PI3K/AKT/mTOR signaling is involved in (-)-epigallocatechin-3-gallate- induced apoptosis of human pancreatic carcinoma cells

American Journal of Chinese Medicine

Volumn 41, Issue 3, 2013, Pages 629-642

  Liu, Shi ^a   Wang, Xiao Jie ^b   Liu, Ying ^c   Cui, Yun Fu ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b Heilongjiang Institute of Dermatology and Sexually Transmitted Disease   (China)

^c QIQIHAR MEDICAL UNIVERSITY   (China)

Author keywords

( ) Epigallocatechin 3 Gallate; AKT; mTOR; Pancreatic Cancer; PI3K

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; EPIGALLOCATECHIN GALLATE; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; PANCREAS CARCINOMA; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CAMELLIA SINENSIS; CATECHIN; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; PANCREATIC NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASE; PHYTOTHERAPY; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; UP-REGULATION;

EID: 84878377687     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X13500444     Document Type: Article

References (48)

1. Bode, A.M. and Z. Dong. Targeting signal transduction pathways by chemopreventive agents. Mutat. Res. 555: 33-51, 2004. (Pubitemid 39345396)
2. Cao, L.Q., X.L. Chen, Q. Wang, X.H. Huang, M.C. Zhen, L.J. Zhang, W. Li and J. Bi. Upregulation of PTEN involved in rosiglitazone-induced apoptosis in human hepatocellular carcinoma cells. Acta. Pharmacol. Sin. 28: 879-887, 2007. (Pubitemid 46817439)
3. Chen, W.C., M.S. Lin and X. Bai. Induction of apoptosis in colorectal cancer cells by peroxisome proliferators-activated receptor-activation up-regulating PTEN and inhibiting PI3K activity. Chin. Med. J. 118: 1477-1481, 2005.
4. Downward, J. PI 3-kinase, Akt and cell survival. Semin. Cell Dev. Biol. 15: 177-182, 2004.
5. Farrow, B. and B.M. Evers. Activation of PPARgamma increases PTEN expression in pancreatic cancer cells. Biochem. Biophys. Res. Commun. 301: 50-53, 2003. (Pubitemid 36268846)
6. Ghaneh, P., E. Costello and J.P. Neoptolemos. Biology and management of pancreatic cancer. Gut 56: 1134-1152, 2007. (Pubitemid 47123247)
7. Hastak, K., S. Gupta, N. Ahmad, M.K. Agarwal, M.L. Agarwal and H. Mukhtar. Role of P53 and NF-kappa B inepigallocatechin3-gallate-induced apoptosis of LNCaP cells. Oncogene 22: 4851-4859, 2003. (Pubitemid 36981273)
8. Hou, Z., S. Sang, H. You, M.J. Lee, J. Hong, K.V. Chin and C.S. Yang. Mechanism of action of (-)-Epigallocatechin-3-Gallate: auto-oxidation dependent inactivation of epidermal growth factor receptor and direct effects on growth inhibition in human esophageal cancer KYSE 150 cells. Cancer Res. 65: 8049-8056, 2005. (Pubitemid 41297287)
9. Huang, H.C., T.D. Way, C.L. Lin and J.K. Lin. EGCG stabilizes p27kip1 in E2-stimulated MCF-7 cells through down-regulation of the Skp2 protein. Endocrinology 149: 5972-5983, 2008.
10. Ichimatsu, D., M. Nomura, S. Nakamura, S. Moritani, K. Yokogawa, S. Kobayashi, T. Nishioka and K. Miyamoto. Structure-activity relationship of flavonoids for inhibition of epidermal growth factor-induced transformation of JB6 Cl 41 cells. Mol. Carcinog. 46: 436-445, 2007. (Pubitemid 46897048)
11. Kang, H.G., J.M. Jenabi, X.F. Liu, C.P. Reynolds, T.J. Triche and P.H. Sorensen. Inhibition of the insulin-like growth factor I receptor by epigallocatechin gallate blocks proliferation and induces the death of Ewing tumor cells. Mol. Cancer Ther. 9: 1396-1407, 2010.
12. Kanwar, J., M. Taskeen, I. Mohammad, C. Huo, T.H. Chan and Q.P. Dou. Recent advances on tea polyphenols. Front. Biosci. (Elite Ed) 4: 111-131, 2012.
13. Kono, S., M. Ikeda, S. Tokudome and M. Kuratsune. A case-control study of gastric cancer and diet in northern Kyushu, Japan. Jpn. J. Cancer Res. 79: 1067-1074, 1988.
14. Lambert, J.D. and C.S. Yang. Cancer chemopreventive activity and bioavailability of tea and tea polyphenols. Mutat. Res. 523-524: 201-208, 2003. (Pubitemid 36293247)
15. Leone, M., D. Zhai, S. Sareth, S. Kitada, J. C. Reed and M. Pellecchia. Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins. Cancer Res. 63: 8118-8121, 2003. (Pubitemid 37549456)
16. Li, D.W., J.P. Liu, Y.W. Mao, H. Xiang, J. Wang, W.Y. Ma, Z. Dong, H.M. Pike, R.E. Brown and J.C. Reed. Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-Crystallin through inhibition of RAS activation. Mol. Biol. Cell 16: 4437-4453, 2005. (Pubitemid 41262909)
17. Li, Y., T. Zhang, Y. Jiang, H.F. Lee, S.J. Schwartz and D. Sun. (-)-Epigallocatechin-3-gallate inhibits Hsp90 function by impairing Hsp90 association with cochaperones in pancreatic cancer cell line Mia Paca-2. Mol. Pharm. 6: 1152-1159, 2009.
18. Lyn-Cook, B.D., T. Rogers, Y. Yan, E.B. Blann, F.F. Kadlubar and G.J. Hammons. Chemopreventive effects of tea extracts and various components on human pancreatic and prostate tumor cells in vitro. Nutr. Cancer 35: 80-86, 1999.
19. Maeda-Yamamoto, M., N. Suzuki, Y. Sawai, T. Miyase, M. Sano, A. Hashimoto-Ohta and M. Isemura. Association of suppression of extracellular signal-regulated kinase phosphorylation by epigallocatechin gallate with the reduction of matrix metalloproteinase activities in human fibrosarcoma HT1080 cells. Agric. Food Chem. 51: 1858-1863, 2003.
20. Mittal, A., M.S. Pata, R.C. Wylie, T.O. Tollefsbol and S.K. Katiyar. EGCG down-regulates telomerase in human breast carcinoma MCF-7cells, leading to suppression of cell viability and induction of apotosis. Int. J. Oncol. 24: 703-710, 2004.
21. Morgan, T.M., T.D. Koreckij and E. Corey. Targeted therapy for advanced prostate cancer: inhibition of the PI3K/Akt/mTOR pathway. Curr. Cancer Drug Targets 9: 237-249, 2009.
22. Mukhtar, H. and N. Ahmad. Tea polyphenols: prevention of cancer and optimizing health. Am. J. Clin. Nutr. 71: 1698-1702S; discussion 1703-1704S, 2000.
23. Pellecchia, M. and J.C. Reed. Inhibition of anti-apoptotic Bcl-2 family proteins by natural polyphenols: new avenues for cancer chemoprevention and chemotherapy. Curr. Pharm. Des. 10: 1387-1398, 2004. (Pubitemid 38559755)
24. Qanungo, S., M. Das, S. Haldar and A. Basu. Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells. Carcinogenesis 26: 958-967, 2005. (Pubitemid 41214325)
25. Ran, Z.H., J. Zou and S.D. Xiao. Experimental study on anti-neoplastic activity of epigallocatechin-3-gallate to digestive tract carcinomas. Chin. Med. J. 118: 1330-1337, 2005. (Pubitemid 41223168)
26. Relat, J., A. Blancafort, G. Oliveras, S. Cufí, D. Haro, P.F. Marrero and T. Puig. Different fatty acid metabolism effects of (-)-epigallocatechin-3-gallate and C75 in adenocarcinoma lung cancer. BMC Cancer 12: 280, 2012.
27. Roy, M., S. Chakrabarty, D. Sinha, R.K. Bhattacharya and M. Siddiqi. Anticlastogenic, antigenotoxic and apoptoic antivity of epigallocatechin gallate: a green tea polyphenol. Mutat. Res. 523-534: 33-41, 2003. (Pubitemid 36293230)
28. Sah, J.F., S. Balasubramanian, R.L. Eckert and E.A. Rorke. Epigallocatechin-3-gallate inhibits epidermal growth factor receptor signaling pathway. Evidence for direct inhibition of ERK1/2 and Akt kinases. J. Biol. Chem. 279: 12755-12762, 2004. (Pubitemid 38445847)
29. Saif, M.W. New developments in the treatment of pancreatic cancer. Highlights from the "44th ASCO Annual Meeting". Chicago, IL, USA. May 30-June 3, 2008. JOP 9: 391-397, 2008.
30. Scandlyn, M.J., E.C. Stuart, T.J. Somers-Edgar, A.R. Menzies and R.J. Rosengren. A new role for tamoxifen in oestrogen receptor-negative breast cancer when it is combined with epigallocatechin gallate. Br. J. Cancer 99: 1056-1063, 2008.
31. Shankar, S., S. Ganapathy and R.K. Srivastava. Green tea polyphenols: biology and therapeutic implications in cancer. Front. Biosci. 12: 4881-4899, 2007.
32. Shimizu, M., Y. Shirakami, H. Sakai, Y. Yasuda, M. Kubota, S. Adachi, H. Tsurumi, Y. Hara and H. Moriwaki. (-)-Epigallocatechin gallate inhibits growth and activation of the VEGF/VEGFR axis in human colorectal cancer cells. Chem. Biol. Interact. 185: 247-252, 2010.
33. Shirakami, Y., M. Shimizu, S. Adachi, H. Sakai, T. Nakagawa, Y. Yasuda, H. Tsurumi, Y. Hara and H. Moriwaki. (-)-Epigallocatechin gallate suppresses the growth of human hepatocellular carcinoma cells by inhibiting activation of the vascular endothelial growth factor-vascular endothelial growth factor receptor axis. Cancer Sci. 100: 1957-1962, 2009.
34. Suganuma, M., S. Okabe, N. Sueoka, E. Sueoka, S. Matsuyama, K. Imai, K. Nakachi and H. Fujiki. Green tea and cancer chemoprevention. Mutat. Res. 428: 339-344, 1999. (Pubitemid 29389704)
35. Surh, Y.J. Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer 3: 768-780, 2003.
36. Takada, M., Y. Nakamura, T. Koizumi, H. Toyama, T. Kamigaki, Y. Suzuki, Y. Takeyama and Y. Kuroda. Suppression of human pancreatic carcinoma cell growth and invasion by epigallocatechin-3-gallate. Pancreas 25: 45-48, 2002. (Pubitemid 34760835)
37. Tang, S.N., J. Fu, S. Shankar and R.K. Srivastava. EGCG enhances the therapeutic potential of gemcitabine and CP690550 by inhibiting STAT3 signaling pathway in human pancreatic cancer. PLoS One 7: e31067, 2012.
38. Vu, H.A., Y. Beppu, H.T. Chi, K. Sasaki, H. Yamamoto, P.T. Xinh, T. Tanii, Y. Hara, T. Watanabe, Y. Sato and I. Ohdomari. Green tea epigallocatechin gallate exhibits anticancer effect in human pancreatic carcinoma cells via the inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor. J. Biomed. Biotechnol. 2010: 290516, 2010.
39. Xiao, H., K.W. Shi and H.Y. Cao. Growth inhibition effect and underlying mechanism of epigallocatechin-3-gallate on human pancreatic cancer cell line PANC-1. J. Clin. Med. Pract. 7: 26-29, 2010.
40. Xu, G., W. Zhang, P. Bertram, X.F. Zheng and H. McLeod. Pharmacogenomic profiling of the PI3K/TEN-Akt-mTOR pathway in common human tumors. Int. J. Oncol. 24: 893-900, 2004.
41. Yang, C.S., J.Y. Chung, G. Yang, S.K. Chhabra and M.J. Lee. Tea and tea polyphenols in cancer prevention. J. Nutr. 130: 472S-478S, 2000. (Pubitemid 30073776)
42. Yang, C.S., J.D. Lambert, Z. Hou, J. Ju, G. Lu and X. Hao. Molecular targets for the cancer preventive activity of tea polyphenols. Mol. Carcinog. 45: 431-435, 2006. (Pubitemid 43865851)
43. Yang, C.S., J. Ju, G. Lu, H. Xiao, X. Hao, S. Sang and J.D. Lambert. Cancer prevention by tea and tea polyphenols. Asia Pac. J. Clin. Nutr. 17(Suppl 1): 245-248, 2008.
44. Yang, S.W., W. Wang, X.Y. Xie, W.P. Zhu and F.Q. Li. In vitro synergistic cytotoxic effect of triptolide combined with hydroxycamptothecin on pancreatic cancer cells. Am. J. Chin. Med. 39: 121-134, 2011.
45. Zhang, Y. and X. Shi. Progress in the chemotherapy of pancreatic carcinoma. World Chin. J. Digestol. 17: 1422-1426, 2009.
46. Zhang, X.Q., J.H. Kim, G.S. Lee, H.B. Pyo, E.Y. Shin, E.G. Kim and Y.H. Zhang. In vitro antioxidant and in vivo anti-inflammatory activities of Ophioglossum thermale. Am. J. Chin. Med. 40: 279-293, 2012.
47. Zhu, Z.N., Z.Q. Liu, D.M. Li, H. Qin, B.J. Wang and Q. Zhao. Inhibitory effects of epigallocatechin-3-gallate (EGCG) on cell proliferation in human pancreatic carcinoma PANC-1 cells. Chin. J. Gastroenterol. Hepatol. 10: 936-938, 2010.
48. Zhu, Z., Y. Wang, Z. Liu, F. Wang and Q. Zhao. Inhibitory effects of epigallocatechin-3-gallate on cell proliferation and the expression of HIF-1-and P-gp in the human pancreatic carcinoma cell line PANC-1. Oncol. Rep. 27: 1567-1572, 2012.