Prefrontal-related functional connectivities within the default network are modulated by COMT val158met in healthy young adults

Journal of Neuroscience

Volumn 30, Issue 1, 2010, Pages 64-69

  Liu, Bing ^a   Song, Ming ^a   Li, Jun ^a,d   Liu, Yong ^a   Li, Kuncheng ^b   Yu, Chunshui ^b   Jiang, Tianzi ^a,c  

^a INSTITUTE OF AUTOMATION   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF ELECTRONIC SCIENCE AND TECHNOLOGY OF CHINA   (China)

^d BEIJING NORMAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL METHYLTRANSFERASE; DOPAMINE; METHIONINE; VALINE;

ADULT; ARTICLE; BRAIN CORTEX; BRAIN DISEASE; CINGULATE GYRUS; CODON; COGNITION; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC ANALYSIS; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; INFORMATION; INFORMATION PROCESSING; MALE; NORMAL HUMAN; PHENOTYPE; PREFRONTAL CORTEX; PRIORITY JOURNAL; RISK ASSESSMENT; TISSUE LEVEL;

ADOLESCENT; ADULT; CATECHOL O-METHYLTRANSFERASE; DOPAMINE; FEMALE; HUMANS; MALE; METHIONINE; NERVE NET; PREFRONTAL CORTEX; VALINE; YOUNG ADULT;

EID: 74849115265     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3941-09.2010     Document Type: Article

References (38)

1. Barnett JH, Scoriels L, Munafò MR (2008) Meta-analysis of the cognitive effects of the catechol-O-methyltransferase gene Val158/108Met polymorphism. Biol Psychiatry 64:137-144.
2. Belmonte M, Yurgelun-Todd D (2001) Permutation testing made practical for functional magnetic resonance image analysis. IEEE Trans Med Imaging 20:243-248.
3. 158met genotype on attentional control. J Neurosci 25:5038 -5045.
4. Bray NJ, Buckland PR, Williams NM, Williams HJ, Norton N, Owen MJ, O'Donovan MC (2003) A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. Am J Hum Genet 73:152-161.
5. Broyd SJ, Demanuele C, Debener S, Helps SK, James CJ, Sonuga-Barke EJ (2009) Default-mode brain dysfunction in mental disorders: a systematic review. Neurosci Biobehav Rev 33:279 -296.
6. Buckner RL, Andrews-Hanna JR, Schacter DL (2008) The brain's default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci 1124:1-38.
7. Camargo A, Azuaje F, Wang H, Zheng H (2008) Permutation-based statistical tests for multiple hypotheses. Source Code Biol Med 3:15.
8. Conneely KN, Boehnke M (2007) So many correlated tests, so little time! Rapid adjustment of P values for multiple correlated tests. Am J Hum Genet 81:1158 -1168.
9. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR (2001) Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci U S A 98:6917- 6922.
10. Esslinger C, Walter H, Kirsch P, Erk S, Schnell K, Arnold C, Haddad L, Mier D, Opitz von Boberfeld C, Raab K, Witt SH, Rietschel M, Cichon S, Meyer-Lindenberg A (2009) Neural mechanisms of a genome-wide supported psychosis variant. Science 324:605.
11. Fair DA, Cohen AL, Dosenbach NU, Church JA, Miezin FM, Barch DM, Raichle ME, Petersen SE, Schlaggar BL (2008) The maturing architecture of the brain's default network. Proc Natl Acad Sci U S A 105:4028-4032.
12. Filippini N, MacIntosh BJ, Hough MG, Goodwin GM, Frisoni GB, Smith SM, Matthews PM, Beckmann CF, Mackay CE (2009) Distinct patterns of brain activity in young carriers of the APOE-e4 allele. Proc Natl Acad Sci U S A 106:7209 -7214.
13. Fox MD, Raichle ME (2007) Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci 8:700 -711.
14. Friston KJ, Frith CD, Liddle PF, Frackowiak RS (1993) Functional connectivity: the principal-component analysis of large (PET) data sets. J Cereb Blood Flow Metab 13:5-14.
15. Goghari VM, Sponheim SR (2008) Differential association of the COMT Val158Met polymorphism with clinical phenotypes in schizophrenia and bipolar disorder. Schizophr Res 103:186 -191.
16. Goldberg TE, Egan MF, Gscheidle T, Coppola R, Weickert T, Kolachana BS, Goldman D, Weinberger DR (2003) Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia. Arch Gen Psychiatry 60:889-896.
17. Hampson M, Driesen NR, Skudlarski P, Gore JC, Constable RT (2006) Brain connectivity related to working memory performance. J Neurosci 26:13338 -13343.
18. He BJ, Snyder AZ, Vincent JL, Epstein A, Shulman GL, Corbetta M (2007) Breakdown of functional connectivity in frontoparietal networks underlies behavioral deficits in spatial neglect. Neuron 53:905-918.
19. Hong J, Shu-Leong H, Tao X, Lap-Ping Y (1998) Distribution of catechol-O-methyltransferase expression in human central nervous system. Neuroreport 9:2861-2864.
20. Karoum F, Chrapusta SJ, Egan MF (1994) 3-Methoxytyramine is the major metabolite of released dopamine in the rat frontal cortex: reassessment of the effects of antipsychotics on the dynamics of dopamine release and metabolism in the frontal cortex, nucleus accumbens, and striatum by a simple two pool model. J Neurochem 63:972-979.
21. Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM (1996) Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 6:243-250.
22. Lotta T, Vidgren J, Tilgmann C, Ulmanen I, Melén K, Julkunen I, Taskinen J (1995) Kinetics of human soluble and membrane-bound catechol Omethyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 34:4202- 4210.
23. Männistö PT, Kaakkola S (1999) Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors. Pharmacol Rev 51:593- 628.
24. Matsumoto M, Weickert CS, Akil M, Lipska BK, Hyde TM, Herman MM, Kleinman JE, Weinberger DR (2003) Catechol O-methyltransferase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function. Neuroscience 116:127-137.
25. McNab F, Varrone A, Farde L, Jucaite A, Bystritsky P, Forssberg H, Klingberg T (2009) Changes in cortical dopamine D1 receptor binding associated with cognitive training. Science 323:800-802.
26. Meyer-Lindenberg A (2009) Neural connectivity as an intermediate phenotype: brain networks under genetic control. Hum Brain Mapp 30:1938-1946.
27. Mukherjee N, Kidd KK, Pakstis AJ, Speed WC, Li H, Tarnok Z, Barta C, Kajuna SL, Kidd JR (2008) The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase. Mol Psychiatry, in press.
28. Nackley AG, Shabalina SA, Tchivileva IE, Satterfield K, Korchynskyi O, Makarov SS, Maixner W, Diatchenko L (2006) Human catechol-Omethyltransferase haplotypes modulate protein expression by altering mRNA secondary structure. Science 314:1930 -1933.
29. Qian Q, Wang Y, Zhou R, Li J, Wang B, Glatt S, Faraone SV (2003) Family-based and case-control association studies of catechol-O- methyltransferase in attention deficit hyperactivity disorder suggest genetic sexual dimorphism. Am J Med Genet B Neuropsychiatr Genet 118B:103-109.
30. Sambataro F, Murty VP, Callicott JH, Tan HY, Das S, Weinberger DR, Mattay VS (2008) Age-related alterations in default mode network: impact on working memory performance. Neurobiol Aging, in press.
31. Seamans JK, Yang CR (2004) The principal features and mechanisms of dopamine modulation in the prefrontal cortex. Prog Neurobiol 74:1-58.
32. Seeley WW, Menon V, Schatzberg AF, Keller J, Glover GH, Kenna H, Reiss AL, GreiciusMD (2007) Dissociable intrinsic connectivity networks for salience processing and executive control. J Neurosci 27:2349 -2356.
33. Smith SM, Fox PT, Miller KL, Glahn DC, Fox PM, Mackay CE, Filippini N, Watkins KE, Toro R, Laird AR, Beckmann CF (2009) Correspondence of the brain's functional architecture during activation and rest. Proc Natl Acad Sci U S A 106:13040 -13045.
34. Song M, Zhou Y, Li J, Liu Y, Tian L, Yu C, Jiang T (2008) Brain spontaneous functional connectivity and intelligence. Neuroimage 41:1168 -1176.
35. Song M, Liu Y, Zhou Y, Wang K, Yu CS, Jiang TZ (2009) Default network and intelligence difference. IEEE Trans Auton Ment Dev 1:101-109.
36. Sowell ER, Kan E, Yoshii J, Thompson PM, Bansal R, Xu D, Toga AW, Peterson BS (2008) Thinning of sensorimotor cortices in children with Tourette syndrome. Nat Neurosci 11:637-639.
37. Tunbridge EM, Harrison PJ, Weinberger DR (2006) Catechol-o- methyltransferase, cognition, and psychosis: Val158Met and beyond. Biol Psychiatry 60:141-151.
38. Westfall PH, Young SS (1993) Resampling-based multiple testing. New York: Wiley.