Emerging drug targets for A β and tau in Alzheimer's disease: A systematic review

British Journal of Clinical Pharmacology

Volumn 80, Issue 2, 2015, Pages 221-234

  West, Sophie ^a   Bhugra, Praveen ^a  

^a UNIVERSITY OF SUNDERLAND   (United Kingdom)

Author keywords

Alzheimer's disease; A ; emerging targets; systematic review; tau

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; NEUROPROTECTIVE AGENT; NOOTROPIC AGENT; TAU PROTEIN;

ALZHEIMER DISEASE; ASCERTAINMENT BIAS; COGNITION; DATA BASE; DRUG EFFECT; DRUG TARGETING; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NERVE CELL DEGENERATION; NONHUMAN; OUTCOME ASSESSMENT; PATHOPHYSIOLOGY; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SYSTEMATIC REVIEW; ANIMAL; CLINICAL TRIAL (TOPIC); DRUG DEVELOPMENT; DRUG EFFECTS; METABOLISM; PRECLINICAL STUDY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; CLINICAL TRIALS AS TOPIC; COGNITION; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; HUMANS; NEUROPROTECTIVE AGENTS; TAU PROTEINS;

EID: 84937513802     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/bcp.12621     Document Type: Review

References (40)

1. The PRISMA Group. Transparent reporting of systematic reviews and meta-analyses, 2009. Available at http://www.prisma-statement.org/statement.htm (last accessed 3 April 2014).
2. Alzheimer's Society. Dementia 2013 Infographic, 2014. Available at http://www.alzheimers.org.uk/infographic (last accessed 21 February 2014).
3. Li SY, Wang XB, Kong LY,. Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease. Eur J Med Chem 2014; 71: 36-45.
4. Avila J, Lucas JJ, Perez M, Hernandez F,. Role of tau protein in both physiological and pathological conditions. Physiol Rev 2004; 84: 361-84.
5. Hernandez F, Gomez de Barreda E, Fuster-Matanzo A. GSK3: A possible link between beta amyloid peptide and tau protein. Exp Neurol 2010; 223: 322-5.
6. Kang IJ, Jeon YE, Yin XF, Nam JS, You SG, Hong MS, Jang BJ, Kim MJ,. Butanol extract of Ecklonia cava prevents production and aggregation of beta-amyloid, and reduces beta-amyloid mediated neuronal death. Food Chem Toxicol 2011; 49: 2252-9.
7. National Institute for Health and Care Excellence. Donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease, 2011. Available at http://publications.nice.org.uk/donepezil-galantamine-rivastigmine-and-memantine-for-the-treatment-of-alzheimers-disease-ta217 (last accessed 4 April 2014).
8. Krauth D, Woodruff T, Bero L,. A Systematic Review of Quality Assessment Tools for Published Animal Studies, 2012. [Online Poster] Available at http://2012.colloquium.cochrane.org/sites/2012.colloquium.cochrane.org/files/uploads/posters/126.pdf (last accessed 13 March 2014).
9. Geekiyanage H, Upadhye A, Chan C,. Inhibition of serine palmitoyltransferase reduce Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease. Neurobiol Aging 2013; 34: 2037-51.
10. Inestrosa NC, Tapia-Rojas C, Griffith TN, Carvajal FJ, Benito MJ, Rivera-Dictter A, Alvarez AR, Serrano FG, Hancke JL, Burgos PV, Parodi J, Varela-Nallar L,. Tetrahydrohyperforin prevents cognitive deficit, Aβ deposition, tau phosphorylation and syntaptotoxicity in the APPswe/PSEN1ΔE9 model of Alzheimer's disease: a possible effect on APP processing. Transl Psychiatry 2011; 1: e20. Published online 12 Jul 2011. doi: 10.1038/tp.2011.19
11. Shytle RD, Tan J, Bickford PC, Rezai-zadeh K, Hou L, Zeng J, Sanberg PR, Sanberg CD, Alberte RS, Fink RC, Roschek Jr B,. Optimized Turmeric Extract Reduces β-Amyloid and Phosphorylated Tau Protein Burden in Alzheimer's Transgenic Mice. Curr Alzheimer Res 2012; 9: 500-6.
12. Hoppe JB, Coradini K, Frozza RL, Oliveira CM, Meneghetti AB, Bernardi A, Simoes Pires E, Beck RCR, Salbego CG,. Free and nanoencapsulated curcumin suppress β-amyloid-induced cognitive impairments in rats: Involvement of BDNF and Akt/GSK-3β signalling pathway. Neurobiol Learn Mem 2013; 106: 134-44.
13. Wang HY, Bakshi K, Frankfurt M, Stucky A, Goberdhan M, Shah SM, Burns LH,. Reducing Amyloid-Related Alzheimer's Disease Pathogenesis by a Small Molecule Targeting Filamen A. J Neurosci 2012; 32: 9773-84.
14. Vepsäläinen S, Koivisto H, Pekkarinen E, Mäkinen P, Dobson G, McDougall GJ, Stewart D, Haapasalo A, Karjalainen RO, Tanila H, Hiltunen M,. Anthocyanin-enriches bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioural abnormalities in the APP/PS1 mouse model of Alzheimer's disease. J Nutr Biochem 2013; 24: 360-70.
15. Camboni M, Wang CM, Miranda C, Yoon JH, Xu R, Zygmunt D, Kaspar BK, Martin PT,. Active and passive immunization strategies based on the SDPM1 peptide demonstrate pre-clinical efficacy in the APPswePSEN1dE9 mouse model for Alzheimer's disease. Neurobiol Dis 2014; 62: 31-43.
16. Barron AM, Garcia-Segura LM, Caruso D, Jayaraman A, Lee JW, Melcangi RC, Pike CJ,. Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease. J Neurosci 2013; 33: 8891-7.
17. Lo AC, Tesseur I, Scopes DIC, Nerou E, Callaerts-Vegh Z, Vermaercke B, Treherne JM, De Strooper B, D'Hooge R,. Dose-dependent improvements in learning and memory deficits in APPPS1-21 transgenic mice treated with the orally active Aβ toxicity inhibitor SEN1500. Neuropharmacology 2013; 75: 458-66.
18. O'Hare E, Scopes DIC, Kim EM, Palmer P, Jones M, Whyment AD, Spanswick D, Amijee H, Nerou E, McMahon B, Treherne JM, Jeggo R,. Orally bioavailable small molecule drug protects memory in Alzheimer's disease models. Neurobiol Aging 2013; 34: 1116-25.
19. Ramalho RM, Nunes AF, Dias RB, Amaral JD, Lo AC, D'Hooge R, Sebastiao AM, Rodrigues CMP,. Tauroursodeoxycholic acid suppresses amyloid β-induced synaptic toxicity in vitro and in APP/PS1 mice. Neurobiol Aging 2013; 34: 551-61.
20. Yang NC, Lin HC, Wu JH, Ou HC, Chai YC, Tseng CY, Liao JW, Song TY,. Ergothioneine protects against neuronal injury induced by β-amyloid in mice. Food Chem Toxicol 2012; 50: 3902-11.
21. Durairajan SSK, Liu LF, Lu JH, Chen LL, Yuan Q, Chung SK, Huang L, Li XS, Huang JD, Li M,. Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model. Neurobiol Aging 2012; 33: 2903-19.
22. Farr SA, Ripley JL, Sultana R, Zhang Z, Niehoff ML, Platt TL, Murphy MP, Morley JE, Kumar V, Butterfield DA,. Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease. Free Radic Biol Med 2014; 67: 387-95.
23. Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LMT, Ciavardelli D, Rizzarelli E, Sensi SL,. Effects of Dietary Supplementation of Carnosine on Mitochondrial Dysfunction, Amyloid Pathology and Cognitive Deficits in 3xTg-AD Mice. Plos One 2011; 6: e17971. Published online 15 Mar 2011. doi: 10.1371/journal.pone.0017971.
24. Perez-Gonzalez R, Pascual C, Antequera D, Bolos M, Redondo M, Perez DI, Perez-Grijalba V, Krzyzanowska A, Sarasa M, Gil C, Ferrer I, Martinez A, Carro E,. Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease. Neurobiol Aging 2013; 34: 2133-45.
25. Sung YM, Lee T, Yoon H, DiBattista AM, Song JM, Sohn Y, Moffat EI, Turner RS, Jung M, Kim J, Hoe HS,. Mercaptoacetamide-based class II HDAC inhibitor lowers Aβ levels and improves learning and memory in a mouse model of Alzheimer's disease. Exp Neurol 2013; 239: 192-201.
26. Bitner RS, Markosyan S, Nikkel AL, Brioni JD,. In vivo histamine H3 receptor antagonism activates cellular signalling suggestive of symptomatic and disease modifying efficacy in Alzheimer's disease. Neuropharmacology 2011; 60: 460-6.
27. Kashiwaya Y, Bergman C, Lee JH, Wan R, King MT, Mughal MR, Okun E, Clarke K, Mattson MP, Veech RL,. A ketone ester diet exhibits anxiolytic and cognition-sparing properties and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease. Neurobiol Aging 2013; 34: 1530-9.
28. Nikkel AL, Martino B, Markoysan S, Brederson JD, Medeiros R, Moeller A, Bitner RS,. The novel calpain inhibitors A-705253 prevents stress-induced tau hyperphosphorylation in vitro and in vivo. Neuropharmacology 2012; 63: 606-12.
29. Xue D, Zhao M, Wang YJ, Wang L, Yang Y, Wang SW, Zhang R, Zhao Y, Liu R,. A multifunctional peptide rescues memory deficits in Alzheimer's disease transgenic mice by inhibiting Aβ42-induced cytotoxicity and increasing microglial phagocytosis. Neurobiol Dis 2012; 46: 701-9.
30. Sierksma ASR, van den Hove DLA, Pfau F, Philippens M, Bruno O, Fedele E, Ricciarelli R, Steinbusch HWM, Vanmierlo T, Prickaerts J,. Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D. Neuropharmacology 2014; 77: 120-30.
31. DeMattos RB, Lu J, Tang Y, Racke MM, DeLong CA, Tzaferis JA, Hole JT, Forster BM, McDonnell PC, Liu F, Kinley RD, Jordan WH, Hutton ML,. A plaque-specific antibody clears existing β-amyloid plaques in Alzheimer's disease mice. Neuron 2012; 76: 908-20.
32. Qosa H, Abuasal BS, Romero IA, Weksler B, Couraud PO, Keller JN, Kaddoumi A,. Differences in amyloid-β clearance across mouse and human blood-brain barrier models: Kinetic analysis and mechanistic modelling. Neuropharmacology 2014; 79: 668-78.
33. Agbemenyah HY, Agis-Balboa RC, Burkhardt S, Delalle I, Fischer A,. Insulin growth factor binding protein 7 is a novel target to treat dementia. Neurobiol Dis 2014; 62: 135-43.
34. Cioanca O, Hritcu L, Mihasan M, Hancianu M,. Cognitive enhancing and antioxidant activities of inhaled coriander volatile oil in amyloid β(1-42) rat model of Alzheimer's disease. Physiol Behav 2013; 120: 193-202.
35. Giuliani D, Bitto A, Galantucci M, Zaffe D, Ottani A, Irrera N, Neri L, Cavallini GM, Altavilla D, Botticelli AR, Squadrito F, Guarini S,. Melanocortins protect against progression of Alzheimer's disease in triple-transgenic mice by targeting multiple pathophysiological pathways. Neurobiol Aging 2014; 35: 538-47.
36. Chen S, An FM, Yin L, Liu AR, Yin DK, Yao WB, Gao XD,. Glucagon-like peptide-1 protects hippocampal neurons against advanced glycation end product-induced tau hyperphosphorylation. J Neurosci 2014; 256: 137-46.
37. Kang IJ, Jan BG, In S, Choi B, Kim M, Kim MJ,. Phlorotannin-rich Ecklonia cava reduces the production of beta-amyloid by modulating alpha- and gamma-secretase expression and activity. Neurotoxicology 2013; 34: 16-24.
38. Niedowicz DM, Studzinski CM, Weidner AM, Platt TL, Kingry KN, Beckett TL, Bruce-Keller AJ, Keller JN, Murphy MP,. Leptin regulates amyloid β production via the γ-secretase complex. Biochim Biophys Acta 2013; 1832: 439-44.
39. Qin L, Zhang J, Qin M,. Protective effect of cyaniding 3-O-glucoside on beta-amyloid peptide-induced cognitive impairment in rats. Neurosci Lett 2013; 534: 285-8.
40. Morris R., Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Meth 1984; 11: 47-60.