Characterization of the 5'-flanking region of the human dopamine transporter gene

Molecular Brain Research

Volumn 74, Issue 1-2, 1999, Pages 167-174

  Sacchetti, Paola ^a   Brownschidle, Lisa A ^a   Granneman, James G ^a,b   Bannon, Michael J ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PFIZER INC   (United States)

Author keywords

cis Regulatory element; Dopamine transporter; Gene; Human; Nurr1; Transcription regulation

Indexed keywords

DOPAMINE TRANSPORTER;

ANIMAL CELL; ARTICLE; DOPAMINERGIC SYSTEM; GENE CONSTRUCT; GENE EXPRESSION REGULATION; GENETIC ANALYSIS; HUMAN; IN VITRO STUDY; MOUSE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REGULATOR GENE; RESTRICTION MAPPING; SEQUENCE ANALYSIS;

ANIMALS; BASE SEQUENCE; BINDING SITES; CARRIER PROTEINS; CELL LINE; CYCLIC AMP; DNA; DNA-BINDING PROTEINS; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FORSKOLIN; HUMANS; LUCIFERASES; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; PC12 CELLS; PROMOTER REGIONS (GENETICS); RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RECOMBINANT FUSION PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; RESPONSE ELEMENTS; SEQUENCE DELETION; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0033402407     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(99)00275-2     Document Type: Article

References (34)

1. Amara S.G., Sonders M.S. Neurotransmitter transporters as molecular targets for addictive drugs. Drug Alcohol Depend. 51:1998;87-96.
2. M.J. Bannon, P. Sacchetti, J.G. Granneman. The dopamine transporter: potential involvement in neuropsychiatric disorders, in: F.E. Bloom, D.J. Kupfer (Eds.), Psychopharmacology: The Fourth Generation of Progress, CD-ROM version, Raven Press, New York, 1999, in press.
3. Castillo S.O., Baffi J.S., Palkovits M., Goldstein D.S., Kopin I.J., Witta J., Magnuson M.A., Nikodem V.M. Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene. Mol. Cell. Neurosc. 11:1998;36-46.
4. Chong J.A., Tapia-Ramirez J., Kim S., Toledo-Aral J.J., Zheng Y., Boutros M.C., Altshuller Y.M., Frohman M.A., Kraner S.D., Mandel G. REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell. 80:1990;949-957.
5. J.R. Cooper, F.E. Bloom, R.H. Roth (Eds.), The Biochemical Basis of Neuropharmacology, Oxford Univ. Press, New York, 1996, 510 pp.
6. Davis I.J., Lau L.F. Endocrine and neurogenic regulation of the orphan nuclear receptors Nur77 and Nurr-1 in the adrenal glands. Mol. Cell. Biol. 14:1994;3469-3483.
7. Donovan D.M., Vandenbergh D.J., Perry M.P., Bird G.S., Ingersoll R., Nanthakumar E., Uhl G.R. Human and mouse dopamine transporter genes: conservation of 5′-flanking sequence elements and gene structures. Mol. Brain Res. 30:1995;327-335.
8. Forman B.M., Umesono K., Chen J., Evans R.M. Unique response pathway are established by allosteric interactions among nuclear hormone receptors. Cell. 81:1995;541-550.
9. Giros B., El Mestikawy S., Godinot N., Zheng K., Han H., Yang-Feng T., Caron M.G. Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. Mol. Pharmacol. 42:1992;383-390.
10. Himmler A., Stratowa C., Czernilofsky A.P. Functional testing of human dopamine D1 and D5 receptors expressed in stable cAMP-responsive luciferase reporter cell lines. J. Recept. Res. 13:1993;79-94.
11. Kawarai T., Kawakami H., Yamamura Y., Nakamura S. Structure and organization of the gene encoding human dopamine transporter. Gene. 195:1997;11-18.
12. Kouzmenko A.P., Pereira A.M., Singh B.S. Intronic sequences are involved in neuronal targeting of human dopamine transporter gene expression. Biochem. Biophys. Res. Commun. 240:1997;807-811.
13. Kraner S.D., Chong J.A., Tsay H., Mandel G. Silencing the type II sodium channel gene: a model for neural-specific gene regulation. Neuron. 9:1992;37-44.
14. Law S.W., Conneely O.M., DeMayo F.J., O'Malley B.G. Identification of a new brain-specific transcription factor, Nurr1. Mol. Endocrinol. 6:1992;2129-2135.
15. Magelsdorf D.J., Thummel C., Beato M., Herrlich P., Schòtz G., Umesono K., Blumberg B., Kastner P., Mark M., Chambon P., Evans R.M. The nuclear receptor superfamily: the second decade. Cell. 83:1995;835-839.
16. Mages H.W., Rilke O., Bravo R., Senger G., Kroczek R.A. NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3. Mol. Endocrinol. 8:1994;1583-1591.
17. Maruyama K., Tsukada T., Ohkura N., Bandoh S., Hosono T., Yamaguchi K. The NGFI-B subfamily of the nuclear receptor superfamily. Int. J. Oncol. 12:1998;1237-1243.
18. Montminy M.R., Gonzalez G.A., Yamamoto K.K. Regulation of cAMP-inducible genes by CREB. Trends Neurosci. 13:1990;184-188.
19. Mori N., Stein R., Sigmund O., Anderson D.J. A cell type-preferred silencer element that controls the neural-specific expression of the SCG10 gene. Neuron. 4:1990;583-594.
20. Murphy E.P., Dobson A.D.W., Keller C., Conneely O.M. Differential regulation of transcription by the NURR1/NUR77 subfamily of nuclear transcription factors. Gene Expression. 5:1996;169-179.
21. Nakatani Y., Horikosh M., Brenner M., Yamamoto T., Besnard F., Roeder R.G., Freese E. A downstream initiation element required for efficient TATA box binding and in vitro function of TFIID. Nature. 348:1990;86-88.
22. Olson L., Cheng H., Zetterström R.H., Solomin L., Jansson L., Giménez-Llort L., Hoffer B.J., Perlmann T. On CNS repair and protection strategies: novel approaches with implications for spinal cord injury and Parkinson's disease. Brain Res. Rev. 26:1998;302-305.
23. S.L. Povlock, S.G. Amara, The structure and function of norepinephrine, dopamine and serotonin transporters, in: M.E.A Reith (Ed.), Neurotransmitter Transporters: Structure, Function, and Regulation, Humana Press, Totowa, 1997, pp. 1-28.
24. Sakurada K., Sakurada M.O., Palmer T.D., Gage F.H. Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain. Development. 126:1999;4017-4026.
25. Saucedo-Cardenas O., Quintana-Hau J.D., Le W.D., Smidt M.P., Cox J.J., De Mayo F., Burbach J.P.H., Conneely O.M. Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc. Natl. Acad. Sci. USA. 95:1998;4013-4018.
26. Schoenherr C.J., Paquette A.J., Anderson D.J. Identification of potential target genes for the neuron-restrictive silencer factor. Proc. Natl. Acad. Sci. USA. 93:1996;9881-9886.
27. Smidt M.P., van Schaick H.S.A., Lanctôt C., Tremblay J.J., Cox J.J., van der Kleij A.A.M., Wolterink G., Drouin J., Burbach J.P.H. A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons. Proc. Natl. Acad. Sci USA. 94:1997;13305-13310.
28. Twyman R.M., Jones E.A. The regulation of neuron-specific gene expression in the mammalian nervous system. J. Neurogenet. 10:1995;67-101.
29. Vandenbergh D.J., Persico A.M., Hawkins A.L., Griffin C.A., Li X., Jabs E.W., Uhl G.R. Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR. Genomics. 14:1992;1104-1106.
30. Wilson T.E., Fahrner T.J., Johnston M., Milbrandt J. Identification of the DNA binding site for NGFI-B by genetic selection in yeast. Science. 252:1991;1296-1300.
31. Wilson T.E., Mouw A.R., Weaver C.A., Milbrandt J., Parke K.L. The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid 21-hydroxylase. Mol. Cell. Biol. 13:1993;861-868.
32. Woronicz J.D., Lina A., Calnan B.J., Szychowski S., Cheng L., Winoto A. Regulation of the Nur77 orphan steroid receptor in activation-induced apoptosis. Mol. Cell. Biol. 15:1995;6364-6376.
33. Zetterström R.H., Williams R., Perlmann T., Olson L. Cellular expression of the immediate-early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system. Mol. Brain Res. 41:1996;111-120.
34. Zetterström R.H., Solomin L., Jansson L., Hoffer B.H., Olson L., Perlmann T. Dopamine neuron agenesis in Nurr1-deficient mice. Science. 276:1997;248-250.