Development of tetrahydroisoquinoline-based hydroxamic acid derivatives: Potent histone deacetylase inhibitors with marked in vitro and in vivo antitumor activities

Journal of Medicinal Chemistry

Volumn 54, Issue 8, 2011, Pages 2823-2838

  Zhang, Yingjie ^a   Feng, Jinhong ^a   Jia, Yuping ^a   Wang, Xuejian ^a   Zhang, Lei ^a   Liu, Chunxi ^a   Fang, Hao ^a   Xu, Wenfang ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 [2 (2 AMINO 3 METHYLBUTANAMIDO) 3 METHYLPENTANOYL] 7 [2 (HYDROXYAMINO) 2 OXOETHOXY] N (4 METHOXYPHENYL) 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXAMIDE; 2 [2 (3,3 DIMETHYLBUTANAMIDO) 3 METHYLPENTYL] 7 [2 (HYDROXYAMINO) 2 OXOETHOXY] N (4 METHOXYPHENYL) 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXAMIDE; 7 [2 (HYDROXYAMINO) 2 OXOETHOXY] N (4 METHOXYPHENYL) 2 [3 METHYL 2 (PYRROLIDINE 2 CARBOXAMIDO)PENTANOYL] 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXAMIDE; ANTINEOPLASTIC AGENT; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID DERIVATIVE; TERT BUTYL 1 [7 [2 (HYDROXYAMINO) 2 OXOETHOXY] 3 (4 METHOXYPHENYLCARBAMOYL) 3,4 DIHYDROISOQUINOLIN 2(1H) YL] 3 METHYL 1 OXOPENTAN 2 YLCARBAMATE; TERT BUTYL 1 [7 [2 (HYDROXYAMINO) 2 OXOETHOXY] 3 (4 METHOXYPHENYLCARBAMOYL) 3,4 DIHYDROISOQUINOLIN 2(1H) YL] 3 METHYLPENTAN 2 YLCARBAMATE; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; VORINOSTAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; TUMOR CELL LINE; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HISTONE DEACETYLASE INHIBITORS; HUMANS; HYDROXAMIC ACIDS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 79955455755     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101605z     Document Type: Article

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