EGCG reverses human neutrophil elastase-induced migration in A549 cells by directly binding to HNE and by regulating α1-AT

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Li, Xuejun ^a,b   Xiaokaiti, Yilixiati ^a,b   Wu, Haoming ^b   Chen, Ya ^a,b   Yang, Haopeng ^a,b   Duan, Jianhui ^a,b   Li, Xin ^a,b   Pan, Yan ^a,b   Tie, Lu ^a,b   Zhang, Liangren ^a,b  

^a PEKING UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; CATECHIN; EPIGALLOCATECHIN GALLATE; LEUKOCYTE ELASTASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BINDING; PROTEIN KINASE B;

ANALOGS AND DERIVATIVES; CELL MOTION; CELL PROLIFERATION; DRUG EFFECTS; GENETIC PROCEDURES; HUMAN; METABOLISM; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE; TUMOR CELL LINE;

ALPHA 1-ANTITRYPSIN; BIOSENSING TECHNIQUES; CATECHIN; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; HUMANS; LEUKOCYTE ELASTASE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE;

EID: 84937210695     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep11494     Document Type: Article

References (37)

1. Jemal, A. et al. Global cancer statistics. CA Cancer J Clin 61, 69-90 (2011
2. Mantovani, A. & Balkwill, F. Cancer-related inflammation. Nature 454, 436-44 (2008
3. Sonoda, J. I. et al. Green tea catechin, epigallocatechin-3-gallate, attenuates the cell viability of human non-small-cell lung cancer A549 cells via reducing Bcl-xL expression. Exp Ther Med 8, 59-63 (2014
4. Liu, S., Wang, X. J. & Cui, Y. F. PI3K/AKT/mTOR signaling is involved in (? )-epigallocatechin-3-gallate-induced apoptosis of human pancreatic carcinoma cells. Am J Chin Med 41, 629-42 (2013
5. Yang, C. S., Maliakal, P. & Meng, X. Inhibition of carcinogenesis by tea. Annu Rev Pharmacol Toxicol 42, 25-54 (2002
6. Surh, Y. J. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3, 768-80 (2003
7. Khan, N., Afaq, F. & Mukhtar, H. Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate. Cancer Res 66, 2500-5 (2006
8. Sah, J. F., Balasubramanian, S. & Rorke, E. A. Epigallocatechin-3-gallate inhibits epidermal growth factor receptor signaling pathway. Evidence for direct inhibition of ERK1/2 and AKT kinases. J Biol Chem 279, 12755-62 (2004
9. Gregory, A. D. & Houghton, A. M. Tumor-Associated neutrophils: new targets for cancer therapy. Cancer Res 71, 2411-6 (2011
10. Bellocq, A. et al. Neutrophil alveolitis in bronchioloalveolar carcinoma: induction by tumor-derived interleukin-8 and relation to clinical outcome. Am J Pathol 152, 83-92 (1998
11. Lungarella, G., Cavarra, E. & Martorana, P. A. The dual role of neutrophil elastase in lung destruction and repair. Int J Biochem Cell Biol 40, 1287-96 (2008
12. Luisetti, M. & Seersholm, N. Alpha1-Antitrypsin deficiency. 1: epidemiology of alpha1-Antitrypsin deficiency. Thorax 59, 164-9 (2004
13. Sun, Z. & Yang, P. Role of imbalance between neutrophil elastase and alpha 1-Antitrypsin in cancer development and progression. Lancet Oncol 5, 182-90 (2004
14. Xu, Y. et al. Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of alpha1-Antitrypsin in lung cancer. Mol Oncol 6, 405-17 (2012
15. Kumari, R., Open Source Drug Discovery, C. & Lynn, A. g-mmpbsa-A GROMACS tool for high-throughput MM-PBSA calculations. J Chem Inf Model 54, 1951-62 (2014
16. Chen, L. et al. Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. J Virol 79, 7095-103 (2005
17. Chen, S. et al. Severe acute respiratory syndrome coronavirus 3C-like proteinase N terminus is indispensable for proteolytic activity but not for enzyme dimerization. Biochemical and thermodynamic investigation in conjunction with molecular dynamics simulations. J Biol Chem 280, 164-73 (2005
18. Loser, B., Kruse, S. O. & Nahrstedt, A. Inhibition of neutrophil elastase activity by cinnamic acid derivatives from Cimicifuga racemosa. Planta Med 66, 751-3 (2000
19. Houghton, A. M. et al. Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nat Med 16, 219-23 (2010
20. Milligan, S. A. et al. The green tea polyphenol EGCG potentiates the antiproliferative activity of c-Met and epidermal growth factor receptor inhibitors in non-small cell lung cancer cells. Clin Cancer Res 15, 4885-94 (2009
21. Mukherjee, S., Siddiqui, M. A. & Malathi, K. Epigallocatechin-3-gallate suppresses proinflammatory cytokines and chemokines induced by Toll-like receptor 9 agonists in prostate cancer cells. J Inflamm Res 7, 89-101 (2014
22. Shim, J. H. et al. Epigallocatechin gallate suppresses lung cancer cell growth through Ras-GTPase-Activating protein SH3 domainbinding protein 1. Cancer Prev Res (Phila) 3, 670-9 (2010
23. Schramm, L. Going Green: The Role of the Green Tea Component EGCG in Chemoprevention. J Carcinog Mutagen 4, 1000142 (2013
24. Koshiol, J. et al. Chronic obstructive pulmonary disease and altered risk of lung cancer in a population-based case-control study. PLoS One 4, e7380 (2009
25. Fingleton, B. Inflammatory proteinase slips into tumor cells. Nat Med 16, 161-3 (2010
26. Granot, Z. et al. Tumor entrained neutrophils inhibit seeding in the premetastatic lung. Cancer Cell 20, 300-14 (2011
27. Sulea, T., Cui, Q. & Purisima, E. O. Solvated interaction energy (SIE) for scoring protein-ligand binding affinities. 2. Benchmark in the CSAR-2010 scoring exercise. J Chem Inf Model 51, 2066-81 (2011
28. Alasbahi, R. & Melzig, M. F. Screening of some Yemeni medicinal plants for inhibitory activity against peptidases. Pharmazie 63, 86-8 (2008
29. Zelvyte, I., Sjogren, H. O. & Janciauskiene, S. Effects of native and cleaved forms of alpha1-Antitrypsin on ME 1477 tumor cell functional activity. Cancer Detect Prev 26, 256-65 (2002
30. Higashiyama, M. & Tateishi, R. An evaluation of the prognostic significance of alpha-1-Antitrypsin expression in adenocarcinomas of the lung: an immunohistochemical analysis. Br J Cancer 65, 300-2 (1992
31. Zelvyte, I., & Janciauskiene, S. alpha1-Antitrypsin and its C-terminal fragment attenuate effects of degranulated neutrophilconditioned medium on lung cancer HCC cells, in vitro. Cancer Cell Int 4, 7 (2004
32. Hopkins, P. C., Chang, W. S. & Stone, S. R. Inhibitory mechanism of serpins. Mobility of the C-terminal region of the reactivesite loop. J Biol Chem 272, 3905-9 (1997
33. Liu, Z. et al. The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo. Cell 102, 647-55 (2000
34. Jones, S. H. Pulmonary emphysema and alpha1-Antitrypsin deficiency. Phys Ther 54, 579-83 (1974
35. El-Akawi, Z. J., Abu-Awad & Khader, Y. The importance of alpha-1 antitrypsin (alpha1-AT) and neopterin serum levels in the evaluation of non-small cell lung and prostate cancer patients. Neuro Endocrinol Lett 31, 113-6 (2010
36. Singh, B. N., Shankar, S. & Srivastava, R. K. Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications. Biochem Pharmacol 82, 1807-21 (2011
37. De Amicis, F. et al. Epigallocatechin gallate inhibits growth and epithelial-to-mesenchymal transition in human thyroid carcinoma cell lines. J Cell Physiol 228, 2054-62 (2013).