Neurotensin-polyplex-mediated brain-derived neurotrophic factor gene delivery into nigral dopamine neurons prevents nigrostriatal degeneration in a rat model of early Parkinson's disease

Journal of Biomedical Science

Volumn 22, Issue 1, 2015, Pages

  Hernandez Chan, Nancy G ^a   Bannon, Michael J ^b   Orozco Barrios, Carlos E ^a   Escobedo, Lourdes ^a   Zamudio, Sergio ^c   De La Cruz, Fidel ^c   Gongora Alfaro, Jose L ^d   Armendáriz Borunda, Juan ^e   Reyes Corona, David ^a   Espadas Alvarez, Armando J ^a   Flores Martínez, Yazmin M ^a   Ayala Davila, Jose ^a   Hernandez Gutierrez, Maria E ^f   Pavón, Lenin ^f   García Villegas, Refugio ^a   Nadella, Rasajna ^a   Martinez Fong, Daniel ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^d UNIVERSIDAD AUTÓNOMA DE YUCATÁN   (Mexico)

^e UNIVERSITY OF GUADALAJARA   (Mexico)

^f INSTITUTO NACIONAL DE PSIQUIATRÍA RAMÓN DE LA FUENTE MUÑIZ   (Mexico)

Author keywords

Gene therapy; Neurodegeneration; Neurorestoration; Neurotrophic therapy; Parkinson's disease

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; DOPAMINE; GREEN FLUORESCENT PROTEIN; NANOCARRIER; NEUROTENSIN POLYPLEX; NEUROTENSIN RECEPTOR; NEUROTENSIN RECEPTOR TYPE 1; UNCLASSIFIED DRUG; NEUROTENSIN; NEUROTENSIN TYPE 1 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; GENE OVEREXPRESSION; GENE TARGETING; GENE THERAPY; GENETIC TRANSFECTION; IMMUNOFLUORESCENCE; INNERVATION; LOCOMOTION; MALE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARKINSON DISEASE; PARKINSONISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBSTANTIA NIGRA; ANIMAL; BIOSYNTHESIS; CHEMISTRY; DISEASE MODEL; GENETICS; METABOLISM; PATHOLOGY; PROCEDURES; WISTAR RAT;

RATTUS;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; DISEASE MODELS, ANIMAL; DOPAMINERGIC NEURONS; GENETIC THERAPY; MALE; NEUROTENSIN; PARKINSON DISEASE; RATS; RATS, WISTAR; RECEPTORS, NEUROTENSIN; SUBSTANTIA NIGRA; TRANSFECTION;

EID: 84937394030     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/s12929-015-0166-7     Document Type: Article

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