Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 4, 2011, Pages 1218-1221

  Choi, Eunhyun ^a   Lee, Chulho ^a   Park, Jung Eun ^a   Seo, Jeong Jea ^a   Cho, Misun ^a   Kang, Jong Soon ^b   Kim, Hwan Mook ^b   Park, Song Kyu ^b   Lee, Kiho ^b   Han, Gyoonhee ^a  

^a Yonsei University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

ADME; Anticancer; Docking study; HDAC; Histone deacetylase; In vitro activity; Inhibitor; Isoform

Indexed keywords

GAMMA LACTAM DERIVATIVE; HISTONE DEACETYLASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CANCER INHIBITION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DESIGN; DRUG HALF LIFE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; HYDROPHOBICITY; MOLECULAR DOCKING; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY;

ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; CELL MEMBRANE PERMEABILITY; COMPUTER SIMULATION; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; LACTAMS; MICE; MICROSOMES, LIVER; NEOPLASMS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS;

EID: 79851512347     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.079     Document Type: Article

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