Effects of Vitamin K on Matrix Metalloproteinase-3 and Rheumatoid Factor in Women with Rheumatoid Arthritis: A Randomized, Double-Blind, Placebo-Controlled Trial

Journal of the American College of Nutrition

Volumn 35, Issue 5, 2016, Pages 392-398

  Shishavan, Neda Ghamarzad ^a,b   Gargari, Bahram Pourghassem ^a   Kolahi, Sousan ^c   Hajialilo, Mehrzad ^c   Jafarabadi, Mohammad Asghari ^d   Javadzadeh, Yousef ^b  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

matrix metalloproteinase 3; phylloquinone; rheumatoid arthritis; rheumatoid factor; vitamin K

Indexed keywords

PHYTOMENADIONE; RHEUMATOID FACTOR; STROMELYSIN; VITAMIN K GROUP; BIOLOGICAL MARKER; MMP3 PROTEIN, HUMAN; PLACEBO;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DIETARY INTAKE; DOUBLE BLIND PROCEDURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; JOINT DESTRUCTION; PROTHROMBIN TIME; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID ARTHRITIS; VITAMIN SUPPLEMENTATION; ARTHRITIS, RHEUMATOID; BLOOD; JOINT; MIDDLE AGED; PATHOPHYSIOLOGY;

ADULT; ARTHRITIS, RHEUMATOID; BIOMARKERS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; JOINTS; MATRIX METALLOPROTEINASE 3; MIDDLE AGED; PLACEBOS; RHEUMATOID FACTOR; VITAMIN K 1;

EID: 84936970704     PISSN: 07315724     EISSN: 15411087     Source Type: Journal    
DOI: 10.1080/07315724.2015.1026004     Document Type: Article

References (33)

1. H.Smith, A.Smith, P.Seidner: Painful rheumatoid arthritis. Pain Physician 14:E427–458, 2011.
2. I.Tchetverikov, L.R.Lard, J.DeGroot, N.Verzijl, J.M.TeKoppele, F.C.Breedveld, T.W.Huizinga, R.Hanemaaijer: Matrix metalloproteinases-3, -8, -9 as markers of disease activity and joint damage progression in early rheumatoid arthritis. Ann Rheum Dis 62:1094–1099, 2003.
3. P.Burrage, K.Mix, C.Brinckerhoff: Matrix metalloproteinases: Role in arthritis. Front Biosci 11:529–543, 2006.
4. A.I.Catrina, J.Lampa, S.Ernestam, E.af Klint, J.Bratt, L.Klareskog, A.K.Ulfgren: Anti-tumour necrosis factor (TNF)-alpha therapy (etanercept) down-regulates serum matrix metalloproteinase (MMP)-3 and MMP-1 in rheumatoid arthritis. Rheumatology (Oxford) 41:484–489, 2002.
5. R.Simmonds, B.Foxwell: Signalling, inflammation and arthritis: NF-kappaB and its relevance to arthritis and inflammation. Rheumatology (Oxford) 47:584–590, 2008.
6. D.Scott, F.Wolfe, T.Huizinga: The Lancet Seminar: Rheumatoid arthritis. Lancet 376:1094–1108, 2010.
7. C.Ribbens, Y.Martin, M.Porras, N.Franchimont, M.J.Kaiser, J.M.Jaspar, P.Damas, F.A.Houssiau, M.G.Malaise: Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment. Ann Rheum Dis 61:161–166, 2002.
8. Y.Song, E.Kang: Autoantibodies in rheumatoid arthritis: Rheumatoid factors and anticitrullinated protein antibodies. QJM 103:139–146, 2010.
9. G.Steiner, J.Smolen: Autoantibodies in rheumatoid arthritis and their clinical significance. Arthritis Res Ther 4:S1–S5, 2002.
10. Y.Mizushina, J.Maeda, Y.Irino, M.Nishida, S.Nishiumi, Y.Kondo, K.Nishio, K.Kuramochi, K.Tsubaki, I.Kuriyama, T.Azuma, H.Yoshida, M.Yoshida: Effects of intermediates between vitamins K2 and K3 on mammalian DNA polymerase inhibition and anti-inflammatory activity. Int J Mol Sci 12:1115–1132, 2011.
11. Y.Ohsaki, H.Shirakawa, K.Hiwatashi, Y.Furukawa, T.Mizutani, M.Komai: Vitamin K suppresses lipopolysaccharide-induced inflammation in the rat. Biosci Biotechnol Biochem 70:926–932, 2006.
12. Y.Ohsaki, H.Shirakawa, A.Miura, P.E.Giriwono, S.Sato, A.Ohashi, M.Iribe, T.Goto, M.Komai: Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the inhibition of the activation of nuclear factor κB through the repression of IKKα/β phosphorylation. J Nutr Biochem 21:1120–1126, 2010.
13. M.K.Shea, S.L.Booth, J.M.Massaro, P.F.Jacques, R.B.D'AgostinoSr, B.Dawson-Hughes, J.M.Ordovas, C.J.O'Donnell, S.Kathiresan, J.F.KeaneyJr, R.S.Vasan, E.J.Benjamin: Vitamin K and vitamin D status: Associations with inflammatory markers in the Framingham Offspring Study. Am J Epidemiol 167:313–320, 2008.
14. H.Okamato: Vitamin K and rheumatoid arthritis. IUBMB Life 60:355–361, 2008.
15. S.Tanaka, S.Nishiumi, M.Nishida, Y.Mizushina, K.Kobayashi, A.Masuda, T.Fujita, Y.Morita, S.Mizuno, H.Kutsumi, T.Azuma, M.Yoshida: Vitamin K3 attenuates lipopolysaccharide-induced acute lung injury through inhibition of nuclear factor-KB activation. Clin Exp Immunol 160:283–292, 2010.
16. M.K.Shea, G.E.Dallal, B.Dawson-Hughes, J.M.Ordovas, C.J.O'Donnell, C.M.Gundberg, J.W.Peterson, S.L.Booth: Vitamin K, circulating cytokines, and bone mineral density in older men and women. Am J Clin Nutr 88:356–363, 2008.
17. S.Bügel, A.D.Sørensen, O.Hels, M.Kristensen, C.Vermeer, J.Jakobsen, A.Flynn, C.Mølgaard, K.D.Cashman. Effect of phylloquinone supplementation on biochemical markers of vitamin K status and bone turnover in postmenopausal women. Br J Nutr 97:373–380, 2007.
18. H.Okamoto, K.Shidara, D.Hoshi, N.Kamatani. Anti-arthritis effects of vitamin K(2) (menaquinone-4)–a new potential therapeutic strategy for rheumatoid arthritis. FEBS J 274:4588–4594, 2007.
19. M.Kristensen, J.Kudsk, S.Bügel: Six weeks phylloquinone supplementation produces undesirable effects on blood lipids with no changes in inflammatory and fibrinolytic markers in postmenopausal women. Eur J Nutr 47:375–379, 2008.
20. G.Wells, J.C.Becker, J.Teng, M.Dougados, M.Schiff, J.Smolen, D.Aletaha, P.L.van Riel: Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythrocyte sedimentation rate. Ann Rheum Dis 68:954–960, 2009.
21. K.Ebina, K.Shi, M.Hirao, S.Kaneshiro, T.Morimoto, K.Koizumi, H.Yoshikawa, J.Hashimoto: Vitamin K2 administration is associated with decreased disease activity in patients with rheumatoid arthritis. Mod Rheumatol 23:1001–1007, 2013.
22. L.Braam, M.Knapen, P.Geusens, F.Brouns, C.Vermeer. Factors affecting bone loss in female endurance athletes: A two-year follow-up study. Am J Sports Med 31:889–895, 2003.
23. A.Craciun, J.Wolf, M.Knapen, F.Brouns, C.Vermeer: Improved bone metabolism in female elite athletes after vitamin K supplementation. Int J Sports Med 19:479–484, 1998.
24. M.Gallagher: The nutrients and their metabolism. In K.Mahan, S.Escott-Stump, (eds): “Krause's food and nutrition therapy,” 12th ed. St. Louis, MO: Elsevier Health Sciences, pp 80–81, 2012.
25. A.Liacini, J.Sylvester, W.Li, M.Zafarullah: Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes. Matrix Biol 21:251–262, 2002.
26. K.Ahn, B.Aggarwal: Transcription factor NF-κB: A sensor for smoke and stress signals. Ann NY Acad Sci 1056:218–233, 2005.
27. F.Mohammed, D.Smookler, R.Khokha: Metalloproteinases, inflammation, and rheumatoid arthritis. Ann Rheum Dis 62:ii43–ii47, 2003.
28. T.Iwamoto, H.Okamoto, Y.Toyama, S.Momohara: Molecular aspects of rheumatoid arthritis: Chemokines in the joints of patients. FEBS J 275:4448–4455, 2008.
29. T.Sen, A.Dutta, A.Chatterjee: Epigallocatechin-3-gallate (EGCG) downregulates gelatinase-B (MMP-9) by involvement of FAK/ERK/NFkappaB and AP-1 in the human breast cancer cell line MDA-MB-231. Anticancer Drugs 21:632–644, 2010.
30. H.Marotte, P.Farge, P.Gaudin, C.Alexandre, B.Mougin, P.Miossec: The association between periodontal disease and joint destruction in rheumatoid arthritis extends the link between the HLA-DR shared epitope and severity of bone destruction. Ann Rheum Dis 65:905–609, 2006.
31. M.de Smit, J.Westra, A.Vissink, B.Doornbos-van der Meer, E.Brouwer, A.van Winkelhoff: Periodontitis in established rheumatoid arthritis patients: A cross-sectional clinical, microbiological and serological study. Arthritis Res Ther 14:R222, 2012.
32. M.Ogrendik, S.Kokino, F.Ozdemir, P.Bird, S.Hamlet: Serum antibodies to oral anaerobic bacteria in patients with rheumatoid arthritis. MedGenMed 7:2, 2005.
33. J.Loyola-Rodriguez, R.Martinez-Martinez, C.Abud-Mendoza, N.Patiño-Marin, G.Seymour: Rheumatoid arthritis and the role of oral bacteria. J Oral Microbiol 2:1–8, 2010.Received January 14, 2015; accepted March 2, 2015.