Discovery of potent carbonic anhydrase and acetylcholine esterase inhibitors: Novel sulfamoylcarbamates and sulfamides derived from acetophenones

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 13, 2015, Pages 3592-3602

  Akincioʇlu, Akin ^a,b   Akincioʇlu, Hülya ^a,b   Gülçin, Ilhami ^b,c   Durdagi, Serdar ^d   Supuran, Claudiu T ^e   Göksu, Süleyman ^b  

^a AGRI IBRAHIM CECEN UNIVERSITY   (Turkey)

^b ATATÜRK UNIVERSITY   (Turkey)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

^d BAHCESEHIR UNIVERSITY   (Turkey)

^e UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Acetylcholine esterase; Carbonic anhydrase; Enzyme inhibition; Hybrid molecules; Molecular docking; Sulfamide; Sulfamoylcarbamate

Indexed keywords

ACETAZOLAMIDE; ACETYLCHOLINESTERASE; BENZYL N [1 (2 METHOXYPHENYL)ETHYL]SULFAMOYL CARBAMATE; BENZYL N [1 (2,5 DIMETHOXYPHENYL)ETHYL]SULFAMOYL CARBAMATE; BENZYL N [1 (2,6 DIMETHOXYPHENYL)ETHYL]SULFAMOYL CARBAMATE; BENZYL N [1 (3,4 DIMETHOXYPHENYL)ETHYL]SULFAMOYL CARBAMATE; BENZYL N [1 (4 METHOXYPHENYL)ETHYL]SULFAMOYL CARBAMATE; CARBAMIC ACID DERIVATIVE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CHOLINESTERASE INHIBITOR; DORZOLAMIDE; GALANTAMINE; N [1 (2 METHOXYPHENYL)ETHYL]SULFAMIDE; N [1 (2,5 DIMETHOXYPHENYL)ETHYL]SULFAMIDE; N [1 (2,6 DIMETHOXYPHENYL)ETHYL]SULFAMIDE; N [1 (3,4 DIMETHOXYPHENYL)ETHYL]SULFAMIDE; N [1 (4 METHOXYPHENYL)ETHYL]SULFAMIDE; SULFAMIDE DERIVATIVE; UNCLASSIFIED DRUG; ACETOPHENONE DERIVATIVE; CHLOROSULFONYL ISOCYANATE; ISOCYANIC ACID DERIVATIVE; SULFONAMIDE;

AMINATION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME PURIFICATION; HUMAN; HUMAN CELL; HYDROGENOLYSIS; IC50; IN VITRO STUDY; INFRARED SPECTROSCOPY; ISOENZYME ANALYSIS; MOLECULAR DOCKING; PROTON NUCLEAR MAGNETIC RESONANCE; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; KINETICS; OXIDATION REDUCTION REACTION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACETOPHENONES; ACETYLCHOLINESTERASE; AMINATION; CARBONIC ANHYDRASE I; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CHOLINESTERASE INHIBITORS; HUMANS; ISOCYANATES; KINETICS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84937420871     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.04.019     Document Type: Article

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