The expression and significance of NLRP3 inflammasome in patients with primary glomerular diseases

Kidney and Blood Pressure Research

Volumn 40, Issue 4, 2015, Pages 344-354

  Xiong, Jing ^a   Wang, Yang ^a   Shao, Ning ^b   Gao, Pao ^a   Tang, Hui ^a   Su, Hua ^a   Zhang, Chun ^a   Meng, Xian Fang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b First People's Hospital of Tianmen   (China)

Author keywords

Glomerular diseases; NLRP3 inflammasome; Podocyte

Indexed keywords

CYCLOPHOSPHAMIDE; CYCLOSPORIN; DESMIN; GLUCOCORTICOID; GLYCOSIDE; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LEFLUNOMIDE; NEPHRIN; NOD LIKE RECEPTOR FAMILY PYRIN DOMAIN CONTAINING 3 INFLAMMASOME; TACROLIMUS; UNCLASSIFIED DRUG; CARRIER PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; NLRP3 PROTEIN, HUMAN;

ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL ASSESSMENT; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE SEVERITY; END STAGE RENAL DISEASE; ENZYME ACTIVATION; FEMALE; FROZEN SECTION; GENE EXPRESSION; GLOMERULONEPHRITIS; GLOMERULUS FILTRATION RATE; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY PARENCHYMA; MALE; PATHOGENESIS; PODOCYTE; PRIMARY GLOMERULONEPHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; PROTEINURIA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; BIOSYNTHESIS; CHEMISTRY; CHINA; ENZYMOLOGY; FOCAL GLOMERULOSCLEROSIS; GENETICS; KIDNEY; KIDNEY FUNCTION TEST; METABOLISM; MIDDLE AGED; PATHOLOGY; RETROSPECTIVE STUDY;

ADULT; CARRIER PROTEINS; CASPASE 1; CHINA; DESMIN; FEMALE; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; KIDNEY; KIDNEY FUNCTION TESTS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; PODOCYTES; PROTEINURIA; RETROSPECTIVE STUDIES; RNA, MESSENGER;

EID: 84936971590     PISSN: 14204096     EISSN: 14230143     Source Type: Journal    
DOI: 10.1159/000368511     Document Type: Article

References (19)

1. Zhang L, Wang F, Wang L, Wang W, Liu B, Liu J, Chen M, He Q, Liao Y, Yu X, Chen N, Zhang JE, Hu Z, Liu F, Hong D, Ma L, Liu H, Zhou X, Chen J, Pan L, Chen W, Li X, Wang H: Prevalence of chronic kidney disease in china: A cross-sectional survey. Lancet 2012;379:815-822.
2. Li Zuo, Mei Wang: Current burdern of ESRD in China and it is estimated to be increasing faster in the near future. Chin J Blood Purif 2010;9:47-49.
3. Wen H, Ting JP, O'Neill LA: A role for the nlrp3 inflammasome in metabolic diseases-did warburg miss inflammation? Nat Immunol 2012;13:352-357.
4. Strowig T, Henao-Mejia J, Elinav E, Flavell R: Inflammasomes in health and disease. Nature 2012;481:278-286.
5. Martinon F, Mayor A, Tschopp J: The inflammasomes: Guardians of the body. Annu Rev Immunol 2009;27:229-265.
6. Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nunez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E: Nlrp3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 2010;464:1357-1361.
7. Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, Fitzgerald KA, Latz E, Moore KJ, Golenbock DT: The nalp3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol 2008;9:857-865.
8. Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J: Gout-associated uric acid crystals activate the nalp3 inflammasome. Nature 2006;440:237-241.
9. Rathinam VA, Vanaja SK, Fitzgerald KA: Regulation of inflammasome signaling. Nat Immunol 2012;13:333-342.
10. Vilaysane A, Chun J, Seamone ME, Wang W, Chin R, Hirota S, Li Y, Clark SA, Tschopp J, Trpkov K, Hemmelgarn BR, Beck PL, Muruve DA: The nlrp3 inflammasome promotes renal inflammation and contributes to ckd. J Am Soc Nephrol 2010;21:1732-1744.
11. Kim SM, Lee SH, Kim YG, Kim SY, Seo JW, Choi YW, Kim DJ, Jeong KH, Lee TW, Ihm CG, Won KY, Moon JY: Hyperuricemia-induced nlrp3 activation of macrophage contributes to the progression of diabetic nephropathy. Am J Physiol Renal Physiol 2015;308:F993-F1003.
12. Shahzad K, Bock F, Dong W, Wang H, Kopf S, Kohli S, Al-Dabet MM, Ranjan S, Wolter J, Wacker C, Biemann R, Stoyanov S, Reymann K, Soderkvist P, Gross O, Schwenger V, Pahernik S, Nawroth PP, Grone HJ, Madhusudhan T, Isermann B: Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy. Kidney Int 2015;87:74-84.
13. Raij L, Azar S, Keane WF: Role of hypertension in progressive glomerular immune injury. Hypertension 1985;7:398-404.
14. Xia M, Zhang C, Boini KM, Thacker AM, Li PL: Membrane raft-lysosome redox signalling platforms in coronary endothelial dysfunction induced by adipokine visfatin. Cardiovasc Res 2011;89:401-409.
15. Mariathasan S, Newton K, Monack DM, Vucic D, French DM, Lee WP, Roose-Girma M, Erickson S, Dixit VM: Differential activation of the inflammasome by caspase-1 adaptors asc and ipaf. Nature 2004;430:213-218.
16. Xia M, Conley SM, Li G, Li PL, Boini KM: Inhibition of hyperhomocysteinemia-induced inflammasome activation and glomerular sclerosis by nlrp3 gene deletion. Cell Physiol Biochem 2014;34:829-841.
17. Boini KM, Xia M, Abais JM, Li G, Pitzer AL, Gehr TW, Zhang Y, Li PL: Activation of inflammasomes in podocyte injury of mice on the high fat diet: Effects of asc gene deletion and silencing. Biochim Biophys Acta 2014;1843:836-845.
18. Zhang C, Boini KM, Xia M, Abais JM, Li X, Liu Q, Li PL: Activation of nod-like receptor protein 3 inflammasomes turns on podocyte injury and glomerular sclerosis in hyperhomocysteinemia. Hypertension 2012;60:154-162.
19. Shigeoka AA, Mueller JL, Kambo A, Mathison JC, King AJ, Hall WF, Correia Jda S, Ulevitch RJ, Hoffman HM, McKay DB: An inflammasome-independent role for epithelial-expressed nlrp3 in renal ischemiareperfusion injury. J Immunol 2010;185:6277-6285.