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Volumn 60, Issue 4, 2014, Pages 1-7

Mesenchymal stem cell physiology can be affected by antibiotics: An in vitro study

Author keywords

Antibiotics; Bone healing; Mesenchymal stem cells; Non union

Indexed keywords

ALKALINE PHOSPHATASE; ANTIBIOTIC AGENT; CALCIUM; CEFUROXIME; FLUCLOXACILLIN; GENTAMICIN; METRONIDAZOLE; PENICILLIN G; VANCOMYCIN; ANTIINFECTIVE AGENT;

EID: 84937440633     PISSN: 01455680     EISSN: 1165158X     Source Type: Journal    
DOI: 10.14715/cmb/2014.60.4.1     Document Type: Article
Times cited : (16)

References (46)
  • 2
    • 77955958400 scopus 로고    scopus 로고
    • Preparation, antibacterial properties and biocompatibility studies on vancomycin-poly(D,L)-lactic loaded plates.
    • Tang, L., Zhao, C., Xiong, Y. and Wang, A., Preparation, antibacterial properties and biocompatibility studies on vancomycin-poly(D,L)-lactic loaded plates. Int Orthop. 2010, 34: 755-9. doi: 10.1007/s00264-009-0808-z.
    • (2010) Int Orthop. , vol.34 , pp. 755-759
    • Tang, L.1    Zhao, C.2    Xiong, Y.3    Wang, A.4
  • 3
    • 48249115152 scopus 로고    scopus 로고
    • Adherence to recommendations designed to decrease intra-operative wound contamination
    • Mackain-Bremner, A.A., Owens, K., Wylde, V., Bannister, G.C. and Blom, A.W., Adherence to recommendations designed to decrease intra-operative wound contamination. Ann R Coll Surg Engl. 2008, 90: 412-6. doi: 10.1308/003588408X301028.
    • (2008) Ann R Coll Surg Engl. , vol.90 , pp. 412-416
    • Mackain-Bremner, A.A.1    Owens, K.2    Wylde, V.3    Bannister, G.C.4    Blom, A.W.5
  • 5
    • 34548041132 scopus 로고    scopus 로고
    • Decreased Staphylococcus epidermis adhesion and increased osteoblast functionality on antibiotic-loaded titania nanotubes
    • Popat, K.C., Eltgroth, M., Latempa, T.J., Grimes, C.A. and Desai, T.A., Decreased Staphylococcus epidermis adhesion and increased osteoblast functionality on antibiotic-loaded titania nanotubes. Biomaterials. 2007, 28: 4880-4888. doi: 10.1016/j.biomaterials.2007.07.037
    • (2007) Biomaterials. , vol.28 , pp. 4880-4888
    • Popat, K.C.1    Eltgroth, M.2    Latempa, T.J.3    Grimes, C.A.4    Desai, T.A.5
  • 6
    • 5444261483 scopus 로고    scopus 로고
    • The current status of material used for depot delivery of drugs
    • Nelson, C.L., The current status of material used for depot delivery of drugs. Clin Orthop Relat Res. 2004, 427: 72-8. doi: 10.1097/01.blo.0000143741.92384.18
    • (2004) Clin Orthop Relat Res. , vol.427 , pp. 72-78
    • Nelson, C.L.1
  • 7
    • 2242442634 scopus 로고    scopus 로고
    • In vivo release of vancomycin from biodegradable beads
    • Liu, S.J., Wen-Neng Ueng, S., Lin, S.S. and Chan, E.C., In vivo release of vancomycin from biodegradable beads. J Biomed Mater Res. 2002, 63: 807-13. doi: 10.1002/jbm.10406
    • (2002) J Biomed Mater Res. , vol.63 , pp. 807-813
    • Liu, S.J.1    Wen-Neng Ueng, S.2    Lin, S.S.3    Chan, E.C.4
  • 8
    • 77952287336 scopus 로고    scopus 로고
    • Treatment of osteomyelitis with teicoplanin-encapsulated biodegradable thermosensitive hydrogel nanoparticles
    • Peng, K.T., Chen, C.F., Chu, I.M., Li, Y.M., Hsu, W.H., Hsu, R.W. and Chang, P.J., Treatment of osteomyelitis with teicoplanin-encapsulated biodegradable thermosensitive hydrogel nanoparticles. Biomaterials. 2010, 31: 5227-36. doi: 10.1016/j.biomaterials.2010.03.027.
    • (2010) Biomaterials. , vol.31 , pp. 5227-5236
    • Peng, K.T.1    Chen, C.F.2    Chu, I.M.3    Li, Y.M.4    Hsu, W.H.5    Hsu, R.W.6    Chang, P.J.7
  • 9
    • 5444276690 scopus 로고    scopus 로고
    • Alternative materials to acrylic bone cement for delivery of depot antibiotics in orthopaedic infections
    • McLaren, A.C., Alternative materials to acrylic bone cement for delivery of depot antibiotics in orthopaedic infections. Clin Orthop Relat Res. 2004, 427: 101-6. doi: 10.1097/01.blo.0000143554.56897.26
    • (2004) Clin Orthop Relat Res. , vol.427 , pp. 101-106
    • McLaren, A.C.1
  • 10
    • 33846573851 scopus 로고    scopus 로고
    • Gentamicin extended release from an injectable polymeric implant
    • Krasko, M.Y., Golenser, J., Nyska, A., Nyska, M., Brin, Y.S. and Domb, A.J., Gentamicin extended release from an injectable polymeric implant. J Control Release. 2007, 117: 90-6. doi: 10.1016/j.jconrel.2006.10.010
    • (2007) J Control Release. , vol.117 , pp. 90-96
    • Krasko, M.Y.1    Golenser, J.2    Nyska, A.3    Nyska, M.4    Brin, Y.S.5    Domb, A.J.6
  • 11
    • 0026573981 scopus 로고
    • In vitro and in vivo evaluation of antibiotic diffusion from antibiotic-impregnated polymethylmethacrylate beads
    • Adams, K., Couch, L., Cierny, G., Calhoun, J. and Mader J.T., In vitro and in vivo evaluation of antibiotic diffusion from antibiotic-impregnated polymethylmethacrylate beads. Clin Orthop Relat Res. 1992, 278: 244-52.
    • (1992) Clin Orthop Relat Res. , vol.278 , pp. 244-252
    • Adams, K.1    Couch, L.2    Cierny, G.3    Calhoun, J.4    Mader, J.T.5
  • 12
    • 0018102833 scopus 로고
    • The release of gentamicin from polymethylmethacrylate beads. An experimental and pharmacokinetic study
    • Wahlig, H., Dingeldein, E., Bergmann, R. and Reuss, K., The release of gentamicin from polymethylmethacrylate beads. An experimental and pharmacokinetic study. J Bone Joint Surg Br. 1978, 60: 270-5.
    • (1978) J Bone Joint Surg Br. , vol.60 , pp. 270-275
    • Wahlig, H.1    Dingeldein, E.2    Bergmann, R.3    Reuss, K.4
  • 13
    • 0036319253 scopus 로고    scopus 로고
    • The treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets
    • Nelson, C.L., McLaren, S.G., Skinner, R.A., Smeltzer, M.S., Thomas, J.R. and Olsen K.M., The treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets. J Orthop Res. 2002, 20: 643-7. doi: 10.1016/S0736-0266(01)00133-4
    • (2002) J Orthop Res. , vol.20 , pp. 643-647
    • Nelson, C.L.1    McLaren, S.G.2    Skinner, R.A.3    Smeltzer, M.S.4    Thomas, J.R.5    Olsen, K.M.6
  • 14
    • 33746985461 scopus 로고    scopus 로고
    • High concentration and bioactivity of vancomycin and aztreonam eluted from Simplex cement spacers in two-stage revision of infected hip implants: a study of 46 patients at an average follow-up of 107 days
    • Hsieh, P.H., Chang, Y.H., Chen, S.H., Ueng, S.W. and Shih, C.H., High concentration and bioactivity of vancomycin and aztreonam eluted from Simplex cement spacers in two-stage revision of infected hip implants: a study of 46 patients at an average follow-up of 107 days. J Orthop Res. 2006, 24: 1615-21. doi: 10.1002/jor.20214
    • (2006) J Orthop Res. , vol.24 , pp. 1615-1621
    • Hsieh, P.H.1    Chang, Y.H.2    Chen, S.H.3    Ueng, S.W.4    Shih, C.H.5
  • 15
    • 62549164780 scopus 로고    scopus 로고
    • Antibiotic-impregnated cement in revision total knee arthroplasty. A prospective cohort study of one hundred and eighty-three knees
    • Chiu, F.Y. and Lin, C.F., Antibiotic-impregnated cement in revision total knee arthroplasty. A prospective cohort study of one hundred and eighty-three knees. J Bone Joint Surg Am. 2009, 91: 628-33. doi: 10.2106/JBJS.G.01570.
    • (2009) J Bone Joint Surg Am. , vol.91 , pp. 628-633
    • Chiu, F.Y.1    Lin, C.F.2
  • 16
    • 80755175793 scopus 로고    scopus 로고
    • Effects of Mixing Techniques on Vancomycin-Impregnated Polymethylmethacrylate
    • Laine, J.C., Nguyen, T.Q., Buckley, J.M. and Kim, H.T., Effects of Mixing Techniques on Vancomycin-Impregnated Polymethylmethacrylate. J Arthroplasty. 2011, 26: 1562-6. doi: 10.1016/j.arth.2011.02.011.
    • (2011) J Arthroplasty. , vol.26 , pp. 1562-1566
    • Laine, J.C.1    Nguyen, T.Q.2    Buckley, J.M.3    Kim, H.T.4
  • 17
    • 34447344043 scopus 로고    scopus 로고
    • The effect of the timing of antibiotics and surgical treatment on infection rates in open long-bone fractures: a 9-year prospective study from a district general hospital
    • Al-Arabi, Y.B., Nader, M., Hamidian-Jahromi, A.R. and Woods, D.A., The effect of the timing of antibiotics and surgical treatment on infection rates in open long-bone fractures: a 9-year prospective study from a district general hospital. Injury. 2007, 38: 900-5. doi: http://dx.doi.org/10.1016/j.injury.2007.02.043
    • (2007) Injury. , vol.38 , pp. 900-905
    • Al-Arabi, Y.B.1    Nader, M.2    Hamidian-Jahromi, A.R.3    Woods, D.A.4
  • 19
    • 77956255227 scopus 로고    scopus 로고
    • The effect of bone morphogenetic protein-2, bone morphogenetic protein-7, parathyroid hormone, and platelet-derived growth factor on the proliferation and osteogenic differentiation of mesenchymal stem cells derived from osteoporotic bone
    • Pountos, I., Georgouli, T., Henshaw, K., Bird, H., Jones, E. and Giannoudis, P.V., The effect of bone morphogenetic protein-2, bone morphogenetic protein-7, parathyroid hormone, and platelet-derived growth factor on the proliferation and osteogenic differentiation of mesenchymal stem cells derived from osteoporotic bone. J Orthop Trauma. 2010, 24: 552-6. doi: 10.1097/BOT.0b013e3181efa8fe.
    • (2010) J Orthop Trauma. , vol.24 , pp. 552-556
    • Pountos, I.1    Georgouli, T.2    Henshaw, K.3    Bird, H.4    Jones, E.5    Giannoudis, P.V.6
  • 20
    • 79953319215 scopus 로고    scopus 로고
    • NSAIDS inhibit in vitro MSC chondrogenesis but not osteogenesis: implications for mechanism of bone formation inhibition in man
    • Pountos, I., Giannoudis, P.V., Jones, E., English, A., Churchman, S., Field, S., Ponchel, F., Bird, H., Emery, P. and McGonagle, D., NSAIDS inhibit in vitro MSC chondrogenesis but not osteogenesis: implications for mechanism of bone formation inhibition in man. J Cell Mol Med. 2011, 15: 525-34. doi: 10.1111/j.1582-4934.2010.01006.x.
    • (2011) J Cell Mol Med. , vol.15 , pp. 525-534
    • Pountos, I.1    Giannoudis, P.V.2    Jones, E.3    English, A.4    Churchman, S.5    Field, S.6    Ponchel, F.7    Bird, H.8    Emery, P.9    McGonagle, D.10
  • 21
    • 58149175883 scopus 로고    scopus 로고
    • The effect of autologous serum obtained after fracture on the proliferation and osteogenic differentiation of mesenchymal stem cells
    • Pountos, I., Georgouli, T. and Giannoudis, P.V., The effect of autologous serum obtained after fracture on the proliferation and osteogenic differentiation of mesenchymal stem cells. Cell Mol Biol (Noisy-le-grand). 2008, 54: 33-9.
    • (2008) Cell Mol Biol (Noisy-le-grand). , vol.54 , pp. 33-39
    • Pountos, I.1    Georgouli, T.2    Giannoudis, P.V.3
  • 23
    • 80054740463 scopus 로고    scopus 로고
    • AHFS drug Information. American Society of Health-System Pharmacists
    • McEvoy, G., AHFS drug Information. American Society of Health-System Pharmacists. ASHP: 2010. pp
    • (2010) ASHP
    • McEvoy, G.1
  • 24
    • 0035742724 scopus 로고    scopus 로고
    • Treatment of pregnant women infected with syphilis with intravenous penicillin G: Pharmacokinetical and clinical study
    • Mavrov, G.I. and Goubenko, T.V., Treatment of pregnant women infected with syphilis with intravenous penicillin G: Pharmacokinetical and clinical study. Gynecol Obstet Invest. 2001, 52: 114-8.
    • (2001) Gynecol Obstet Invest. , vol.52 , pp. 114-118
    • Mavrov, G.I.1    Goubenko, T.V.2
  • 26
    • 0020510301 scopus 로고
    • Pharmacokinetics of amoxicillin and flucloxacillin following the simultaneous intravenous administration of 4 g and 1 g, respectively
    • Adam, D., Koeppe P. and Heilmann, H.D., Pharmacokinetics of amoxicillin and flucloxacillin following the simultaneous intravenous administration of 4 g and 1 g, respectively. Infection. 1983, 11: 150-4. doi: 10.1007/BF01641294
    • (1983) Infection. , vol.11 , pp. 150-154
    • Adam, D.1    Koeppe, P.2    Heilmann, H.D.3
  • 27
    • 0017693606 scopus 로고
    • The pharmacokinetics of cefuroxime after intravenous injection.
    • Gower, P.E. and Dash, C.H. The pharmacokinetics of cefuroxime after intravenous injection. Eur J Clin Pharmacol. 1977, 12: 221-7. doi: 10.1007/BF00609865
    • (1977) Eur J Clin Pharmacol. , vol.12 , pp. 221-227
    • Gower, P.E.1    Dash, C.H.2
  • 28
    • 0018342086 scopus 로고
    • Cefuroxime: a review of its antibacterial activity, pharmacological properties and therapeutic use.
    • Brogden, R.N., Heel, R.C., Speight, T.M. and Avery, G.S., Cefuroxime: a review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs. 1979, 17: 233-66. doi: 10.2165/00003495-197917040-00001
    • (1979) Drugs. , vol.17 , pp. 233-266
    • Brogden, R.N.1    Heel, R.C.2    Speight, T.M.3    Avery, G.S.4
  • 29
    • 0018662677 scopus 로고
    • Comparison of the pharmacokinetics of metronidazole in healthy female volunteers following either a single oral or intravenous dose
    • Houghton, G.W., Thorne, P.S., Smith, J., Templeton, R. and Collier, J., Comparison of the pharmacokinetics of metronidazole in healthy female volunteers following either a single oral or intravenous dose. Br J Clin Pharmacol. 1979, 8: 337-41. doi: 10.1111/j.1365-2125.1979.tb04715.x
    • (1979) Br J Clin Pharmacol. , vol.8 , pp. 337-341
    • Houghton, G.W.1    Thorne, P.S.2    Smith, J.3    Templeton, R.4    Collier, J.5
  • 30
    • 84961998614 scopus 로고    scopus 로고
    • Metronidazole datacheet
    • Metronidazole datacheet http://www.medsafe.govt.nz/Profs/Datasheet/m/MetronidazoleAFTinf.pdf
  • 31
    • 0030454517 scopus 로고    scopus 로고
    • Effect of cefazolin and vancomycin on osteoblasts in vitro
    • Edin, M.L., Miclau, T., Lester, G.E., Lindsey, R.W. and Dahners, L.E., Effect of cefazolin and vancomycin on osteoblasts in vitro. Clin Orthop Relat Res. 1996, 333: 245-51. doi http://dx.doi.org/10.1097/00003086-199612000-00027
    • (1996) Clin Orthop Relat Res. , vol.333 , pp. 245-251
    • Edin, M.L.1    Miclau, T.2    Lester, G.E.3    Lindsey, R.W.4    Dahners, L.E.5
  • 32
    • 34548443707 scopus 로고    scopus 로고
    • Antibiotics for local delivery systems cause skeletal cell toxicity in vitro
    • Antoci, V., Adams, C.S., Hickok, N.J., Shapiro, I.M. and Parvizi, J., Antibiotics for local delivery systems cause skeletal cell toxicity in vitro. Clin Orthop Relat Res. 2007, 462: 200-6. doi: 10.1097/BLO.0b013e31811ff866
    • (2007) Clin Orthop Relat Res. , vol.462 , pp. 200-206
    • Antoci, V.1    Adams, C.S.2    Hickok, N.J.3    Shapiro, I.M.4    Parvizi, J.5
  • 33
    • 33750633626 scopus 로고    scopus 로고
    • Toxic effects of gentamicin on marrow-derived human mesenchymal stem cells
    • Chang, Y., Goldberg, V.M. and Caplan, A.I., Toxic effects of gentamicin on marrow-derived human mesenchymal stem cells. Clin Orthop Relat Res. 2006, 452: 242-9. doi: 10.1097/01.blo.0000229324.75911.c7
    • (2006) Clin Orthop Relat Res. , vol.452 , pp. 242-249
    • Chang, Y.1    Goldberg, V.M.2    Caplan, A.I.3
  • 34
    • 0037350503 scopus 로고    scopus 로고
    • Gentamicin may have an adverse effect on osteogenesis
    • Isefuku, S., Joyner, C.J. and Simpson, A.H., Gentamicin may have an adverse effect on osteogenesis. J Orthop Trauma. 2003; 17: 212-6. doi: http://dx.doi.org/10.1097/00005131-200303000-00010
    • (2003) J Orthop Trauma. , vol.17 , pp. 212-216
    • Isefuku, S.1    Joyner, C.J.2    Simpson, A.H.3
  • 35
    • 0023733135 scopus 로고
    • Effects of gentamicin and monomer on bone. An in vitro study
    • Pedersen, J.G. and Lund, B., Effects of gentamicin and monomer on bone. An in vitro study. J Arthroplasty. 1988. 3: S63-8.
    • (1988) J Arthroplasty. , vol.3 , pp. S63-S68
    • Pedersen, J.G.1    Lund, B.2
  • 36
    • 33947521610 scopus 로고    scopus 로고
    • Effect of polyhexanide and gentamicin on human osteoblasts and endothelial cells
    • Ince, A., Schütze, N., Hendrich, C., Jakob, F., Eulert, J. and Löhr, J.F., Effect of polyhexanide and gentamicin on human osteoblasts and endothelial cells. Swiss Med Wkly. 2007, 137: 139-45.
    • (2007) Swiss Med Wkly. , vol.137 , pp. 139-145
    • Ince, A.1    Schütze, N.2    Hendrich, C.3    Jakob, F.4    Eulert, J.5    Löhr, J.F.6
  • 37
    • 34248357157 scopus 로고    scopus 로고
    • Gentamicin negatively influenced osteogenic function in vitro
    • Ince, A., Schütze, N., Karl, N., Löhr, J.F. and Eulert, J., Gentamicin negatively influenced osteogenic function in vitro. Int Orthop. 2007, 31: 223-8. doi:10.1007/s00264-006-0144-5
    • (2007) Int Orthop. , vol.31 , pp. 223-228
    • Ince, A.1    Schütze, N.2    Karl, N.3    Löhr, J.F.4    Eulert, J.5
  • 39
    • 65449156489 scopus 로고    scopus 로고
    • Elution of gentamicin and vancomycin from polymethylmethacrylate beads and hip spacers in vivo
    • Anagnostakos, K., Wilmes, P., Schmitt, E. and Kelm J., Elution of gentamicin and vancomycin from polymethylmethacrylate beads and hip spacers in vivo. Acta Orthop. 2009, 80: 193-7. doi: 10.3109/17453670902884700.
    • (2009) Acta Orthop. , vol.80 , pp. 193-197
    • Anagnostakos, K.1    Wilmes, P.2    Schmitt, E.3    Kelm, J.4
  • 42
    • 40649084758 scopus 로고    scopus 로고
    • Pharmacological agents and impairment of fracture healing: what is the evidence?
    • Pountos, I., Georgouli, T., Blokhuis, T.J., Pape, H.C. and Giannoudis, P.V., Pharmacological agents and impairment of fracture healing: what is the evidence? Injury. 2008, 39: 384-94. doi: 10.1016/j.injury.2007.10.035
    • (2008) Injury. , vol.39 , pp. 384-394
    • Pountos, I.1    Georgouli, T.2    Blokhuis, T.J.3    Pape, H.C.4    Giannoudis, P.V.5
  • 43
    • 84856397304 scopus 로고    scopus 로고
    • Do nonsteroidal anti-inflammatory drugs affect bone healing? A critical analysis
    • Pountos, I., Georgouli, T., Calori, G.M. and Giannoudis, P.V., Do nonsteroidal anti-inflammatory drugs affect bone healing? A critical analysis. ScientificWorldJournal. 2012: 606404. doi: 10.1100/2012/606404.
    • (2012) ScientificWorldJournal. , pp. 606404
    • Pountos, I.1    Georgouli, T.2    Calori, G.M.3    Giannoudis, P.V.4
  • 44
    • 33846005185 scopus 로고    scopus 로고
    • Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines
    • Duewelhenke, N., Krut, O. and Eysel, P., Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. Antimicrob Agents Chemother. 2007, 51: 54-63. doi: 10.1128/AAC.00729-05
    • (2007) Antimicrob Agents Chemother. , vol.51 , pp. 54-63
    • Duewelhenke, N.1    Krut, O.2    Eysel, P.3
  • 46
    • 0036014836 scopus 로고    scopus 로고
    • Doxycycline and tissue repair in rats
    • Lamparter, S., Slight, S.H. and Weber K.T., Doxycycline and tissue repair in rats. J Lab Clin Med. 2002, 139: 295-302. doi:10.1067/mlc.2002.122624
    • (2002) J Lab Clin Med. , vol.139 , pp. 295-302
    • Lamparter, S.1    Slight, S.H.2    Weber, K.T.3


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