Attachment of carbohydrates to methoxyaryl moieties leads to highly selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 19, 2014, Pages 5308-5314

  Riafrecha, Leonardo E ^a   Rodríguez, Oscar M ^a   Vullo, Daniela ^b   Supuran, Claudiu T ^b   Colinas, Pedro A ^a  

^a UNIVERSIDAD NACIONAL DE LA PLATA   (Argentina)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Cancer; Enzyme inhibitors; Glycomimetics

Indexed keywords

1 (2' ,3' ,4' ,6' TETRA O ACETYL BETA DEXTRO GALACTOPYRANOSYL) 4 (3 METHOXYPHENYL)BUT 3 EN 2 ONE; 1 (2' ,3' ,4' ,6' TETRA O ACETYL BETA DEXTRO GALACTOPYRANOSYL) 4 (3,4 DIMETHOXY PHENYL)BUT 3 EN 2 ONE; 1 (2' ,3' ,4' ,6' TETRA O ACETYL BETA DEXTRO GALACTOPYRANOSYL) 4 (6 METHOXY 2 NAPHTHYL)BUT 3 EN 2 ONE; 1 (2' ,3' ,4' ,6' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) 4 (3 METHOXYPHENYL)BUT 3 EN 2 ONE; 1 (2' ,3' ,4' ,6' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) 4 (3,4 DIMETHOXY PHENYL)BUT 3 EN 2 ONE; 1 (2' ,3' ,4' ,6' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) 4 (6 METHOXY 2 NAPHTHYL)BUT 3 EN 2 ONE; 1 (BETA DEXTRO GALACTOPYRANOSYL) 4 (3 METHOXYPHENYL)BUT 3 EN 2 ONE; 1 (BETA DEXTRO GALACTOPYRANOSYL) 4 (3,4 DIMETHOXYPHENYL)BUT 3 EN 2 ONE; 1 (BETA DEXTRO GALACTOPYRANOSYL) 4 (6 METHOXY 2 NAPHTHYL)BUT 3 EN 2 ONE; 1 (BETA DEXTRO GLUCOPYRANOSYL) 4 (3 METHOXYPHENYL)BUT 3 EN 2 ONE; 1 (BETA DEXTRO GLUCOPYRANOSYL) 4 (3,4 DIMETHOXYPHENYL)BUT 3 EN 2 ONE; 1 (BETA DEXTRO GLUCOPYRANOSYL) 4 (6 METHOXY 2 NAPHTHYL)BUT 3 EN 2 ONE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; GLYCOSIDE; UNCLASSIFIED DRUG;

ALDOL REACTION; ARTICLE; CELL DEATH; DEPROTECTION REACTION; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

EID: 84907532691     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.07.052     Document Type: Article

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