Epigenetic DNA methylation in the promoters of the Igf1 receptor and insulin receptor genes in db/db mice

Epigenetics

Volumn 6, Issue 4, 2011, Pages 405-409

  Nikoshkov, Andrej ^a   Sunkari, Vivekananda ^a   Savu, Octavian ^a   Forsberg, Elisabete ^a   Catrina, Sergiu Bogdan ^a   Brismar, Kerstin ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Db db mice; Epigenetic methylation; Insulin receptor; Type 1 insulin like growth factor receptor; Type 2 diabetes

Indexed keywords

INSULIN RECEPTOR; MESSENGER RNA; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CONTROLLED STUDY; DIABETES MELLITUS; DNA METHYLATION; EPIGENETICS; FEMALE; HEART MUSCLE; MALE; MOUSE; NONHUMAN; SEQUENCE ANALYSIS; SKELETAL MUSCLE;

MUS;

EID: 79954470614     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.6.4.14791     Document Type: Article

References (33)

1. Wren JD, Garner HR. Data-mining analysis suggests an epigenetic pathogenesis for type 2 diabetes. J Biomed Biotechnol 2005; 2005:104-12.
2. Villeneuve LM, Natarajan R. The role of epigenetics in the pathology of diabetic complications. Am J Physiol Renal Physiol 2010; 299:14-25.
3. Pinney SE, Simmons RA. Epigenetic mechanisms in the development of type 2 diabetes. Trends Endocrinol Metab 2010; 21:223-9.
4. Villeneuve LM, Reddy MA, Lanting LL, Wang M, Meng L, Natarajan R. Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes. Proc Natl Acad Sci USA 2008; 105:9047-52.
5. Ling C, Poulsen P, Simonsson S, Ronn T, Holmkvist J, Almgren P, et al. Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle. J Clin Invest 2007; 117:3427-35.
6. Ronn T, Poulsen P, Hansson O, Holmkvist J, Almgren P, Nilsson P, et al. Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle. Diabetologia 2008; 51:1159-68.
7. Barres R, Osler ME, Yan J, Rune A, Fritz T, Caidahl K, et al. Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density. Cell Metab 2009; 10:189-98.
8. Shafrir E, Ziv E. A useful list of spontaneously arising animal models of obesity and diabetes. Am J Physiol Endocrinol Metab 2009; 296:1450-2.
9. Hummel KP, Dickie MM, Coleman DL. Diabetes, a new mutation in the mouse. Science 1966; 153:1127-8.
10. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 1996; 84:491-5.
11. Rees DA, Alcolado JC. Animal models of diabetes mellitus. Diabet Med 2005; 22:359-70.
12. Davis RC, Castellani LW, Hosseini M, Ben-Zeev O, Mao HZ, Weinstein MM, et al. Early hepatic insulin resistance precedes the onset of diabetes in obese C57BLKS-db/db mice. Diabetes 2010; 59:1616-25.
13. Brozinick JT Jr, McCoid SC, Reynolds TH, Nardone NA, Hargrove DM, Stevenson RW, et al. GLUT4 overexpression in db/db mice dose-dependently ameliorates diabetes but is not a lifelong cure. Diabetes 2001; 50:593-600.
14. Goncalves AC, Tank J, Diedrich A, Hilzendeger A, Plehm R, Bader M, et al. Diabetic hypertensive leptin receptor-deficient db/db mice develop cardioregulatory autonomic dysfunction. Hypertension 2009; 53:387-92.
15. Sharma K, McCue P, Dunn SR. Diabetic kidney disease in the db/db mouse. Am J Physiol Renal Physiol 2003; 284:1138-44.
16. Clements RS Jr, Robison WG Jr, Cohen MP. Anti-glycated albumin therapy ameliorates early retinal microvascular pathology in db/db mice. J Diabetes Complications 1998; 12:28-33.
17. Clee SM, Attie AD. The genetic landscape of type 2 diabetes in mice. Endocr Rev 2007; 28:48-83.
18. Accili D. Lilly lecture 2003: the struggle for mastery in insulin action: from triumvirate to republic. Diabetes 2004; 53:1633-42.
19. Nakae J, Kido Y, Accili D. Distinct and overlapping functions of insulin and IGF-I receptors. Endocr Rev 2001; 22:818-35.
20. Leroith D, Accili D. Mechanisms of disease: using genetically altered mice to study concepts of type 2 diabetes. Nat Clin Pract Endocrinol Metab 2008; 4:164-72.
21. Alfieri CM, Evans-Anderson HJ, Yutzey KE. Developmental regulation of the mouse IGF-I exon 1 promoter region by calcineurin activation of NFAT in skeletal muscle. Am J Physiol Cell Physiol 2007; 292:1887-94.
22. Werner H, Stannard B, Bach MA, LeRoith D, Roberts CT Jr. Cloning and characterization of the proximal promoter region of the rat insulin-like growth factor I (IGF-I) receptor gene. Biochem Biophys Res Commun 1990; 169:1021-7.
23. Moreno-Aliaga MJ, Swarbrick MM, Lorente-Cebrian S, Stanhope KL, Havel PJ, Martinez JA. Sp1-mediated transcription is involved in the induction of leptin by insulin-stimulated glucose metabolism. J Mol Endocrinol 2007; 38:537-46.
24. Li T, Bai L, Li J, Igarashi S, Ghishan FK. Sp1 is required for glucose-induced transcriptional regulation of mouse vesicular glutamate transporter 2 gene. Gastroenterology 2008; 134:1994-2003.
25. Ikeda Y, Suehiro T, Arii K, Kumon Y, Hashimoto K. High glucose induces transactivation of the human paraoxonase 1 gene in hepatocytes. Metabolism 2008; 57:1725-32.
26. Moon YA, Kim KS, Cho UH, Yoon DJ, Park SW. Characterization of regulatory elements on the promoter region of human ATP-citrate lyase. Exp Mol Med 1999; 31:108-14.
27. Daniel S, Zhang S, DePaoli-Roach AA, Kim KH. Dephosphorylation of Sp1 by protein phosphatase 1 is involved in the glucose-mediated activation of the acetyl-CoA carboxylase gene. J Biol Chem 1996; 271:14692-7.
28. Maor S, Mayer D, Yarden RI, Lee AV, Sarfstein R, Werner H, et al. Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells: involvement of transcription factor Sp1. J Endocrinol 2006; 191:605-12.
29. Hafstad AD, Solevag GH, Severson DL, Larsen TS, Aasum E. Perfused hearts from Type 2 diabetic (db/db) mice show metabolic responsiveness to insulin. Am J Physiol Heart Circ Physiol 2006; 290:1763-9.
30. Utriainen T, Takala T, Luotolahti M, Ronnemaa T, Laine H, Ruotsalainen U, et al. Insulin resistance characterizes glucose uptake in skeletal muscle but not in the heart in NIDDM. Diabetologia 1998; 41:555-9.
31. Szyf M. Epigenetics, DNA methylation and chromatin modifying drugs. Annu Rev Pharmacol Toxicol 2009; 49:243-63.
32. Bang P, Eriksson U, Sara V, Wivall IL, Hall K. Comparison of acid ethanol extraction and acid gel filtration prior to IGF-I and IGF-II radioimmunoassays: improvement of determinations in acid ethanol extracts by the use of truncated IGF-I as radioligand. Acta Endocrinol (Copenh) 1991; 124:620-9.
33. Li JM, Datto MB, Shen X, Hu PP, Yu Y, Wang XF. Sp1, but not Sp3, functions to mediate promoter activation by TGFbeta through canonical Sp1 binding sites. Nucleic Acids Res 1998; 26:2449-56.