Differential Promoter Methylation of Macrophage Genes Is Associated with Impaired Vascular Growth in Ischemic Muscles of Hyperlipidemic and Type 2 Diabetic Mice: Genome-Wide Promoter Methylation Study

Circulation Research

Volumn 117, Issue 3, 2015, Pages 289-299

  Babu, Mohan ^a   Devi, Thota Durga ^a   Mäkinen, Petri ^a   Kaikkonen, Minna ^a   Lesch, Hanna P ^a   Junttila, Sini ^b   Laiho, Asta ^b   Ghimire, Bishwa ^b   Gyenesei, Attila ^b   Ylä Herttuala, Seppo ^a,c  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b TURKU CENTRE FOR BIOTECHNOLOGY   (Finland)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

angiogenesis; diabetes mellitus; DNA methylation; epigenomics; hypercholesterolemia; macrophage; peripheral vascular disease

Indexed keywords

MESSENGER RNA; APOLIPOPROTEIN B100; FAT INTAKE; LOW DENSITY LIPOPROTEIN RECEPTOR;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOLE; ARTERY LIGATION; ARTICLE; CAPILLARY; CONTROLLED STUDY; DNA METHYLATION; DNA SEQUENCE; ECHOGRAPHY; ENDOTHELIUM CELL; EPIGENETICS; FEMORAL ARTERY; GENETIC ASSOCIATION; HINDLIMB ISCHEMIA; HYPERLIPIDEMIA; IMMUNOHISTOCHEMISTRY; LIMB ISCHEMIA; MACROPHAGE; MOUSE; MUSCLE ISCHEMIA; NEOVASCULARIZATION (PATHOLOGY); NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; ADAPTATION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DEFICIENCY; DISEASE MODEL; FAT INTAKE; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; HINDLIMB; INFLAMMATION; ISCHEMIA; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; REPERFUSION; REPERFUSION INJURY; SKELETAL MUSCLE; TOXICITY; VASCULARIZATION;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; APOLIPOPROTEIN B-100; ARTERIOLES; CAPILLARIES; DIABETES MELLITUS, TYPE 2; DIETARY FATS; DISEASE MODELS, ANIMAL; DNA METHYLATION; ENDOTHELIAL CELLS; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; GENOME-WIDE ASSOCIATION STUDY; HINDLIMB; HYPERLIPIDEMIAS; INFLAMMATION; ISCHEMIA; MACROPHAGES; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SKELETAL; NEOVASCULARIZATION, PHYSIOLOGIC; PROMOTER REGIONS, GENETIC; RECEPTORS, LDL; REPERFUSION; REPERFUSION INJURY; RNA, MESSENGER;

EID: 84937551587     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.115.306424     Document Type: Article

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