Sodium-coupled transport of the short chain fatty acid butyrate by SLC5A8 and its relevance to colon cancer

Journal of Gastrointestinal Surgery

Volumn 12, Issue 10, 2008, Pages 1773-1782

  Thangaraju, Muthusamy ^a   Cresci, Gail ^a   Itagaki, Shiro ^a   Mellinger, John ^a   Browning, Darren D ^a   Berger, Franklin G ^b   Prasad, Puttur D ^a   Ganapathy, Vadivel ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Colon cancer; Commensal bacteria; Dietary fiber; DNA methylation; Histone deacetylation; Tumor suppression

Indexed keywords

EID: 52549103966     PISSN: 1091255X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11605-008-0573-0     Document Type: Conference Paper

References (31)

1. PB Mortensen MR Clausen 1996 Short-chain fatty acids in the human colon: relation to gastrointestinal health and disease Scand J Gastroenterol 216 132 148
2. DL Topping PM Clifton 2001 Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides Physiol Rev 81 1031 1064
3. P Marks RA Rifkind VM Richon R Breslow T Miller WK Kelly 2001 Histone deacetylases and cancer: causes and therapies Nat Rev Cancer 1 194 202
4. DC Drummond CO Noble DB Kirpotin Z Guo GK Scott CC Benz 2005 Clinical development of histone deacetylase inhibitors as anticancer agents Annu Rev Pharmacol Toxicol 45 495 528
5. +-coupled transporter for short-chain fatty acids J Biol Chem 279 13293 13296
6. +-coupled transport of lactate J Biol Chem 279 44522 44532
7. +-monocarboxylate cotransporter J Physiol 557 719 731
8. +/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: molecular characterization of SMCT Proc Natl Acad Sci U S A 103 7270 7275
9. V Ganapathy E Gopal S Miyauchi PD Prasad 2005 Biological functions of SLC5A8, a candidate tumor suppressor Biochem Soc Trans 33 237 240
10. N Gupta PM Martin PD Prasad V Ganapathy 2006 SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter Life Sci 78 2419 2425
11. VM Rajendran HJ Binder 2000 Characterization and molecular localization of anion transporters in colonic epithelial cells Ann N Y Acad Sci 915 15 29
12. JH Sellin 1999 SCFAs: the enigma of weak electrolyte transport in the colon News Physiol Sci 14 58 64
13. RK Gill S Saksena WA Alrefai Z Sarwar JL Goldstein RE Carroll 2005 Expression and membrane localization of MCT isoforms along the length of the human intestine Am J Physiol Cell Physiol 289 C846 C852
14. A Ritzhaupt IS Wood A Ellis KB Hosie SP Shirazi-Beechey 1998 Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport L-lactate as well as butyrate J Physiol 513 719 732
15. CK Garcia JL Goldstein RK Pathak RG Anderson MS Brown 1994 Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle Cell 76 865 873
16. T Iwanaga K Takebe I Kato S Karaki A Kuwahara 2006 Cellular expression of monocarboxylate transporters (MCT) in the digestive tract of the mouse, rat, and humans, with special reference to slc5a8 Biomed Res 27 243 254
17. +-coupled transporter for short-chain fatty acids (slc5a8) in the intestine and kidney of the mouse Biomed Res 26 213 221
18. E Gopal S Miyauchi PM Martin S Ananth P Roon SB Smith 2007 Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract Pharm Res 24 575 584
19. H Li L Myeroff D Smiraglia MF Romero TP Pretlow L Kasturi 2003 SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers Proc Natl Acad Sci U S A 100 8412 8417
20. 0,+ (SLC6A14) in colorectal cancer and metastasis in humans Biochim Biophys Acta 1741 215 223
21. M Thangaraju E Gopal PM Martin S Ananth SB Smith PD Prasad 2006 SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases Cancer Res 66 11560 11564
22. BH Lee S Yegnasubramanian X Lin WG Nelson 2005 Procainamide is a specific inhibitor of DNA methyltransferase 1 J Biol Chem 280 40749 40756
23. TC He AB Sparks C Rago H Hermeking L Zawel LT da Costa 1998 Identification of c-MYC as a target of the APC pathway Science 281 1509 1512
24. M van de Watering E Sancho C Verweij W de Lau I Oving A Hurlstone 2002 The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells Cell 111 241 250
25. RB Canani G Terrin P Cirillo G Castaldo F Salvatore G Cardillo 2004 Butyrate as an effective treatment of congenital chloride diarrhea Gastroenterology 127 630 634
26. GH Rabbani MJ Albert H Rahman AK Chowdhury 1999 Short-chain fatty acids inhibit fluid and electrolyte loss induced by cholera toxin in proximal colon of rabbit in vivo Dig Dis Sci 44 1547 1553
27. PC Dagher RW Egnor A Taglietta-Kohlbrecher AN Charney 1996 Short-chain fatty acids inhibit cAMP-mediated chloride secretion in rat colon Am J Physiol 27 C1853 C1860
28. 3 secretion Am J Physiol 288 G1217 G1226
29. M Field 2003 Intestinal ion transport and pathophysiology of diarrhea J Clin Invest 111 931 943
30. NK Ganguly T Kaur 1996 Mechanism of action of cholera toxin and other toxins Indian J Med Res 104 28 37
31. RL Guerrant BA Carneiro-Filho RA Dillingham 2003 Cholera, diarrhea, and oral rehydration therapy: triumph and indictment Clin Infect Dis 37 398 405