Association between cathecol-O-methyltyranferase and phobic anxiety

American Journal of Psychiatry

Volumn 161, Issue 9, 2004, Pages 1703-1705

  McGrath, Monica ^a   Kawachi, Ichiro ^b   Ascherio, Alberto ^b   Colditz, Graham A ^b   Hunter, David J ^b   De Vivo, Immaculata ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL METHYLTRANSFERASE; DOPAMINE;

ARTICLE; CONTROLLED STUDY; FEMALE; GENE DOSAGE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PHOBIA; PRIORITY JOURNAL; RATING SCALE; RISK; STATISTICAL ANALYSIS; CHROMOSOME 22; ENZYMOLOGY; GENETIC PREDISPOSITION; GENETICS; HEALTH SURVEY; LONGITUDINAL STUDY; METABOLISM; PERSONALITY TEST; PREFRONTAL CORTEX; QUESTIONNAIRE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; STATISTICAL MODEL; STATISTICS; UNITED STATES;

CATECHOL O-METHYLTRANSFERASE; CHROMOSOMES, HUMAN, PAIR 22; DOPAMINE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEALTH SURVEYS; HUMANS; LOGISTIC MODELS; LONGITUDINAL STUDIES; PERSONALITY INVENTORY; PHOBIC DISORDERS; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PREFRONTAL CORTEX; QUESTIONNAIRES; UNITED STATES;

EID: 4444269807     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.161.9.1703     Document Type: Article

References (14)

1. Axelrod J, Tomchick R: Enzymatic O-methylation of epinephrine and other catechols. J Biol Chem 1958; 233:702-705
2. Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM: Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 1996; 6:243-250
3. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR: Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 2001; 98:6917-6922
4. Crown S, Crisp AH: A short clinical diagnostic self-rating scale for psychoneurotic patients: the Middlesex Hospital Questionnaire (MHQ). Br J Psychiatry 1966; 112:917-923
5. Haines A, Cooper J, Meade TW: Psychological characteristics and fatal ischaemic heart disease. Heart 2001; 85:385-389
6. Espejo EF: Selective dopamine depletion within the medial prefrontal cortex induces anxiogenic-like effects in rats placed on the elevated plus maze. Brain Res 1997; 762:281-284
7. Hamilton SP, Slager SL, Heiman GA, Deng Z, Haghighi F, Klein DF, Hodge SE, Weissman MM, Fyer AJ, Knowles JA: Evidence for a susceptibility locus for panic disorder near the catechol-O-methyltransferase gene on chromosome 22. Biol Psychiatry 2002; 51:591-601
8. Ohara K, Nagai M, Suzuki Y, Ochiai M: No association between anxiety disorders and catechol-O-methyltransferase polymorphism. Psychiatry Res 1998; 80:145-148
9. Woo J-M, Yoon K-S, Yu B-H: Catechol O-methyltransferase genetic polymorphism in panic disorder. Am J Psychiatry 2002; 159:1785-1787
10. Enoch MA, Xu K, Ferro E, Harris CR, Goldman D: Genetic origins of anxiety in women: a role for a functional catechol-O-methyltransferase polymorphism. Psychiatr Genet 2003; 13:33-41
11. Weissman MM, Bland RC, Canino GJ, Faravelli C, Greenwald S, Hwu HG, Joyce PR, Karam EG, Lee CK, Lellouch J, Lepine JP, Newman SC, Oakley-Browne MA, Rubio-Stipec M, Wells JE, Wickramaratne PJ, Wittchen HU, Yeh EK: The cross-national epidemiology of panic disorder. Arch Gen Psychiatry 1997; 54: 305-309
12. Xie T, Ho SL, Ramsden D: Characterization and implications of estrogenic down-regulation of human catechol-O-methyltransferase gene transcription. Mol Pharmacol 1999; 56:31-38
13. Gogos JA, Morgan M, Luine V, Santha M, Ogawa S, Pfaff D, Karayiorgou M: Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc Natl Acad Sci USA 1998; 95:9991-9996
14. Bray NJ, Buckland PR, Williams NM, Williams HJ, Norton N, Owen MJ, O'Donovan MC: A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. Am J Hum Genet 2003; 73:152-161