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Volumn 351, Issue 1, 2014, Pages 30-40

A critical review of HER2-positive gastric cancer evaluation and treatment: From trastuzumab, and beyond

(11)  Gomez Martín, Carlos a,b   Lopez Rios, Fernando b   Aparicio, Jorge c   Barriuso, Jorge d   García Carbonero, Rocio e   Pazo, Roberto f   Rivera, Fernando g   Salgado, Mercedes h   Salud, Antonieta i   Vázquez Sequeiros, Enrique j   Lordick, Florian k  


Author keywords

Gastric cancer; HER2; Review; Trastuzumab

Indexed keywords

CAPECITABINE; CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FLUOROURACIL; LAPATINIB; PERTUZUMAB; TRASTUZUMAB;

EID: 84903710545     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.05.019     Document Type: Review
Times cited : (58)

References (120)
  • 2
    • 80054717683 scopus 로고    scopus 로고
    • The role of chemotherapy in metastatic gastric cancer
    • Pasini F., Fraccon A.P., DE Manzoni G. The role of chemotherapy in metastatic gastric cancer. Anticancer Res. 2011, 31(10):3543-3554.
    • (2011) Anticancer Res. , vol.31 , Issue.10 , pp. 3543-3554
    • Pasini, F.1    Fraccon, A.P.2    De Manzoni, G.3
  • 3
    • 84903723650 scopus 로고    scopus 로고
    • American Cancer Society, Survival Rates for Stomach Cancer by Stage, 2013, (accessed 05.09.13).
    • American Cancer Society, Survival Rates for Stomach Cancer by Stage, 2013, (accessed 05.09.13). http://www.cancer.org/cancer/stomachcancer/detailedguide/stomach-cancer-survival-rates.
  • 6
    • 77956262693 scopus 로고    scopus 로고
    • ToGA Trial Investigators, Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial
    • Bang Y.J., Van Cutsem E., Feyereislova A., Chung H.C., Shen L., Sawaki A., Lordick F., Ohtsu A., Omuro Y., Satoh T., Aprile G., Kulikov E., Hill J., Lehle M., Rüschoff J., Kang Y.K. ToGA Trial Investigators, Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 2010, 376(9742):687-697.
    • (2010) Lancet , vol.376 , Issue.9742 , pp. 687-697
    • Bang, Y.J.1    Van Cutsem, E.2    Feyereislova, A.3    Chung, H.C.4    Shen, L.5    Sawaki, A.6    Lordick, F.7    Ohtsu, A.8    Omuro, Y.9    Satoh, T.10    Aprile, G.11    Kulikov, E.12    Hill, J.13    Lehle, M.14    Rüschoff, J.15    Kang, Y.K.16
  • 7
    • 0024538399 scopus 로고
    • Detection of early gastric cancer in an aggressive endoscopy unit
    • Longo W.E., Zucker K.A., Zdon M.J., Modlin I.M. Detection of early gastric cancer in an aggressive endoscopy unit. Am. Surg. 1989, 55(2):100-104.
    • (1989) Am. Surg. , vol.55 , Issue.2 , pp. 100-104
    • Longo, W.E.1    Zucker, K.A.2    Zdon, M.J.3    Modlin, I.M.4
  • 10
    • 0025801994 scopus 로고
    • Brushing cytology of the upper gastrointestinal tract. obsolete or not?
    • Wang H.H., Jonasson J.G., Ducatman B.S. Brushing cytology of the upper gastrointestinal tract. obsolete or not?. Acta Cytol. 1991, 35(2):195-198.
    • (1991) Acta Cytol. , vol.35 , Issue.2 , pp. 195-198
    • Wang, H.H.1    Jonasson, J.G.2    Ducatman, B.S.3
  • 11
    • 0020047043 scopus 로고
    • Prospective evaluation of biopsy number in the diagnosis of esophageal and gastric carcinoma
    • Graham D.Y., Schwartz J.T., Cain G.D., Gyorkey F. Prospective evaluation of biopsy number in the diagnosis of esophageal and gastric carcinoma. Gastroenterology 1982, 82(2):228-231.
    • (1982) Gastroenterology , vol.82 , Issue.2 , pp. 228-231
    • Graham, D.Y.1    Schwartz, J.T.2    Cain, G.D.3    Gyorkey, F.4
  • 14
    • 82755195152 scopus 로고    scopus 로고
    • Usefulness of magnifying endoscopy with narrow-band imaging for determining the horizontal extent of early gastric cancer when there is an unclear margin by chromoendoscopy (with video)
    • Nagahama T., Yao K., Maki S., Yasaka M., Takaki Y., Matsui T., Tanabe H., Iwashita A., Ota A. Usefulness of magnifying endoscopy with narrow-band imaging for determining the horizontal extent of early gastric cancer when there is an unclear margin by chromoendoscopy (with video). Gastrointest. Endosc. 2011, 74(6):1259-1267.
    • (2011) Gastrointest. Endosc. , vol.74 , Issue.6 , pp. 1259-1267
    • Nagahama, T.1    Yao, K.2    Maki, S.3    Yasaka, M.4    Takaki, Y.5    Matsui, T.6    Tanabe, H.7    Iwashita, A.8    Ota, A.9
  • 15
    • 0027996338 scopus 로고
    • Endoscopic and histologic diagnosis of submucosal tumors of the gastrointestinal tract using combined strip biopsy and bite biopsy
    • Karita M., Tada M. Endoscopic and histologic diagnosis of submucosal tumors of the gastrointestinal tract using combined strip biopsy and bite biopsy. Gastrointest. Endosc. 1994, 40(6):749-753.
    • (1994) Gastrointest. Endosc. , vol.40 , Issue.6 , pp. 749-753
    • Karita, M.1    Tada, M.2
  • 16
  • 17
    • 84903709153 scopus 로고    scopus 로고
    • WHO classification of tumours of the digestive system, in: F.T. Bosman, F. Carneiro, R.H. Hruban, N.D. Theise (Eds.), WHO Classification of Tumours. Fourth Edition. Lyon, France, International Agency for Research in Cancer
    • WHO classification of tumours of the digestive system, in: F.T. Bosman, F. Carneiro, R.H. Hruban, N.D. Theise (Eds.), WHO Classification of Tumours. Fourth Edition. Lyon, France, International Agency for Research in Cancer, 2010, pp. 43.
    • (2010) , pp. 43
  • 18
    • 84903750997 scopus 로고    scopus 로고
    • Herceptin Summary of Product Characteristics. Roche, 2010, (accessed 14.12.13).
    • Herceptin Summary of Product Characteristics. Roche, 2010, (accessed 14.12.13). http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000278/WC500074922.pdf.
  • 20
    • 84857361082 scopus 로고    scopus 로고
    • HER2 status in unusual histological variants of gastric adenocarcinomas
    • Giuffre G., Ieni A., Barresi V., Caruso R.A., Tuccari G. HER2 status in unusual histological variants of gastric adenocarcinomas. J. Clin. Pathol. 2012, 65(3):237-241.
    • (2012) J. Clin. Pathol. , vol.65 , Issue.3 , pp. 237-241
    • Giuffre, G.1    Ieni, A.2    Barresi, V.3    Caruso, R.A.4    Tuccari, G.5
  • 21
    • 79952079704 scopus 로고    scopus 로고
    • HER2 status in gastro-oesophageal adenocarcinomas assessed by two rabbit monoclonal antibodies (SP3 and 4B5) and two in situ hybridization methods (FISH and SISH)
    • Boers J.E., Meeuwissen H., Methorst N. HER2 status in gastro-oesophageal adenocarcinomas assessed by two rabbit monoclonal antibodies (SP3 and 4B5) and two in situ hybridization methods (FISH and SISH). Histopathology 2011, 58(3):383-394.
    • (2011) Histopathology , vol.58 , Issue.3 , pp. 383-394
    • Boers, J.E.1    Meeuwissen, H.2    Methorst, N.3
  • 23
    • 80053201474 scopus 로고    scopus 로고
    • Dual-colour HER2/chromosome 17 chromogenic in situ hybridisation assay enables accurate assessment of HER2 genomic status in gastric cancer and has potential utility in HER2 testing of biopsy samples
    • Yan B., Yau E.X., Choo S.N., Ong C.W., Yong K.J., Pang B., Salto-Tellez M. Dual-colour HER2/chromosome 17 chromogenic in situ hybridisation assay enables accurate assessment of HER2 genomic status in gastric cancer and has potential utility in HER2 testing of biopsy samples. J. Clin. Pathol. 2011, 64(10):880-883.
    • (2011) J. Clin. Pathol. , vol.64 , Issue.10 , pp. 880-883
    • Yan, B.1    Yau, E.X.2    Choo, S.N.3    Ong, C.W.4    Yong, K.J.5    Pang, B.6    Salto-Tellez, M.7
  • 25
    • 79960460895 scopus 로고    scopus 로고
    • Hybridization for human epidermal growth factor receptor 2 testing in gastric carcinoma: a comparison of fluorescence in-situ hybridization with a novel fully automated dual-colour silver in situ hybridization method
    • García-García E., Gómez-Martín C., Angulo B., Conde E., Suárez-Gauthier A., Adrados M., Perna C., Rodríguez-Peralto J.L., Hidalgo M., López-Ríos F. Hybridization for human epidermal growth factor receptor 2 testing in gastric carcinoma: a comparison of fluorescence in-situ hybridization with a novel fully automated dual-colour silver in situ hybridization method. Histopathology 2011, 59(1):8-17.
    • (2011) Histopathology , vol.59 , Issue.1 , pp. 8-17
    • García-García, E.1    Gómez-Martín, C.2    Angulo, B.3    Conde, E.4    Suárez-Gauthier, A.5    Adrados, M.6    Perna, C.7    Rodríguez-Peralto, J.L.8    Hidalgo, M.9    López-Ríos, F.10
  • 26
    • 84860589791 scopus 로고    scopus 로고
    • HER2 amplification in gastroesophageal adenocarcinoma: correlation of two antibodies using gastric cancer scoring criteria H score, and digital image analysis with fluorescence in situ hybridization
    • Radu O.M., Foxwell T., Cieply K., Navina S., Dacic S., Nason K.S., Davison J.M. HER2 amplification in gastroesophageal adenocarcinoma: correlation of two antibodies using gastric cancer scoring criteria H score, and digital image analysis with fluorescence in situ hybridization. Am. J. Clin. Pathol. 2012, 137(4):583-594.
    • (2012) Am. J. Clin. Pathol. , vol.137 , Issue.4 , pp. 583-594
    • Radu, O.M.1    Foxwell, T.2    Cieply, K.3    Navina, S.4    Dacic, S.5    Nason, K.S.6    Davison, J.M.7
  • 29
    • 80052392916 scopus 로고    scopus 로고
    • Study Group HER2 Monitor, quality assessment of HER2 testing by monitoring of positivity rates
    • Choritz H., Busche G., Kreipe H. Study Group HER2 Monitor, quality assessment of HER2 testing by monitoring of positivity rates. Virchows Arch. 2011, 459(3):283-289.
    • (2011) Virchows Arch. , vol.459 , Issue.3 , pp. 283-289
    • Choritz, H.1    Busche, G.2    Kreipe, H.3
  • 31
    • 84855567211 scopus 로고    scopus 로고
    • Intratumoral heterogeneity determines discordant results of diagnostic tests for human epidermal growth factor receptor (HER) 2 in gastric cancer specimens
    • Yang J., Luo H., Li Y., Li J., Cai Z., Su X., Dai D., Du W., Chen T., Chen M. Intratumoral heterogeneity determines discordant results of diagnostic tests for human epidermal growth factor receptor (HER) 2 in gastric cancer specimens. Cell Biochem. Biophys. 2012, 62(1):221-228.
    • (2012) Cell Biochem. Biophys. , vol.62 , Issue.1 , pp. 221-228
    • Yang, J.1    Luo, H.2    Li, Y.3    Li, J.4    Cai, Z.5    Su, X.6    Dai, D.7    Du, W.8    Chen, T.9    Chen, M.10
  • 32
    • 81555209828 scopus 로고    scopus 로고
    • Heterogeneous amplification of ERBB2 in primary lesions is responsible for the discordant ERBB2 status of primary and metastatic lesions in gastric carcinoma
    • Kim M.A., Lee H.J., Yang H.K., Bang Y.J., Kim W.H. Heterogeneous amplification of ERBB2 in primary lesions is responsible for the discordant ERBB2 status of primary and metastatic lesions in gastric carcinoma. Histopathology 2011, 59(5):822-831.
    • (2011) Histopathology , vol.59 , Issue.5 , pp. 822-831
    • Kim, M.A.1    Lee, H.J.2    Yang, H.K.3    Bang, Y.J.4    Kim, W.H.5
  • 33
    • 79956150965 scopus 로고    scopus 로고
    • HER-2 discordance between primary gastric carcinoma and paired lymph node metastasis
    • (author reply 910-911)
    • Negri F.V., Bozzetti C., Ardizzoni A., Lagrasta C., Crafa P., Silini E.M. HER-2 discordance between primary gastric carcinoma and paired lymph node metastasis. Hum. Pathol. 2011, 42(6):909-910. (author reply 910-911).
    • (2011) Hum. Pathol. , vol.42 , Issue.6 , pp. 909-910
    • Negri, F.V.1    Bozzetti, C.2    Ardizzoni, A.3    Lagrasta, C.4    Crafa, P.5    Silini, E.M.6
  • 34
    • 81555209827 scopus 로고    scopus 로고
    • Human epidermal growth factor receptor 2 testing in gastric carcinoma: issues related to heterogeneity in biopsies and resections
    • Lee S., de Boer W.B., Fermoyle S., Platten M., Kumarasinghe M.P. Human epidermal growth factor receptor 2 testing in gastric carcinoma: issues related to heterogeneity in biopsies and resections. Histopathology 2011, 59(5):832-840.
    • (2011) Histopathology , vol.59 , Issue.5 , pp. 832-840
    • Lee, S.1    de Boer, W.B.2    Fermoyle, S.3    Platten, M.4    Kumarasinghe, M.P.5
  • 36
    • 79959734128 scopus 로고    scopus 로고
    • Counterpoint: both immunohistochemistry and fluorescence in situ hybridization play important roles for HER2 evaluation
    • Bloom K.J., Cote R.J. Counterpoint: both immunohistochemistry and fluorescence in situ hybridization play important roles for HER2 evaluation. Clin. Chem. 2011, 57(7):983-985.
    • (2011) Clin. Chem. , vol.57 , Issue.7 , pp. 983-985
    • Bloom, K.J.1    Cote, R.J.2
  • 37
    • 79958793745 scopus 로고    scopus 로고
    • Where and by whom should gastric cancer HER2/neu status be assessed? Lessons from breast cancer
    • Salto-Tellez M., Yau E.X., Yan B., Fox S.B. Where and by whom should gastric cancer HER2/neu status be assessed? Lessons from breast cancer. Arch. Pathol. Lab. Med. 2011, 135(6):693-695.
    • (2011) Arch. Pathol. Lab. Med. , vol.135 , Issue.6 , pp. 693-695
    • Salto-Tellez, M.1    Yau, E.X.2    Yan, B.3    Fox, S.B.4
  • 39
    • 82555194531 scopus 로고    scopus 로고
    • Human epidermal growth factor receptor 2 testing in gastroesophageal cancer: correlation between immunohistochemistry and fluorescence in situ hybridization
    • Tafe L.J., Janjigian Y.Y., Zaidinski M., Hedvat C.V., Hameed M.R., Tang L.H., Hicks J.B., Shah M.A., Barbashina V. Human epidermal growth factor receptor 2 testing in gastroesophageal cancer: correlation between immunohistochemistry and fluorescence in situ hybridization. Arch. Pathol. Lab. Med. 2011, 135(11):1460-1465.
    • (2011) Arch. Pathol. Lab. Med. , vol.135 , Issue.11 , pp. 1460-1465
    • Tafe, L.J.1    Janjigian, Y.Y.2    Zaidinski, M.3    Hedvat, C.V.4    Hameed, M.R.5    Tang, L.H.6    Hicks, J.B.7    Shah, M.A.8    Barbashina, V.9
  • 41
    • 83655163939 scopus 로고    scopus 로고
    • HER2 expression in gastric and gastroesophageal junction adenocarcinoma in a US population: clinicopathologic analysis with proposed approach to HER2 assessment
    • Kunz P.L., Mojtahed A., Fisher G.A., Ford J.M., Chang D.T., Balise R.R., Bangs C.D., Cherry A.M., Pai R.K. HER2 expression in gastric and gastroesophageal junction adenocarcinoma in a US population: clinicopathologic analysis with proposed approach to HER2 assessment. Appl. Immunohistochem. Mol. Morphol. 2012, 20(1):13-24.
    • (2012) Appl. Immunohistochem. Mol. Morphol. , vol.20 , Issue.1 , pp. 13-24
    • Kunz, P.L.1    Mojtahed, A.2    Fisher, G.A.3    Ford, J.M.4    Chang, D.T.5    Balise, R.R.6    Bangs, C.D.7    Cherry, A.M.8    Pai, R.K.9
  • 42
    • 78649959817 scopus 로고    scopus 로고
    • Estrogen and HER-2 receptor discordance between primary breast cancer and metastasis
    • Pusztai L., Viale G., Kelly C.M., Hudis C.A. Estrogen and HER-2 receptor discordance between primary breast cancer and metastasis. Oncologist 2010, 15(11):1164-1168.
    • (2010) Oncologist , vol.15 , Issue.11 , pp. 1164-1168
    • Pusztai, L.1    Viale, G.2    Kelly, C.M.3    Hudis, C.A.4
  • 44
    • 33745547767 scopus 로고    scopus 로고
    • Chemotherapy in advanced gastric cancer: a systematic review and meta-analysis based on aggregate data
    • Wagner A.D., Grothe W., Haerting J., Kleber G., Grothey A., Fleig W.E. Chemotherapy in advanced gastric cancer: a systematic review and meta-analysis based on aggregate data. J. Clin. Oncol. 2006, 24(18):2903-2909.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 , pp. 2903-2909
    • Wagner, A.D.1    Grothe, W.2    Haerting, J.3    Kleber, G.4    Grothey, A.5    Fleig, W.E.6
  • 45
    • 33750949065 scopus 로고    scopus 로고
    • V325 Study Group, Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 study group
    • Van Cutsem E., Moiseyenko V.M., Tjulandin S., Majlis A., Constenla M., Boni C., Rodrigues A., Fodor M., Chao Y., Voznyi E., Risse M.L., Ajani J.A. V325 Study Group, Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 study group. J. Clin. Oncol. 2006, 24(31):4991-4997.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.31 , pp. 4991-4997
    • Van Cutsem, E.1    Moiseyenko, V.M.2    Tjulandin, S.3    Majlis, A.4    Constenla, M.5    Boni, C.6    Rodrigues, A.7    Fodor, M.8    Chao, Y.9    Voznyi, E.10    Risse, M.L.11    Ajani, J.A.12
  • 46
    • 84898771115 scopus 로고    scopus 로고
    • Optimal chemotherapy for advanced gastric cancer: is there a global consensus?
    • September 19 (Epub ahead of print)
    • Lordick F., Lorenzen S., Yamada Y., Ilson D. Optimal chemotherapy for advanced gastric cancer: is there a global consensus?. Gastric Cancer 2013, September 19 (Epub ahead of print).
    • (2013) Gastric Cancer
    • Lordick, F.1    Lorenzen, S.2    Yamada, Y.3    Ilson, D.4
  • 47
    • 38049047178 scopus 로고    scopus 로고
    • Upper Gastrointestinal Clinical Studies Group of the National Cancer Research Institute of the United Kingdom Capecitabine and oxaliplatin for advanced esophagogastric cancer
    • Cunningham D., Starling N., Rao S., Iveson T., Nicolson M., Coxon F., Middleton G., Daniel F., Oates J., Norman A.R. Upper Gastrointestinal Clinical Studies Group of the National Cancer Research Institute of the United Kingdom Capecitabine and oxaliplatin for advanced esophagogastric cancer. New Engl. J. Med. 2008, 358(1):36-46.
    • (2008) New Engl. J. Med. , vol.358 , Issue.1 , pp. 36-46
    • Cunningham, D.1    Starling, N.2    Rao, S.3    Iveson, T.4    Nicolson, M.5    Coxon, F.6    Middleton, G.7    Daniel, F.8    Oates, J.9    Norman, A.R.10
  • 48
    • 48849094297 scopus 로고    scopus 로고
    • Randomized phase III study comparing irinotecan combined with 5-fluorouracil and folinic acid to cisplatin combined with 5-fluorouracil in chemotherapy naive patients with advanced adenocarcinoma of the stomach or esophagogastric junction
    • Dank M., Zaluski J., Barone C., Valvere V., Yalcin S., Peschel C., Wenczl M., Goker E., Cisar L., Wang K., Bugat R. Randomized phase III study comparing irinotecan combined with 5-fluorouracil and folinic acid to cisplatin combined with 5-fluorouracil in chemotherapy naive patients with advanced adenocarcinoma of the stomach or esophagogastric junction. Ann. Oncol. 2008, 19(8):1450-1457.
    • (2008) Ann. Oncol. , vol.19 , Issue.8 , pp. 1450-1457
    • Dank, M.1    Zaluski, J.2    Barone, C.3    Valvere, V.4    Yalcin, S.5    Peschel, C.6    Wenczl, M.7    Goker, E.8    Cisar, L.9    Wang, K.10    Bugat, R.11
  • 49
    • 77951888102 scopus 로고    scopus 로고
    • Multicenter phase III comparison of cisplatin/S-1 with cisplatin/infusional fluorouracil in advanced gastric or gastroesophageal adenocarcinoma study: the FLAGS trial
    • Ajani J.A., Rodriguez W., Bodoky G., Moiseyenko V., Lichinitser M., Gorbunova V., Vynnychenko I., Garin A., Lang I., Falcon S. Multicenter phase III comparison of cisplatin/S-1 with cisplatin/infusional fluorouracil in advanced gastric or gastroesophageal adenocarcinoma study: the FLAGS trial. J. Clin. Oncol. 2010, 28(9):1547-1553.
    • (2010) J. Clin. Oncol. , vol.28 , Issue.9 , pp. 1547-1553
    • Ajani, J.A.1    Rodriguez, W.2    Bodoky, G.3    Moiseyenko, V.4    Lichinitser, M.5    Gorbunova, V.6    Vynnychenko, I.7    Garin, A.8    Lang, I.9    Falcon, S.10
  • 52
    • 77955174673 scopus 로고    scopus 로고
    • Advanced gastric cancer-slow but steady progress
    • Power D.G., Kelsen D.P., Shah M.A. Advanced gastric cancer-slow but steady progress. Cancer Treat. Rev. 2010, 36(5):384-392.
    • (2010) Cancer Treat. Rev. , vol.36 , Issue.5 , pp. 384-392
    • Power, D.G.1    Kelsen, D.P.2    Shah, M.A.3
  • 53
    • 28244462779 scopus 로고    scopus 로고
    • The effectiveness of trastuzumab (herceptin) combined with chemotherapy for gastric carcinoma with overexpression of the c-erbB-2 protein
    • Rebischung C., Barnoud R., Stefani L., Faucheron J.L., Mousseau M. The effectiveness of trastuzumab (herceptin) combined with chemotherapy for gastric carcinoma with overexpression of the c-erbB-2 protein. Gastric Cancer 2005, 8(4):249-252.
    • (2005) Gastric Cancer , vol.8 , Issue.4 , pp. 249-252
    • Rebischung, C.1    Barnoud, R.2    Stefani, L.3    Faucheron, J.L.4    Mousseau, M.5
  • 55
    • 67650395446 scopus 로고    scopus 로고
    • Early results of a trial of trastuzumab, cisplatin and docetaxel (TCD) for the treatment of metastatic gastric cancer overexpressing HER2
    • ix316 (abstract 1105P)
    • Nicholas G., Cripps C., Au H.J., Jonker D., Salim M., Bjarnason G., Chiritescu G. Early results of a trial of trastuzumab, cisplatin and docetaxel (TCD) for the treatment of metastatic gastric cancer overexpressing HER2. Ann. Oncol. 2006, 17(suppl. 9). ix316 (abstract 1105P).
    • (2006) Ann. Oncol. , vol.17 , Issue.SUPPL. 9
    • Nicholas, G.1    Cripps, C.2    Au, H.J.3    Jonker, D.4    Salim, M.5    Bjarnason, G.6    Chiritescu, G.7
  • 56
    • 50849143901 scopus 로고    scopus 로고
    • A pilot study of trastuzumab monotherapy in patients who progressed while on chemotherapy for metastatic or locally advanced HER positive gastric cancer
    • ix314 (abstract 1096P)
    • Rech J., Arnold D., Folprecht G., Hejna M., Hofmann M., Gramatzki M. A pilot study of trastuzumab monotherapy in patients who progressed while on chemotherapy for metastatic or locally advanced HER positive gastric cancer. Ann. Oncol. 2006, 17(suppl. 9). ix314 (abstract 1096P).
    • (2006) Ann. Oncol. , vol.17 , Issue.SUPPL. 9
    • Rech, J.1    Arnold, D.2    Folprecht, G.3    Hejna, M.4    Hofmann, M.5    Gramatzki, M.6
  • 58
    • 20044372721 scopus 로고    scopus 로고
    • Amplification of HER-2 in gastric carcinoma: Association with topoisomerase IIalpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab
    • Tanner M., Hollmén M., Junttila T.T., Kapanen A.I., Tommola S., Soini Y., Helin H., Salo J., Joensuu H., Sihvo E., Elenius K., Isola J. Amplification of HER-2 in gastric carcinoma: Association with topoisomerase IIalpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab. Ann. Oncol. 2005, 16(2):273-278.
    • (2005) Ann. Oncol. , vol.16 , Issue.2 , pp. 273-278
    • Tanner, M.1    Hollmén, M.2    Junttila, T.T.3    Kapanen, A.I.4    Tommola, S.5    Soini, Y.6    Helin, H.7    Salo, J.8    Joensuu, H.9    Sihvo, E.10    Elenius, K.11    Isola, J.12
  • 61
    • 64949201263 scopus 로고    scopus 로고
    • Diffuse type advanced gastric cancer showing dismal prognosis is characterized by deeper invasion and emerging peritoneal cancer cell: the latest comparative study to intestinal advanced gastric cancer
    • Yamashita K., Sakuramoto S., Katada N., Futawatari N., Moriya H., Hirai K., Kikuchi S., Watanabe M. Diffuse type advanced gastric cancer showing dismal prognosis is characterized by deeper invasion and emerging peritoneal cancer cell: the latest comparative study to intestinal advanced gastric cancer. Hepatogastroenterology 2009, 56(89):276-281.
    • (2009) Hepatogastroenterology , vol.56 , Issue.89 , pp. 276-281
    • Yamashita, K.1    Sakuramoto, S.2    Katada, N.3    Futawatari, N.4    Moriya, H.5    Hirai, K.6    Kikuchi, S.7    Watanabe, M.8
  • 62
    • 34547986616 scopus 로고    scopus 로고
    • Prevalence and prognosis of gastric cancer detected by screening in a large japanese population: data from a single institute over 30years
    • Miyahara R., Niwa Y., Matsuura T., Maeda O., Ando T., Ohmiya N., Itoh A., Hirooka Y., Goto H. Prevalence and prognosis of gastric cancer detected by screening in a large japanese population: data from a single institute over 30years. J. Gastroenterol. Hepatol. 2007, 22(9):1435-1442.
    • (2007) J. Gastroenterol. Hepatol. , vol.22 , Issue.9 , pp. 1435-1442
    • Miyahara, R.1    Niwa, Y.2    Matsuura, T.3    Maeda, O.4    Ando, T.5    Ohmiya, N.6    Itoh, A.7    Hirooka, Y.8    Goto, H.9
  • 63
    • 84903695794 scopus 로고    scopus 로고
    • NCCN guidelines version 2.2012 gastric cancer, Principles of Systemic Therapy (GAST-E), 2012, (accessed 16.12.13).
    • NCCN guidelines version 2.2012 gastric cancer, Principles of Systemic Therapy (GAST-E), 2012, (accessed 16.12.13). http://www.nccn.org/professionals/physician_gls/pdf/gastric.pdf.
  • 64
    • 79952216192 scopus 로고    scopus 로고
    • NICE guidance on trastuzumab for the treatment of HER2-positive metastatic gastric cancer
    • Holden J., Garrett Z., Stevens A. NICE guidance on trastuzumab for the treatment of HER2-positive metastatic gastric cancer. Lancet Oncol. 2011, 12(1):16-17.
    • (2011) Lancet Oncol. , vol.12 , Issue.1 , pp. 16-17
    • Holden, J.1    Garrett, Z.2    Stevens, A.3
  • 65
    • 84864649856 scopus 로고    scopus 로고
    • SEOM clinical guidelines for the diagnosis and treatment of gastric adenocarcinoma
    • Rivera F., Gravalos C., Garcia-Carbonero R. SEOM clinical guidelines for the diagnosis and treatment of gastric adenocarcinoma. Clin. Transl. Oncol. 2012, 14(7):528-535.
    • (2012) Clin. Transl. Oncol. , vol.14 , Issue.7 , pp. 528-535
    • Rivera, F.1    Gravalos, C.2    Garcia-Carbonero, R.3
  • 66
    • 77954322183 scopus 로고    scopus 로고
    • ESMO Guidelines Working Group Gastric cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up
    • Okines A., Verheij M., Allum W., Cunningham D., Cervantes A. ESMO Guidelines Working Group Gastric cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 2010, 21(suppl. 5):v50-v54.
    • (2010) Ann. Oncol. , vol.21 , Issue.SUPPL. 5
    • Okines, A.1    Verheij, M.2    Allum, W.3    Cunningham, D.4    Cervantes, A.5
  • 67
    • 84872077784 scopus 로고    scopus 로고
    • Trastuzumab combined with docetaxel-based regimens in previously treated metastatic gastric cancer patients with HER2 over-expression
    • Dai G.H., Shi Y., Chen L., Lv Y.L., Zhong M. Trastuzumab combined with docetaxel-based regimens in previously treated metastatic gastric cancer patients with HER2 over-expression. Hepatogastroenterology 2012, 59(120):2439-2444.
    • (2012) Hepatogastroenterology , vol.59 , Issue.120 , pp. 2439-2444
    • Dai, G.H.1    Shi, Y.2    Chen, L.3    Lv, Y.L.4    Zhong, M.5
  • 68
    • 0343415168 scopus 로고    scopus 로고
    • Relevant prognostic factors in gastric cancer: ten-year results of the German Gastric Cancer Study
    • Siewert J.R., Böttcher K., Stein H.J., Roder J.D. Relevant prognostic factors in gastric cancer: ten-year results of the German Gastric Cancer Study. Ann. Surg. 1998, 228(4):449-461.
    • (1998) Ann. Surg. , vol.228 , Issue.4 , pp. 449-461
    • Siewert, J.R.1    Böttcher, K.2    Stein, H.J.3    Roder, J.D.4
  • 71
    • 41649111490 scopus 로고    scopus 로고
    • Combined lapatinib and cetuximab enhance cytotoxicity against gefitinib-resistant lung cancer cells
    • Kim H.P., Han S.W., Kim S.H., Im S.A., Oh D.Y., Bang Y.J., Kim T.Y. Combined lapatinib and cetuximab enhance cytotoxicity against gefitinib-resistant lung cancer cells. Mol. Cancer Ther. 2008, 7:607-615.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 607-615
    • Kim, H.P.1    Han, S.W.2    Kim, S.H.3    Im, S.A.4    Oh, D.Y.5    Bang, Y.J.6    Kim, T.Y.7
  • 73
    • 80054057131 scopus 로고    scopus 로고
    • Southwest oncology group study S0413: a phase II trial of lapatinib (GW572016) as first-line therapy in patients with advanced or metastatic gastric cancer
    • Iqbal S., Goldman B., Fenoglio-Preiser C.M., Lenz H.J., Zhang W., Danenberg K.D., Shibata S.I., Blanke C.D. Southwest oncology group study S0413: a phase II trial of lapatinib (GW572016) as first-line therapy in patients with advanced or metastatic gastric cancer. Ann. Oncol. 2011, 22(12):2610-2615.
    • (2011) Ann. Oncol. , vol.22 , Issue.12 , pp. 2610-2615
    • Iqbal, S.1    Goldman, B.2    Fenoglio-Preiser, C.M.3    Lenz, H.J.4    Zhang, W.5    Danenberg, K.D.6    Shibata, S.I.7    Blanke, C.D.8
  • 75
    • 84903750280 scopus 로고    scopus 로고
    • A randomized, open-label, phase III study of lapatinib in combination with weekly paclitaxel versus weekly paclitaxel alone in the second-line treatment of HER2 amplified advanced gastric cancer (AGC) in Asian population: Tytan study. ASCO Gastrointestinal Cancers Symposium Abstracts
    • Y.J. Bang, A randomized, open-label, phase III study of lapatinib in combination with weekly paclitaxel versus weekly paclitaxel alone in the second-line treatment of HER2 amplified advanced gastric cancer (AGC) in Asian population: Tytan study. ASCO Gastrointestinal Cancers Symposium Abstracts, vol. 30, 2013 (suppl 34; abstr 11).
    • (2013) , vol.30 , Issue.11 SUPPL. 34
    • Bang, Y.J.1
  • 77
    • 79955475247 scopus 로고    scopus 로고
    • Trastuzumab-DM1 is highly effective in preclinical models of HER2-positive gastric cancer
    • Barok M., Tanner M., Koninki K., Isola J. Trastuzumab-DM1 is highly effective in preclinical models of HER2-positive gastric cancer. Cancer Lett. 2011, 306(2):171-179.
    • (2011) Cancer Lett. , vol.306 , Issue.2 , pp. 171-179
    • Barok, M.1    Tanner, M.2    Koninki, K.3    Isola, J.4
  • 78
    • 84863169318 scopus 로고    scopus 로고
    • Evaluation of the antitumor effects and mechanisms of PF00299804, a pan-HER inhibitor, alone or in combination with chemotherapy or targeted agents in gastric cancer
    • Nam H.J., Ching K.A., Kan J., Kim H.P., Han S.W., Im S.A., Kim T.Y., Christensen J.G., Oh D.Y., Bang Y.J. Evaluation of the antitumor effects and mechanisms of PF00299804, a pan-HER inhibitor, alone or in combination with chemotherapy or targeted agents in gastric cancer. Mol. Cancer Ther. 2012, 11(2):439-451.
    • (2012) Mol. Cancer Ther. , vol.11 , Issue.2 , pp. 439-451
    • Nam, H.J.1    Ching, K.A.2    Kan, J.3    Kim, H.P.4    Han, S.W.5    Im, S.A.6    Kim, T.Y.7    Christensen, J.G.8    Oh, D.Y.9    Bang, Y.J.10
  • 79
    • 79951580512 scopus 로고    scopus 로고
    • Antitumor activity of HM781-36B, an irreversible pan-HER inhibitor, alone or in combination with cytotoxic chemotherapeutic agents in gastric cancer
    • Nam H.J., Kim H.P., Yoon Y.K., Hur H.S., Song S.H., Kim M.S., Lee G.S., Han S.W., Im S.A., Kim T.Y., Oh D.Y., Bang Y.J. Antitumor activity of HM781-36B, an irreversible pan-HER inhibitor, alone or in combination with cytotoxic chemotherapeutic agents in gastric cancer. Cancer Lett. 2011, 302(2):155-165.
    • (2011) Cancer Lett. , vol.302 , Issue.2 , pp. 155-165
    • Nam, H.J.1    Kim, H.P.2    Yoon, Y.K.3    Hur, H.S.4    Song, S.H.5    Kim, M.S.6    Lee, G.S.7    Han, S.W.8    Im, S.A.9    Kim, T.Y.10    Oh, D.Y.11    Bang, Y.J.12
  • 80
    • 84873525706 scopus 로고    scopus 로고
    • A phase II open-label trial of dacomitinib monotherapy in patients with HER2-positive advanced gastric cancer after failure of at least one prior chemotherapy regimen
    • D. Oh, K. Lee, J.Y. Cho, W.K. Kang, S.Y. Rha, Y. Bang, A phase II open-label trial of dacomitinib monotherapy in patients with HER2-positive advanced gastric cancer after failure of at least one prior chemotherapy regimen, ASCO Meeting Abstracts, vol. 30(4_suppl), 2012, pp. 54.
    • (2012) ASCO Meeting Abstracts , vol.30 , Issue.4 SUPPL. , pp. 54
    • Oh, D.1    Lee, K.2    Cho, J.Y.3    Kang, W.K.4    Rha, S.Y.5    Bang, Y.6
  • 81
    • 84873521765 scopus 로고    scopus 로고
    • A phase II study of afatinib (BIBW 2992) in patients with advanced HER2-positive trastuzumab-refractory esophagogastric cancer
    • Y.Y. Janjigian, D. Ilson, D.P. Kelsen, M. Schattner, A. Heguy, E. Vakiani, A phase II study of afatinib (BIBW 2992) in patients with advanced HER2-positive trastuzumab-refractory esophagogastric cancer, ASCO Meeting Abstracts, vol. 30(15_suppl), 2012, pp. TPS4144.
    • (2012) ASCO Meeting Abstracts , vol.30 , Issue.15 SUPPL. , pp. 4144
    • Janjigian, Y.Y.1    Ilson, D.2    Kelsen, D.P.3    Schattner, M.4    Heguy, A.5    Vakiani, E.6
  • 82
    • 77649162889 scopus 로고    scopus 로고
    • Lapatinib, a dual EGFR and HER2 kinase inhibitor, selectively inhibits HER2-amplified human gastric cancer cells and is synergistic with trastuzumab in vitro and in vivo
    • Wainberg Z.A., Anghel A., Desai A.J., Ayala R., Luo T., Safran B., Fejzo M.S., Hecht J.R., Slamon D.J., Finn R.S. Lapatinib, a dual EGFR and HER2 kinase inhibitor, selectively inhibits HER2-amplified human gastric cancer cells and is synergistic with trastuzumab in vitro and in vivo. Clin. Cancer Res. 2010, 16(5):1509-1519.
    • (2010) Clin. Cancer Res. , vol.16 , Issue.5 , pp. 1509-1519
    • Wainberg, Z.A.1    Anghel, A.2    Desai, A.J.3    Ayala, R.4    Luo, T.5    Safran, B.6    Fejzo, M.S.7    Hecht, J.R.8    Slamon, D.J.9    Finn, R.S.10
  • 83
  • 87
    • 79960972076 scopus 로고    scopus 로고
    • Pertuzumab in combination with trastuzumab shows significantly enhanced antitumor activity in HER2-positive human gastric cancer xenograft models
    • Yamashita-Kashima Y., Iijima S., Yorozu K., Furugaki K., Kurasawa M., Ohta M., Fujimoto-Ouchi K. Pertuzumab in combination with trastuzumab shows significantly enhanced antitumor activity in HER2-positive human gastric cancer xenograft models. Clin. Cancer Res. 2011, 17(15):5060-5070.
    • (2011) Clin. Cancer Res. , vol.17 , Issue.15 , pp. 5060-5070
    • Yamashita-Kashima, Y.1    Iijima, S.2    Yorozu, K.3    Furugaki, K.4    Kurasawa, M.5    Ohta, M.6    Fujimoto-Ouchi, K.7
  • 88
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin D.A., Sabatini D.M. Defining the role of mTOR in cancer. Cancer Cell 2007, 12(1):9-22.
    • (2007) Cancer Cell , vol.12 , Issue.1 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 94
    • 0036145250 scopus 로고    scopus 로고
    • P53 mutation pattern and expression of c-erbB2 and c-met in gastric cancer: relation to histological subtypes, helicobacter pylori infection, and prognosis
    • Kubicka S., Claas C., Staab S., Kühnel F., Zender L., Trautwein C., Wagner S., Rudolph K.L., Manns M. P53 mutation pattern and expression of c-erbB2 and c-met in gastric cancer: relation to histological subtypes, helicobacter pylori infection, and prognosis. Dig. Dis. Sci. 2002, 47(1):114-121.
    • (2002) Dig. Dis. Sci. , vol.47 , Issue.1 , pp. 114-121
    • Kubicka, S.1    Claas, C.2    Staab, S.3    Kühnel, F.4    Zender, L.5    Trautwein, C.6    Wagner, S.7    Rudolph, K.L.8    Manns, M.9
  • 95
    • 84859377144 scopus 로고    scopus 로고
    • MET activation mediates resistance to lapatinib inhibition of HER2-amplified gastric cancer cells
    • Chen C.T., Kim H., Liska D., Gao S., Christensen J.G., Weiser M.R. MET activation mediates resistance to lapatinib inhibition of HER2-amplified gastric cancer cells. Mol. Cancer Ther. 2012, 11(3):660-669.
    • (2012) Mol. Cancer Ther. , vol.11 , Issue.3 , pp. 660-669
    • Chen, C.T.1    Kim, H.2    Liska, D.3    Gao, S.4    Christensen, J.G.5    Weiser, M.R.6
  • 96
    • 84866738718 scopus 로고    scopus 로고
    • Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks
    • Kataoka Y., Mukohara T., Tomioka H., Funakoshi Y., Kiyota N., Fujiwara Y., Yashiro M., Hirakawa K., Hirai M., Minami H. Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks. Invest. New Drugs 2012, 30(4):1352-1360.
    • (2012) Invest. New Drugs , vol.30 , Issue.4 , pp. 1352-1360
    • Kataoka, Y.1    Mukohara, T.2    Tomioka, H.3    Funakoshi, Y.4    Kiyota, N.5    Fujiwara, Y.6    Yashiro, M.7    Hirakawa, K.8    Hirai, M.9    Minami, H.10
  • 98
    • 84899992807 scopus 로고    scopus 로고
    • Evaluation of MET pathway biomarkers in a phase II study of rilotumumab (R, AMG 102) or placebo (P) in combination with epirubicin, cisplatin, and capecitabine (ECX) in patients (pts) with locally advanced or metastatic gastric (G) or esophagogastric junction (EGJ) cancer
    • (suppl; abstr 4005)
    • Iveson T. Evaluation of MET pathway biomarkers in a phase II study of rilotumumab (R, AMG 102) or placebo (P) in combination with epirubicin, cisplatin, and capecitabine (ECX) in patients (pts) with locally advanced or metastatic gastric (G) or esophagogastric junction (EGJ) cancer. J. Clin. Oncol. 2012, 30. (suppl; abstr 4005).
    • (2012) J. Clin. Oncol. , vol.30
    • Iveson, T.1
  • 101
    • 3042622482 scopus 로고    scopus 로고
    • HER2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissues
    • Owens M.A., Horten B.C., Da Silva M.M. HER2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissues. Clin. Breast Cancer 2004, 5(1):63-69.
    • (2004) Clin. Breast Cancer , vol.5 , Issue.1 , pp. 63-69
    • Owens, M.A.1    Horten, B.C.2    Da Silva, M.M.3
  • 104
    • 50849123421 scopus 로고    scopus 로고
    • HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target
    • Gravalos C., Jimeno A. HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target. Ann. Oncol. 2008, 19(9):1523-1529.
    • (2008) Ann. Oncol. , vol.19 , Issue.9 , pp. 1523-1529
    • Gravalos, C.1    Jimeno, A.2
  • 105
    • 79952161741 scopus 로고    scopus 로고
    • Trastuzumab: a new treatment option for HER2-positive metastatic gastric and gastroesophageal junction cancer
    • Lordick F. Trastuzumab: a new treatment option for HER2-positive metastatic gastric and gastroesophageal junction cancer. Future Oncol. 2011, 7(2):187-199.
    • (2011) Future Oncol. , vol.7 , Issue.2 , pp. 187-199
    • Lordick, F.1
  • 106
    • 84871229995 scopus 로고    scopus 로고
    • Trastuzumab: updated mechanisms of action and resistance in breast cancer
    • Vu T., Claret F.X. Trastuzumab: updated mechanisms of action and resistance in breast cancer. Front Oncol. 2012, 2:62.
    • (2012) Front Oncol. , vol.2 , pp. 62
    • Vu, T.1    Claret, F.X.2
  • 107
    • 35548932394 scopus 로고    scopus 로고
    • E-cadherin and hereditary diffuse gastric cancer
    • Pedrazzani C., Corso G., Marrelli D., Roviello F. E-cadherin and hereditary diffuse gastric cancer. Surgery 2007, 142(5):645-657.
    • (2007) Surgery , vol.142 , Issue.5 , pp. 645-657
    • Pedrazzani, C.1    Corso, G.2    Marrelli, D.3    Roviello, F.4
  • 112
    • 84860595433 scopus 로고    scopus 로고
    • UKNEQAS, HER2 gene amplification in breast cancer: a rogues' gallery of challenging diagnostic cases: UKNEQAS interpretation guidelines and research recommendations
    • Starczynski J., Atkey N., Connelly Y., O'Grady T., Campbell F.M., di Palma S., Wencyk P., Jasani B., Gandy M., Bartlett J.M. UKNEQAS, HER2 gene amplification in breast cancer: a rogues' gallery of challenging diagnostic cases: UKNEQAS interpretation guidelines and research recommendations. Am. J. Clin. Pathol. 2012, 137(4):595-605.
    • (2012) Am. J. Clin. Pathol. , vol.137 , Issue.4 , pp. 595-605
    • Starczynski, J.1    Atkey, N.2    Connelly, Y.3    O'Grady, T.4    Campbell, F.M.5    di Palma, S.6    Wencyk, P.7    Jasani, B.8    Gandy, M.9    Bartlett, J.M.10
  • 113
    • 45149133723 scopus 로고    scopus 로고
    • Evaluation of and quality assurance in HER2 analysis in breast carcinomas from patients registered in danish breast cancer group (DBCG) in the period of 2002-2006. A nationwide study including correlation between HER-2 status and other prognostic variables
    • Rasmussen B.B., Andersson M., Christensen I.J., Moller S. Evaluation of and quality assurance in HER2 analysis in breast carcinomas from patients registered in danish breast cancer group (DBCG) in the period of 2002-2006. A nationwide study including correlation between HER-2 status and other prognostic variables. Acta Oncol. 2008, 47(4):784-788.
    • (2008) Acta Oncol. , vol.47 , Issue.4 , pp. 784-788
    • Rasmussen, B.B.1    Andersson, M.2    Christensen, I.J.3    Moller, S.4
  • 117
    • 84862882707 scopus 로고    scopus 로고
    • HER2 amplification status in gastric and gastro-oesophageal junction cancer in routine clinical practice: which sample should be used?
    • Perrone G., Amato M., Callea M., Rabitti C., Righi D., Crucitti P., Coppola R., Onetti Muda A. HER2 amplification status in gastric and gastro-oesophageal junction cancer in routine clinical practice: which sample should be used?. Histopathology 2012, 61(1):134-135.
    • (2012) Histopathology , vol.61 , Issue.1 , pp. 134-135
    • Perrone, G.1    Amato, M.2    Callea, M.3    Rabitti, C.4    Righi, D.5    Crucitti, P.6    Coppola, R.7    Onetti Muda, A.8


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