Psychology, 28, 40-55.
43. Lipska, B. K., Mitkus, S., Caruso, M., Hyde, T. M., Chen, J., Vakkalanka, R., et al. (2006). RGS4 mRNA expression in postmortem human cortex is associated with COMT Val158Met genotype and COMT enzyme activity. Human Molecular Genetics, 15, 2804-2812.
44. Lipsky, R. H., Sparling, M. B., Ryan, L. M., Xu, K., Salazar, A. M., Goldman, D., et al. (2005). Association of COMT Val158Met genotype with executive functioning following traumatic brain injury. Journal of Neuropsychiatry, 17, 465-471.
45. Liu, B., Song, M., Li, J., Liu, Y., Li, K., Yu, C., et al. (2010). Prefrontal-related functional connectivities within the default network are modulated by COMT Val158Met in healthy young adults. Journal of Neuroscience, 30, 64-69.
46. Lotta, T., Vidgren, J., Tilgmann, C., Ulmanen, I., Melen, K., Julkunen, I., et al. (1995). Kinetics of human soluble and membrane-bound catechol-O-methyltransferase: A revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry, 34, 4202-4210.
47. Luby, J. L., Heffelfinger, A. K., Mrakotsky, C., Brown, K. M., Hessler, M. J., Wallis, J. M., et al. (2003). The clinical picture of depression in preschool children. Journal of the American Academy of Child & Adolescent Psychiatry, 42, 340-348.
48. Malhotra, A. K., Kestler, L. J., Mazzanti, C., Bates, J. A., Goldberg, T. E., &Goldman, D. (2002). A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. American Journal of Psychiatry, 159, 652-654.
49. McCrae, R. R., & Costa, P. T. (1987). Validation of the five-factor model of personality across instruments and observers. Journal of Personality and Social Psychology, 85, 81-90.
50. McGrath, M., Kawachi, I., Ascherio, A., Colditz, G. A., Hunter, D. J., & De Vivo, I. (2004). Association between catechol-O-methyltransferase and phobic anxiety. American Journal of Psychiatry, 161, 1703-1705.
51. McLeod, B. D., Weisz, J. R., & Wood, J. J. (2007). Examining the association between parenting and childhood depression: A meta-analysis. Clinical Psychology Review, 27, 986-1003.
52. McLeod, B. D., Wood, J. J., & Weisz, J. R. (2007). Examining the association between parenting and childhood anxiety: A meta-analysis. Clinical Psychology Review, 27, 155-172.
53. Meyer-Lindenberg, A., Nichols, T., Callicott, J. H., Ding, J., Kolachana, B., Buckholtz, J., et al. (2006). Impact of complex genetic variation in COMT on human brain function. Molecular Psychiatry, 11, 867-877.
54. Mier, D., Kirsch, P., & Meyer-Lindenberg, A. (2009). Neural substrates of pleiotropic action of genetic variation in COMT: A meta-analysis. Molecular Psychiatry, 15, 918-927.
55. Monroe, S. M., & Simons, A. D. (1991). Diathesis-stress theories in the context of life stress research: Implications for the depressive disorders. Psychological Bulletin, 110, 406-425.
56. Montag, C., Buckholtz, J. W., Hartmann, P., Merz, M., Burk, C., Hennig, J., et al. (2008). COMT genetic variation affects fear processing: Psychophysiological evidence. Behavioral Neuroscience, 122, 901-909.
57. Nobile, M., Rusconi, M., Bellina, M., Marino, C., Giorda, R., Carlet, O., et al. (2009). COMT Val158Met polymorphism and socioeconomic status interact to predict attention deficit/hyperactivity problems in children aged 10-14. European Child and Adolescent Psychiatry, 19, 549-557.
58. Obradović, J., Bush, N. R., Stampterdahl, J., Adler, N. E., & Boyce, W. T. (2010). Biological sensitivity to context: The interactive effects of stress reactivity and family adversity on socioemotional behavior and school readiness. Child Development, 81, 270-289.
59. Oldehinkel, A. J., Hartman, C. A., Ferdinand, R. F., Verhulst, F. C., & Ormel, J. (2007). Effortful control as modifier of the association between negative emotionality and adolescents' mental health problems. Development and Psychopathology, 19, 523-539.
60. Olsson, C. A., Anney, R. J., Lotfi-Miri, M., Byrnes, G. B., Williamson, R., &Patton, G. C. (2005). Association between the COMT Val158Met polymorphism and propensity to anxiety in an Australian population-based longitudinal study of adolescent health. Psychiatric Genetics, 15, 109-115.
61. Pluess, M., & Belsky, J. (2012). Vantage sensitivity: Individual differences in response to positive experiences. Psychological Bulletin. Advance online publication.
62. Pritchard, J. K., Stephens, M., & Donnelly, P. (2000). Inference of population structure using multilocus genotype data. Genetics, 155, 945-959.
63. Propper, C., Willoughby, M., Halpern, C. T., Carbone, M. A., & Cox, M. (2007). Parenting quality, DRD4, and the prediction of externalizing and internalizing behaviors in early childhood. Developmental Psychobiology, 49, 619-632.
64. Roisman, G. I., Newman, D. A., Fraley, R. C., Haltigan, J. D., Groh, A. M., &Haydon, K. C. (2012). Distinguishing differential susceptibility from diathesis-stress: Recommendations for evaluating interaction effects. Development and Psychopathology, 24, 389-409.
65. Rothbart, M. K., Ahadi, S. A., Hershey, K., & Fisher, P. (2001). Investigations of temperament at three to seven years: The Children's Behavior Questionnaire. Child Development, 72, 1394-1408.
66. th ed., pp. 99-166). Hoboken, NJ: Wiley.
67. Sambrook, J., & Russell, D. W. (2001). Molecular cloning: A laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
68. Schafer, J. L., & Graham, J. W. (2002). Missing data: Our view of the state of the art. Psychological Methods, 7, 147-177.
69. Shifman, S., Bronstein, M., Sternfeld, M., Pisanté-Shalom, A., Lev-Lehman, E., Weizman, A., et al. (2002). A highly significant association between a COMT haplotype and schizophrenia. American Journal of Human Genetics, 71, 1296-1302.
70. Singer, J. A., & Willett, J. B. (2003). Applied longitudinal data analysis. New York: Oxford University Press.
71. Smolka, M. N., Bühler, M., Schumann, G., Klein, S., Hu, X., Moayer, M., et al. (2007). Gene-gene effects on central processing of aversive stimuli. Molecular Psychiatry, 12, 307-317.
72. Spinrad, T. L., Eisenberg, N., Gaertner, B., Popp, T., Smith, C. L., Kupfer, A., et al. (2007). Relations of maternal socialization and toddlers' effortful control to children's adjustment and social competence. Developmental Psychology, 43, 1170-1186.
73. Stein, M. B., Fallin, M. D., Schork, N. J., & Gelernter, J. (2005). COMT polymorphisms and anxiety-related personality traits. Neuropsychopharmacology, 30, 2092-2102.
74. Stephens, M., Smith, N. J., & Donnelly, P. (2001). A new statistical method for haplotype reconstruction from population data. American Journal of Human Genetics, 68, 978-989.
75. Stifter, C. A., Spinrad, T. L., & Braungart-Rieker, J. M. (1999). Toward a developmental model of child compliance: The role of emotion regulation in infancy. Child Development, 70, 21-32.
76. Straub, R. E., Speer, M. C., Luo, Y., Rojas, K., Overhauser, J., Ott, J., et al. (1993). A microsatellite genetic linkage map of human chromosome 18. Genomics, 15, 48-56.
77. Sulik, M. J., Eisenberg, N., Lemery-Chalfant, K., Spinrad, T. L., Silva, K. M., Eggum, N. D., et al. (2012). Interactions between serotonin transporter gene haplotypes and quality of mothers' parenting predict the development of children's noncompliance. Developmental Psychology, 48, 740-754.
78. th ed.). Needham Heights, MA: Pearson/Allyn & Bacon.
79. Taylor, Z. E., Sulik, M. J., Eisenberg, N., Spinrad, T. L., Silva, K. M., Lemery-Chalfant, K., et al. (2013). Development of ego-resiliency: Relations to observed parenting and polymorphisms in the serotonin transporter gene during early childhood. Social Development. Advance online publication.
80. Tenhunen, J., Salminen, M., Lundstrom, K., Kiviluoto, T., Savolainen, R., &Ulmanen, I. (1994). Genomic organization of the human catechol-Omethyltransferase gene and its expression from two distinct promoters. European Journal of Biochemistry, 223, 1049-1059.
81. Tunbridge, E. M., Weickert, C. S., Kleinman, J. E., Herman, M. M., Chen, J., Kolachana, B. S., et al. (2007). Catechol-O-methyltransferase enzyme activity and protein expression in human prefrontal cortex across the postnatal lifespan. Cerebral Cortex, 17, 1206-1212.
82. Voelker, P., Sheese, B. E., Rothbart, M. K., & Posner, M. I. (2009). Variations in catechol-O-methyltransferase gene interact with parenting to influence attention in early development. Neuroscience, 164, 121-130.
83. White, L. K., McDermott, J. M., Degnan, K. A., Henderson, H. A., & Fox, N. A. (2011). Behavioral inhibition and anxiety: The moderating roles of inhibitory control and attention shifting. Journal of Abnormal Child Psychology, 39, 735-747.
84. Yavich, L., Forsberg, M. M., Karayiorgou, M., Gogos, J. A., & Männistö, P. T. (2007). Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum. Journal of Neuroscience, 27, 10196-10209.
85. Zuckerman, M. (1999). Vulnerability to psychopathology: A biosocial model. Washington, DC: American Psychological Association.