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Volumn 23, Issue 15, 2015, Pages 4728-4736
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Design, synthesis and preliminary biological evaluation of indoline-2,3-dione derivatives as novel HDAC inhibitors
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Author keywords
Biological evaluation; HDAC inhibitors; Indoline 2,3 dione derivatives; QSAR; Synthesis
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Indexed keywords
2 [5' BROMO 2' OXOSPIRO[[1,3]DIOXOLANE 2,3' INDOLIN] 1' YL] N [2 (HYDROXYAMINO) 2 OXOETHYL]ACETAMIDE;
3 [4 [2 [5' BROMO 2' OXOSPIRO[[1,3]DIOXOLANE 2,3' INDOLIN] 1' YL]ACETAMIDO]PHENYL] N HYDROXYACRYLAMIDE;
4 [2 [5' BROMO 2' OXOSPIRO[[1,3]DIOXANE 2,3' INDOLIN] 1' YL]ACETAMIDO] N HYDROXYBENZAMIDE;
4 [2 [5' BROMO 2' OXOSPIRO[[1,3]DIOXANE 2,3' INDOLIN] 1' YL]ACETAMIDO]BENZOIC ACID;
4 [2 [5' BROMO 2' OXOSPIRO[[1,3]DIOXEPANE 2,3' INDOLIN] 1' YL]ACETAMIDO] N HYDROXYBENZAMIDE;
4 [2 [5' BROMO 2' OXOSPIRO[[1,3]DIOXOLANE 2,3' INDOLIN] 1' YL]ACETAMIDO] N HYDROXYBUTANAMIDE;
4 [2 [5' BROMO 2' OXOSPIRO[[1,3]DIOXOLANE 2,3' INDOLIN] 10 YL]ACETAMIDO] N HYDROXYBENZAMIDE;
4 [2 [5' CHLORO 2' OXOSPIRO[[1,3]DIOXANE 2,3' INDOLIN] 1' YL]ACETAMIDO] N HYDROXYBENZAMIDE;
4 [2 [5' CHLORO 2' OXOSPIRO[[1,3]DIOXEPANE 2,3' INDOLIN] 1' YL]ACETAMIDO] N HYDROXYBENZAMIDE;
4 [2 [5' CHLORO 2' OXOSPIRO[[1,3]DIOXOLANE 2,3' INDOLIN] 10 YL]ACETAMIDO] N HYDROXYBENZAMIDE;
4 [2 [5' FLUORO 2' OXOSPIRO[[1,3]DIOXOLANE 2,3' INDOLIN] 10 YL]ACETAMIDO] N HYDROXYBENZAMIDE;
4 [3 [5' BROMO 2' OXOSPIRO[[1,3]DIOXANE 2,3' INDOLIN] 1' YL]PROPANAMIDO] N HYDROXYBENZAMIDE;
4 [4 [5' BROMO 2' OXOSPIRO[[1,3]DIOXANE 2,3' INDOLIN] 1' YL]BUTANAMIDO] N HYDROXYBENZAMIDE;
6 [2 [5' BROMO 2' OXOSPIRO[[1,3]DIOXOLANE 2,3' INDOLIN] 1' YL]ACETAMIDO] N HYDROXYHEXANAMIDE;
HISTONE DEACETYLASE INHIBITOR;
INDOLINE 2,3 DIONE DERIVATIVE;
METHYL 4 [2 [2' OXOSPIRO[[1,3]DIOXOLANE 2,3' INDOLIN] 1' YL]ACETAMIDO]BENZOATE;
METHYL 4 [2 [5' BROMO 2' OXOSPIRO[[1,3]DIOXANE 2,3' INDOLIN] 1' YL]ACETAMIDO]BENZOATE;
METHYL 4 [2 [5' BROMO 2' OXOSPIRO[[1,3]DIOXOLANE 2,3' ININDOLIN] 1' YL]ACETAMIDO]BENZOATE;
METHYL 4 [2 [5' CHLORO 2' OXOSPIRO[[1,3]DIOXOLANE 2,3' ININDOLIN] 1' YL]ACETAMIDO]BENZOATE;
METHYL 4 [2 [5' FLUORO 2' OXOSPIRO[[1,3]DIOXOLANE 2,3' ININDOLIN] 1' YL]ACETAMIDO]BENZOATE;
METHYL 4 [2 [5' METHYL 2' OXOSPIRO[[1,3]DIOXOLANE 2,3' INDOLIN] 1' YL]ACETAMIDO]BENZOATE;
METHYL 4 [2 [5' NITRO 2' OXOSPIRO[[1,3]DIOXOLANE 2,3' INDOLIN] 1' YL]ACETAMIDO]BENZOATE;
N (2 AMINOPHENYL) 4 [2 [5' BROMO 2' OXOSPIRO[[1,3]DIOXANE 2,3' INDOLIN] 1' YL]ACETAMIDO]BENZAMIDE;
N HYDROXY 4 [2 [2' OXOSPIRO[[1,3]DIOXOLANE 2,3' INDOLIN] 1' YL]ACETAMIDO]BENZAMIDE;
N HYDROXY 4 [2 [5' METHYL 2' OXOSPIRO[[1,3]DIOXOLANE 2, 3' INDOLIN] 1' YL]ACETAMIDO]BENZAMIDE;
N HYDROXY 4 [2 [5' NITRO 2' OXOSPIRO[[1,3]DIOXOLANE 2, 3' INDOLIN] 1' YL]ACETAMIDO]BENZAMIDE;
UNCLASSIFIED DRUG;
VORINOSTAT;
4-(3-(5'-BROMO-2'-OXOSPIRO((1,3)DIOXANE-2,3'-INDOLINE)-1'-YL)PROPANAMIDO)-N-HYDROXYBENZAMIDE;
ANTINEOPLASTIC AGENT;
FUSED HETEROCYCLIC RINGS;
HISTONE DEACETYLASE;
INDOLE DERIVATIVE;
INDOLINE-2,3-DIONE;
SPIRO COMPOUND;
ANIMAL EXPERIMENT;
ANIMAL MODEL;
ANIMAL TISSUE;
ANTINEOPLASTIC ACTIVITY;
ANTIPROLIFERATIVE ACTIVITY;
ARTICLE;
CONTROLLED STUDY;
DRUG DESIGN;
DRUG EFFICACY;
DRUG IDENTIFICATION;
DRUG MECHANISM;
DRUG SCREENING;
DRUG STRUCTURE;
DRUG SYNTHESIS;
ENZYME INHIBITION;
HELA CELL LINE;
HUMAN;
HUMAN CELL;
HYDROPHOBICITY;
IC50;
IN VITRO STUDY;
IN VIVO STUDY;
LIVER CELL CARCINOMA;
MALE;
MOUSE;
NONHUMAN;
OUTCOME ASSESSMENT;
SUBSTITUTION REACTION;
TUMOR VOLUME;
ANIMAL;
BINDING SITE;
CELL PROLIFERATION;
CHEMISTRY;
DRUG EFFECTS;
LIVER NEOPLASMS;
METABOLISM;
MOLECULAR DOCKING;
NUDE MOUSE;
PATHOLOGY;
PROTEIN TERTIARY STRUCTURE;
QUANTITATIVE STRUCTURE ACTIVITY RELATION;
SYNTHESIS;
XENOGRAFT;
ANIMALS;
ANTINEOPLASTIC AGENTS;
BINDING SITES;
CELL PROLIFERATION;
DRUG DESIGN;
DRUG SCREENING ASSAYS, ANTITUMOR;
HELA CELLS;
HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS;
HISTONE DEACETYLASE INHIBITORS;
HISTONE DEACETYLASES;
HUMANS;
INDOLES;
LIVER NEOPLASMS;
MICE;
MICE, NUDE;
MOLECULAR DOCKING SIMULATION;
PROTEIN STRUCTURE, TERTIARY;
QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;
SPIRO COMPOUNDS;
TRANSPLANTATION, HETEROLOGOUS;
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EID: 84937521120
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2015.05.048 Document Type: Article |
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Times cited : (19)
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References (18)
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