Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the inhibition of the activation of nuclear factor αB through the repression of IKKα/β phosphorylation

Journal of Nutritional Biochemistry

Volumn 21, Issue 11, 2010, Pages 1120-1126

  Ohsaki, Yusuke ^a   Shirakawa, Hitoshi ^a   Miura, Akihito ^a   Giriwono, Puspo E ^a   Sato, Shoko ^a   Ohashi, Ai ^a   Iribe, Maiko ^a   Goto, Tomoko ^a   Komai, Michio ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Anti inflammation; IKK; Macrophage; Nuclear factor B; Vitamin K

Indexed keywords

2 METHYL 1,4 NAPHTOQUINONE; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MENAQUINONE; MENATETRENONE; UNCLASSIFIED DRUG; VITAMIN K GROUP; WARFARIN;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; ISOPRENYLATION; MACROPHAGE; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

1-CARBOXYGLUTAMIC ACID; ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOTTING, WESTERN; CELL LINE; CYTOKINES; HUMANS; I-KAPPA B KINASE; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; NF-KAPPA B; PHOSPHORYLATION; RNA, MESSENGER; VITAMIN K;

MAMMALIA; RATTUS;

EID: 77958151829     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2009.09.011     Document Type: Article

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