Post-lesion administration of 7-NI attenuated motor and non-motor deficits in 6-OHDA induced bilaterally lesioned female rat model of Parkinson's disease

Neuroscience Letters

Volumn 589, Issue , 2015, Pages 191-195

  Kumari, Rita ^a   Kumar, J B Senthil ^a   Luthra, Pratibha Mehta ^a  

^a UNIVERSITY OF DELHI   (India)

Author keywords

6 OHDA induced bilateral lesions; 7 Nitroindazole; Forced swim test; Parkinson's disease; Post lesion; Rota rod test

Indexed keywords

7 NITROINDAZOLE; CATALASE; DOPAMINE; GLUTATHIONE; OXIDOPAMINE; SUPEROXIDE DISMUTASE; 7-NITROINDAZOLE; INDAZOLES; NEUROPROTECTIVE AGENTS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EXPERIMENTAL LOCOMOTOR ACTIVITY TEST; FEMALE; FORCED SWIM TEST; LIPID PEROXIDATION; LOCOMOTION; MALE; MOTOR ACTIVITY; MOTOR COORDINATION; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; MOUSE; NEUROPROTECTION; NONHUMAN; OPEN FIELD TEST; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; ROTA ROD TEST; TREATMENT DURATION; ANIMALS; BRAIN; DRUG EFFECTS; METABOLISM; MOTOR SKILLS; PHYSIOPATHOLOGY; RATS, SPRAGUE-DAWLEY;

ANIMALS; BRAIN; CATALASE; DOPAMINE; FEMALE; GLUTATHIONE; INDAZOLES; LIPID PEROXIDATION; MOTOR SKILLS; NEUROPROTECTIVE AGENTS; OXIDOPAMINE; PARKINSON DISEASE; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE;

EID: 84921971544     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2014.12.030     Document Type: Article

References (22)

1. Cookson M.R. The biochemistry of Parkinson's disease. Annu. Rev. Biochem. 2005, 74:29-52.
2. Alderton W.K., Cooper Knowles C.E.R.G. Nitric oxide synthases: structure, function and inhibition. Biochem. J. 2001, 357(Pt 3):593-615.
3. Di Matteo V., et al. Involvement of nitric oxide in nigrostriatal dopaminergic system degeneration: a neurochemical study. Ann. N. Y. Acad. Sci. 2009, 1155:309-315.
4. Haik K.L., et al. 7-Nitroindazole attenuates 6-hydroxydopamine-induced spatial learning deficits and dopamine neuron loss in a presymptomatic animal model of Parkinson's disease. Exp. Clin. Psychopharmacol. 2008, 16:178-189.
5. Novaretti N., et al. Lack of tolerance for the anti-dyskinetic effects of 7-nitroindazole, a neuronal nitric oxide synthase inhibitor, in rats. Braz. J. Med. Biol. Res. 2010, 43:1047-1053.
6. Blandini F., Armentero M.-T., Martignoni E. The 6-hydroxydopamine model: news from the past. Parkinsonism Relat. Disord. 2008, 14(Suppl. 2):S124-S129.
7. Luthra P.M., Barodia S.K., Raghubir R. Antagonism of haloperidol-induced swim impairment in l-dopa and caffeine treated mice: a pre-clinical model to study Parkinson's disease. J. Neurosci. Methods 2009, 178(2):284-290.
8. Porsolt R.D., Bertin A., Jalfre M. Behavioral despair in mice: a primary screening test for antidepressants. Arch. Int. de Pharmacodyn. Ther. 1977, 229(2):327-336.
9. Dekundy A., et al. Modulation of l-DOPA-induced abnormal involuntary movements by clinically tested compounds: further validation of the rat dyskinesia model. Behav. Brain Res. 2007, 179(1):76-89.
10. Prediger R.D., De-Mello N., Takahashi R.N. Pilocarpine improves olfactory discrimination and social recognition memory deficits in 24 month-old rats. Eur. J. Pharmacol. 2006, 531(1-3):176-182.
11. Utley G.H., Bernheim F., Hochstein P. Effect of sulph-hydryl reagents on peroxidation in microsomes. Arch. Biochem. Biophys. 1967, 118:2-29.
12. Jollow D.J., et al. Bromobenzene-induced liver necrosis protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite. Pharmacology 1974, 11(3):151-169.
13. Beers R.F., Sizer I.W. Spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J. Biol. Chem. 1952, 195(1):133-140.
14. Marklund S., Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 1974, 47(3):469-474.
15. Straub V.A., et al. Modulation of serotonergic neurotransmission by nitric oxide. J. Neurophysiol. 2007, 97(2):1088-1099.
16. Crespi F. Is a divergent central serotonergic activity responsible for either despair or learning behavior in intact wistar or sprague-dawley cd rats,respectively? A Concomitant behavioral and electrochemical analysis. Psychology 2010, 1:209-219.
17. Spolidorio P.C., et al. Anxiolytic effects induced by inhibition of the nitric oxide-cGMP pathway in the rat dorsal hippocampus. Psychopharmacology (Berl) 2007, 195(2):183-192.
18. Yildiz Akar F., et al. 7-Nitroindazole, a neuronal nitric oxide synthase inhibitor, impairs passive-avoidance and elevated plus-maze memory performance in rats. Pharmacol. Biochem. Behav. 2007, 87:434-443.
19. Mutlu O., Ulak G., Belzung C. Effects of nitric oxide synthase inhibitors 1-(2-trifluoromethylphenyl)-imidazole (TRIM) and 7-nitroindazole (7-NI) on learning and memory in mice. Fundam. Clin. Pharmacol. 2011, 25(3):368-377.
20. Thomas B., Saravanan K.S., Mohanakumar K.P. In vitro and in vivo evidences that antioxidant action contributes to the neuroprotective effects of the neuronal nitric oxide synthase and monoamine oxidase-B inhibitor, 7-nitroindazole. Neurochem. Int. 2008, 52:990-1001.
21. Uttara B., et al. Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr. Neuropharmacol. 2009, 7(1):65-74.
22. Del Bel, E.a, et al. Motor effects of acute and chronic inhibition of nitric oxide synthesis in mice. Psychopharmacology 2002, 161:32-37.