Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines

Antimicrobial Agents and Chemotherapy

Volumn 51, Issue 1, 2007, Pages 54-63

  Duewelhenke, N ^a   Krut, O ^a   Eysel, P ^a  

^a UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; ANTIBIOTIC AGENT; AZITHROMYCIN; CEFAZOLIN; CHLORAMPHENICOL; CLINDAMYCIN; ERYTHROMYCIN; FLUCLOXACILLIN; FOSFOMYCIN; GENTAMICIN; LINCOMYCIN; LINEZOLID; MACROLIDE; MOXIFLOXACIN; PENICILLIN G; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RIFAMPICIN; ROXITHROMYCIN; STREPTOMYCIN; TETRACYCLINE; TOBRAMYCIN; VANCOMYCIN;

ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENERGY METABOLISM; GROWTH INHIBITION; HELA CELL; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; OSTEOBLAST; OSTEOSARCOMA CELL; PRIORITY JOURNAL; RESPIRATORY CHAIN;

ACETAMIDES; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; ANTIMYCIN A; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CHLORAMPHENICOL; CLINDAMYCIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUOROQUINOLONES; GLYCOLYSIS; HELA CELLS; HUMANS; LACTIC ACID; MACROLIDES; MITOCHONDRIA; OSTEOBLASTS; OXAZOLIDINONES; ROTENONE; TETRACYCLINES; TIME FACTORS;

EID: 33846005185     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00729-05     Document Type: Article

References (51)

1. Adams, K., L. Couch, G. Cierny, J. Calhoun, and J. T. Mader. 1992. In vitro and in vivo evaluation of antibiotic diffusion from antibiotic-impregnated polymethylmethacrylate beads. Clin. Orthop. Relat. Res. 244-252.
2. Apodaca, A. A., and R. M. Rakita. 2003. Linezolid-induced lactic acidosis. N. Engl. J. Med. 348:86-87.
3. Berridge, M. V., and A. S. Tan. 1993. Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction. Arch. Biochem. Biophys. 303:474-482.
4. Bordat, C., J. L. Guerquin-Kern, M. Lieberherr, and G. Cournot. 2004. Direct visualization of intracellular calcium in rat osteoblasts by energy-filtering transmission electron microscopy. Histochem. Cell Biol. 121:31-38.
5. Bronner, F., and M. C. Farach-Carson. 2004. Bone formation. Springer-Verlag, Heidelberg, Germany.
6. Buchholz, H. W., and H. Engelbrecht. 1970. Depot effects of various antibiotics mixed with Palacos resins. Chirurg 41:511-515.
7. Burkhardt, J. E., M. A. Hill, and W. W. Carlton. 1992. Morphologic and biochemical changes in articular cartilages of immature beagle dogs dosed with difloxacin. Toxicol. Pathol. 20:246-252.
8. Buss, W. C., and E. Kun. 1978. Effects of rifampicin on RNA and protein synthesis in isolated rat liver mitochondria. Biochem. Pharmacol. 27:2139-2145.
9. Buss, W. C., R. Morgan, J. Guttmann, T. Barela, and K. Stalter. 1978. Rifampicin inhibition of protein synthesis in mammalian cells. Science 200: 432-434.
10. Castora, F. J., F. F. Vissering, and M. V. Simpson. 1983. The effect of bacterial DNA gyrase inhibitors on DNA synthesis in mammalian mitochondria. Biochim. Biophys. Acta 740:417-427.
11. Clark, R. J. 1971. Antiviral action of rifampin. N. Engl. J. Med. 284:675.
12. Corallo, C. E., and A. E. Paull. 2002. Linezolid-induced neuropathy. Med. J. Aust. 177:332.
13. D'Aurelio, M., P. M. Merlo, L. Catani, G. L. Sgarbi, C. Bovina, G. Formiggini, C. G. Parenti, H. Baum, S. Tura, and G. Lenaz. 2001. Decreased Pasteur effect in platelets of aged individuals. Mech. Ageing Dev. 122:823-833.
14. Davey, P. J., J. M. Haslam, and A. W. Linnane. 1970. Biogenesis of mitochondria. 12. The effects of aminoglycoside antibiotics on the mitochondrial and cytoplasmic protein-synthesizing systems of Saccharomyces cerevisiae. Arch. Biochem. Biophys. 136:54-64.
15. DeZengotita, V. M., W. M. Miller, J. G. Aunins, and W. Zhou. 2000. Phosphate feeding improves high-cell-concentration NSO myeloma culture performance for monoclonal antibody production. Biotechnol. Bioeng. 69:566-576.
16. Edin, M. L., T. Miclau, G. E. Lester, R. W. Lindsey, and L. E. Banners. 1996. Effect of cefazolin and vancomycin on osteoblasts in vitro. Clin. Orthop. 333:245-251.
17. Egerbacher, M., G. Seiberl, B. Wolfesberger, and I. Walter. 2000. Ciprofloxacin causes cytoskeletal changes and detachment of human and rat chondrocytes in vitro. Arch. Toxicol. 73:557-563.
18. Freshney, R. I. 1994. Culture of animal cells. Wiley-Liss, New York, N.Y.
19. Gray, M. W., G. Burger, and B. F. Lang. 1999. Mitochondrial evolution. Science 283:1476-1481.
20. Green, D. R., and J. C. Reed. 1998. Mitochondria and apoptosis. Science 281:1309-1312.
21. Green, S. L., J. C. Maddox, and E. D. Huttenbach. 2001. Linezolid and reversible myelosuppression. JAMA 285:1291.
22. Hand, W. L., and N. L. King-Thompson. 1982. Membrane transport of clindamycin in alveolar macrophages. Antimicrob. Agents Chemother. 21: 241-247.
23. Huddleston, P. M., J. M. Steckelberg, A. D. Hanssen, M. S. Rouse, M. E. Bolander, and R. Patel. 2000. Ciprofloxacin inhibition of experimental fracture healing. J. Bone Joint Surg. Am. 82:161-173.
24. Hutchinson, D. K. 2003. Oxazolidinone antibacterial agents: a critical review. Curr. Top. Med. Chem. 3:1021-1042.
25. Isefuku, S., C. J. Joyner, and A. H. Simpson. 2003. Gentamicin may have an adverse effect on osteogenesis. J. Orthop. Trauma. 17:212-216.
26. Isefuku, S., C. J. Joyner, and A. H. Simpson. 2001. Toxic effect of rifampicin on human osteoblast-like cells. J. Orthop. Res. 19:950-954.
27. Jaiswal, N., S. E. Haynesworth, A. I. Caplan, and S. P. Bruder. 1997. Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J. Cell Biochem. 64:295-312.
28. Kanellakopoulou, K., and E. J. Giamarellos-Bourboulis. 2000. Carrier systems for the local delivery of antibiotics in bone infections. Drugs 59:1223-1232.
29. Kartsogiannis, V., and K. W. Ng. 2004. Cell lines and primary cell cultures in the study of bone cell biology. Mol. Cell Endocrinol. 228:79-102.
30. Klemm, K. 1979. Gentamicin-PMMA-beads in treating bone and soft tissue infections. Zentralbl. Chir. 104:934-942.
31. Kroon, A. M., and B. C. Van den. 1983. Antibacterial drugs and their interference with the biogenesis of mitochondria in animal and human cells. Pharm. Weekbl. Sci. 5:81-87.
32. Lawrence, J. W., D. C. Claire, V. Weissig, and T. C. Rowe. 1996. Delayed cytotoxicity and cleavage of mitochondrial DNA in ciprofloxacin-treated mammalian cells. Mol. Pharmacol. 50:1178-1188.
33. Lawrence, J. W., S. Darkin-Rattray, F. Xie, A. H. Neims, and T. C. Rowe. 1993. 4-Quinolones cause a selective loss of mitochondrial DNA from mouse L1210 leukemia cells. J. Cell Biochem. 51:165-174.
34. Manston, J., and E. Katchburian. 1984. Demonstration of mitochondrial mineral deposits in osteoblasts after anhydrous fixation and processing. J. Microsc. 134:177-182.
35. Moestrup, S. K., S. Cui, H. Vorum, C. Bregengard, S. E. Bjorn, K. Norris, J. Gliemann, and E. I. Christensen. 1995. Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs. J. Clin. Investig. 96:1404-1413.
36. Montenez, J. P., F. Van Bambeke, J. Piret, R. Brasseur, P. M. Tulkens, and M. P. Mingeot-Leclercq. 1999. Interactions of macrolide antibiotics (erythromycin A, roxithromycin, erythromycylamine [dirithromycin], and azithromycin) with phospholipids: computer-aided conformational analysis and studies on acellular and cell culture models. Toxicol. Appl. Pharmacol. 156:129-140.
37. Muscari, C., C. Gamberini, F. Bonafe', E. Giordano, C. Bianchi, G. Lenaz, and C. M. Caldarera. 2004. Evaluation of cellular energetics by the Pasteur effect in intact cardiomyoblasts and isolated perfused hearts. Mol. Cell Biochem. 258:91-97.
38. Pedersen, J. G., and B. Lund. 1988. Effects of gentamicin and monomer on bone. An in vitro study. J. Arthroplasty 3(Suppl.):S63-S68.
39. Reyes, M., T. Lund, T. Lenvik, D. Aguiar, L. Koodie, and C. M. Verfaillie. 2001. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells. Blood 98:2615-2625.
40. Riesbeck, K., A. Bredberg, and A. Forsgren. 1990. Ciprofloxacin does not inhibit mitochondrial functions but other antibiotics do. Antimicrob. Agents Chemother. 34:167-169.
41. Robey, P. G., and J. D. Termine. 1985. Human bone cells in vitro. Calcif. Tissue Int. 37:453-460.
42. Sakaguchi, Y., I. Sekiya, K. Yagishita, S. Ichinose, K. Shinomiya, and T. Muneta. 2004. Suspended cells from trabecular bone by collagenase digestion become virtually identical to mesenchymal stem cells obtained from marrow aspirates. Blood 104:2728-2735.
43. Salvioli, S., G. Storci, M. Pinti, D. Quaglino, L. Moretti, M. Merlo-Pich, G. Lenaz, S. Filosa, A. Fico, M. Bonafe, D. Monti, L. Troiano, M. Nasi, A. Cossarizza, and C. Franceschi. 2003. Apoptosis-resistant phenotype in HL-60-derived cell HCW-2 is related to changes in expression of stress-induced proteins that impact on redox status and mitochondrial metabolism. Cell Death Differ. 10:163-174.
44. Schmitz, C., J. Hilpert, C. Jacobsen, C. Boensch, E. I. Christensen, F. C. Luft, and T. E. Willnow. 2002. Megalin deficiency offers protection from renal aminoglycoside accumulation. J. Biol. Chem. 277:618-622.
45. Shapiro, I. M., E. E. Golub, S. Kakuta, J. Hazelgrove, J. Havery, B. Chance, and P. Frasca. 1982. Initiation of endochondral calcification is related to changes in the redox state of hypertrophic chondrocytes. Science 217:950-952.
46. Shapiro, I. M., and J. S. Greenspan. 1969. Are mitochondria directly involved in biological mineralisation? Calcif. Tissue Res. 3:100-102.
47. Sottile, V., C. Halleux, F. Bassilana, H. Keller, and K. Seuwen. 2002. Stem cell characteristics of human trabecular bone-derived cells. Bone 30:699-704.
48. Tyteca, D., A. Schanck, Y. F. Dufrene, M. Deleu, P. J. Courtoy, P. M. Tulkens, and M. P. Mingeot-Leclercq. 2003. The macrolide antibiotic azithromycin interacts with lipids and affects membrane organization and fluidity: studies on Langmuir-Blodgett monolayers, liposomes and J774 macrophages. J. Membr. Biol. 192:203-215.
49. Villa, P., D. Sassella, M. Corada, and I. Bartosek. 1988. Toxicity, uptake, and subcellular distribution in rat hepatocytes of roxithromycin, a new semisynthetic macrolide, and erythromycin base. Antimicrob. Agents Chemother. 32:1541-1546.
50. Wahlig, H., and E. Dingeldein. 1980. Antibiotics and bone cements. Experimental and clinical long-term observations. Acta Orthop. Scand. 51:49-56.
51. Walenkamp, G. H. I. M. 2001. Two-Stage revision of infected arthroplasty, p. 143-146. In G. H. I. M. Walenkamp and D. W. Murray (ed.), Bone cements and cementing technique. Springer Verlag, Berlin, Germany.